Cited by 27Sepsis Diagnosis and TreatmentElectrolyte and hormonal disordersHemodynamic Monitoring and Therapy

Vasopressin in Vasodilatory Shock

Ukor, Ida-Fong, Walley, Keith R.·2019·Critical Care Clinics

Abstract

Vasodilatory shock is the final common pathway for all forms of severe shock, with sepsis the most common primary etiology and the leading cause of critical illness-related mortality. The pathophysiology of this condition remains incompletely elucidated. Deficiency of the neuropeptide hormone vasopressin seems to play a significant role. The physiology of vasopressin and its interaction with the pathophysiology of vasodilatory shock are described in this review. A brief review of the major randomized controlled trials assessing the efficacy and safety of vasopressin and its analogs in this complex patient cohort is also provided.

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Crossref · 10.1016/j.ccc.2018.11.004

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89 of 89 references verified0 citation errors · 0 not checkable

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Authors
Ukor, I.-F., & Walley, K. R.
Affiliations
University of British Columbia (CA)
Corresponding author
Walley, Keith R.
Venue
Critical Care Clinics
Publisher
Elsevier BV
Published
2019-04
Volume
35
Issue
2
Pages
247-261
ISSN
0749-0704 (ISSN-L)
OpenAlex
W2913184667
Cited by
27
References
89
Citations by year
2026: 3 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 6 · 2020: 1 · 2019: 5
FWCI
0.55
Type
journal article
Language
en
Open access
closed
Locations
  • Critical Care Clinics (publishedVersion)
  • PubMed (publishedVersion)
Funders
Canadian Institutes of Health Research (FDN 154311)
Topics
  • Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Electrolyte and hormonal disorders
  • Health Sciences › Medicine › Surgery › Hemodynamic Monitoring and Therapy
Keywords
vasopressin, vasodilatory shock, sepsis, vasopressin analogue, shock pathophysiology, vasopressin deficiency, vasopressin therapy, critical illness mortality
MeSH terms
Humans, Shock, Septic, Vasoconstrictor Agents, Vasodilation, Vasopressins, Vasoplegia

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