The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Spatiotemporal Evolution of the Primary Glioblastoma Genome
Open accessAbstract
Tumor recurrence following treatment is the major cause of mortality for glioblastoma multiforme (GBM) patients. Thus, insights on the evolutionary process at recurrence are critical for improved patient care. Here, we describe our genomic analyses of the initial and recurrent tumor specimens from each of 38 GBM patients. A substantial divergence in the landscape of driver alterations was associated with distant appearance of a recurrent tumor from the initial tumor, suggesting that the genomic profile of the initial tumor can mislead targeted therapies for the distally recurred tumor. In addition, in contrast to IDH1-mutated gliomas, IDH1-wild-type primary GBMs rarely developed hypermutation following temozolomide (TMZ) treatment, indicating low risk for TMZ-induced hypermutation for these tumors under the standard regimen.
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MGMT Gene Silencing and Benefit from Temozolomide in Glioblastoma
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IDH1 and IDH2 Mutations in Gliomas
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Cited by
Clonal evolution of glioblastoma under therapy
Wang, J., Cazzato, E., Ladewig, E., Frattini, V., Rosenbloom, D. I. S., Zairis, S., Abate, F., Liu, Z., Elliott, O., Shin, Y.-J., et al. (2016) · Nature Genetics · doi:10.1038/ng.3590 · Cited by 720
Self-citationLongitudinal molecular trajectories of diffuse glioma in adults
Barthel, F. P., Johnson, K. C., Varn, F. S., Moskalik, A. D., Tanner, G., Kocakavuk, E., Anderson, K. J., Abiola, O., Aldape, K., Alfaro, K. D., et al. (2019) · Nature · doi:10.1038/s41586-019-1775-1 · Cited by 561
Self-citationGlioblastoma stem cells: lessons from the tumor hierarchy in a lethal cancer
Gimple, R. C., Bhargava, S., Dixit, D., & Rich, J. N. (2019) · Genes & Development · doi:10.1101/gad.324301.119 · Cited by 514
Transcriptome analysis reveals tumor microenvironment changes in glioblastoma
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Myc-Driven glycolysis is a therapeutic target in glioblastoma
Tateishi, K., Iafrate, A. J., Ho, Q., Curry, W. T., Batchelor, T. T., Flaherty, K. T., Onozato, M. L., Lelic, N., Sundaram, S., Cahill, D. P., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-2274 · Cited by 160
Metadata
- Authors
- Kim, J., Lee, I.-H., Cho, H. J., Park, C.-K., Jung, Y.-S., Kim, Y., Nam, S. H., Kim, B. S., Johnson, M. D., Kong, D.-S., Seol, H. J., Lee, J.-I., Joo, K. M., Yoon, Y., Park, W.-Y., Lee, J., Park, P. J., & Nam, D.-H.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2015-09
- Volume
- 28
- Issue
- 3
- Pages
- 318-328
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W1959444207
- Cited by
- 314
- References
- 53
- FWCI
- 13.37
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kim, J., Lee, I.-H., Cho, H. J., Park, C.-K., Jung, Y.-S., Kim, Y., Nam, S. H., Kim, B. S., Johnson, M. D., Kong, D.-S., Seol, H. J., Lee, J.-I., Joo, K. M., Yoon, Y., Park, W.-Y., Lee, J., Park, P. J., & Nam, D.-H. (2015). Spatiotemporal Evolution of the Primary Glioblastoma Genome. Cancer Cell. https://doi.org/10.1016/j.ccell.2015.07.013
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
