Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress

Schug, Zachary T., Peck, Barrie, Jones, Dylan T., Zhang, Qifeng, Grosskurth, Shaun, Alam, Israt S., Goodwin, Louise M., Smethurst, Elizabeth +25 more·2015·Cancer Cell
DOI 10.1016/j.ccell.2014.12.002

Cited by (818)

Items 701–800 of 818

  1. De Novo Lipogenesis in Clear Cell Renal Cell Carcinoma: Mechanistic Insights and Therapeutic Implications
    Kha Cong Le Bui, Yen Thi Do, Jin Young Kim, Ji Hae Seo · 2026 · International Journal of Molecular Sciences
  2. Stearoyl‐CoA Desaturase‐1 Drives Tumor Growth by Interacting With Histone Deacetylase‐2 and Deacetylating Nucleophosmin‐1
    Coline Wéry, Laetitia Montero‐Ruiz, Éric Bonneil, Mohammad Farran, Robin Jehay, Quentin Herrera Garfia, Grégory Fettweis, Silvia Blacher, Charles Pottier, Gaël Cobraiville et al. · 2026 · MedComm
  3. ACSS2 promotes macrophage senescence and atherosclerosis by upregulating histone H3 lysine 9 crotonylation
    Quanwen Yin, Jie Yang, Yaoyuan Xu, Zejun Qi, Xinyu Wang, Xuechi Zhu, Y J Jing, Jiayue Chen, Jiao Min, Hongyu Lu et al. · 2026 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  4. Lipid droplets as stress-buffering organelles in cancer cell homeostasis
    Ruolun Wei, Claudia Katharina Petritsch · 2026 · Communications Biology
  5. Gut microbiota interaction in host lipid metabolism
    Rachel M. Golonka, Ahmed A. Abokor, James Mukasa Ntambi, Matam Vijay–Kumar · 2020 · Elsevier eBooks
  6. Fundamentals of cell metabolism and cancer
    Ragunathan Devendran, Vignesh Ramesh, Prabu Gnanasekaran · 2022 · Elsevier eBooks
  7. Unravelling the Nexus: Mitochondrial Oxidative Stress, Tumour Microenvironment, and Escape from Immune Surveillance
    Moitreyee Chattopadhyay, Ananya Chanda, Bhaskar Pal · 2024 · Cancer drug discovery and develogment/Cancer drug discovery and development
  8. Contribution of glucose and glutamine to hypoxia-induced lipid synthesis decreases, while contribution of acetate increases, during 3T3-L1 differentiation
    Lucie Ryskova, Kateřina Pospíšilová, Jiří Vávra, Tomas Wolf, Aleš Dvořák, Libor Vı́tek, Jan Polak · 2024 · Scientific Reports
  9. A Computational Approach for Designing a Peptide-Based Acetyl-CoA Synthetase 2 Inhibitor: A New Horizon for Anticancer Development
    Musab A. M. Ali, Ernest Oduro‐Kwateng, Ibrahim Oluwatobi Kehinde, Narasimham L. Parinandi, Mahmoud E. S. Soliman · 2025 · Cell Biochemistry and Biophysics
  10. Gene expression profiling of rat livers after continuous whole-body exposure to low-dose rate of gamma rays
    Kim Ngan Tran, Jong‐il Choi · 2018 · International Journal of Radiation Biology
  11. Reducing acetyl-CoA enhances BET inhibition
    Elie A. Traer · 2019 · Blood
  12. Metastatic potential
    Laura Cristina Ceafalan, Andrei Marian Niculae, Octavian Costin Ioghen, Mihaela Gherghiceanu, Mihail Eugen Hinescu · 2022 · Elsevier eBooks
  13. Investigation into survival mechanisms of malignant B cells in the central nervous system
    Antony Cousins · 2019 · Enlighten: Theses (The University of Glasgow)
  14. HAT1 drives a gene-metabolite circuit that links nutrient metabolism to histone production
    Joshua James Gruber, Benjamin S. Geller, Andrew M. Lipchik, Justin Chen, Ameen Abdulla Salahudeen, Ashwin N. Ram, James M. Ford, Calvin Jay Kuo, Michael P. Snyder · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  15. Adipocytes reprogram glucose metabolism in cancer cells promoting metastasis
    Abir Mukherjee, Divya Bezwada, Malu Zandbergen, Francesco Greco, Chun-Yi Chiang, Medine Tasdemir, Johannes Francois Fahrmann, Dmitry Grapov, Michael R. La Frano, Hieu Vu et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  16. Anticancer action of caloric restrictions via microbiota
    Laurence Zitvogel, Guido Kroemer · 2023 · Nature Metabolism
  17. Targeting ACSS2 activity suspends the formation of chemoresistance through suppressed histone H3 acetylation in human breast cancer
    Xiaoxi Shui, Liying Tian, Yuepeng Zhou, Baohua Zhao · 2024 · Research Square
  18. SIRT2-Mediated ACSS2 K271 Deacetylation Suppresses Lipogenesis Under Nutrient Stress
    Rezwana Karim, Wendi Teng, Hening Lin · 2024 · eLife
  19. Study on the Mechanism of Niclosamide Ethanolamine Salt-Hydroxypropyl-Β-Cyclodextrin in the Treatment of Colon Cancer Based on Metabolomics and 16s Rrna Technology
    Yuyang Shi, Yu Chen, Xinyu Liu, Rong Yue, Tiantian Wang, Yibo Wang, Miao Wang · 2024 · SSRN Electronic Journal
  20. SIRT2-Mediated ACSS2 K271 Deacetylation Suppresses Lipogenesis Under Nutrient Stress
    Rezwana Karim, Wendi Teng, Cameron D Behram, Hening Lin · 2024 · eLife
  21. MyoScore: a Genetically Anchored Transcriptomic Scoring System for Quantifying Human Skeletal Muscle Health
    Huahua Zhong, Shang Ma, Victoria Lillback, Mingshi Gao, Wenhan Zhang, Mridul Johari, Ali Oghabian, Per Harald Jonson, Jianying Xi, Wenhua Zhu et al. · 2026 · medRxiv
  22. Personalized Metabolic Analysis of Diseases
    Ali Cakmak, M. Hasan Celik · 2020 · IEEE Transactions on Computational Biology and Bioinformatics
  23. OECI-EACR precision medicine for cancer: Conference report 1–4 March 2015, Luxembourg
    Anna Golebiewska · 2015 · ecancermedicalscience
  24. InterFeriNg with Acetγlation: Stress-Levels of Acetate Improve Memory T Cell Function
    Caroline A. Lewis, Matthew G. Vander Heiden · 2016 · Immunity
  25. Metabolism: The Sweet Spot in Melanoma Precision Medicine?
    Franziska Baenke, Nathalie S. Dhomen, Eyal Gottlieb, Richard Marais · 2017 · Springer eBooks
  26. Electron transfer dictates metabolic reprogramming in proliferating cells under hypoxia
    Yuanyuan Wang, Miao Liu, Yuxia Ruan, Qiaoyun Chu, Yanfen Cui, Ceshi Chen, Guoguang Ying, Binghui Li · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
  27. Intracytoplasmic lipid droplets in high grade glioma : metabolism and target for therapy
    Robert Murren · 2018 · University of Birmingham Institutional Research Archive (University of Birmingham)
  28. Looking for Molecular Changes in Blood of Cancer Patients after Applying IWCT. (A Scientific Hypothesis to Test)
    Nooshin Abbasi, Giordana Bettini · 2018 · Qeios
  29. Análise do perfil metabólico e epidemiológico de portadores de carcinoma epidermoide de cavidade oral
    Luis Fabiano Soares Smarra · 2018 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
  30. EFFECT OF ETHANOL ON GASTROINTESTINAL TIGHT JUNCTIONS AND P-GLYCOPROTEIN EXPRESSION AND FUNCTIONALITY
    Armin Sadighi · 2018
  31. Nutriments et cancer : alliés ou ennemis ?
    Fabienne Guillaumond, Sophie Vasseur · 2020 · Cahiers de Nutrition et de Diététique
  32. Integrins are key mediators of cell state and tumour heterogeneity
    Allison M.L. Nixon · 2018 · TSpace (University of Toronto)
  33. De Novo Acetate Production is Coupled to Central Carbon Metabolism in Mammals
    Xiaojing Liu, Daniel E. Cooper, Ahmad A. Cluntun, Marc O. Warmoes, Steven Zhao, Michael A. Reid, Juan Liu, Kathryn E. Wellen, David G. Kirsch, Jason W. Locasale · 2018 · SSRN Electronic Journal
  34. Cómo afrontar el comportamiento irracional del otro
    Ana Ma Martín Almagro · 2012 · Diálogo: Familia Colegio
  35. Targeting Metabolism
    Yoshiaki Sunami · 2020 · Molecular and translational medicine
  36. Nutraceuticals for Prevention and Treatment of Cancer
    Neeladrisingha Das, Sandip Nathani, Viney Kumar, Himanshu Agrawal, Debabrata Sircar, Partha Roy · 2022 · Wiley eBooks
  37. ACSS2-Mediated Deacetylation of Autophagy Proteins Inhibits Malignancy of Epithelial Ovarian Cancer by Inhibiting Glycolysis
    Yang Jiang, Bingshu Li, Ming Hu, Xiaoyi Zhang, Jingchun Liu, Ying Wang, Haoyu Wang, Jiaxin Peng, Likun Gao, Li Hong · 2022 · SSRN Electronic Journal
  38. Akt protein boosts cancer metabolism through a two-pronged attack
    Philipp Poeller, Almut Schulze · 2022 · Nature
  39. The role of fatty acids metabolism on cancer progression and therapeutics development
    Catarina Moreira-Barbosa, Andreia Matos, Rui Fernandes, Miguel Mendes-Ferreira, Rafaela C. Rodrigues, Tânia Cruz, Ângela M. Costa, Ana Patrícia Cardoso, Carmen Ghilardi, María José Oliveira et al. · 2022 · Elsevier eBooks
  40. Acidic ascites inhibits ovarian cancer cell proliferation and correlates with the metabolomic, lipidomic and inflammatory phenotype of human patients
    Qianlu Yang, Gyuntae Bae, Giorgi Nadiradze, Arianna Castagna, Georgy Berezhnoy, Laimdota Zizmare, Aditi Kulkarni, Yogesh Singh, Frank‐Jürgen Weinreich, Stefan Kommoss et al. · 2022 · Research Square
  41. Flavonoids Attentuate Cancer Metabolism by Modulating Redox State, lipid metabolism, and use of amino acids or ketone bodies
    Marek Samec, Alena Mazuráková, Vincent Lučanský, Lenka Koklesová, Renata Péčová, Martin Jozef Péč, Olga Golubnitschaja, Raghad Khalid AL-Ishaq, Martin Čaprnda, Ľudovít Gašpar et al. · 2022 · Research Square
  42. Rewiring of Drug Metabolism and Its Cross‐talk with Metabolic Reprogramming in Cancer
    Subhabrata Majumder, Soumen K. Manna · 2022 · Wiley eBooks
  43. Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stresses
    Jinyang Wang, Yaxin Wen, Wentao Zhao, Yan Ting Zhang, Furong Lin, Cong Ouyang, Huihui Wang, Lizheng Yao, Huanhuan Ma, Yue Zhuo et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  44. Data from Targeting ACSS2 with a Transition-State Mimetic Inhibits Triple-Negative Breast Cancer Growth
    Katelyn D. Miller, Katherine A. Pniewski, Caroline E. Perry, Sara B. Papp, Joshua D. Shaffer, Jesse N. Velasco‐Silva, Jessica C. Casciano, Tomas M. Aramburu, Yellamelli V. V. Srikanth, Joel A. Cassel et al. · 2023
  45. Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stresses
    Jinyang Wang, Yaxin Wen, Wentao Zhao, Yan Ting Zhang, Furong Lin, Cong Ouyang, Huihui Wang, Lizheng Yao, Huanhuan Ma, Yue Zhuo et al. · 2023 · eLife
  46. Biochemical Changes in the Local Onco-Sphere
    Phei Er Saw, Erwei Song · 2023 · Springer eBooks
  47. Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stresses
    Jinyang Wang, Yaxin Wen, Wentao Zhao, Yan Zhang, Furong Lin, Cong Ouyang, Huihui Wang, Lizheng Yao, Huanhuan Ma, Yue Zhuo et al. · 2023 · eLife
  48. BAP18 acting as a novel peroxisome proliferator-activated receptor α co-regulator contributes to hepatocellular carcinoma progression
    Wei Liu, Shengli Wang, Lin Lin, Renlong Zou, Hongmiao Sun, Kai Zeng, Yi Ming Wu, Yiling Li, Kato Shigeaki, Xiuxia Wang et al. · 2023 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  49. Approaches to Study Tumor Metabolism in Mice
    Yetiş Gültekin, Matthew G. Vander Heiden, Evan C. Lien · 2023 · Cold Spring Harbor Perspectives in Medicine
  50. Cytosolic acetyl-CoA synthetase (ACSS2) does not generate butyryl- and crotonyl-CoA
    Nour Zeaiter, Laura Belot, Valérie Cunin, Roland Abi Nahed, Małgorzata Tokarska-Schlattner, Audrey Le Gouëllec, Carlo Petosa, Saadi Khochbin, Uwe Schlattner · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  51. KRAS mutation-selective requirement for ACSS2 in colorectal adenoma formation.
    Jonathan Chernoff, Konstantin Budagyan, Alexa Christine Cannon, Adam G. Chatoff, Nathaniel W. Snyder, Alison Kurimchak, James S. Duncan · 2024 · Research Square
  52. β cell acetate production and release are negligible
    Kai Xu, Chioma Nnyamah, Nupur Pandya, Nadia Saib Sweis, Irene Corona‐Avila, Medha Priyadarshini, Barton L. Wicksteed, Brian Thomas Layden · 2024 · Islets
  53. Effects of temperature to the liver transcriptome in the hybrid puffer fish (Takifugu rubripes ♀ × Takifugu obscurus ♂)
    Meiyuan Li, Chenqi Wang, Huiting Zhou, Jinfeng Chen, Liu Wang, Yuyu Xiong, Yushun Tian, Hongwei Yan, Xinyan Liang, Qi Liu et al. · 2024 · Comparative Biochemistry and Physiology Part D Genomics and Proteomics
  54. Interplay of nutrient stress and lipid dynamics in colorectal cancer cells
    Sumaira Kousar, Sidra Gull, Muslim Bin Aqeel, Fatima Iftikhar Shah, Ishrat Mahjabeen, Adeel Shahid, Naila Shoaib, Zaman Khan · 2025 · Clinical Nutrition Open Science
  55. Decoupling AMPK from fatty acid synthesis allows maintenance of fitness late in life
    Hanane Hadj‐Moussa, Megan Ulusan, Dorottya Horkai, Mohammed Kamran Afzal Mirza, Jonathan M. Houseley · 2026 · eLife
  56. SLFN11 Loss-Induced Chemoresistance is Associated with Overexpression of Glycerophospholipid Biosynthesis in Ewing Sarcoma
    Kasturee Chakraborty, Ritambhar Burman, Saharsh Satheesh, Matthew Kieffer, Chandni Karuhatty, Zuo‐Fei Yuan, Haiyan Tan, Ankhbayar Lkhagva, Anthony A. High, Xusheng Wang et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  57. Metabolic Adaptations of Prostate Cancer Cells Under Chronic Fructose Stimulation
    Carolina E. Echeverría, Vanessa I. Oyarzún, Claudia Jara, Emilia Flores-Faúndez, Catalina Ramírez, Verónica A. Torres-Estay, Cheril Tapia‐Rojas, Jorge Díaz, Manuel F. Meneses, Jorge Cancino et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  58. Biodeterioration Aspects of the 16th Century Icon "Deesis Tier of Thirteen Figures" by the Fungus Iodophanus Sp. Stg-150: A Range of Materials for Biodestruction and Selection of Target Antiseptics
    Daria A. Avdanina · 2025 · SSRN Electronic Journal
  59. Biodeterioration aspects of the 16th century icon “Deesis tier of thirteen figures” by the fungus Iodophanus sp. STG-150: a range of materials for biodegradation and selection of target antiseptics
    Darya A. Avdanina, Olga Borisovna Vorobyova, Anna A. Ermolyuk, Nikolay P. Simonenko, Ivan A. Volkov, Liudmila A. Alexandrova, Maxim V. Jasko, Dmitry A. Makarov, М. А. Хомутов, Elena N. Khurs et al. · 2025 · Journal of Cultural Heritage
  60. Coke Oven Emission Exposure Triggers Malignant Transformation of Lung Epithelial Cells by SFTA1P -Dependent Alteration of Acetyl-CoA Metabolism
    Qiang Ju, Xinmei Li, Zhaoxu Wu, Pimei Zhang, Hongguang Chen, Jing Ji, Wei Gao, Yuxin Zheng, Dianke Yu, Yanjie Zhao · 2025 · Environment & Health
  61. Additional file 2 of ACSS2-dependent histone acetylation improves cognition in mouse model of Alzheimer’s disease
    Yingbin Lin, Anlan Lin, Cai, Lili, Huang, Weibin, Shanzhi Yan, Yuanxiang Wei, Ruan, Xinglin, Fang, Wenting, Dai, Xiaoman, Cheng, Jinbo et al. · 2024 · Figshare
  62. Additional file 1 of Identifying potential biomarkers of nonalcoholic fatty liver disease via genome-wide analysis of copy number variation
    Li, Yang fan, Zheng, Jing, Peng, He wei, Xiao lin Cai, Xin Pan, Hui Quan Li, Hong, Qi zhu, Zhi jian Hu, Wu, Yun li, Peng, Xian-E. · 2021 · Figshare
  63. Additional file 1 of ACSS2-dependent histone acetylation improves cognition in mouse model of Alzheimer’s disease
    Yingbin Lin, Anlan Lin, Cai, Lili, Huang, Weibin, Shanzhi Yan, Yuanxiang Wei, Ruan, Xinglin, Fang, Wenting, Dai, Xiaoman, Cheng, Jinbo et al. · 2024 · Figshare
  64. Additional file 3 of ACSS2-dependent histone acetylation improves cognition in mouse model of Alzheimer’s disease
    Yingbin Lin, Anlan Lin, Cai, Lili, Huang, Weibin, Shanzhi Yan, Yuanxiang Wei, Ruan, Xinglin, Fang, Wenting, Dai, Xiaoman, Cheng, Jinbo et al. · 2024 · Figshare
  65. Additional file 1 of Association between human blood metabolome and the risk of breast cancer
    Wang, Yu, Liu, Fanghua, Sun, Lulu, Yiming Jia, Pinni Yang, Guo, Daoxia, Shi, Mengyao, Wang, Aili, Chen, Guo-Chong, Zhang, Yonghong et al. · 2023 · Figshare
  66. Additional file 4 of ACSS2-dependent histone acetylation improves cognition in mouse model of Alzheimer’s disease
    Yingbin Lin, Anlan Lin, Cai, Lili, Huang, Weibin, Shanzhi Yan, Yuanxiang Wei, Ruan, Xinglin, Fang, Wenting, Dai, Xiaoman, Cheng, Jinbo et al. · 2024 · Figshare
  67. Additional file 5 of ACSS2-dependent histone acetylation improves cognition in mouse model of Alzheimer’s disease
    Yingbin Lin, Anlan Lin, Cai, Lili, Huang, Weibin, Shanzhi Yan, Yuanxiang Wei, Ruan, Xinglin, Fang, Wenting, Dai, Xiaoman, Cheng, Jinbo et al. · 2024 · Figshare
  68. Additional file 1 of Acidic ascites inhibits ovarian cancer cell proliferation and correlates with the metabolomic, lipidomic and inflammatory phenotype of human patients
    Yang, Qianlu, Gyuntae Bae, Giorgi Nadiradze, Castagna, Arianna, Georgy Berezhnoy, Laimdota Zizmare, Kulkarni, Aditi, Singh, Yogesh, Weinreich, Frank J., Kommoss, Stefan et al. · 2024 · Figshare
  69. ¹H-NMR serum metabolomic profiling from clinical routine identifies signatures of progressive melanoma metastasis
    Frank Friedrich Gellrich, Cosima Hufnagel, Alexander Max Funk, Sophie Jonas, Heidi Altmann, Sarah Hobelsberger, Julian Steininger, Ricarda Rauschenberg, Marlene Garzarolli, Sophia Lehr et al. · 2026 · Scientific Reports
  70. Targeting lipid metabolism in CAFs: A therapeutic opportunity in solid tumors
    Qi Ai, Wang Hong Bin, Wei Zhang, Xin-Yun Xu · 2026 · Translational research
  71. Acetate Metabolism in Thyroid Cancer Progression
    Enke Baldini, Silvia Cardarelli, Eleonora Lori, Poupak Fallahi, Camilla Virili, Marco Centanni, Vito D’Andrea, Alessandro Antonelli, Salvatore Sorrenti, Salvatore Ulisse · 2026 · International Journal of Molecular Sciences
  72. WBP2 Attenuates Metformin Response in HER2-Positive Breast Cancer Cells by Repressing AMPK Activation and Inducing a Lower AMP:ATP Ratio State Through Enhanced ATP Production
    Hexian Lin, S. Deborah Kang, Fei Xie, Yvonne Xinyi Lim, Sock Hong Seah, Amir Sabbaghian, Ssu-Yi Lu, Ting Gang Chew, Lih‐Wen Deng, Shu Wang et al. · 2026 · Cells
  73. Intestinal-hepatic axis-mediated hepatocarcinogenesis and traditional Chinese medicine intervention strategies
    Lulu Song, Ying Zhou, Zhajun Zhan, Libin Pan, Luo Fang · 2026 · Pharmacological Research - Modern Chinese Medicine
  74. Co-targeting an AMPK–MAPK axis reprograms fibroblasts and suppresses PDAC
    Ryodai Yamamura, Yusuke Satoh, Junki Fukuda, Taku Kimura, Takuya Otsuka, Sho Sekiya, Taiga Hirata, Soichiro Hata, Reo Sato, Chihiro Kamijo et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  75. Acetate Metabolism in Malignant Tumors
    Dmitriy A. Korshunov, Elena E. Sereda, Сиденко Евгения Александровна, Какурина Гелена Валерьевна, И. В. Кондакова · 2026 · Russian Journal of Bioorganic Chemistry
  76. Mathematical modeling of the early differentiation of helper T cells
    Philippe Auguste Robert · 2017
  77. Regulation of Autophagy by Acetyl Coenzime A : From the Mechanisms to a Revised Definition of Caloric Restriction Mimetics
    Federico Pietrocola · 2015 · theses.fr (ABES)
  78. Rôle de l'autophagie dans l'émergence des cellules souches cancéreuses : implication du métabolisme
    Mouradi El-Hout · 2019 · theses.fr (ABES)
  79. Caractérisation de la cohorte ovocytaire normale et pathologique après stimulation ovarienne : exemple de l'endométriose
    Khaled Pocate-Cheriet · 2020 · theses.fr (ABES)
  80. Transfert de mitochondries des cellules souches mésenchymateuses aux cellules souches de glioblastome : effets sur le métabolisme et la résistance à la chimiothérapie
    Jean Nakhle · 2020 · theses.fr (ABES)
  81. Etude du rôle de la mitophagie et de la tafazzin dans la résistance des cellules cancéreuses du sein à la doxorubicine
    Séyédéh Tayébéh Ahmad Pour · 2021
  82. Dialogue entre cellules tumorales mammaires et cellules adipeuses : implication du transporteur d'acides gras CD36
    Mehdi Morel · 2021 · theses.fr (ABES)
  83. Deciphering the metabolic bases of Drosophila intestinal tumors
    Pierre Delamotte · 2024 · theses.fr (ABES)
  84. Phosphoproteomic and kinase networks reveal partial EMT and stress-adaptive growth programs in pediatric Peutz-Jeghers polyps
    Irina Pushel, Badal C. Roy, Whitney M. Nolte, Lisa K. Harvey, Amber Bagherian, Michaella J. Rekowski, Zachary D Clark, Michael P. Washburn, Shahid Umar, Thomas Mario Attard · 2026 · Pediatric Research
  85. Stiripentol induces ER stress and pyroptosis in pancreatic cancer cells under metabolic stress by dysregulating SFAs/UFAs homeostasis
    Jie Ding, Jingbing Pan, Wenduo Xue, Siyuan Ying, Siyu Zuo, Runhe Xia, Yandong Li, Ming Quan · 2026 · Cellular Oncology
  86. Intratumoral microbiota promote pancreatic cancer progression via NaAc-mediated activation of the GPR43/AMPK/HADH pathway
    Zhou Chen, Dacheng Jin, Hu Wang, Qizhou Bai, Yan Wang, Yunjiu Gou · 2026 · Journal of Translational Medicine
  87. ACSS2 drives Lenvatinib resistance in hepatocellular carcinoma through palmitoylation
    Hao Xu, Hongxia Wang, Shi-Zhe Yu, Tiantian Zou, Sun‐Zhe Xie, Ke-Yu Shen, C H I Zhang, Jianfeng Xu, Jun-Jie Pan, Sami Yang et al. · 2026 · Pharmacological Research
  88. Acetyl-CoA synthetase 2 nuclear translocation impediment contributes to nickel induced histone hypoacetylation and neurite outgrowth impairment
    Chao Zhou, Jianbo Zhang, Wei Zhang, Ya Xu, Xiang Mei, Ping Deng, Qinlong Ma, Chunhai Chen, L Zhang, Huifeng Pi et al. · 2026 · Toxicology Letters
  89. HDAC6 and SSAT2 orchestrate acetyllysine metabolism and protein homeostasis
    Fang Wu, Santhosh Paramasivam, Satish Kumar Reddy Noonepalle, Albert Batushansky, Miroslava Vošahlíková, Alejandro Villagra, Cyril Bařinka, Eyal Arbely · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  90. Metabolic plasticity in the pancreatic cancer metastatic cascade
    Biwen Zhu, Yibing Guo, Yuhua Lu · 2026 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  91. Iron-driven regulation of nucleotide synthesis reveals metabolic vulnerabilities in colorectal cancer
    Luke Villareal, Yanshan Liang, Young‐Yon Kwon, Sheng Tony Hui, Xiang Xue · 2026 · Genes & Diseases
  92. LPAR4 mediates resistance to interferon-induced stress in soft tissue sarcoma
    Jin-Fen Xiao, Emily Y. Ko, Ashley Smith, Roberta Piras, Annaliese Fowler, Kristin Ishaya, Longqiang Wang, Bin Wang, Adriana A. Paulucci-Holthauzen, Sharon M. Landers et al. · 2026 · Science Advances
  93. Cannabis Oil and Exploratory Gut–Immune Signatures During Breast Cancer Chemotherapy: A Randomized Pilot Trial
    May Soe Thu, Thunnicha Ondee, Barry James Campbell, Joanne L. Fothergill, Mawin Vongsaisuwon, Chanida Vinayanuwattikun, Kamonwan Banchuen, Sunchai Payungporn, Phanupong Phutrakool, Preecha Nootim et al. · 2026 · Biomedicines
  94. Precision metabolic therapy for propionic acidemia
    Boopathi Subramaniyan, Fang Lu, Huan Li, Chorlada Paiboonrungruang, Yahui Li, Zhaohui Xiong, Guo-Fang Zhang, Xiaoxin Chen · 2026 · Biochemical Pharmacology
  95. Dual-Tracer Autoradiography and Positron Emission Tomography (PET) Scans Using In-Yolk-Sac Tracer Delivery in the Chicken Chorioallantoic Membrane (CAM) Tumor Model
    Emil L. Villumsen, Signe Bauenmand, Marie B. Thuesen, Mikkel Holm Vendelbo, Lars Thrane, Jörg Männer, Niels Bassler, Michael R. Horsman, Michael Pedersen, Morten Busk · 2026 · Biomedicines
  96. Tumoral Metabolism at the Intersection of Oncogene Signaling, Epigenetics and Immunology: Emerging Therapeutic Strategies in Cancer
    Bhoomendra A. Bhongade, Areeg Anwer Ali, Mohamed El‐Tanani, Shakta Mani Satyam, Sirajunisa Talath, Adil Farooq Wali, Syed Arman Rabbani, Walaa Ibraheem, Karolina Hoffmann, Авагимян Ашот Арманович et al. · 2026 · Current Issues in Molecular Biology
  97. Central nervous system involvement in acute lymphoblastic leukemia: pathogenesis and targeted therapy
    Luke Quinlan, David T. O. Yeung, Susan L. Heatley, Deborah L. White, Elyse C. Page · 2026 · Leukemia
  98. ACSS2 is required for colorectal cancer progression and a druggable target for colorectal cancer treatment
    Lei Wang, Urszula Dougherty, Wenliang He, Lu Gao, Caleb Nwongbouwoh Muefong, Rajesh Sarkar, Jie Du, Ardaman P. Shergill, Hening Lin, Marc Bissonnette et al. · 2026 · iScience
  99. Fatty Acid Metabolism and Hypoxia in the Tumor Microenvironment: Metabolic Adaptation and Clinical Potential in Colorectal Cancer
    Junqi Zhang, Sian Xie, Yongjun Wang · 2026 · Biomedicines
  100. Enhanced acetate uptake and metabolism in endothelial cells promote tumour angiogenesis and immunosuppression by increasing histone acetylation
    Jieying Chen, Yu-Chen Ji, Chen-Hui Wu, Jun-Guang Chen, Hui-Xian Zeng, Chen Xie, Jian‐Hong Fang, Shi‐Mei Zhuang · 2026 · Gut