Increased breath nitrous oxide after ingesting nitrate in patients with atrophic gastritis and partial gastrectomy
Abstract
Background Toxic nitrite and N-nitroso compounds due to gastric bacterial growth are often detected in the stomach of patients with atrophic gastritis and partial gastrectomy. The aim of this study is to investigate whether breath N2O, a major metabolite of denitrification, detected after ingestion of nitrate is associated with atrophic gastritis and partial gastrectomy.Methods Nine young, 16 normal older, nine atrophic gastritis and six partial gastrectomy subjects ingested 100 g lettuce, equal to 130 mg nitrate, and breath N2O was measured at 15-min intervals for 5 h. N2O was analyzed using an infrared-photoacoustic analyzer, and atrophic gastritis was diagnosed by pepsinogen test.Results The mean breath N2O concentrations were higher in the following order at all times: partial gastrectomy>atrophic gastritis>normal>young. The maximum N2O concentrations in the patients with partial gastrectomy and atrophic gastritis were 1655 +/- 296 and 1350 +/- 200 (mean +/- S.E.) ppb, respectively, which were higher than that of the normal subjects, 827 +/- 91 ppb (P < 0.05). The maximum N2O concentration in young people was 527 +/- 86 ppb, which was lower than that of the normal older people (P < 0.051).Conclusion These higher N2O concentrations in gastric patients reflect bacterial growth in the stomach due to the reduction of gastric acid.
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N2O has been detected in exhaled breath of humans.
“Yet, N2O has been detected in exhaled breath of humans [101].”
From On the chemical biology of the nitrite/sulfide interaction (2015) · cites this paper as [101]
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- Authors
- Mitsui, T., & Kondo, T.
- Affiliations
- Research Center of Health, Physical Fitness and Sports, Nagoya University (JP)
- Corresponding author
- Mitsui, Takahiro
- ORCID
- Mitsui, Takahiro
- Venue
- Clinica Chimica Acta
- Publisher
- Elsevier BV
- Published
- 2004-07
- Volume
- 345
- Issue
- 1-2
- Pages
- 129-133
- ISSN
- 0009-8981 (ISSN-L)
- OpenAlex
- W2067992069
- Cited by
- 16
- References
- 23
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2019: 1 · 2016: 1 · 2015: 1 · 2014: 2 · 2012: 1
- FWCI
- 0.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinica Chimica Acta (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology (13001343)
- Topics
- Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- atrophic gastritis, partial gastrectomy, dietary nitrate, denitrification, nitrite toxicity, N-nitroso compounds, age differences
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Aging, Breath Tests, Female, Gastrectomy, Gastritis, Atrophic, Humans, Male, Middle Aged, Nitrates, Nitrous Oxide, Spectrophotometry, Infrared, Lactuca, Pepsinogen C, Pepsinogen A
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