Cited by 66Cancer-related molecular mechanisms researchRNA modifications and cancerFerroptosis and cancer prognosis

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Long non-coding RNA in lung cancer

Chen, Zhenyao, Lei, Tianyao, Chen, Xin, Gu, Jingyao, Huang, Jiali, Lu, Binbin, Wang, Zhaoxia·2020·Clinica Chimica Acta

DOI 10.1016/j.cca.2019.11.031

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Abstract

Lung cancer is the leading cause of cancer-related death worldwide. Owing to the difficulty in early diagnosis and the lack of effective treatment strategies, the 5-year survival rates for lung cancer remain very low. With the development of whole genome and transcriptome sequencing technology, long non-coding RNA (lncRNA) has attracted increasing attention. LncRNAs regulate gene expression at the epigenetic, transcriptional and post-transcriptional levels and are widely involved in a variety of diseases, including tumorigenesis. In lung cancer studies, multiple differentially expressed lncRNAs have been identified; several lncRNAs were identified as oncogenic lncRNAs with tumor-driving effects, while other lncRNAs play a role in tumor inhibition and are called tumor-suppressive lncRNAs. These tumor-suppressive lncRNAs are involved in multiple physiological processes such as cell proliferation, apoptosis, and metastasis and thus participate in tumor progression. In this review, we discussed the oncogenic and tumor-suppressive lncRNAs in lung cancer, as well as their biological functions and regulatory mechanisms. Furthermore, we found the potential significance of lncRNAs in clinical diagnosis and treatment.

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See all 66

Authors: Chen, Z., Lei, T., Chen, X., Gu, J., Huang, J., Lu, B., & Wang, Z.
Affiliations: Second Affiliated Hospital of Nanjing Medical University (CN)
Corresponding author: Lu, Binbin
Wang, Zhaoxia
ORCID: Chen, Zhenyao
Chen, Xin
Wang, Zhaoxia
Venue: Clinica Chimica Acta
Publisher: Elsevier BV
Published: 2020-05
Volume: 504
Pages: 190-200
ISSN: 0009-8981 (ISSN-L)
DOI: 10.1016/j.cca.2019.11.031
OpenAlex: W2990143159
Cited by: 65
References: 171
Citations by year: 2026: 2 · 2025: 8 · 2024: 11 · 2023: 9 · 2022: 18 · 2021: 9 · 2020: 8
FWCI: 0.85
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Clinica Chimica Acta (publishedVersion)
PubMed (publishedVersion)
Funders: Jiangsu Science and Technology Department (BE2019760)
National Natural Science Foundation of China (81672307, 81871871, 81902333)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
Keywords: long non-coding RNA, lung cancer, oncogenic lncRNA, lncRNA regulation of gene expression, epigenetic regulation, tumor progression, metastasis, cell proliferation, apoptosis
MeSH terms: Humans, Lung Neoplasms, Gene Expression Regulation, Neoplastic, RNA, Long Noncoding

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.

Long non-coding RNA in lung cancer

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks

Data sources