Vasopressin in Vasodilatory Shock
Abstract
Vasodilatory shock is the final common pathway for all forms of severe shock, with sepsis the most common primary etiology and the leading cause of critical illness-related mortality. The pathophysiology of this condition remains incompletely elucidated. Deficiency of the neuropeptide hormone vasopressin seems to play a significant role. The physiology of vasopressin and its interaction with the pathophysiology of vasodilatory shock are described in this review. A brief review of the major randomized controlled trials assessing the efficacy and safety of vasopressin and its analogs in this complex patient cohort is also provided.
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Restricting antimicrobial therapy to the shortest course associated with better outcomes is an important part of antimicrobial stewardship.
“Restricting antimicrobial therapy to the shortest course associated with better outcomes is an important part of antimicrobial stewardship (281-285).”
From Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021. (2021) · cites this paper as [282]
VANISH and VASST demonstrated a catecholamine-sparing effect of vasopressin.
“Both VANISH and VASST demonstrated a catecholamine-sparing effect of vasopressin; as such, the early use of vasopressin in combination with norepinephrine may help reduce the adrenergic burden associated with traditional vasoactive agents [357].”
From Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 (2021) · cites this paper as [357]
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Krishnaswamy, G. A. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000004893 · Cited by 30 · see citing works
Honarmand, K., Um, K. J., Belley‐Côté, E. P., Alhazzani, W. A., Farley, C., Fernando, S. M., Fiest, K. M., Grey, D., Hajdini, E., Herridge, M. S., et al. (2019) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/s12630-019-01546-x · Cited by 20 · see citing works
Cardiovascular Neuroendocrinology: Emerging Role for Neurohypophyseal Hormones in Pathophysiology
Aikins, A. O., Nguyen, D. H., Paundralingga, O. T. K., Farmer, G. E., Shimoura, C. G., Brock, C., & Cunningham, J. T. (2021) · Endocrinology · doi:10.1210/endocr/bqab082 · Cited by 17 · see citing works
Yao, R.-Q., Xia, D., Wang, L., Wu, G., Zhu, Y., Zhao, H., Liu, Q., Xia, Z., Ren, C., & Yao, Y.-M. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00563 · Cited by 17 · see citing works
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Baik, S. M., Yang, N. R., Kim, T. Y., & Hong, K. S. (2023) · PLoS ONE · doi:10.1371/journal.pone.0285035 · Cited by 11 · see citing works
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Ricksten, S., Bragadottir, G., Lannemyr, L., Redfors, B., & Larsson, J. S. (2021) · Kidney360 · doi:10.34067/kid.0007012020 · Cited by 10 · see citing works
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Screening technology of cyclic peptide library based on gene encoding
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Terlipressin as a first choice in septic shock—not yet
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Modern Critical Care Endocrinology and Its Impact on Critical Care Medicine
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Hemodynamic Challenges in Critically Ill Patients with Cirrhosis
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- Authors
- Ukor, I.-F., & Walley, K. R.
- Affiliations
- University of British Columbia (CA)
- Corresponding author
- Walley, Keith R.
- Venue
- Critical Care Clinics
- Publisher
- Elsevier BV
- Published
- 2019-04
- Volume
- 35
- Issue
- 2
- Pages
- 247-261
- ISSN
- 0749-0704 (ISSN-L)
- OpenAlex
- W2913184667
- Cited by
- 27
- References
- 89
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 6 · 2020: 1 · 2019: 5
- FWCI
- 0.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Critical Care Clinics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research (FDN 154311)
- Topics
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Electrolyte and hormonal disorders
- Health Sciences › Medicine › Surgery › Hemodynamic Monitoring and Therapy
- Keywords
- vasopressin, vasodilatory shock, sepsis, vasopressin analogue, shock pathophysiology, vasopressin deficiency, vasopressin therapy, critical illness mortality
- MeSH terms
- Humans, Shock, Septic, Vasoconstrictor Agents, Vasodilation, Vasopressins, Vasoplegia
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