Tumor Suppression by the Fbw7 Ubiquitin Ligase: Mechanisms and Opportunities
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Items 201–300 of 347
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- N6-Isopentenyladenosine Inhibits Colorectal Cancer and Improves Sensitivity to 5-Fluorouracil Targeting FBXW7 Tumor SuppressorDonatella Fiore, Chiara Piscopo, Maria Proto, Michele Vasaturo, Fabrizio Dal Piaz, Bruno Fusco, Cristina Pagano, Chiara Laezza, Maurizio Bifulco, Patrizia Gazzerro · 2019 · Cancers
- Co-regulation of the antagonistic RepoMan:Aurora-B pair in proliferating cellsMaria Giulia Manzione, Jan Rombouts, Mikhail Yu. Steklov, Lorenzo Pasquali, Anna A. Sablina, Lendert Gelens, Junbin Qian, Mathieu Bollen · 2020 · Molecular Biology of the Cell
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- Hepatocyte FBXW7-dependent activity of nutrient-sensing nuclear receptors controls systemic energy homeostasis and NASH progression in male miceHui Xia, Catherine R. Dufour, Younes Medkour, Charlotte Scholtes, Yonghong Chen, Christina Guluzian, Wafa B'Chir, Vincent Giguère · 2023 · Nature Communications
- FBXW7 and human tumors: mechanisms of drug resistance and potential therapeutic strategiesWanqing Wang, Kaipeng Jiang, Xue Liu, Ju Li, Wenshuo Zhou, Chang Wang, Jiuwei Cui, Tingting Liang · 2023 · Frontiers in Pharmacology
- The dimeric deubiquitinase USP28 integrates 53BP1 and MYC functions to limit DNA damageChao Jin, Elias Einig, Wenshan Xu, Ravi Babu Kollampally, Andreas Schlösser, M. Flentje, Nikita Popov · 2024 · Nucleic Acids Research
- Stabilization of nuclear oncoproteins by RNF4 and the ubiquitin system in cancerMarkus E. Diefenbacher, Amir Orian · 2016 · Molecular & Cellular Oncology
- CK1δ/GSK3β/FBXW7α axis promotes degradation of the ZNF322A oncoprotein to suppress lung cancer progressionS-Y Liao, C-W Chiang, Chun‐Hua Hsu, Y-T Chen, Jayu Jen, Hsueh‐Fen Juan, W-W Lai, Y-C Wang · 2017 · Oncogene
- A negative feedback loop between XBP1 and Fbw7 regulates cancer developmentUnbin Chae, Heejin Lee, Bokyung Kim, Haiyoung Jung, Byeong Mo Kim, Ann- Hwee Lee, Dong‐Seok Lee, Sang‐Hyun Min · 2019 · Oncogenesis
- Targeting Msx2 as a brake in the fusion fate of osteoclasts and an anabolic therapy in pre-clinical models of osteoporosisMa, Qingliang, Wang, Shiyu, Xue, Hong, Ni, Linhui, Yuan, Putao, Shen, Yang, Zheng, Bingjie, Wang, Qingqing, Zhang, Jiateng, Wang, Haoming et al. · 2025 · Nature Communications
- The PP2A-B56 phosphatase opposes cyclin E autocatalytic degradation via site-specific dephosphorylationDavis, Ryan J., Swanger, Jherek, Hughes, Bridget T., Clurman, Bruce E. · 2017 · Molecular and Cellular Biology
- High‐risk endometrial cancer proteomic profiling reveals that FBXW7 mutation alters L1CAM and TGM2 protein levelsMary Ellen Urick, Eun‐Jeong Yu, Daphne W. Bell · 2021 · Cancer
- Early growth response-1 is a new substrate of the GSK3β-FBXW7 axisLu Yin, Jiagui Zhang, Yi Sun · 2022 · Neoplasia
- The SCF–FBXW7 E3 ubiquitin ligase triggers degradation of histone 3 lysine 4 methyltransferase complex component WDR5 to prevent mitotic slippageSimon Hänle-Kreidler, Kai T. Richter, Ingrid Hoffmann · 2022 · Journal of Biological Chemistry
- Role of CELF2 in ferroptosis: Potential targets for cancer therapy (Review)Jiahao Li, Lei Xian, Zifeng Zhu, Yang Wang, Wenlei Zhang, Ruipeng Zheng, Xue Wang, Jiarui Li · 2023 · International Journal of Molecular Medicine
- Active AKT2 stimulation of SREBP1/SCD1-mediated lipid metabolism boosts hepatosteatosis and cancerFuqiang Huang, Na Zhao, Pei Cai, Mengjie Hou, Shuhui Yang, Bohao Zheng, Qian Ma, Jingpeng Jiang, Xiaochen Gai, Yilei Mao et al. · 2024 · Translational research
- Single allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancerNathan F. Schachter, Jessica R. Adams, Patryk Skowron, Katelyn J. Kozma, Christian A. Lee, Nandini Raghuram, Joanna Yang, Amanda J. Loch, Wei Wang, Aaron Kucharczuk et al. · 2021 · Nature Communications
- E3 ligase FBXW7 aggravates TMPD-induced systemic lupus erythematosus by promoting cell apoptosisZhenlu Chong, Chunjing Bao, Jia He, Tianxiao Chen, Lijia Zhong, Gaopeng Li, Huanle Li, Lutong Fang, Yinjing Song, Guoxiang Fu et al. · 2018 · Cellular and Molecular Immunology
- E3 ubiquitin ligase FBXW7 enhances radiosensitivity of non-small cell lung cancer cells by inhibiting SOX9 regulation of CDKN1A through ubiquitinationHongge Zhu, Xiuli Wang, Xin Zhou, Suqiong Lu, Guomin Gu, Chunling Liu · 2022 · Laboratory Investigation
- FBW7 suppresses cell proliferation and G2/M cell cycle transition via promoting γ-catenin K63-linked ubiquitylationYu Li, Kaishun Hu, Xing Xiao, Wenjing Wu, Haiyan Yan, Hengxing Chen, Zhen Chen, Dong Yin · 2018 · Biochemical and Biophysical Research Communications
- FBW7 in hematological tumors (Review)Qiaojuan Zhu, Linjun Hu, Yang Guo, Zunqiang Xiao, Qiuran Xu, Xiangmin Tong · 2020 · Oncology Letters
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- Ubiquitin Ligase, Fbw7, Targets CDX2 for Degradation via Two Phosphodegron Motifs in a GSK3β-Dependent MannerYogesh Kumar, Nidhi Shukla, Gatha Thacker, Isha Kapoor, Savita Lochab, Madan Lal Brahma Bhatt, Naibedya Chattopadhyay, Sabyasachi Sanyal, Arun Kumar Trivedi · 2016 · Molecular Cancer Research
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- GPX4 methylation puts a brake on ferroptosisGraeme Iain Lancaster, Andrew James Murphy · 2025 · Nature Cell Biology
- The role of FBXW7, a cell-cycle regulator, as a predictive marker of recurrence of gastrointestinal stromal tumorsYuki Koga, Masaaki Iwatsuki, Kohei Yamashita, Yuki Kiyozumi, Junji Kurashige, Toshiro Masuda, Kojiro Eto, Shiro Iwagami, Kazuto Harada, Takatsugu Ishimoto et al. · 2019 · Gastric Cancer
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- Role of the ubiquitin–proteasome system on macrophages in the tumor microenvironmentYue Xiao, Ruiqian Liu, Na Li, Yong Li, Xuan Huang · 2024 · Journal of Cellular Physiology
- Downregulation of specific FBXW7 isoforms with differential effects in T-cell lymphoblastic lymphomaIrene Vázquez-Domínguez, Laura González-Sánchez, Pilar López‐Nieva, Pablo Fernández‐Navarro, María Villa‐Morales, María Cobos-Fernández, Isabel Sastre, Mario F. Fraga, Agustín F. Fernández, Marcos Malumbres et al. · 2019 · Oncogene
- RNAi screen reveals synthetic lethality between cyclin G-associated kinase and FBXW7 by inducing aberrant mitosesSaoirse Olivia Dolly, Mark D. J. Gurden, Konstantinos G. Drosopoulos, Paul Andrew Clarke, Johann Sebastian De Bono, Stan B. Kaye, Paul Workman, Spiros Linardopoulos · 2017 · British Journal of Cancer
- Correlation between high FBXW7 expression in pretreatment biopsy specimens and good response to chemoradiation therapy in patients with locally advanced esophageal cancer: A retrospective studyNavchaa Gombodorj, Takehiko Yokobori, Naritaka Tanaka, Shigemasa Suzuki, Kengo Kuriyama, Yuji Kumakura, Tomonori Yoshida, Makoto Sakai, Makoto Sohda, Seded Baatar et al. · 2018 · Journal of Surgical Oncology
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- Revealing the contribution of somatic gene mutations to shaping tumor immune microenvironmentLiwen Xu, Shiwei Zhu, Yujia Lan, Min Yan, Zedong Jiang, Jiali Zhu, Gaoming Liao, Yanyan Ping, Jinyuan Xu, Bo Pang et al. · 2022 · Briefings in Bioinformatics
- Erythropoietin regulates energy metabolism through EPO-EpoR-RUNX1 axisWeiqin Yin, Praveen Kumar Rajvanshi, Heather Marie Rogers, Teruhiko Yoshida, Jeffrey B. Kopp, Xiuli An, Max Gassmann, Constance Tom Noguchi · 2024 · Nature Communications
- Targeting PD-1 post-translational modifications for improving cancer immunotherapyJie Shi, Chuan He, Li Chen, Xixin Xing, Wenyi Wei, Jinfang Zhang · 2025 · Cell Insight
- Characterization of the F-box Proteins FBXW2 and FBXL14 in the Initiation of Bone Regeneration in Transplants given to Nude MiceMari Akiyama · 2018 · The Open Biomedical Engineering Journal
- NEDD4L suppresses PD-L1 expression and enhances anti-tumor immune response in A549 cellsBin Zhong, Jie Zheng, Huilan Wen, Xinhui Liao, Xingxiang Chen, Yunwei Rao, Ping Yuan · 2022 · Genes & Genomics
- Global and context-specific transcriptional consequences of oncogenic Fbw7 mutationsH. Nayanga Thirimanne, Feinan Wu, Derek H. Janssens, Jherek Swanger, Ahmed Diab, Heather M Feldman, Robert A. Amezquita, Raphaël Gottardo, Patrick J Paddison, Steven Henikoff et al. · 2022 · eLife
- An innate pathogen sensing strategy involving ubiquitination of bacterial surface proteinsShruti Apte, Smita Bhutda, Sourav Ghosh, Kuldeep Sharma, Thomas E. Barton, Soham Dibyachintan, Osheen Sahay, Suvapriya Roy, Akash Raj Sinha, Harikrishna Adicherla et al. · 2023 · Science Advances
- MicroRNA-92b targets tumor suppressor gene FBXW7 in glioblastomaGrafals-Ruiz, Nilmary, Sánchez-Álvarez, Annelis O., Santana-Rivera, Yasmarie, Lozada-Delgado, Eunice L., Rabelo-Fernandez, Robert J., Rios-Vicil, Christian I., Valiyeva, Fatima, Vivas-Mejia, Pablo E. · 2023 · Frontiers in Oncology
- Poor prognosis in cholangiocarcinoma patients with low FBXW7 expression is improved by chemotherapyNorihiro Ishii, Kenichiro Araki, Takehiko Yokobori, Akira Watanabe, Mariko Tsukagoshi, Norio Kubo, Hideki Suzuki, Fumiyoshi Saito, Bolag Altan, Yasuo Hosouchi et al. · 2017 · Oncology Letters
- The ubiquitin-proteasome pathway in adult and pediatric brain tumors: biological insights and therapeutic opportunitiesWafik Tharwat Zaky, Christa A. Manton, Claudia P. Miller, Soumen Khatua, Vidya Gopalakrishnan, Joya Chandra · 2017 · Cancer and Metastasis Reviews
- Retracted Article: Iso-pencillixanthone A from a marine-derived fungus reverses multidrug resistance in cervical cancer cells through down-regulating P-gp and re-activating apoptosisLi Chen, Xinxin Li, Miaomiao Cheng, Siyuan Wang, Qiuhong Zheng, Qinying Liu · 2018 · RSC Advances · Retracted
- Critical roles of the E3 ubiquitin ligase FBW7 in B‐cell response and the pathogenesis of experimental autoimmune arthritisChunlei Feng, Lingyun Li, Lei Zhou, Dali Li, Mingyao Liu, Shuhua Han, Biao Q Zheng · 2021 · Immunology
- E3 Ubiquitin Ligases: Structures, Biological Functions, Diseases, and TherapyHaochen Wang, Junbo Peng, Hongchan Li, Yuzhe Lan, Jing Guo, Qiang Qiu, Xuan Huang · 2025 · MedComm
- The FBXW7–KMT2 axis in cancer-associated fibroblasts controls tumor growth via an epigenetic-paracrine mechanismLu Yin, Jiagui Zhang, Zhipeng Zhu, Xiaojuan Peng, Huiyin Lan, Alex M. Ayoub, Mingjia Tan, Bo O. Zhou, Yaohui He, Siyuan Wang et al. · 2025 · Proceedings of the National Academy of Sciences
- Protein Ubiquitination Modification in Pulmonary FibrosisJinping Shen, Yuling Jiang, Wenxia Bu, Mengjiao Yu, Ruiyao Huang, Can Tang, Zeyun Yang, Haiping Gao, Liling Su, Demin Cheng et al. · 2025 · Comprehensive physiology
- The DCDC2/ENO1 axis promotes tumor progression and immune evasion in intrahepatic cholangiocarcinoma via activating FGL1-LAG3 checkpointWenze Wan, Yuan Li, Wentao Sun, Zewei Cheng, Fen Ma, Sheng Shen, Houbao Liu, Jiwei Zhang · 2025 · Journal of Experimental & Clinical Cancer Research
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- The ubiquitin ligase FBXW7 targets the centriolar assembly protein HsSAS-6 for degradation and thereby regulates centriole duplicationBinshad Badarudeen, Ria Gupta, Sreeja V. Nair, Aneesh Chandrasekharan, Tapas K. Manna · 2020 · Journal of Biological Chemistry
- FBXW7γ is a tumor-suppressive and prognosis-related FBXW7 transcript isoform in ovarian serous cystadenocarcinomaZhou Xu, Lin Zhuang, Xiaoyin Wang, Qianrong Li, Sang Yan, Jiao Xu · 2020 · Future Oncology
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- Epigenetic Regulation of IL-23 by E3 Ligase FBXW7 in Dendritic Cells Is Critical for Psoriasis-like InflammationYinjing Song, Xiangtong Zhao, Hao Qu, Yixin Su, Rukun He, Luxia Chen, Lutong Fang, Jiaying Li, Ziqi Zou, Jia He et al. · 2023 · The Journal of Immunology
- The FBXW7‐RPAP2 Axis Controls the Growth of Hepatocellular Carcinoma Cells and Determines the Fate of Liver Cell DifferentiationDanrui Cui, Shengpeng Shao, Ruirui Qu, Xiaoyu Chen, Shanghong Jiang, Linchen Wang, Longyuan Gong, Tianqi Li, Danyi Zhai, Wenfeng Song et al. · 2025 · Advanced Science
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- Comprehensive Study of Human FBXW7 Deleterious nsSNP’s Functional Inference and Susceptibility to Gynaecological CancerK. Archana Vasuki, Jemmy Christy · 2021 · Applied Biochemistry and Biotechnology
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- Ubiquitin signaling in the control of centriole duplicationBinshad Badarudeen, Ushma Anand, Swarnendu Mukhopadhyay, Tapas K. Manna · 2021 · FEBS Journal
- FBXW7β isoform drives transcriptional activation of the proinflammatory TNF cluster in human pro-B cellsScarlett Y. Yang, Katharina E. Hayer, Hossein Fazelinia, Lynn A. Spruce, Mukta Asnani, Kathryn L. Black, Ammar S. Naqvi, Vinodh Pillai, Yoseph Barash, Kojo S.J. Elenitoba‐Johnson et al. · 2022 · Blood Advances
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