The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Drug-Associated Disease: Hematologic Dysfunction
Abstract
Hematologic dysfunction, including thrombocytopenia, anemia, neutropenia, thromboses, and coagulopathy, occur commonly during critical illnesses. A major challenge is to identify drug-induced causes of hematologic dysfunction. Given the wide variety of drug-induced hematologic effects, clinicians always should consider any concomitant drugs in the differential diagnosis of acquired hematologic dysfunction. The most severe effects include drug-induced aplastic anemia, heparin-induced thrombocytopenia, and drug-induced thrombotic microangiopathy. Certain drugs are associated with multiple hematologic effects. For example, cisplatin can cause hemolytic uremia syndrome and erythropoietin deficiency, and quinine can precipitate immune-mediated thrombocytopenia, immune-mediated thrombocytopenia, and thrombotic microangiopathy.
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“Drugs and bacterial toxins can also directly destroy RBC and further aggravate the degree of ACI (Vandendries and Drews, 2006).”
From Iron in infection and immunity (2020) · cites this paper as Vandendries and Drews, 2006
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Metadata
- Authors
- Vandendries, E. R., & Drews, R. E.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Vandendries, Erik R.
- Drews, Reed E.
- ORCID
- Drews, Reed E.
- Venue
- Critical Care Clinics
- Publisher
- Elsevier BV
- Published
- 2006-04
- Volume
- 22
- Issue
- 2
- Pages
- 347-355
- ISSN
- 0749-0704 (ISSN-L)
- OpenAlex
- W2033363768
- Cited by
- 39
- References
- 46
- Citations by year
- 2025: 1 · 2024: 4 · 2021: 1 · 2020: 6 · 2019: 1 · 2018: 2 · 2017: 4 · 2014: 7 · 2013: 1 · 2012: 1
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Critical Care Clinics (publishedVersion)
- PubMed (publishedVersion)
- UCLA - Biblioteca de Ciencias de la Salud (submittedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Hematological disorders and diagnostics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
- Keywords
- thrombocytopenia, anemia, neutropenia, thrombosis, coagulopathy, drug-induced aplastic anemia, heparin-induced thrombocytopenia, thrombotic microangiopathy, cisplatin, hemolytic uremic syndrome, erythropoietin deficiency, quinine, immune-mediated thrombocytopenia, critical illness, differential diagnosis
- MeSH terms
- Anemia, Aplastic, Anticoagulants, Erythropoietin, Hematologic Diseases, Heparin, Humans, Methyltransferases, Severity of Illness Index, Thrombocytopenia
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