A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations
Zhang, Yiqun, Kwok-Shing Ng, Patrick, Kucherlapati, Melanie, Chen, Fengju, Liu, Yuexin, Tsang, Yiu Huen, de Velasco, Guillermo, Jeong, Kang Jin +34 more·2017·Cancer Cell
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- Additional file 3 of Integrated multi-omics analysis and machine learning developed a prognostic model based on mitochondrial function in a large multicenter cohort for Gastric CancerMa, Yimeng, Jin, Jingjing, Xue, Zixuan, Zhao, Jungang, Cai, Weiyang, Zhang, Wanli · 2024 · Figshare
- Additional file 10 of Integrated multi-omics analysis and machine learning developed a prognostic model based on mitochondrial function in a large multicenter cohort for Gastric CancerMa, Yimeng, Jin, Jingjing, Xue, Zixuan, Zhao, Jungang, Cai, Weiyang, Zhang, Wanli · 2024 · Figshare
- Additional file 7 of Integrated multi-omics analysis and machine learning developed a prognostic model based on mitochondrial function in a large multicenter cohort for Gastric CancerMa, Yimeng, Jin, Jingjing, Xue, Zixuan, Zhao, Jungang, Cai, Weiyang, Zhang, Wanli · 2024 · Figshare
- Additional file 2 of Novel cellular systems unveil mucosal melanoma initiating cells and a role for PI3K/Akt/mTOR pathway in mucosal melanoma fitnessMatilde Monti, Benerini Gatta, Luisa, Bugatti, Mattia, Irene Pezzali, Sara Picinoli, Marcello Manfredi, Antonio Lavazza, Virginia Vita Vanella, Veronica De Giorgis, Lucia Zanatta et al. · 2024 · Figshare
- Additional file 6 of Integrated multi-omics analysis and machine learning developed a prognostic model based on mitochondrial function in a large multicenter cohort for Gastric CancerMa, Yimeng, Jin, Jingjing, Xue, Zixuan, Zhao, Jungang, Cai, Weiyang, Zhang, Wanli · 2024 · Figshare
- Additional file 3 of Novel cellular systems unveil mucosal melanoma initiating cells and a role for PI3K/Akt/mTOR pathway in mucosal melanoma fitnessMatilde Monti, Benerini Gatta, Luisa, Bugatti, Mattia, Irene Pezzali, Sara Picinoli, Marcello Manfredi, Antonio Lavazza, Virginia Vita Vanella, Veronica De Giorgis, Lucia Zanatta et al. · 2024 · Figshare
- Additional file 1 of Multiple PIK3CA mutation clonality correlates with outcomes in taselisib + fulvestrant-treated ER+/HER2–, PIK3CA-mutated breast cancersKatherine E. Hutchinson, Jessica W. Chen, Heidi M. Savage, Thomas J. Stout, Frauke Schimmöller, Javier Cortés, Dent, Susan, Nadia Harbeck, William Jacot, Ian E. Krop et al. · 2023 · Figshare
- Additional file 8 of Integrated multi-omics analysis and machine learning developed a prognostic model based on mitochondrial function in a large multicenter cohort for Gastric CancerMa, Yimeng, Jin, Jingjing, Xue, Zixuan, Zhao, Jungang, Cai, Weiyang, Zhang, Wanli · 2024 · Figshare
- Additional file 1 of Body fatness and breast cancer risk in relation to phosphorylated mTOR expression in a sample of predominately Black womenCheng, Ting-Yuan David, Angela R. Omilian, Yao, Song, Zhang, Weizhou, Datta, Susmita, Bshara, Wiam, Ondracek, Rochelle Payne, Warren Davis, Song Liu, Hong, Chi-Chen et al. · 2021 · Figshare
- Additional file 1 of Novel cellular systems unveil mucosal melanoma initiating cells and a role for PI3K/Akt/mTOR pathway in mucosal melanoma fitnessMatilde Monti, Benerini Gatta, Luisa, Bugatti, Mattia, Irene Pezzali, Sara Picinoli, Marcello Manfredi, Antonio Lavazza, Virginia Vita Vanella, Veronica De Giorgis, Lucia Zanatta et al. · 2024 · Figshare
- Additional file 8 of 2,6-DMBQ is a novel mTOR inhibitor that reduces gastric cancer growth in vitro and in vivoXueyin Zu, Ma, Xiaoli, Xie, Xiaomeng, Lu, Bingbing, Kyle Vaughn Laster, Liu, Kangdong, Dong, Zigang, Kim, Dong Joon · 2020 · Figshare
- Additional file 14 of Integrated multi-omics analysis and machine learning developed a prognostic model based on mitochondrial function in a large multicenter cohort for Gastric CancerMa, Yimeng, Jin, Jingjing, Xue, Zixuan, Zhao, Jungang, Cai, Weiyang, Zhang, Wanli · 2024 · Figshare
- Additional file 5 of Novel cellular systems unveil mucosal melanoma initiating cells and a role for PI3K/Akt/mTOR pathway in mucosal melanoma fitnessMatilde Monti, Benerini Gatta, Luisa, Bugatti, Mattia, Irene Pezzali, Sara Picinoli, Marcello Manfredi, Antonio Lavazza, Virginia Vita Vanella, Veronica De Giorgis, Lucia Zanatta et al. · 2024 · Figshare
- Additional file 4 of 2,6-DMBQ is a novel mTOR inhibitor that reduces gastric cancer growth in vitro and in vivoXueyin Zu, Ma, Xiaoli, Xie, Xiaomeng, Lu, Bingbing, Kyle Vaughn Laster, Liu, Kangdong, Dong, Zigang, Kim, Dong Joon · 2020 · Figshare
- Unveiling bioactive compounds in kola nut seeds: GC-MS identification and computational analysis for anticancer potentialAzzah Alshehri, Saleh O. S. Bahaffi, Mohd Rehan, Mohd Suhail, Ahmed Ibrahim Al-Asmari, Diaa T. A. Youssef, Alaa Khedr, Torki A. Zughaibi · 2026 · Frontiers in Nutrition
- Impact of PIK3CAH1047R Mutation on Glioblastoma Survival: Insights from a Preliminary StudyMistry Mittal, Shruti Patel, Hemang Patel, Trivedi Trupti I · 2026 · Gujarat Cancer Society Research Journal
- pKAKA: a protein language model for prioritizing kinase-disrupting variants in diseases.Jun-Teng Li, Hao-Yang Cheng, Zhuoran Liang, Jiamin Hu, Yi-Ting Chu, Ruoxi Cai, Bijin Cao, Ying Jin, Yutao Xie, Huai-Qiang Ju et al. · 2026 · Journal of genetics and genomics = Yi chuan xue bao
- The Role of Protein Kinases in the Management of Oncological Diseases by Acting on Ferroptotic PathwaysValentina Folgiero, Matteo Caforio · 2026 · International Journal of Molecular Sciences
- Inferring signaling pathway abnormalities from histopathological images via logic-constrained gene-pathway heterogeneous knowledge graphYu Yu, Wen Shi, Xin Chen, Jinghui Feng, Simin Huang, Shixian Zeng, Xiaolin Bo, Jianing Xi · 2026 · npj Biomedical Innovations.
- Cartographie du phosphoprotéome régulé par les isoformes du PI3K de classe I dans le cancer du pancréasCélia Cintas · 2017 · theses.fr (ABES)
- Implication des enzymes de déubiquitination associés au protéasome dans la pathogénie du mélanomeRobin Didier · 2018
- New Mechanism of Action of Rapalogs : Transcriptional Regulation of TRIB3 and Alteration of Pre-mRNA SplicingBojana Stefanovska · 2019 · theses.fr (ABES)
- Exploring PI3K signalling dynamics in pancreatic cancerCarmen Fernanda Ramos Delgado · 2020 · theses.fr (ABES)
- Overcoming drug resistance in diffuse large b-cell lymphoma by targeting cell metabolism and the alternative NF-kB pathwayStéphanie Nuan-Aliman · 2021 · theses.fr (ABES)
- Characterizing and targeting the microenviromental changes in PIK3CA related overgrowth syndromesIlaria Galasso · 2024
- Modulation of the PI3K/Akt signaling pathway by steroidal saponins: therapeutic implications in cancerMohammad Bagher Majnooni, Maryam Naseri, Shayan Bakhshy-Chenary, Younes Zeinalii, Mahdis Azadi, Mohammad Hosein Farzaei, Sajad Fakhri, Syed Mustafa Ghanadian, Javier Echeverría · 2026 · Frontiers in Pharmacology
- Pan-cancer analysis reveals the prognostic and therapeutic relevance of MEX3A with a focus on chromophobe renal cell carcinomaShuang Wang, Jiejun Zhang, Mengyu Zheng, Yi Feng, Tao Li · 2026 · Frontiers in Oncology
- Activation of the PI3K/AKT/mTOR signaling pathway in bladder cancer pathogenesis and its therapeutic significanceDereje E. Bogale · 2026 · Cancer Treatment and Research Communications
- Chromatin Landscape of Cancer Cell Lines Identifies Enhancer SubtypesM. Mattohti, E. Arslan, Ayush T. Raman, Christopher J. Terranova, Zhi-Yi Liu, Elias Orouji, Sanjana Srinivasan, V. Kochat, M. Tang, S. Amin et al. · 2026 · bioRxiv
- Single-Cell Analysis Reveals STARD10 as a Fatty Acid Metabolism Regulator of Breast Cancer Progression via the PI3K/Akt PathwayYining Han, Jiacheng Fan, Yue Xi, Pengxiang Zhu, Qiyue Sun, Xiaofeng Li · 2026 · International Journal of Molecular Sciences
- TET1-mediated DNA demethylation and transcription activation of MRPS17 induces lung adenocarcinoma through PI3K-AKT-mTOR pathwayNan Zhou, Lei Song, Yang Wu, Ying Wei, Wenwen Zhang, Bingbing Wang, Yanbin Zhao, Yan Wang · 2026 · Journal of Molecular Histology
- An Evaluation of the Anti‐Cancer Effect of Phenylalanyl‐Tyrosine Dipeptide: Molecular Docking, Molecular Dynamics Simulation, Biological Activity‐Toxicity Predictions and In Vitro StudiesBilge Bıçak, Serda Kecel‐Gunduz, Gizem Akman · 2026 · Peptide Science
- PTEN homozygous deletion is a negative prognostic factor in tumor treating fields‐treated glioblastoma, IDH wildtype patientsJakob Nückles, Claudius Jelgersma, Christin Siewert, Brendan Osberg, Simone Schmid, Arend Koch, Eilís Pérez, Daniel Teichmann, Martin Misch, Anna-Gila Karbe et al. · 2026 · Brain Pathology
- Discovery of Tetrasubstituted Quinazolin-4(3 H )-ones as Wild-type-sparing, Highly Selective PI3KαH1047R InhibitorsChun Chen, Ryan Holmes, Jack Carter, Soham Maity, Sarah B. Pawley, Nicholaas Stahl, Amy Crossan, Joseph D. Rager, Ashish Juvekar, Min Wang et al. · 2026 · Journal of Medicinal Chemistry
- Interpreting human genetic variation at atomic resolutionMichael T. Zimmermann, Raul A. Urrutia · 2026 · Nature Genetics
- Deciphering the Medicinal Chemistry Aspects of Akt Inhibitors for the Management of Cancer: Structure–Activity Relationship Frameworks, Landscapes, and Optimization ApproachesMayur S. Dhangar, Mahesh B. Palkar · 2026 · Chemistry & Biodiversity
- COL10A1 at the crossroads of tumor signaling networks and environment remodelingEr Wei, Xiaoyue Guo, Kexin Wang, Wenqi Gu, Yang Zhang, Wang Xianli, Chuanyu Sun · 2026 · Pathology - Research and Practice
- The Transcription Factor PRDM15 Activates the PPP2R5C / PI3K ‐Akt Pathway to Promote Steroid Hormone Secretion in Goat Granulosa CellsPeng Wang, Senxuan Hou, Runqing Chi, Kai Liu, Xiaoyun He, Yuliang Wen, Yufang Liu, Mingxing Chu · 2026 · The FASEB Journal
- Low Expression of PINK1 Suppresses Mitophagy in Sonic Hedgehog–Driven Medulloblastoma in Association With Activation of the PI3K / AKT Signaling PathwayQi Zhang, Hui Yang, Chao Hu, C. Zhang, Longtao He · 2026 · Microscopy Research and Technique
- Dysregulated AKT signaling reprograms osteosarcoma to drive selective reliance on EP300Ian Michael Delahunty, Stephanie Nance, Yang Zhang, François Lamoureux, Qi Liu, William C. Wright, Kristina Ritter, Noha A.M. Shendy, Bénédicte Brounais-Le Royer, Sandra J. Kietlinska et al. · 2026 · The Journal of Experimental Medicine
- Natural compounds targeting cancer-associated genes: Multi-omics mechanisms and therapeutic potentialThakur Prava Jyoti, Manisha Sharma, Karan Sidana, Sunanda Choudhary, Neeraj Choudhary, Dinesh Kumar, Pooja Shivappa · 2026 · Advances in Cancer Biology - Metastasis
- BindingDB Entry 50016411: Molecular design of dual inhibitors of PI3K and potential molecular target of cancer for its treatment: A review.BindingDB · 2023 · UC San Diego
- BindingDB Entry 50021993: Rational Design of a Novel 6H-Benzo[c]chromen Series as Selective PI3Kα Inhibitors.BindingDB · 2025 · UC San Diego
- BindingDB Entry 50015996: Discovery of 2-Methyl-2-(4-(2-methyl-8-(1BindingDB · 2023 · UC San Diego
- BindingDB Entry 50007976: Design, Synthesis, and Biological Evaluation of Imidazo[1,2-BindingDB · 2021 · UC San Diego