Comprehensive pan-genomic characterization of adrenocortical carcinoma
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Update on Adrenal Tumours in 2017 World Health Organization (WHO) of Endocrine Tumours
Lam, A. K.-Y. (2017) · Endocrine Pathology · doi:10.1007/s12022-017-9484-5 · Cited by 463 · see citing works
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“Other advances include the use of molecular biology techniques to predict prognosis in patients with ACC (165,354-356) which may give the promise of delivering a more personalized approach to prognostication, treatment, and follow-up.”
BackgroundGopal, R. K., Kübler, K., Calvo, S. E., Polak, P. P., Livitz, D. G., Rosebrock, D., Sadow, P. M., Campbell, B., Donovan, S. E., Amin, S., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.06.013 · Cited by 266 · see citing works
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FACER: comprehensive molecular and functional characterization of epigenetic chromatin regulators
Lu, J., Xu, J., Li, J., Pan, T., Bai, J., Wang, L., Jin, X., Li, X., Zhang, Y., Li, Y., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky679 · Cited by 107 · see citing works
Exquisite sensitivity of adrenocortical carcinomas to induction of ferroptosis
Belavgeni, A., Bornstein, S. R., von Mäßenhausen, A., Tonnus, W., Stumpf, J., Meyer, C., Othmar, E., Latk, M., Kanczkowski, W., Kroiß, M., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1912700116 · Cited by 99 · see citing works
“More recently, comprehensive studies of genetic changes within these cancers (4, 5) have indicated clinical care guided by genomics (6), but molecular mechanisms of the evolution of ACCs remain elusive.”
BackgroundRambau, P., McIntyre, J. B., Taylor, J. L., Lee, S., Ogilvie, T., Sienko, A. E., Morris, D. G., Duggan, M. A., McCluggage, W. G., & Köbel, M. (2017) · The American Journal of Surgical Pathology · doi:10.1097/pas.0000000000000812 · Cited by 93 · see citing works
Estrogen Receptors-Mediated Apoptosis in Hormone-Dependent Cancers
Chimento, A., Luca, A. D., Avena, P., Amicis, F. D., Casaburi, I., Sirianni, R., & Pezzi, V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031242 · Cited by 91 · see citing works
Activating PRKACB somatic mutation in cortisol-producing adenomas
Espiard, S., Knape, M. J., Bathon, K., Assié, G., Rizk‐Rabin, M., Faillot, S., Rondof, W., Abid, D., Guignat, L., Calebiro, D., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.98296 · Cited by 85 · see citing works
“The Cancer Genome Atlas reveals alteration of PRKACB in various cancer (26) but not in adrenocortical carcinoma (27).”
BackgroundSelf-citationTerzolo, M., Faßnacht, M., Perotti, P., Libé, R., Kaštelan, D., Lacroix, A., Arlt, W., Haak, H. R., Loli, P., Decoudier, B., et al. (2023) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(23)00193-6 · Cited by 90 · see citing works
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The role of regulated necrosis in endocrine diseases
Tonnus, W., Belavgeni, A., Beuschlein, F., Eisenhofer, G., Faßnacht, M., Kroiß, M., Krone, N. P., Reincke, M., Bornstein, S. R., & Linkermann, A. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00499-w · Cited by 72 · see citing works
DNA methylation is an independent prognostic marker of survival in adrenocortical cancer
Jouinot, A., Assié, G., Libé, R., Faßnacht, M., Papathomas, T. G., Barreau, O., Villéon, B. D. L., Faillot, S., Hamzaoui, N., Néou, M., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-3205 · Cited by 71 · see citing works
Self-citationCalabrese, A., Basile, V., Puglisi, S., Perotti, P., Pia, A., Saba, L., Berchialla, P., Porpiglia, F., Veltri, A., Volante, M., et al. (2019) · European Journal of Endocrinology · doi:10.1530/eje-18-0923 · Cited by 59 · see citing works
Cloutier, J. M., Charville, G. W., Mertens, F., Sukov, W. R., Fritchie, K., Perry, K., Edgar, M. A., Rowsey, R. A., & Folpe, A. L. (2020) · Modern Pathology · doi:10.1038/s41379-020-00703-8 · Cited by 53 · see citing works
Adjuvant Therapy in Adrenocortical Carcinoma: Reflections and Future Directions
Bedrose, S. S. D., Daher, M., Altameemi, L., & Habra, M. A. (2020) · Cancers · doi:10.3390/cancers12020508 · Cited by 53 · see citing works
Emerging Opportunities for Target Discovery in Rare Cancers
Sharifnia, T., Hong, A. L., Painter, C., & Boehm, J. S. (2017) · Cell chemical biology · doi:10.1016/j.chembiol.2017.08.002 · Cited by 51 · see citing works
Genetics, Diagnosis, and Management of Hürthle Cell Thyroid Neoplasms
McFadden, D. G., & Sadow, P. M. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.696386 · Cited by 48 · see citing works
RPL22L1 induction in colorectal cancer is associated with poor prognosis and 5-FU resistance
Rao, S., Peri, S., Hoffmann, J., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0222392 · Cited by 47 · see citing works
Adrenocortical Carcinoma in Childhood: A Systematic Review
Riedmeier, M., Decarolis, B., Haubitz, I., Müller, S., Uttinger, K., Boerner, K., Reibetanz, J., Wiegering, A., Härtel, C., Schlegel, P., et al. (2021) · Cancers · doi:10.3390/cancers13215266 · Cited by 46 · see citing works
Klein, O., Senko, C., Carlino, M. S., Markman, B., Jackett, L. A., Gao, B., Lum, C., Kee, D., Behren, A., Palmer, J., et al. (2021) · OncoImmunology · doi:10.1080/2162402x.2021.1908771 · Cited by 45 · see citing works
“The majority of tumors in our cohort had a low TMB in keeping with previous reports demonstrating that ACC is one of the malignancies with the lowest TMB.(22) The tumor with the highest TMB next to an MSI-H tumor was mismatch repair protein proficient and harbored a biallelic RB1 deletion.”
BackgroundResultInfluentialMizdrak, M., Kurir, T. T., & Božić, J. (2021) · Biomedicines · doi:10.3390/biomedicines9020174 · Cited by 44 · see citing works
“Zheng et al. have summarized proposed genes as potential drivers involved in sporadic adrenocortical tumorigenesis, including insulin-like growth factor 2, β-catenin (CTNNB1), TP53, ZNRF3 and TERT, as well as novel nominated drivers such as PRKAR1A, RPL22, TERF2, CCNE1 and NF1 [161].”
BackgroundInfluentialCastro, M. A., Corrales, E. P., Molina‐Cerrillo, J., & Alonso‐Gordoa, T. (2021) · Biomedicines · doi:10.3390/biomedicines9030304 · Cited by 43 · see citing works
“In this scenario, an altered DNA methylation status of the IGF2 locus has been associated with ACC tumorigenesis [51].”
BackgroundInfluentialRNA Sequencing and Somatic Mutation Status of Adrenocortical Tumors: Novel Pathogenetic Insights
Dalmazi, G. D., Altieri, B., Scholz, C. J., Sbiera, S., Luconi, M., Waldman, J., Kaštelan, D., Ceccato, F., Chiodini, I., Arnaldi, G., et al. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa616 · Cited by 43 · see citing works
Adrenocortical carcinoma and succinate dehydrogenase gene mutations: an observational case series
Else, T., Lerário, A. M., Everett, J. N., Haymon, L., Wham, D., Mullane, M. P., Wilson, T. L. S., Rainville, I. R., Rana, H. Q., Worth, A. J., et al. (2017) · European Journal of Endocrinology · doi:10.1530/eje-17-0358 · Cited by 33 · see citing works
Self-citationAdrenocortical carcinoma: a literature review
Thampi, A., Shah, E., Elshimy, G., & Correa, R. (2020) · Translational Cancer Research · doi:10.21037/tcr.2019.12.28 · Cited by 32 · see citing works
“Hypercortisolism Table 1 WHO TNM staging of ACC (16,17)”
BackgroundResultInfluentialJiménez, C., Armaiz-Peña, G., Dahia, P. L. M., Lü, Y., Toledo, R. A., Varghese, J. M., & Habra, M. A. (2022) · Cancers · doi:10.3390/cancers14030467 · Cited by 29 · see citing works
Cullin 3 targets the tumor suppressor gene ARMC5 for ubiquitination and degradation
Cavalcante, I. P., Vaczlavik, A., Drougat, L., Lotfi, C. F. P., Perlemoine, K., Ribes, C., Rizk‐Rabin, M., Clauser, É., Fragoso, M. C. B. V., Bertherat, J. Y., et al. (2020) · Endocrine Related Cancer · doi:10.1530/erc-19-0502 · Cited by 32 · see citing works
MYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and Epitranscriptome
Qiu, Z., Lin, A., Jiang, S., Elkashef, S. M., Myers, J., Srikantan, S., Sasi, B. K., Cao, J. Z., Godley, L. A., Rakheja, D., et al. (2020) · Cell chemical biology · doi:10.1016/j.chembiol.2020.02.002 · Cited by 30 · see citing works
“3 was selected based on previous reports(Zheng et al., 2016), as well as on manual examination of the beta value distribution.”
MethodSelf-citationMedical Approaches in Adrenocortical Carcinoma
Paragliola, R. M., Corsello, A., Locantore, P., Papi, G., Pontecorvi, A., & Corsello, S. M. (2020) · Biomedicines · doi:10.3390/biomedicines8120551 · Cited by 29 · see citing works
β-Catenin-driven adrenocortical carcinoma is characterized with immune exclusion
Liu, S., Ding, G., Zhou, Z., et al. (2018) · OncoTargets and Therapy · doi:10.2147/ott.s159979 · Cited by 26 · see citing works
“Driving genetic alterations have recently been identified owing to the second-generation sequencing technique, showing driver genes including CTNNB1, TP53, CDKN2A, RB1, MEN1, and newly identified PRKAR1A, RPL22, TERF2, and CCNE1.(2,3) CTNNB1 encodes β-catenin, an essential component of the canonical Wnt/ β-catenin pat…”
Adrenocortical carcinoma in patients with MEN1: a kindred report and review of the literature
Wang, W., Han, R., Ye, L., Xie, J., Tao, B., Sun, F., Zhuo, R., Chen, X., Deng, X., Ye, C., et al. (2019) · Endocrine Connections · doi:10.1530/ec-18-0526 · Cited by 29 · see citing works
Alterations in Sod2-Induced Oxidative Stress Affect Endocrine Cancer Progression
Ashtekar, A., Huk, D. J., Magner, A., Perle, K. M. D. L., Boucai, L., & Kirschner, L. S. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-01039 · Cited by 26 · see citing works
HOX genes promote cell proliferation and are potential therapeutic targets in adrenocortical tumours
Francis, J. C., Gardiner, J. R., Renaud, Y., Chauhan, R., Weinstein, Y., Gómez-Sánchez, C. E., Lefrançois‐Martinez, A., Bertherat, J. Y., Val, P., & Swain, A. (2020) · British Journal of Cancer · doi:10.1038/s41416-020-01166-z · Cited by 25 · see citing works
Baker, T. G., Alden, J., Dubuc, A. M., et al. (2020) · Neuro-Oncology Advances · doi:10.1093/noajnl/vdaa155 · Cited by 22 · see citing works
“cell carcinoma(19, 20), adrenocortical carcinoma(21), and peripheral chondrosarcoma(22).”
BackgroundSelf-citationZhang, F., Zhang, F., Liu, Z., Wu, K., Zhu, Y., & Lu, Y. (2019) · Advances in Therapy · doi:10.1007/s12325-019-01050-0 · Cited by 24 · see citing works
Zeng, J., Zhang, Y., Zhang, H., Zhang, Y., Gao, L., Tong, X., Xie, Y., Hu, Q., Chen, C., Ding, S., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.699900 · Cited by 21 · see citing works
“(25), but have not been reported in inflammatory skin diseases such as psoriasis.”
BackgroundAdvances in adrenocortical carcinoma pharmacotherapy: what is the current state of the art?
Cremaschi, V., Abate, A., Cosentini, D., Grisanti, S., Rossini, E., Laganà, M., Tamburello, M., Turla, A., Sigala, S., & Berruti, A. (2022) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2022.2106128 · Cited by 21 · see citing works
“As a relevant number of receptor tyrosine kinases were frequently found overexpressed in ACC [41], many preclinical ACC papers were focused on other tyrosine kinases inhibitors (TKIs).”
BackgroundThe Wnt Signaling Landscape of Mammary Stem Cells and Breast Tumors
Alexander, C. M. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2017.11.020 · Cited by 20 · see citing works
Bulzico, D., Pires, B. R. B., de Faria, P. A. S., Neto, L. V., & Abdelhay, E. (2018) · Anticancer Research · doi:10.21873/anticanres.13094 · Cited by 20 · see citing works
Heat Shock Protein 90 as a Prognostic Marker and Therapeutic Target for Adrenocortical Carcinoma
Siebert, C., Ciato, D., Murakami, M., Frei‐Stuber, L., Perez‐Rivas, L. G., Garcia, J. L. M., Nölting, S., Maurer, J., Feuchtinger, A., Walch, A. K., et al. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00487 · Cited by 19 · see citing works
Dehner, C. A., Geiersbach, K. B., Rowsey, R. A., Murugan, P., Broski, S. M., Meis, J. M., Rosenberg, A. E., & Folpe, A. L. (2023) · Modern Pathology · doi:10.1016/j.modpat.2023.100131 · Cited by 19 · see citing works
Germline NGS targeted analysis in adult patients with sporadic adrenocortical carcinoma
Scatolini, M., Grisanti, S., Tomaiuolo, P., Grosso, E., Basile, V., Cosentini, D., Puglisi, S., Laganà, M., Perotti, P., Saba, L., et al. (2024) · European Journal of Cancer · doi:10.1016/j.ejca.2024.114088 · Cited by 19 · see citing works
Lippert, J., Altieri, B., Morrison, B., Steinhauer, S., Smith, G., Lorey, A., Urlaub, H., Kircher, S., Sitch, A. J., Faßnacht, M., et al. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac470 · Cited by 18 · see citing works
“Third, other molecular markers previously proposed to be potentially associated with survival, such as gene expression of BUB1BPINK1 (20, 21), somatic copy number alteration patterns, single nucleotide variants, or small insertions and deletions in genes of ß-catenin or TP53 signaling pathway (7, 8, 22), have not been…”
BackgroundDedhia, P. H., Sivakumar, H., Rodríguez, M., Nairon, K. G., Zent, J. M., Zheng, X., Jones, K. E., Popova, L. V., Leight, J. L., & Skardal, A. (2023) · Scientific Reports · doi:10.1038/s41598-023-42659-0 · Cited by 20 · see citing works
Clay, M. R., Pinto, E. M., Cline, C., Tran, Q. T., Lin, T., Dyer, M. A., Shi, L. G., Wu, H., Pounds, S. B., Zambetti, G. P., et al. (2019) · JCO Precision Oncology · doi:10.1200/po.19.00163 · Cited by 21 · see citing works
“All tumors in the TCGA cohort were carcinomas, and median age at diagnosis was 49 years.(14) Visualization with t-SNE highlighted the previously appreciated A1, A2, and pediatric control groups.”
BackgroundSelf-citationIntegrative computational immunogenomic profiling of cortisol‐secreting adrenocortical carcinoma
Baechle, J. J., Hanna, D. N., Sekhar, K. R., Rathmell, J. C., Rathmell, W. K., & Baregamian, N. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16936 · Cited by 17 · see citing works
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“As previously reported, the low ESR1 expression was related to high differentiation, high cell adhesion genes, and low immune response genes expression in adrenocortical and thyroid carcinoma.(4,46) In contrast, low ESR1 expression and high ESR2 expression subtypes present proliferative phenotype in hepatocellular can…”
BackgroundPlaska, S. W., Liu, C., Lim, J. S., et al. (2020) · Hormone and Metabolic Research · doi:10.1055/a-1212-8803 · Cited by 16 · see citing works
Self-citationNew and Emerging Biomarkers in Endocrine Pathology
Papathomas, T. G., & Nosé, V. (2019) · Advances in Anatomic Pathology · doi:10.1097/pap.0000000000000227 · Cited by 16 · see citing works
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TERT Copy Number Alterations, Promoter Mutations and Rearrangements in Adrenocortical Carcinomas
Gupta, S., Won, H. H., Chadalavada, K., Nanjangud, G. J., Chen, Y., Al‐Ahmadie, H. A., Fine, S. W., Sirintrapun, S. J., Strong, V. E. M., Raj, N. P., et al. (2021) · Endocrine Pathology · doi:10.1007/s12022-021-09691-0 · Cited by 15 · see citing works
“32e34 platform was used to analyze data from The Cancer Genome Atlas (TCGA) pertaining to pan-genomic characterization of adrenocortical carcinomas [24, 25].”
MethodThe role of molecular profiling in adrenocortical carcinoma
Lippert, J., Faßnacht, M., & Ronchi, C. L. (2021) · Clinical Endocrinology · doi:10.1111/cen.14629 · Cited by 14 · see citing works
“A very limited number of therapeutic alternatives is available for ACC.”
BackgroundMethodResultInfluentialLippert, J., Smith, G., Appenzeller, S., Landwehr, L., Prete, A., Steinhauer, S., Asia, M. F., Urlaub, H., Elhassan, Y., Kircher, S., et al. (2024) · European Journal of Endocrinology · doi:10.1093/ejendo/lvae022 · Cited by 15 · see citing works
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“J Clin Endocrinol Metab (2005) 90(2):615–9.”
BackgroundInfluentialHistopathologic Features of Adrenal Cortical Carcinoma
Gambella, A., Volante, M., & Papotti, M. G. (2022) · Advances in Anatomic Pathology · doi:10.1097/pap.0000000000000363 · Cited by 16 · see citing works
Mouat, I. C., Omata, K., McDaniel, A. S., Hattangady, N. G., Talapatra, D., Cani, A. K., Hovelson, D. H., Tomlins, S. A., Rainey, W. E., Hammer, G. D., et al. (2018) · Endocrine Related Cancer · doi:10.1530/erc-18-0385 · Cited by 14 · see citing works
Self-citationHuman Adrenal Cortex: Epigenetics and Postnatal Functional Zonation
Baquedano, M. S., & Belgorosky, A. (2018) · Hormone Research in Paediatrics · doi:10.1159/000487995 · Cited by 14 · see citing works
Determinants of survival of common childhood cancers in Iran
Movafagh, A., Keramatinia, A., Mohseny, M., et al. (2018) · Journal of Research in Medical Sciences · doi:10.4103/jrms.jrms_835_17 · Cited by 13 · see citing works
“Genetic defects have found to be responsible for 15% of children’s cancers in general, but they play a more important role in specific types of pediatric cancers such as adrenocortical carcinoma[15] and a less important role in some other types such as acute lymphocytic leukemia (ALL).”
BackgroundAvena, P., Luca, A. D., Chimento, A., et al. (2022) · Cancers · doi:10.3390/cancers14163885 · Cited by 12 · see citing works
Lippert, J., Dischinger, U., Appenzeller, S., et al. (2023) · European Journal of Endocrinology · doi:10.1093/ejendo/lvad112 · Cited by 12 · see citing works
Mitotane Targets Lipid Droplets to Induce Lipolysis in Adrenocortical Carcinoma
Warde, K. M., Lim, Y. J., Martínez, E. R., Beuschlein, F., O’Shea, P. M., Hantel, C., & Dennedy, M. C. (2022) · Endocrinology · doi:10.1210/endocr/bqac102 · Cited by 12 · see citing works
Martinerie, L., Bouligand, J., North, M.-O., Bertherat, J. Y., Assié, G., & Espiard, S. (2024) · Annales d Endocrinologie · doi:10.1016/j.ando.2024.01.005 · Cited by 11 · see citing works
Self-citationSbiera, I., Kircher, S., Altieri, B., Faßnacht, M., Kroiß, M., & Sbiera, S. (2021) · Cancers · doi:10.3390/cancers13071736 · Cited by 12 · see citing works
The underlying molecular mechanism and drugs for treatment in adrenal cortical carcinoma
Ma, C., Xiong, J. P., Su, H., & Li, H. (2021) · International Journal of Medical Sciences · doi:10.7150/ijms.60261 · Cited by 11 · see citing works
“In particular, the ACC-TCGA sub-project which represents the base of the present works [12].”
BackgroundPassaia, B. D. S., Lima, K., Kremer, J. L., da Conceição, B. B., Mariani, B. M. P., da Silva, J. C. L., Zerbini, M. C. N., Fragoso, M. C. B. V., Machado‐Neto, J. A., & Lotfi, C. F. P. (2019) · Investigational New Drugs · doi:10.1007/s10637-019-00846-9 · Cited by 11 · see citing works
Gara, S. K., Tyagi, M. V., Patel, D. T., Gaskins, K., Lack, J., Liu, Y., & Kebebew, E. (2020) · Oncotarget · doi:10.18632/oncotarget.27703 · Cited by 11 · see citing works
Identifying Immune-Specific Subtypes of Adrenocortical Carcinoma Based on Immunogenomic Profiling
Lu, Q., Nie, R., Luo, J., Wang, X., & You, L. (2023) · Biomolecules · doi:10.3390/biom13010104 · Cited by 11 · see citing works
‘Big data’ approaches for novel anti-cancer drug discovery
Benstead-Hume, G., Wooller, S. K., & Pearl, F. M. G. (2017) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2017.1319356 · Cited by 10 · see citing works
“[24] collected the clinical and pathologic features, genomic alterations, DNA-methylation profiles, and RNA and proteomic signatures of 91 cases of Adrenocortical Carcinoma identifying at least 6 driver genes including TP53, ZNFR3, CTNNB1, PRKAR1A, CCNE1, and TERF2.”
BackgroundWu, L., Xie, J., Jiang, L., Su, T., Ye, L., Zhou, W., Jiang, Y., Zhang, C., Ning, G., & Wang, W. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-00689 · Cited by 10 · see citing works
Tsoli, M., Daskalakis, K., Kassi, E. N., Kaltsas, G., & Tsolakis, A. V. (2021) · Biology · doi:10.3390/biology10070580 · Cited by 10 · see citing works
Allegra, S., Puglisi, S., Brescia, I. V., Chiara, F., Basile, V., Calabrese, A., Reimondo, G., & Francia, S. D. (2021) · Life · doi:10.3390/life11030266 · Cited by 10 · see citing works
“This could be due to the association between hormone secretion and transcriptome signature, as reported in aggressive ACC [40].”
BackgroundGan, W., Han, X., Gong, Y., Yang, Y., Wang, C., & Zhang, Z. (2024) · Diagnostic Pathology · doi:10.1186/s13000-024-01496-z · Cited by 9 · see citing works
“Gain-of-function mutations in β-catenin are found in approximately 25% of both benign and malignant sporadic adrenocortical neoplasms [30].”
BackgroundDuan, T., Xu, M., Zhang, H., et al. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1453895 · Cited by 9 · see citing works
Adrenocortical cancer cell line mutational profile reveals aggressive genetic background
Nicolson, N. G., Korah, R. M., & Carling, T. (2019) · Journal of Molecular Endocrinology · doi:10.1530/jme-18-0262 · Cited by 9 · see citing works
Wang, C., Sun, Y.-J., Yin, X., Feng, R.-Q., Feng, R.-Y., Xu, M., Liang, K., Zhao, R., Gu, G., Jiang, X.-W., et al. (2021) · Clinical Epigenetics · doi:10.1186/s13148-021-01205-3 · Cited by 6 · see citing works
“Most studies indicated that an aberrant expression of luteinizing hormone (LH)/human chorionic gonadotropin (hCG) receptor (LHCGR) in CPA played a critical role in the pathogenesis and exacerbation of CPA during pregnancy [5, 6].”
BackgroundDing, G., Liu, S., Ding, Q., & Feng, C. (2017) · Oncotarget · doi:10.18632/oncotarget.22827 · Cited by 8 · see citing works
“We therefore carefully screened the pathways based on the recently published studies on genomic characterization of ACC [20, 21], including the TCGA ACC project whose data were used and reproduced in our study.”
MethodSMARCA4-Deficient Undifferentiated Tumor Diagnosed on Adrenal Sampling
Ashour, S., REYNOLDS, J. P., Mukhopadhyay, S., et al. (2021) · American Journal of Clinical Pathology · doi:10.1093/ajcp/aqab101 · Cited by 7 · see citing works
Zhou, Y., Wang, X., Zhu, X. D., Liu, F.-C., Ye, F., Wu, D., & Zhong, P. (2019) · Translational Cancer Research · doi:10.21037/tcr.2019.09.34 · Cited by 8 · see citing works
“The clinical data for 79 ACC patients were downloaded from the TCGA Database (25).”
MethodIdentification of Seven Aberrantly Methylated and Expressed Genes in Adrenocortical Carcinoma
Xiao, H., He, W., Chen, P., Xu, D., Zeng, G., Li, Z. Y., Huang, M., Wang, X., DiSanto, M. E., & Zhang, X. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00472 · Cited by 7 · see citing works
Inflammatory rhabdomyoblastic tumor: A review and update
Folpe, A. L. (2025) · Seminars in Diagnostic Pathology · doi:10.1016/j.semdp.2025.150917 · Cited by 6 · see citing works
Schiavon, A., Saba, L., Evaristo, C., Petiti, J., Pignochino, Y., Ferrero, G., Giordano, G., Tucciarello, C., Puglisi, S., Reimondo, G., et al. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.117917 · Cited by 7 · see citing works
Gong, Y., Ma, H., Ruan, G., et al. (2021) · Journal of Cancer · doi:10.7150/jca.51524 · Cited by 6 · see citing works
“gov, Accessed time: November 27, 2018) [17, 18].”
Construction of a risk signature for adrenocortical carcinoma using immune-related genes
Fu, Y., Sun, S., Bi, J., & Kong, C. (2020) · Translational Andrology and Urology · doi:10.21037/tau-20-485 · Cited by 6 · see citing works
“For example, one study showed that among the three ACC subsets integrated through cluster analysis, immune-mediated pathways were significantly upregulated in the subset with the best prognosis (11).”
Computational prediction of therapeutic response and cancer outcomesPreprint
Griffiths, M., Kubeyev, A., Laurie, J., Giorni, A., da Silva, L. A. Z., Sivasubramaniam, P., Foster, M. T., Biankin, A. V., & Asghar, U. S. (2024) · medRxiv · doi:10.1101/2024.01.17.24301444 · Cited by 5 · see citing works
PLK1 inhibitors as a new targeted treatment for adrenocortical carcinoma
Warmington, E., Smith, G., Chortis, V., et al. (2023) · Endocrine Connections · doi:10.1530/ec-23-0403 · Cited by 5 · see citing works
“This is of interest, given that TP53 mutations are present in approximately 30% of sporadic ACC cases (8, 30).”
Hescot, S., Faron, M., Kordahi, M., Cao, C. D., Naman, A., Lamartina, L., Hadoux, J., Leboulleux, S., Pattou, F. N., Aubert, S., et al. (2022) · Cancers · doi:10.3390/cancers14092225 · Cited by 4 · see citing works
Development and Characterization of 3-Dimensional Cell Culture Models of Adrenocortical Carcinoma
Feely, S., Mullen, N., Donlon, P. T., Reidy, E., Challapalli, R. S., Hassany, M., Sorushanova, A., Martínez, E. R., Owens, P., Quinn, A. M., et al. (2024) · Endocrinology · doi:10.1210/endocr/bqae159 · Cited by 6 · see citing works
Childhood adrenocortical tumor
Wu, X., Xu, J. H., Wang, J., Gu, W., & Zou, C. (2019) · Medicine · doi:10.1097/md.0000000000017921 · Cited by 4 · see citing works
“Genomic profiling of human tumors has found activation of cell-cycle programs,([5]) supporting the notion that p53-sensitive checkpoints is a critical step in the process of adrenal tumorigenesis.”
BackgroundAdrenocortical Cancer: A 20-Year Experience of a Single Referral Center in Prognosis and Outcomes
Zografos, G., Kassi, E. N., Parianos, C., Kyriakopoulos, G., Kostakis, I. D., Ansari, N. N., Aggeli, C., Dimitriadi, A., Angelousi, A. G., Papavassiliou, A. G., et al. (2021) · Hormone and Metabolic Research · doi:10.1055/a-1666-9026 · Cited by 4 · see citing works
“In the context of adult ACC the TP53 somatic mutations are presented in 16 and 21 % according to two recent genome-wide studies [48, 49].”
BackgroundRege, J., & Udager, A. M. (2024) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2024.106666 · Cited by 3 · see citing works
Recurrent Amplification of the Osmotic Stress Transcription Factor NFAT5 in Adrenocortical Carcinoma
Brown, T. C., Nicolson, N. G., Man, J., Gibson, C. E., Stenman, A., Juhlin, C. C., Korah, R. M., & Carling, T. (2020) · Journal of the Endocrine Society · doi:10.1210/jendso/bvaa060 · Cited by 3 · see citing works
Yuan, T.-J., Yang, Y., Zhu, M., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.907019 · Cited by 3 · see citing works
Peng, H., Chen, Q., Ye, L., & Wang, W. (2025) · Biomedicines · doi:10.3390/biomedicines13040894 · Cited by 4 · see citing works
“Notably, mutations in the Wnt/ β -catenin pathway, one of the most common genetic alterations in ACC [52] (17% in our study), have been shown to impair anticancer immune responses [53–55].”
Pathology Associated with Hormones of Adrenal Cortex
Nigam, L. K., Vanikar, A. V., Patel, R., Kanodia, K. V., & Suthar, K. S. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.84815 · Cited by 3 · see citing works
Ettaieb, M. H. T. (2020) · doi:10.26481/dis.20201218me · Cited by 4 · see citing works
Mariniello, K., Pittaway, J. F. H., Altieri, B., Borges, K. S., Hadjidemetriou, I., Ribeiro, C. H. T., Ruiz‐Babot, G., Lim, J. A., Foster, J., Cleaver, J., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.22.609117 · Cited by 3 · see citing works
From hyperplasia to carcinoma: a molecular driven adrenal disease
Dybal, E., Decaussin‐Petrucci, M., Descôtes, F., et al. (2025) · European Journal of Endocrinology · doi:10.1093/ejendo/lvaf105 · Cited by 2 · see citing works
Estrogen-secreting adrenocortical tumor in a postmenopausal woman: a challenging diagnosis
Mermejo, L. M., de Carvalho, F. G., Molina, C. A. F., et al. (2021) · Endocrinology Diabetes and Metabolism Case Reports · doi:10.1530/edm-20-0214 · Cited by 2 · see citing works
- Authors
- Zheng, S., Cherniack, A. D., Dewal, N., Moffitt, R. A., Danilova, L., Murray, B. A., Lerario, A. M., Else, T., Knijnenburg, T. A., Ciriello, G., Kim, S., Assie, G., Morozova, O., Akbani, R., Shih, J., Hoadley, K. A., Choueiri, T. K., Waldmann, J., Mete, O., Robertson, A. G., Wu, H.-T., Raphael, B. J., Shao, L., Meyerson, M., Demeure, M. J., Beuschlein, F., Gill, A. J., Sidhu, S. B., Almeida, M. Q., Fragoso, M. C. B. V., Cope, L. M., Kebebew, E., Habra, M. A., Whitsett, T. G., Bussey, K. J., Rainey, W. E., Asa, S. L., Bertherat, J., Fassnacht, M., Wheeler, D. A., Zheng, S., Verhaak, R. G. W., Giordano, T. J., Hammer, G. D., Cherniack, A. D., Dewal, N., Moffitt, R. A., Danilova, L., Murray, B. A., Lerario, A. M., Else, T., Knijnenburg, T. A., Ciriello, G., Kim, S., Assié, G., Morozova, O., Akbani, R., Shih, J., Hoadley, K. A., Choueiri, T. K., Waldmann, J., Mete, O., Robertson, A. G., Wu, H.-T., Raphael, B. J., Meyerson, M., Demeure, M. J., Beuschlein, F., Gill, A. J., Sidhu, S. B., Almeida, M., Barisson Fragoso, M. C., Cope, L. M., Kebebew, E., Habra, M. A., Whitsett, T. G., Bussey, K. J., Rainey, W. E., Asa, S. L., Bertherat, J., Fassnacht, M., Wheeler, D. A., Benz, C., Ally, A., Balasundaram, M., Bowlby, R., Brooks, D., Butterfield, Y. S. N., Carlsen, R., Dhalla, N., Guin, R., Holt, R. A., Jones, S. J. M., Kasaian, K., Lee, D., Li, H. I., Lim, L., Ma, Y., Marra, M. A., Mayo, M., Moore, R. A., Mungall, A. J., Mungall, K., Sadeghi, S., Schein, J. E., Sipahimalani, P., Tam, A., Thiessen, N., Park, P. J., Kroiss, M., Gao, J., Sander, C., Schultz, N., Jones, C. D., Kucherlapati, R., Mieczkowski, P. A., Parker, J. S., Perou, C. M., Tan, D., Veluvolu, U., Wilkerson, M. D., Hayes, D. N., Ladanyi, M., Quinkler, M., Auman, J. T., Latronico, A. C., Mendonca, B. B., Sibony, M., Sanborn, Z., Bellair, M., Buhay, C., Covington, K., Dahdouli, M., Dinh, H., Doddapaneni, H., Downs, B., Drummond, J., Gibbs, R., Hale, W., Han, Y., Hawes, A., Hu, J., Kakkar, N., Kalra, D., Khan, Z., Kovar, C., Lee, S., Lewis, L., Morgan, M., Morton, D., Muzny, D., Santibanez, J., Xi, L., Dousset, B., Groussin, L., Libé, R., Chin, L., Reynolds, S., Shmulevich, I., Chudamani, S., Liu, J., Lolla, L., Wu, Y., Yeh, J. J., Balu, S., Bodenheimer, T., Hoyle, A. P., Jefferys, S. R., Meng, S., Mose, L. E., Shi, Y., Simons, J. V., Soloway, M. G., Wu, J., Zhang, W., Mills Shaw, K. R., Demchok, J. A., Felau, I., Sheth, M., Tarnuzzer, R., Wang, Z., Yang, L., Zenklusen, J. C., Zhang, J. (., Davidsen, T., Crawford, C., Hutter, C. M., Sofia, H. J., Roach, J., Bshara, W., Gaudioso, C., Morrison, C., Soon, P., Alonso, S., Baboud, J., Pihl, T., Raman, R., Sun, Q., Wan, Y., Naresh, R., Arachchi, H., Beroukhim, R., Carter, S. L., Cho, J., Frazer, S., Gabriel, S. B., Getz, G., Heiman, D. I., Kim, J., Lawrence, M. S., Lin, P., Noble, M. S., Saksena, G., Schumacher, S. E., Sougnez, C., Voet, D., Zhang, H., Bowen, J., Coppens, S., Gastier-Foster, J. M., Gerken, M., Helsel, C., Leraas, K. M., Lichtenberg, T. M., Ramirez, N. C., Wise, L., Zmuda, E., Baylin, S., Herman, J. G., LoBello, J., Watanabe, A., Haussler, D., Radenbaugh, A., Rao, A., Zhu, J., Bartsch, D. K., Sbiera, S., Allolio, B., Deutschbein, T., Ronchi, C., Raymond, V. M., Vinco, M., Shao, L., Amble, L., Bootwalla, M. S., Lai, P. H., Van Den Berg, D. J., Weisenberger, D. J., Robinson, B., Ju, Z., Kim, H., Ling, S., Liu, W., Lu, Y., Mills, G. B., Sircar, K., Wang, Q., Yoshihara, K., Laird, P. W., Fan, Y., Wang, W., Shinbrot, E., Reincke, M., Weinstein, J. N., Meier, S., Defreitas, T., Hammer, G. D., Giordano, T. J., & Verhaak, R. G. W.
- ORCID
- Benz, Christopher
- Holt, Robert A.
- Jones, Steven J.M.
- Kasaian, Katayoon
- Lee, Darlene
- Lim, Lynette
- Marra, Marco A.
- Mayo, Michael
- Mungall, Andrew J.
- Sadeghi, Sara
- Park, Peter J.
- Kroiss, Matthias
- Gao, Jianjiong
- Sander, Chris
- Schultz, Nikolaus
- Jones, Corbin D.
- Kucherlapati, Raju
- Mieczkowski, Piotr A.
- Parker, Joel S.
- Perou, Charles M.
- Wilkerson, Matthew D.
- Hayes, D. Neil
- Ladanyi, Marc
- Quinkler, Marcus
- Latronico, Ana Claudia
- Mendonca, Berenice B.
- Sibony, Mathilde
- Sanborn, Zack
- Covington, Kyle
- Dinh, Huyen
- Gibbs, Richard
- Hu, Jianhong
- Kalra, Divya
- Khan, Ziad
- Morgan, Margaret
- Muzny, Donna
- Dousset, Bertrand
- Groussin, Lionel
- Libé, Rossella
- Liu, Jia
- Yeh, Jen Jen
- Hoyle, Alan P.
- Shi, Yan
- Zhang, Wei
- Felau, Ina
- Sheth, Margi
- Tarnuzzer, Roy
- Yang, Liming
- Zenklusen, Jean C.
- Zhang, Jiashan (Julia)
- Davidsen, Tanja
- Sofia, Heidi J.
- Roach, Jeffrey
- Bshara, Wiam
- Soon, Patsy
- Pihl, Todd
- Sun, Qiang
- Beroukhim, Rameen
- Carter, Scott L.
- Gabriel, Stacey B.
- Getz, Gad
- Heiman, David I.
- Kim, Jaegil
- Lawrence, Michael S.
- Lin, Pei
- Noble, Michael S.
- Saksena, Gordon
- Schumacher, Steven E.
- Zhang, Hailei
- Bowen, Jay
- Coppens, Sara
- Lichtenberg, Tara M.
- Ramirez, Nilsa C.
- Zmuda, Erik
- Baylin, Stephen
- Herman, James G.
- LoBello, Janine
- Haussler, David
- Radenbaugh, Amie
- Rao, Arjun
- Zhu, Jingchun
- Bartsch, Detlef K.
- Sbiera, Silviu
- Deutschbein, Timo
- Ronchi, Cristina
- Raymond, Victoria M.
- Vinco, Michelle
- Weisenberger, Daniel J.
- Ju, Zhenlin
- Kim, Hoon
- Liu, Wenbin
- Lu, Yiling
- Mills, Gordon B.
- Sircar, Kanishka
- Wang, Qianghu
- Yoshihara, Kosuke
- Laird, Peter W.
- Fan, Yu
- Wang, Wenyi
- Shinbrot, Eve
- Weinstein, John N.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2016-08
- Volume
- 30
- Issue
- 2
- Pages
- 363
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2590587190
- Cited by
- 165
- References
- 0
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 9 · 2023: 14 · 2022: 16 · 2021: 33 · 2020: 22 · 2019: 25 · 2018: 21 · 2017: 10 · 2016: 2
- FWCI
- 21.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 372 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cancer Cell (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Keywords
- adrenocortical carcinoma, driver genes, whole-genome duplication, tumor progression, tumor subtypes, clinical outcomes, genetic alterations
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