A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations
Zhang, Yiqun, Kwok-Shing Ng, Patrick, Kucherlapati, Melanie, Chen, Fengju, Liu, Yuexin, Tsang, Yiu Huen, de Velasco, Guillermo, Jeong, Kang Jin +34 more·2017·Cancer Cell
Cited by (645)
Items 401–500 of 645
- Identification and validation of core genes in tumor-educated platelets for human gastrointestinal tumor diagnosis using network-based transcriptomic analysisYuhong Jiang, Jun He, Xiaobo Wang, Chao Liu, Weihan Zhou, Dekun Liu, Zhushu Guo, Kuijie Liu · 2023 · Platelets
- Emerging Roles of Signal Transduction Pathways in Neurodegenerative Diseases. Hunting New Possible Therapeutic Molecular TargetsVincenza Rita Lo Vasco · 2023 · OBM Geriatrics
- Promoter hypomethylated PDZK1 acts as a tumorigenic gene in glioma by interacting with AKT1Xing Ren, Dan Deng, Shasha Xiang, Jianbo Feng · 2024 · Aging
- Modulation of the PI3K/mTOR pathwaysArpine Galstyan, Janice M. Cho, Daniel E. Johnson, Jennifer Rubin Grandis · 2020 · Elsevier eBooks
- Proteomic profiling of bladder cancer for precision medicine in the clinical setting: A review for the busy urologistJayoung Kim, Peng Jin, Wei Yang, Wun‐Jae Kim · 2020 · Korean journal of urology
- MNS1 promotes hepatocarcinogenesis and metastasis via activating PI3K/AKT by translocating β‐catenin and predicts poor prognosisYong Yi, Mincheng Yu, Pei‐Yao Fu, Gao Liu, Pei‐Yun Zhou, Ruo‐Yu Guan, Cheng Zhou, Bao‐Ye Sun, Shuang–Jian Qiu · 2021 · Liver International
- Role of Tumor Suppressor PTEN and Its Regulation in Malignant Transformation of EndometriumAlina M. Perevalova, Vyacheslav S. Kobelev, В Г Сисакян, Lyudmila F Gulyaeva, Vladimir O. Pustylnyak · 2022 · Biochemistry (Moscow)
- Energy Stress-Mediated Cytotoxicity in Tuberous Sclerosis Complex 2-Deficient Cells with Nelfinavir and Mefloquine TreatmentHenry D. McCann, Charlotte E. Johnson, Rachel J. Errington, David Mark Davies, Elaine A. Dunlop, Andrew R. Tee · 2018 · Cancers
- An Overview of the Oncogenic Signaling Pathways in Different Types of CancersAfshin Derakhshani, Zeinab Rostami, Sina Taefehshokr, Hossein Safarpour, Reza Vaezi Astamal, Nima Taefehshokr, Nazila Alizadeh, Antonella Argentiero, Nicola Silvestris, Behzad Baradaran · 2020 · Preprints.org
- Predicting the Prognosis of Bladder Cancer Patients Through Integrated Multi-omics Exploration of Chemotherapy-Related Hypoxia GenesWensheng Shi, Jiaming Dong, Bowen Zhong, Xiheng Hu, Chunguang Zhao · 2024 · Molecular Biotechnology
- Phosphatidic acid as a cofactor of mTORC1 in platinum-based chemoresistance: Mechanisms and therapeutic potentialHadi Alizadeh, Sana Kerachian, Keyvan Jabbari, Bahram Mohammad Soltani · 2024 · European Journal of Pharmacology
- Sera from women with different metabolic and menopause states differentially regulate cell viability and Akt activation in a breast cancer in-vitro modelLaura Cecilia Flores-García, José Luis Ventura-Gallegos, Sandra Lorena Romero-Cordoba, Alfredo J. Hernández-Juárez, M. Augusta Naranjo-Meneses, Eduardo García‐García, Juan Pablo Méndez, Alberto Jose Cabrera-Quintero, Antonio Ramírez-Ruíz, Sigifredo Pedraza‐Sánchez et al. · 2022 · PLoS ONE
- Tl(I) and Tl(III)-induce genotoxicity, reticulum stress and autophagy in PC12 Adh cellsDamiana M. Salvatierra Fréchou, Sandra Viviana Verstraeten · 2024 · Archives of Toxicology
- Identification of genes that promote PI3K pathway activation and prostate tumour formationJeffrey C. Francis, Amy Capper, Alistair G. Rust, Klea Ferro, Jian Ning, Wei Yuan, Johann Sebastian De Bono, Stephen J. Pettitt, Amanda Swain · 2024 · Oncogene
- Targeting Mps1 in combination with paclitaxel inhibits osteosarcoma progression by modulating spindle assembly checkpoint and Akt/mTOR signalingLu Lu, Yuhai Wang, Jian Chen, Li Ye, Qingyang Liang, Feng Li, Chuanchuan Zhen, Kegong Xie · 2021 · Oncology Letters
- Copy number alterations and epithelial‑mesenchymal transition genes in diffuse and intestinal gastric cancers in Mexican patientsVioleta Larios‐Serrato, José Darío Martínez‐Ezquerro, Hilda-Alicia Valdez‐Salazar, Javier Torres, Margarita Camorlinga‐Ponce, Patricia Piña‐Sánchez, Martha Eugenia Ruiz Tachiquín · 2022 · Molecular Medicine Reports
- Detection of a novel panel of 24 genes with high frequencies of mutation in gastric cancer based on next-generation sequencingHui-Hui Zeng, Ze Ran Yang, Yebei Qiu, Shoaib Bashir, Yin Li, Meng Qing Xu · 2022 · World Journal of Clinical Cases
- Refining sugar's involvement in cholesterol synthesisNicole Fenton, Tina B. Nguyen, Laura Jane Sharpe, Andrew John Brown · 2022 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- Immune Pathways with Aging Characteristics Improve Immunotherapy Benefits and Drug Prediction in Human CancerXinyue Wang, Shuang Guo, Hanxiao Zhou, Yue Sun, Jing Gan, Yakun Zhang, Wen Zheng, Caiyu Zhang, Xiaoxi Zhao, Jiebin Xiao et al. · 2023 · Cancers
- Prognostic value of RGS1 and mTOR Immunohistochemical expression in Egyptian multiple myeloma patients; A single center studyNora Hafez, Lobna Refaat, Omnia K. ElGebaly, Hossam M. Elhariry, Mohamed Ghareeb, Lamiaa Abdelfattah Fathalla · 2023 · PLoS ONE
- A phase Ib, open-label, dose-escalation study of the safety and pharmacology of taselisib (GDC-0032) in combination with either docetaxel or paclitaxel in patients with HER2-negative, locally advanced, or metastatic breast cancerVandana Gupta Abramson, Mafalda Oliveira, Andrès M.R. Cervantes, Hans P. M. W. Wildiers, Manish R. Patel, Todd Michael Bauer, Philippe Lucien Bedard, Carlos Roberto Becerra, Stephen Lane Richey, Michael C. Wei et al. · 2019 · Breast Cancer Research and Treatment
- Genomic landscape analyses in cervical carcinoma and consequences for treatmentDominik Diefenbach, Henry Johannes Greten, Thomas Efferth · 2020 · Current Opinion in Pharmacology
- Oncogenic Signaling Pathways in Cancer: An OverviewAfshin Derakhshani, Zeinab Rostami, Sina Taefehshokr, Hossein Safarpour, Reza Vaezi Astamal, Nima Taefehshokr, Nazila Alizadeh, Antonella Argentiero, Nicola Silvestris, Behzad Baradaran · 2020 · Preprints.org
- Biological insights from the whole genome analysis of human embryonic stem cellsFlorian T. Merkle, Sulagna Dia Ghosh, Giulio Genovese, Robert E. Handsaker, Seva Kashin, Konrad J. Karczewski, Colm T. O’Dushlaine, Carlos N. Pato, Michele T. Pato, Daniel G. MacArthur et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Design, Synthesis, and Biological Evaluation of Rapamycin Derivatives as the First Mammalian Target of Rapamycin and GLS1 Dual InhibitorsLin Wu, Minglei Lyu, Dong-Quan Gu, Yin Li, Ying Li, Hongsu Zhao, Tongsheng Wang, Feng-Qing Xu, Deling Wu, Wu-Xi Zhou · 2025 · Journal of Medicinal Chemistry
- Antibody reliability influences observed mRNA–protein correlations in tumour samplesSwathi Ramachandra Upadhya, Colm J. Ryan · 2023 · Life Science Alliance
- Early Detection of Wellness-to-Disease Transitions in the AI Era: Implications for Pharmacology and ToxicologyNoa Rappaport, Bartek Nogal, Kevin M. Perrott, Vincenzo Domina, Leroy Hood, Nathan D. Price · 2025 · The Annual Review of Pharmacology and Toxicology
- Integrated analysis of the ubiquitination mechanism reveals the specific signatures of tissue and cancerDeyu Long, Ruiqi Zhang, Changjian Du, Jiapei Tong, Yu Ni, Yaqi Zhou, Yongchun Zuo, Mingzhi Liao · 2023 · BMC Genomics
- Phosphorylation at tyrosine 317 and 508 are crucial for PIK3CA/p110α to promote CRC tumorigenesisTing Wang, Longci Sun, Chengkun Chen, Yingchao Zhang, Baoyu He, Yanhua Zhang, Zhenghe Wang, Hanbing Xue, Yujun Hao · 2023 · Cell & Bioscience
- PI3Kα-specific inhibitor BYL-719 synergizes with cisplatin in vitro in PIK3CA-mutated ovarian cancer cellsBenoît Thibault, Adrien Thole, Romina D’Angelo, Céline Basset, Julie Guillermet‐Guibert · 2025 · Scientific Reports
- Global DNA methylation differences involving germline structural variation impact gene expression in pediatric brain tumorsFengju Chen, Yiqun Zhang, Wei Li, Fritz Joachim Sedlazeck, Lanlan Shen, Chad J. Creighton · 2025 · Nature Communications
- Ipatasertib in Patients with Tumors with AKT Mutations: Results from the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol Z1KCarolyn Kay McCourt, Zihan Wei, Kevin M. Kalinsky, Robert J. Gray, Victoria Wang, Lisa M. McShane, Larry Rubinstein, David R. Patton, Paul Mickey Williams, Stanley R. Hamilton et al. · 2025 · Clinical Cancer Research
- Feed‐forward activation of STAT3 signaling limits the efficacy of c‐Met inhibitors in esophageal squamous cell carcinoma (ESCC) treatmentDi Zhao, Jie Chen, Yan Wang, Lingyuan Zhang, Jing Zhang, Weimin Zhang, Jiawen Fan, Jinting Li, Qimin Zhan · 2021 · Molecular Carcinogenesis
- Diverse Roles and Therapeutic Potentials of Circular RNAs in Urological CancersSong Wang, Yufan Ying, Xueyou Ma, Weiyu Wang, Xiao Wang, Liping Xie · 2021 · Frontiers in Molecular Biosciences
- Inaugurating a novel adjuvant therapy in urological cancers: FerroptosisZhaoxiang Xie, Qianghua Zhou, Cheng Qiu, Dingjun Zhu, Kaiwen Li, Hai Wei Huang · 2022 · Cancer Pathogenesis and Therapy
- Epigenetic upregulation of MNAT1 by SMYD2 is linked to PI3K/AKT activation and tumorigenesis of pancreatic adenocarcinoma.Zhen Cheng Xu, Yan Liu, Zhi Pan, Lei Qin · 2024 · PubMed
- JAK3/STAT5 signaling‐triggered upregulation of PIK3CD contributes to gastric carcinoma developmentQingqing Hu, Ning Dou, Qiong Wu, Yong Gao, Yandong Li, Jingde Chen · 2024 · Journal of Cell Communication and Signaling
- Sacral Bioneuromodulation: The Role of Bone Marrow Aspirate in Spinal Cord InjuriesJosé Fábio Lana, Annu H. Navani, Madhan Jeyaraman, Napoliane Santos, Luyddy Pires, Gabriel Silva Santos, Izair Jefthé Rodrigues, Douglas Santos, Tomas Mosaner, Gabriel Ohana Marques Azzini et al. · 2024 · Bioengineering
- Rebound pathway overactivation by cancer cells following discontinuation of PI3K or mTOR inhibition promotes cancer cell growthSeraina Faes, Tania Santoro, Laëtitia Troquier, Olga De Souza Silva, Olivier Dormond · 2019 · Biochemical and Biophysical Research Communications
- PI3Kδ activation, IL6 over-expression, and CD37 loss cause resistance to the targeting of CD37-positive lymphomas with the antibody-drug conjugate naratuximab emtansineAlberto J. Arribas, Eugenio Gaudio, Sara Napoli, Charles Herbaux, Chiara Tarantelli, Roberta Pittau Bordone, Luciano Cascione, Nicolas Munz, Luca Aresu, Jacopo Sgrignani et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- The WW domain of IQGAP1 binds directly to the p110α catalytic subunit of PI 3-kinase2023
- Comparison of somatic variant oncogenicity classification using ClinGen/CGC/VICC guidelines and QIAGEN Clinical Insight Interpret decision support softwareAarthi Goverdhan, Lisa G. Mullineaux, Amber L. Pryzbylski, Claire Teigen, Kevin C. Halling, Sheryl Krevsky Elkin, Beth A. Pitel · 2025 · Cancer Genetics
- Overcoming Curcumin's Limitations: Synthetic Derivatives in Diabetes and Cancer ManagementAdesola Oluwaseun Adeleye, S Moftah Dena, Oluwafemi Omoniyi Oguntibeju, Salam J.J. Titinchi, Chinyerum Sylvia Opuwari · 2025 · Applied Research
- Phosphoinositide-dependent kinase 1 (PDK1) in cancer: molecular insights and therapeutic strategiesShatha Algheribe, Ayat Zagzoog, Mohamed Boudjelal, Imadul Islam · 2026 · Frontiers in Chemistry
- The mechanism of the PI3K-AKT-mTOR signaling pathway in renal cell carcinoma: current developments and future prospectsCan Zou, Y J Wang, Qiuyan Chen, Jianyou Shi, Xianbo Wu, Quan Luo · 2026 · Frontiers in Oncology
- Interactions between the nervous system and PDAC progression: Regulatory mechanisms and therapeutic implicationsJoelson Germano Crispim, Camila Neiva Porto Silva, Moacyr Jesus Barreto de Melo Rêgo, Michelle Melgarejo da Rosa · 2026 · European Journal of Pharmacology
- Real world clinicopathologic observations of patients with metastatic solid tumors receiving immune checkpoint inhibitor therapy: Analysis from Kentucky Cancer RegistryAasems Jacob, Jianrong Wu, Jill Kolesar, Eric B. Durbin, Aju Mathew, Susanne M. Arnold, Aman Chauhan · 2021 · Cancer Medicine
- Protein biomarkers for subtyping breast cancer and implications for future research: a 2024 updateClaudius Mueller, Justin B. Davis, Virginia A. Espina · 2024 · Expert Review of Proteomics
- Prevalence and clinical implications of PIK3CA aberrations across cancer types: A real-world next-generation sequencing approachJunkyu Kim, Hye‐Lim Jang, Jung Young Hong, Seung Tae Kim, Se Hoon Park, Joon Oh Park, Kyoung‐Mee Kim, Deok geun Kim, Jeeyun Lee, Sung Hee Lim · 2025 · Cancer Genetics
- High incidence of PI3K pathway gene mutations in South Indian cervical cancersMathew Maria Rose, Shankar Dhamodharan, Sundaramoorthy Revathidevi, Sundaram Reddy Chakkarappan, Mani G Jagadeesan, Subbiah Shanmugam, Hirofumi Nakaoka, Ituro Inoue, Avaniyapuram Kannan Murugan, Arasambattu Kannan Munirajan · 2022 · Cancer Genetics
- Moquiniastrum polymorphum subsp. polymorphum extract inhibits the proliferation of an activated hepatic stellate cell line (GRX) by regulating the p27 pathway to generate cell cycle arrestMatheus Scherer Bastos, Rafaela Mallmann Saalfeld, Bruna Pasqualotto Costa, Maria Cláudia Rosa Garcia, Krist Helen Antunes, Kétlin Fernanda Rodrigues, Denizar Alberto da Silva Melo, Eliane Romanato Santarém, Jarbas Rodrigues de Oliveira · 2022 · Journal of Ethnopharmacology
- Impact of somatic mutations and transcriptomic alterations on cancer aneuploidyKeiichi Hatakeyama, Takeshi NAGASHIMA, Keiichi Ohshima, Sumiko Ohnami, Shumpei Ohnami, Yuji Shimoda, Akane Naruoka, Koji Maruyama, Akira Iizuka, Tadashi Ashizawa et al. · 2023 · Biomedical Research
- Bromodomain and Extraterminal Domain Protein 2 in Multiple Human DiseasesYikang Ji, Wantao Chen, Xu Wang · 2024 · Journal of Pharmacology and Experimental Therapeutics
- Quantitative Assessment of Preanalytic Variables on Clinical Evaluation of PI3/AKT/mTOR Signaling Activity in Diffuse GliomaSol Beccari, Esraa Mohamed, Viva Voong, Stephanie Hilz, Marisa Lafontaine, Anny Shai, Yunita Lim, Jerry Martinez, Benjamin Switzman, Ryon L Yu et al. · 2024 · Modern Pathology
- Signaling dynamics in coexisting monoclonal cell subpopulations unveil mechanisms of resistance to anti-cancer compoundsClaire Blanchard, Alison Gomeiz, Kyle Avery, Emna El Gazzah, Abduljalil M. Alsubaie, Masoumeh Sikaroodi, Ylenia Chiari, Chelsea Ward, Jonathan Sanchez, Virginia A. Espina et al. · 2024 · Cell Communication and Signaling
- Translational regulation of SND1 governs endothelial homeostasis during stressZhenbo Han, Gege Yan, Jordan Jousma, S. B. Nukala, Mehdi Amiri, Stephen J. Kiniry, Negar Tabatabaei, Y. Kwon, Sen Zhang, Jalees Rehman et al. · 2025 · Journal of Clinical Investigation
- Identifying and validating PLAU as a potential prognostic biomarker for PDACPeng An, Junhong Wang, Rong Fan · 2025 · Scientific Reports
- The Pan-Omics Landscape of Renal Cell Carcinoma and Its Implication on Future Clinical PracticeJennifer Jing Huang, James J.-D. Hsieh · 2020 · Kidney Cancer
- The Genomic Landscape of Prostate Cancer Brain MetastasesAntonio Rodrı́guez, John Gallon, Dilara Akhoundova, Sina Maletti, Alison M. Ferguson, Joanna Cyrta, Ursula Amstutz, Andrea Garofoli, Viola Paradiso, Scott A. Tomlins et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Loss of epigenetic regulation disrupts lineage integrity, reactivates multipotency and promotes breast cancerEllen R. Langille, Khalid N. Al‐Zahrani, Zhibo Ma, Ahmad Malik, Sampath Kumar Loganathan, Daniel Trcka, Jeff Liu, Katelyn J. Kozma, Ricky Tsai, Katie Teng et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Verbascoside induces the cell cycle arrest and apoptosis of breast cancer via suppression of the PI3K/AKT signaling pathwayYuying Ou, Ye Zhang, Xinbing Zhu, Demiao Zhu · 2022 · Research Square
- Nullomer peptide increases immune cell infiltration and reduces tumor metabolism in triple negative breast cancer mouse modelN. Ali, Cody L. Wolf, Swarna Kanchan, S. Veerabhadraiah, L. Bond, M. Turner, C. Jorcyk, G. Hampikian · 2023 · Research Square
- The multifaceted functions of SPC25 in cancer: from molecular pathways to targeted therapyYigang Jin, Minjie Chen, Fei Chen, Zhaofeng Gao, Xiaoping Li, Lingyu Hu, Dandan Cai, Siqi Zhao, Zhengwei Song · 2025 · Frontiers in Medicine
- Vaginal Adenocarcinoma: A Review of a Rare Gynecologic CancerMun-Kun Hong, Dah‐Ching Ding · 2025 · Cancers
- Farrerol inhibits proliferation and migration of colorectal cancer via the VEGF signaling pathway: evidence from network pharmacology, molecular docking, molecular dynamics simulation, and in vitro experimentsLonghui Zhang, Qinghua Xu, Guanduo Sun, Xiaokang Zhang, Jialong Xue, Chun Yao, Dechun Liu, Jingming Zhai · 2025 · Frontiers in Pharmacology
- Genomic landscape of pediatric germ cell tumors reveals oncogenic mutations and copy number alterationsJ. Galvão, Ana Flavia Souza Peres Bezerra, Felipe Antonio de Oliveira Garcia, Ana Glenda Santarosa Vieira, E. C. Albino da Silva, André van Helvoort Lengert, R. M. Reis, L. Lopes, A. Evangelista, M. Pinto · 2026 · Frontiers in Oncology
- Crosstalk of Molecular Signaling in Hepatocellular CarcinomaHua-Rong Chen, Jun Yu · 2020 · Springer eBooks
- Improving the Genome Annotation of Rhizoctonia solani Using ProteogenomicsJiantao Shu, Mingkun Yang, Cheng Zhang, Pingfang Yang, Feng Ge, Ming Li · 2021 · Current Genomics
- PIK3CA Mutational Analysis in Patients With MacrodactylyJakob Becker, Ulrike Camenisch Gross, Daniel Max Weber, Lisa Weibel, Martin Theiler, Simone Brandt, Peter K. Bode · 2022 · Pediatric and Developmental Pathology
- Altered PI3K/AKT/mTOR Signaling Pathway and Cancer Stem CellsAyse Ertay · 2024 · Stem cell biology and regenerative medicine
- Blocking p85β nuclear translocation by importazole enhances Alpelisib efficacy against PIK3CA-helical-domain-mutant tumorsBaoyu He, Xiangyu Li, Meilian Yao, Yanhua Zhang, Xinyuan Zhou, Jun Gu, Yujun Hao, Dong Zhang, Longci Sun · 2025 · Biochemical and Biophysical Research Communications
- Personalized therapy in metastatic colorectal cancer: biomarker-driven use of biologicsFrancesco Giulio Sullo, Chiara Gallio, Laura Matteucci, Alessandro Bittoni, Margherita Muratore, Luca Esposito, Bianca Ceredi, Graziana Gallo, Paola Ulivi, Ilario Giovanni Rapposelli et al. · 2025 · Expert Opinion on Biological Therapy
- Mutational pattern of PIK3CA exon 20 in circulating DNA in breast cancerIman Hassan Ibrahim, Heba Gamal Abd El-Aziz, Noha N. Amer, hesham abd al-samee · 2022 · Saudi Journal of Biological Sciences
- Molecular subtype classification of papillary renal cell cancer using miRNA expressionChangwen Yu, Danjing Dai, Juan Xie · 2019 · OncoTargets and Therapy
- Molecular characteristics and clinical implications of serine/arginine-rich splicing factors in human cancerJinjin Zhang, Zhicheng Fang, Congkuan Song · 2023 · Aging
- Practical management of renal cell carcinoma: integrating current approaches with advances in bone metastasis treatmentIrina Anca Eremia, Bogdan Şerban, Mihnea Ioan Gabriel Popa, Adela Iancu, Silvia Nica, Cătălin Cîrstoiu · 2024 · EFORT Open Reviews
- Granulocyte‐colony stimulating factor‐producing uterine cervical cancer treated with chemoradiotherapy: A case report with mutation analysis and literature reviewShintaro Shiba, Takahiro Oike, Ken Ando, Yuya Yoshimoto, Yoshiyasu Takayama, Tatsuya Ohno · 2020 · Clinical Case Reports
- Multiomics integrative analysis reveals antagonistic roles of CBX2 and CBX7 in metabolic reprogramming of breast cancerIqbal Mohammad Askandar, Siddiqui Shumaila, Asad Ur Rehman, Siddiqui Farid Ahmad, Prithvi Kumar Singh, Bhupender Kumar, Saluja Daman · 2022 · UTUPub (University of Turku)
- An integrative pan-cancer investigation reveals common genetic and transcriptional alterations of AMPK pathway genes as important predictors of clinical outcomes across major cancer typesWai Hoong Chang, Alvina Grace Lai · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
- Transcriptomically-inferred PI3K activity and stemness show a counterintuitive correlation with PIK3CA genotype in breast cancerRalitsa Radostinova Madsen, Oscar M. Rueda, Xavier Robin, Carlos Caldas, Robert K. Semple, Bart Vanhaesebroeck · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Aberrant Signaling Pathways in CancerLuca Grumolato, Stuart A. Aaronson · 2022 · Holland‐Frei Cancer Medicine
- Multiple Mutations within Individual Oncogenes: Examples and Clinical ImplicationsKeisuke Kataoka, Yuki Saito · 2023 · The Keio Journal of Medicine
- Proteomics Analysis of Renal Cell Line Caki-2 with AFMID Overexpression and Potential Biomarker Discovery in UrineJiameng Sun, Jinchun Chang, Zhengguang Guo, Haidan Sun, Jiyu Xu, Xiaoyan Liu, Wei Sun · 2024 · Journal of Proteome Research
- RECENT ADVANCES IN SELECTIVELY TARGETING PI3KαDavid J. St. Jean, Trang Tieu, Angel Guzmán-Pérez, Alexander M. Taylor · 2024 · Medicinal chemistry reviews
- Effect of elastin on abnormal proliferation of pulmonary artery smooth muscle cells at an early stage of hypoxic exposureHao Dong, Pengshuai Li, Xuefei Julie Wang, Yuxin Zhang, Fei Han, Shan Gao, Wenqing Hu, Xuewei Hao · 2024 · Journal of Receptors and Signal Transduction
- A mode of action protein based approach that characterizes the relationships among most major diseasesHongyi Zhou, Brice Edelman, Jeffrey Skolnick · 2025 · Scientific Reports
- Comprehensive Molecular and Genomic Analysis of NCI-MATCH Subprotocol Y: Capivasertib in Patients With an AKT1 E17K –Mutated TumorCarolyn Kay McCourt, Jacob Gross, Kevin M. Kalinsky, Ping Guan, Lisa M. McShane, Victoria Wang, Peter James O'Dwyer, Matthew T. Lahey, Cayden Maican, Xiangning Bu et al. · 2025 · JCO Precision Oncology
- N-(5-(2-morpholino-4-oxo-3,4-dihydroquinazolin-8-yl)pyridin-2-yl)acylamides as novel multi-PI3K/DNA-PK/P-gp inhibitors for efficient chemosensitization and MDR alleviationMartina Sukupova, Karolina Knittelova, Elham Parsimehr, David Maliňák, Denisa Noskova, Jana Kurcova, Ester Marakova, Zdenek Kratochvil, Vladimír Pekařík, Miroslav Psotka et al. · 2025 · European Journal of Medicinal Chemistry
- Conventional and alternative approaches for targeting PIK3CA and PTEN alterations in head and neck, breast, and other cancersJovanka Gencel‐Augusto, Jennifer Rubin Grandis, Daniel E. Johnson · 2025 · Advances in Biological Regulation
- Early phase development of PI3kinase inhibitors for anticancer therapiesCarlo Caputo, Angela Lombardi, Miryam DEL VICARIO, Domenico Cautela, Raffaele Addeo, Federica Melisi, Anna Grimaldi, Alois Nečas, Evžen Amler, Rossella Sperlongano et al. · 2025 · Expert Opinion on Investigational Drugs
- Targeting PI3Kδ in cancer: a setback or the endZhonglin Hao, Susanne M. Arnold, Jill Kolesar · 2025 · Frontiers in Oncology
- Adenovirus E4ORF1 activates isoform-specific phosphatidylinositol 3-kinase signaling in human endothelial cellsFuqiang Geng, Mariko Kobayashi, Yang Lin, Jesús M. Gómez-Salinero, Dominick Romano, Jean E. Kanyo, Jennifer Geng, Ying Liu, Michael D. Ginsberg, Jae-Hung Shieh et al. · 2025 · Journal of Biological Chemistry
- Multiple Testing of Mix‐and‐Match Feature Sets in Multi‐OmicsMitra Ebrahimpoor, Renee Xavier de Menezes, Ningning Xu, Jelle J. Goeman · 2026 · Statistics in Medicine
- Chlorella pyrenoidosa-derived extracellular vesicles ameliorate ulcerative colitis through microbiota-mediated AKT/mTOR/ferroptosis pathwayDanya Lu, X. Chelsea Chen, Demei Wang, Xian Zheng, Tianlong Zhao, Mengmeng Qiu, Ting Li, Lihong Ding, Zhishu Tang, 严宝飞 et al. · 2026 · Phytomedicine
- Body fatness and breast cancer risk in relation to phosphorylated mTOR expression in a sample of predominately Black womenTing‐Yuan David Cheng, Angela R. Omilian, Song Yao, Weizhou Zhang, Susmita Datta, Wiam Bshara, Rochelle Payne Ondracek, Warren Davis, Song Liu, Chi‐Chen Hong et al. · 2021 · Breast Cancer Research
- Identification of Pathway-Based Biomarkers with Crosstalk Analysis for Overall Survival Risk Prediction in Breast CancerXiaohua Liu, Lili Su, Jingcong Li, Guoping Ou · 2021 · Frontiers in Genetics
- [Intrauterine invagination in a newborn infant].Wilco C. W. R. Zijlmans, F A Nabben · 1993 · PubMed
- Targeting p85β nuclear translocation for the tumors with PIK3CA helical domain mutationsBaoyu He, Yujun Hao · 2022 · Genes & Diseases
- LncRNA CAI2 Contributes to Poor Prognosis of Glioma through the PI3K-Akt Signaling PathwayYu Jiang, Jinhui Zhang, Shengjin Yu, Linlin Zheng, Yue Shen, Weiwei Ju, Lijuan Lin · 2023 · Combinatorial Chemistry & High Throughput Screening
- Rare Case of a Turner Syndrome Patient with Metastatic Dysgerminoma and No Y-Chromosomal Material with Pathogenic Variants Found in KIT and MTORCamilla Mains Balle, Christine Gaasdal Kassentoft, Jolinda Iris van Heusden, Michael Knudsen, Line Raaby, Claus Højbjerg Gravholt · 2023 · Sexual Development