The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Drug-Associated Disease: Hematologic Dysfunction
Abstract
Hematologic dysfunction, including thrombocytopenia, anemia, neutropenia, thromboses, and coagulopathy, occur commonly during critical illnesses. A major challenge is to identify drug-induced causes of hematologic dysfunction. Given the wide variety of drug-induced hematologic effects, clinicians always should consider any concomitant drugs in the differential diagnosis of acquired hematologic dysfunction. The most severe effects include drug-induced aplastic anemia, heparin-induced thrombocytopenia, and drug-induced thrombotic microangiopathy. Certain drugs are associated with multiple hematologic effects. For example, cisplatin can cause hemolytic uremia syndrome and erythropoietin deficiency, and quinine can precipitate immune-mediated thrombocytopenia, immune-mediated thrombocytopenia, and thrombotic microangiopathy.
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“Drugs and bacterial toxins can also directly destroy RBC and further aggravate the degree of ACI (Vandendries and Drews, 2006).”
From Iron in infection and immunity (2020) · cites this paper as Vandendries and Drews, 2006
Citations
Cites
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Hemorrhagic Complications of Anticoagulant Treatment
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Thrombotic Thrombocytopenic Purpura Associated with Clopidogrel
Bennett, C. L., Connors, J. M., Carwile, J. M., Moake, J. L., Bell, W. R., Tarantolo, S., McCarthy, L. J., Sarode, R., Hatfield, A. J., Feldman, M. D., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200006153422402 · Cited by 630
Hirsh, J., Dalen, J. E., Deykin, D., & Toller, L. (1992) · Chest · doi:10.1378/chest.102.4_supplement.337s · Cited by 558
Hemorrhagic Complications of Anticoagulant Treatment
Levine, M. N., Raskob, G. E., Beyth, R. J., Kearon, C., & Schulman, S. (2004) · CHEST Journal · doi:10.1378/chest.126.3_suppl.287s · Cited by 522
Pure Red-Cell Aplasia and Epoetin Therapy
Bennett, C. L., Luminari, S., Nissenson, A. R., Tallman, M. S., Klinge, S. A., McWilliams, N., McKoy, J. M., Kim, B., Lyons, E. A., Trifilio, S. M., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040528 · Cited by 437
Thrombotic Thrombocytopenic Purpura Associated with Ticlopidine: A Review of 60 Cases
Bennett, C. L., Weinberg, P. D., Rozenberg-Ben-Dror, K., Yarnold, P. R., Kwaan, H. C., & Green, D. (1998) · Annals of Internal Medicine · doi:10.7326/0003-4819-128-7-199804010-00004 · Cited by 434
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Cited by
Iron in infection and immunity
Nairz, M., & Weiss, G. (2020) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100864 · Cited by 359
Wang, Y., Juan, L. V., Ma, X., Wang, D., Ma, H., Chang, Y., Nie, G., Jia, L., Duan, X., & Liang, X. (2010) · Current Drug Metabolism · doi:10.2174/138920010791636149 · Cited by 65
Toxicity as a result of immunostimulation by biologics
Gribble, E. J., Sivakumar, P. V., Ponce, R. A., & Hughes, S. D. (2007) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.3.2.209 · Cited by 51
Role of epigenetic mechanisms in cisplatin-induced toxicity
Quintanilha, J. C. F., Saavedra, K., Visacri, M. B., Moriel, P., & Salazar, L. A. (2019) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2019.03.004 · Cited by 44
Banerjee, S., Sinha, K., Chowdhury, S., & Sil, P. C. (2017) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2017.11.019 · Cited by 36
Metadata
- Authors
- Vandendries, E. R., & Drews, R. E.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Vandendries, Erik R.
- Drews, Reed E.
- ORCID
- Drews, Reed E.
- Venue
- Critical Care Clinics
- Publisher
- Elsevier BV
- Published
- 2006-04
- Volume
- 22
- Issue
- 2
- Pages
- 347-355
- ISSN
- 0749-0704 (ISSN-L)
- OpenAlex
- W2033363768
- Cited by
- 39
- References
- 46
- Citations by year
- 2025: 1 · 2024: 4 · 2021: 1 · 2020: 6 · 2019: 1 · 2018: 2 · 2017: 4 · 2014: 7 · 2013: 1 · 2012: 1
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Critical Care Clinics (publishedVersion)
- PubMed (publishedVersion)
- UCLA - Biblioteca de Ciencias de la Salud (submittedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Hematological disorders and diagnostics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
- Keywords
- thrombocytopenia, anemia, neutropenia, thrombosis, coagulopathy, drug-induced aplastic anemia, heparin-induced thrombocytopenia, thrombotic microangiopathy, cisplatin, hemolytic uremic syndrome, erythropoietin deficiency, quinine, immune-mediated thrombocytopenia, critical illness, differential diagnosis
- MeSH terms
- Anemia, Aplastic, Anticoagulants, Erythropoietin, Hematologic Diseases, Heparin, Humans, Methyltransferases, Severity of Illness Index, Thrombocytopenia
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
