Cited by 16Helicobacter pylori-related gastroenterology studiesGut microbiota and healthGastrointestinal motility and disorders

Increased breath nitrous oxide after ingesting nitrate in patients with atrophic gastritis and partial gastrectomy

Mitsui, Takahiro, Kondo, Takaharu·2004·Clinica Chimica Acta

Abstract

Background Toxic nitrite and N-nitroso compounds due to gastric bacterial growth are often detected in the stomach of patients with atrophic gastritis and partial gastrectomy. The aim of this study is to investigate whether breath N2O, a major metabolite of denitrification, detected after ingestion of nitrate is associated with atrophic gastritis and partial gastrectomy.Methods Nine young, 16 normal older, nine atrophic gastritis and six partial gastrectomy subjects ingested 100 g lettuce, equal to 130 mg nitrate, and breath N2O was measured at 15-min intervals for 5 h. N2O was analyzed using an infrared-photoacoustic analyzer, and atrophic gastritis was diagnosed by pepsinogen test.Results The mean breath N2O concentrations were higher in the following order at all times: partial gastrectomy>atrophic gastritis>normal>young. The maximum N2O concentrations in the patients with partial gastrectomy and atrophic gastritis were 1655 +/- 296 and 1350 +/- 200 (mean +/- S.E.) ppb, respectively, which were higher than that of the normal subjects, 827 +/- 91 ppb (P < 0.05). The maximum N2O concentration in young people was 527 +/- 86 ppb, which was lower than that of the normal older people (P < 0.051).Conclusion These higher N2O concentrations in gastric patients reflect bacterial growth in the stomach due to the reduction of gastric acid.

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Crossref · 10.1016/j.cccn.2004.03.011

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Authors
Mitsui, T., & Kondo, T.
Affiliations
Research Center of Health, Physical Fitness and Sports, Nagoya University (JP)
Corresponding author
Mitsui, Takahiro
Venue
Clinica Chimica Acta
Publisher
Elsevier BV
Published
2004-07
Volume
345
Issue
1-2
Pages
129-133
ISSN
0009-8981 (ISSN-L)
OpenAlex
W2067992069
Cited by
16
References
23
Citations by year
2026: 2 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2019: 1 · 2016: 1 · 2015: 1 · 2014: 2 · 2012: 1
FWCI
0.32
Type
journal article
Language
en
Open access
closed
Locations
  • Clinica Chimica Acta (publishedVersion)
  • PubMed (publishedVersion)
Funders
Ministry of Education, Culture, Sports, Science and Technology (13001343)
Topics
  • Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
atrophic gastritis, partial gastrectomy, dietary nitrate, denitrification, nitrite toxicity, N-nitroso compounds, age differences
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Aging, Breath Tests, Female, Gastrectomy, Gastritis, Atrophic, Humans, Male, Middle Aged, Nitrates, Nitrous Oxide, Spectrophotometry, Infrared, Lactuca, Pepsinogen C, Pepsinogen A

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