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Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis

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COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

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Reprogramming of Fatty Acid Metabolism in Gynaecological Cancers: Is There a Role for Oestradiol?

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Tracking acetate through a journey of living world: Evolution as alternative cellular fuel with potential for application in cancer therapeutics

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Host and microbiome lipid metabolism in colorectal cancer development and therapy

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TCA-cycle metabolites in the nucleus: drivers of chromatin and epigenetic control

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Dynamic Evolution of the Tumor Immune Microenvironment in Malignant Tumors and Emerging Therapeutic Paradigms

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Transcriptomics Reveal the Effects of Breeding Temperature on Growth and Metabolism in the Early Developmental Stage of Platax teira

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Impact of Diet and Nutrition on Cancer Hallmarks

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Aspirin impairs acetyl-coenzyme A metabolism in redox-compromised yeast cells

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Druggable Metabolic Vulnerabilities Are Exposed and Masked during Progression to Castration Resistant Prostate Cancer

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The role of noncoding RNAs in cancer lipid metabolism

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Exploring the crosstalk of glycolysis and mitochondrial metabolism in psychiatric disorders and brain tumours

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NAD+ regeneration drives cancer cell proliferation

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Fatty acid metabolic reprogramming in the tumor microenvironment: Unraveling mechanisms and therapeutic prospects

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A novel gene signature unveils three distinct immune-metabolic rewiring patterns conserved across diverse tumor types and associated with outcomes

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Impact of ATP-citrate lyase catalytic activity and serine 455 phosphorylation on histone acetylation and inflammatory responses in human monocytic THP-1 cells

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Prostate Cancer and the Mevalonate Pathway

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Acetate drives ovarian cancer quiescence via ACSS2-mediated acetyl-CoA production

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Deciphering microbial and metabolic influences in gastrointestinal diseases-unveiling their roles in gastric cancer, colorectal cancer, and inflammatory bowel disease

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Path to Clonal Theranostics in Luminal Breast Cancers

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Potential Therapeutic Use of Aptamers against HAT1 in Lung Cancer

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Determination of HIF-1α degradation pathways via modulation of the propionyl mark

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Novel prognostication biomarker adipophilin reveals a metabolic shift in uveal melanoma and new therapeutic opportunities

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RNA mutations in the moth pheromone gland

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The effects of restricted glycolysis on stem-cell like characteristics of breast cancer cells

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Single-walled carbon nanohorn aggregates promotes mitochondrial dysfunction-induced apoptosis in hepatoblastoma cells by targeting SIRT3

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Alternative transcription start site selection in ACSS2 controls its nuclear localization and promotes ribosome biosynthesis in hepatocellular carcinoma

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The Crucial Roles of Intermediate Metabolites in Cancer

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Formation of supramolecular structures in aqueous medium by noncovalent interactions between surfactant and resorcin[4]arene

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Intracellular spatiotemporal metabolism in connection to target engagement

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Exploring the significance of fatty acid metabolism reprogramming in the pathogenesis of cancer and anticancer therapy

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Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis

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KRAS G12V mutation-selective requirement for ACSS2 in colorectal adenoma formation

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Activation of epigenetic reprogramming via crotonylation overcomes resistance to EGFR-TKI therapy in lung cancer

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Microenvironmental Factors Modulating Tumor Lipid Metabolism: Paving the Way to Better Antitumoral Therapy

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Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stress

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[11C]acetate PET Imaging is not Always Associated with Increased Lipogenesis in Hepatocellular Carcinoma in Mice

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Metabonomic analysis of metastatic lung tissue in breast cancer mice by an integrated NMR-based metabonomics approach

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Design, synthesis and biological evaluation of novel chroman derivatives as non-selective acetyl-CoA carboxylase inhibitors

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Metabolic cell communication within tumour microenvironment: models, methods and perspectives

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Cancer Microbiome; Opportunities and Challenges

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Targeting acetate metabolism: Achilles’ nightmare

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Measuring MYC-Mediated Metabolism in Tumorigenesis

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Predicted Role of Acetyl-CoA Synthetase and HAT p300 in Extracellular Lactate Mediated Lactylation in the Tumor: In vitro and In silico Models

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Hypoxia-driven metabolic and molecular reprogramming: From tumor microenvironment to therapeutic interventions

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Application of Metabolic Reprogramming to Cancer Imaging and Diagnosis

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ACSS2-related autophagy has a dual impact on memory

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A cholesterogenic gene signature for predicting the prognosis of young breast cancer patients

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Metastatic-initiating cells and lipid metabolism

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Microbial Metabolites in Cancer Promotion or Prevention

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Cancer Cell Metabolites: Updates on Current Tracing Methods

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Cancer Metabolism under Limiting Oxygen ConditionsPreprint

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Targeting metabolic pathway enhance CAR-T potency for solid tumor

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Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit altered liver lipid metabolism on a ketogenic diet

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Mitochondrial VHL rewires cell metabolism in hypoxia

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Immune-and Metabolism-Associated Molecular Classification of Ovarian Cancer

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Intestinal acetic acid regulates the synthesis of sex pheromones in captive giant pandas

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Acetyl-CoA synthetase 2 contributes to a better prognosis for liver cancer by switching acetate-glucose metabolism

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Nutritionally physiological cell culture medium and 3D culture influence breast tumour proteomics and anti-cancer drug effectiveness

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Adaptation mechanisms in cancer: Lipid metabolism under hypoxia and nutrient deprivation as a target for novel therapeutic strategies (Review)

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Acetyl-CoA Counteracts the Inhibitory Effect of Antiandrogens on Androgen Receptor Signaling in Prostate Cancer Cells

Makhov, P. B., Fazliyeva, R., Tufano, A., Uzzo, R. G., Cai, K. Q., Serebriiskii, I. G., Snyder, N. W., Andrews, A. J., & Kolenko, V. M. (2022) · Cancers · doi:10.3390/cancers14235900 · Cited by 7

Mutant KRAS and CK2 Cooperatively Stimulate SLC16A3 Activity to Drive Intrahepatic Cholangiocarcinoma Progression

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The microbiota-m6A-metabolism axis: Implications for therapeutic strategies in gastrointestinal cancers

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Metabolic reprogramming in colorectal cancer: Mechanisms and therapeutic insights

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The short-chain fatty acid acetate coordinates with CD30 to modulate T-cell survival

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Dysregulation of Fatty Acid Metabolism in Breast Cancer and Its Targeted Therapy

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Metabolomics integrated genomics approach: Understanding multidrug resistance phenotype in MCF-7 breast cancer cells exposed to doxorubicin and ABCA1/EGFR/PI3k/PTEN crosstalk

Kadry, M. O., Abd-Ellatef, G. E. F., Ammar, N. M., Hassan, H. A., Hussein, N. S., Kamel, N. N., Soltan, M. M., Megeed, R. M. A., & Abdel‐Hamid, A. Z. (2024) · Toxicology Reports · doi:10.1016/j.toxrep.2024.101884 · Cited by 7

Integrative Analysis Reveals Comprehensive Altered Metabolic Genes Linking with Tumor Epigenetics Modification in Pan-Cancer

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Development of a Physiologically Based Pharmacokinetic Model for Prediction of Ethanol Concentration-Time Profile in Different Organs

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Metabolic targeting of malignant tumors: a need for systemic approach

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Pieces of the Complex Puzzle of Cancer Cell Energy Metabolism: An Overview of Energy Metabolism and Alternatives for Targeted Cancer Therapy

Ghasemishahrestani, Z., Mattos, L. M. M., Tilli, T. M., dos Santos, A. L. S., & Pereira, M. D. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867327999200819123357 · Cited by 6

Biomarker selection and imaging design in cancer: A link with biochemical pathways for imminent engineering

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Identification of Fasnall as a therapeutically effective Complex I inhibitorPreprint

Mukha, D., Dessain, J., O’Connor, S., Pniewski, K. A., Bertolazzi, F., Patel, J. H., Mullins, M. C., & Schug, Z. T. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.03.592013 · Cited by 7

Metabolomics Biomarkers for Breast Cancer: An updated perspective

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Spatial imaging features derived from SUVmax location in resectable NSCLC are associated with tumor aggressiveness

Jiang, Z., Spielvogel, C. P., Haberl, D., Yu, J., Krisch, M., Szakáll, S., Molnár, P. J., Fillinger, J., Horváth, L., Renyi-Vamos, F., et al. (2025) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-025-07528-0 · Cited by 6

Featured intestinal microbiota associated with hepatocellular carcinoma in various liver disease states

Sun, X. L., Zhou, Z., Chi, X., Cheng, D., Zhang, Y., Xu, Y., Hao, Y., Duan, Y., Li, W., Zhao, Y., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1674838 · Cited by 6

Alcohol-driven metabolic reprogramming promotes development of RORγt-deficient thymic lymphoma

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Metabolic signatures and potential biomarkers for the diagnosis and treatment of colon cancer cachexia

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Proteogenomic Landscape of Breast Ductal Carcinoma Reveals Tumor Progression Characteristics and Therapeutic Targets

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Role of ATP citrate lyase and its complementary partner on fatty acid synthesis in gastric cancer

Li, C., Liu, W., Liu, Y., Wang, W., & Deng, W. (2024) · Scientific Reports · doi:10.1038/s41598-024-81448-1 · Cited by 6

Transcriptome Profiling Analysis Reveals Changes in the Antioxidant Defense System, Morphology, and Gene Expression in the Gills of Macrobrachium nipponense Caused by Alkalinity Exposure

Jin, S., Zhang, Y., Fu, H., Zhang, W., Qiao, H., Xiong, Y., & Jiang, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26094321 · Cited by 6

ATP citrate lyase links increases in glycolysis to diminished release of vesicular suppressor of cytokine signaling 3 by alveolar macrophages

Haggadone, M. D., Speth, J. M., Hong, H. S., Penke, L. R. K., Zhang, E., Lyssiotis, C. A., & Peters-Golden, M. L. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2022.166458 · Cited by 6

Metabolic Adaptation as Potential Target in Papillary Renal Cell Carcinomas Based on Their In Situ Metabolic Characteristics

Krencz, I., Vetlényi, E., Dankó, T., Petővári, G., Moldvai, D., Sztankovics, D., Raffay, R. E., Mészáros, K. V., Sebestyén, E., Végső, G., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810587 · Cited by 7

Identification and Validation of a Novel Glycolysis-Related Gene Signature for Predicting the Prognosis and Therapeutic Response in Triple-Negative Breast Cancer

Zheng, J., Zhang, Y., Han, G., Fan, M., Du, M.-H., Zhang, G., Zhang, B., Qiao, J., Zhang, S., & Cao, J. (2022) · Advances in Therapy · doi:10.1007/s12325-022-02330-y · Cited by 6

Acetate: Friend or foe against breast tumour growth in the context of obesity?

Yelek, C., Mignion, L., Joudiou, N., Terrasi, R., Gourgue, F., Hul, M. V., Delzenne, N. M., Gallez, B., Corbet, C., Muccioli, G. G., et al. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16034 · Cited by 6

Potential of electron transfer and its application in dictating routes of biochemical processes associated with metabolic reprogramming

Yang, R., Ying, G., & Li, B. (2021) · Frontiers of Medicine · doi:10.1007/s11684-021-0866-1 · Cited by 6

Pancreatic cancer epigenetics: adaptive metabolism reprograms starving primary tumors for widespread metastatic outgrowth

Franco, A., Duryea, J., & McDonald, O. G. (2023) · Cancer and Metastasis Reviews · doi:10.1007/s10555-023-10116-z · Cited by 5

PYCR1-dependent proline synthesis in cancer-associated fibroblasts is required for the deposition of pro-tumorigenic extracellular matrixPreprint

Kay, E. J., Paterson, K., Domingo, C. R., Sumpton, D. P., Daebritz, H., Tardito, S., Boldrini, C., Hernandez-Fernaud, J. R., Athineos, D., Dhayade, S., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.30.125237 · Cited by 6

Molecular Targets and Small Molecules Modulating Acetyl Coenzyme A in Physiology and Diseases

Ewida, H. A., Benson, H., Tareq, S., & Ahmed, M. S. (2024) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.4c00476 · Cited by 5

Acetyl-CoA synthetase 2 alleviates brain injury following cardiac arrest by promoting autophagy in brain microvascular endothelial cells

Zhang, W., Yu, X., Lin, Y., Wu, C., Zhu, R., Jiang, X., Tao, J., Chen, Z., He, J., Zhang, X., et al. (2025) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-025-05689-7 · Cited by 5

High fructose promotes MYCN-amplified neuroblastoma progression through NgBR-ACSS2-mediated biosynthesis of acetyl-CoA

Hu, W., Wang, X., Fang, Z. H., Zhang, J., Tirumalasetty, M. B., & Miao, Q. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115947 · Cited by 5

ACLY promotes NK cell effector function by regulating glycolysis and histone acetylation

Sohn, H., Kolicheski, A., Poursine‐Laurent, J., Tran, J., Wang, Y., Gan, K., Tobin, J. M., Saucier, N., Fehniger, T. A., Payton, J. E., et al. (2025) · The Journal of Immunology · doi:10.1093/jimmun/vkaf209 · Cited by 6

Shaping death: how the microbiome regulates tumour cell demise and therapy response

Raudenská, M., Balvan, J., Zgarbová, E., Kalfeřt, D., Plzák, J., & Masařík, M. (2026) · Cancer and Metastasis Reviews · doi:10.1007/s10555-026-10318-1 · Cited by 5

Mitochondrial respiration supports cancer growth independent of OXPHOS

Chinopoulos, C. (2026) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2026.189593 · Cited by 5

Alcohol consumption modulates Candida albicans-induced oral carcinogenesis and progression

O’Grady, I., & O’Sullivan, J. (2023) · Journal of Oral Biosciences · doi:10.1016/j.job.2023.10.002 · Cited by 6

Genomic and Epigenomic Plasticity in the Hypoxic Environment

Cricchi, E., Bertozzo, A., Minisini, M., & Brancolini, C. (2025) · DNA · doi:10.3390/dna5020022 · Cited by 6

SIRT2-mediated ACSS2 K271 deacetylation suppresses lipogenesis under nutrient stressPreprint

Karim, R., Teng, W., Behram, C. D., & Lin, H. (2024) · eLife · doi:10.7554/elife.97019.3 · Cited by 6

An Oncolytic Vaccinia Virus Expressing Aphrocallistes Vastus Lectin Modulates Hepatocellular Carcinoma Metabolism via ACSS2/TFEB-Mediated Autophagy and Lipid Accumulation

Wang, Q., Zhou, S., Wang, Y., Gao, Y., Zhou, Y., Ye, T., Li, G., & Chen, K. (2025) · Marine Drugs · doi:10.3390/md23080297 · Cited by 5

Histone Acyl Code in Precision Oncology: Mechanistic Insights from Dietary and Metabolic Factors

Neja, S. A., Dashwood, W. M., Dashwood, R. H., & Rajendran, P. (2024) · Nutrients · doi:10.3390/nu16030396 · Cited by 7

Proteomic profiling reveals ACSS2 facilitating metabolic support in acute myeloid leukemia

Mochmann, L. H., Treue, D., Bockmayr, M. L., Silva, P., Zasada, C., Mastrobuoni, G., Bayram, Ş., Forbes, M., Jurmeister, P. S., Liebig, S., et al. (2024) · Cancer Gene Therapy · doi:10.1038/s41417-024-00785-5 · Cited by 6

Untargeted Metabolomics and Liquid Biopsy Investigation of Circulating Biomarkers in Soft Tissue Sarcoma

Grasso, D., Marzocchi, B., Scoccianti, G., Palchetti, I., Campanacci, D. A., Antonuzzo, L., Scolari, F., Pillozzi, S., & Bernini, A. (2025) · Cancers · doi:10.3390/cancers17030553 · Cited by 6

Acetyl-coA synthetase 2 promotes acetate utilization and maintains cell growth under metabolic stress

Schug, Z. T., Peck, B., Jones, D. T., Zhang, Q., Alam, I. S., Witney, T. H., Smethurst, E. A., Grosskurth, S. E., Harris, A. L., Critchlow, S. E., et al. (2014) · Cancer & Metabolism · doi:10.1186/2049-3002-2-s1-o9 · Cited by 13

Acetyl-CoA Synthetase 2 Confers a Growth Advantage under Metabolic Stress

(2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-rw2015-011 · Cited by 1

Abstract PL02-01: The metabolic phase of the cell cycle.

Gottlieb, E. (2013) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.targ-13-pl02-01

Acetate dependence of tumors

Comerford, S. A., Huang, Z., Du, X., Wang, Y., Cai, L., Witkiewicz, A. K., Walters, H., Tantawy, M. N., Fu, A., Manning, H. C., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.020 · Cited by 681

Acetyl-CoA synthetase 2(ACSS2): a review with a focus on metabolism and tumor development

Ling, R., Chen, G., Tang, X., Liu, N., Zhou, Y., & Chen, D. (2022) · Discover Oncology · doi:10.1007/s12672-022-00521-1 · Cited by 95