A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations

Zhang, Yiqun, Kwok-Shing Ng, Patrick, Kucherlapati, Melanie, Chen, Fengju, Liu, Yuexin, Tsang, Yiu Huen, de Velasco, Guillermo, Jeong, Kang Jin +34 more·2017·Cancer Cell

Cited by (645)

Items 601–645 of 645

  1. Additional file 3 of Integrated multi-omics analysis and machine learning developed a prognostic model based on mitochondrial function in a large multicenter cohort for Gastric Cancer
    Ma, Yimeng, Jin, Jingjing, Xue, Zixuan, Zhao, Jungang, Cai, Weiyang, Zhang, Wanli · 2024 · Figshare
  2. Additional file 10 of Integrated multi-omics analysis and machine learning developed a prognostic model based on mitochondrial function in a large multicenter cohort for Gastric Cancer
    Ma, Yimeng, Jin, Jingjing, Xue, Zixuan, Zhao, Jungang, Cai, Weiyang, Zhang, Wanli · 2024 · Figshare
  3. Additional file 7 of Integrated multi-omics analysis and machine learning developed a prognostic model based on mitochondrial function in a large multicenter cohort for Gastric Cancer
    Ma, Yimeng, Jin, Jingjing, Xue, Zixuan, Zhao, Jungang, Cai, Weiyang, Zhang, Wanli · 2024 · Figshare
  4. Additional file 2 of Novel cellular systems unveil mucosal melanoma initiating cells and a role for PI3K/Akt/mTOR pathway in mucosal melanoma fitness
    Matilde Monti, Benerini Gatta, Luisa, Bugatti, Mattia, Irene Pezzali, Sara Picinoli, Marcello Manfredi, Antonio Lavazza, Virginia Vita Vanella, Veronica De Giorgis, Lucia Zanatta et al. · 2024 · Figshare
  5. Additional file 6 of Integrated multi-omics analysis and machine learning developed a prognostic model based on mitochondrial function in a large multicenter cohort for Gastric Cancer
    Ma, Yimeng, Jin, Jingjing, Xue, Zixuan, Zhao, Jungang, Cai, Weiyang, Zhang, Wanli · 2024 · Figshare
  6. Additional file 3 of Novel cellular systems unveil mucosal melanoma initiating cells and a role for PI3K/Akt/mTOR pathway in mucosal melanoma fitness
    Matilde Monti, Benerini Gatta, Luisa, Bugatti, Mattia, Irene Pezzali, Sara Picinoli, Marcello Manfredi, Antonio Lavazza, Virginia Vita Vanella, Veronica De Giorgis, Lucia Zanatta et al. · 2024 · Figshare
  7. Additional file 1 of Multiple PIK3CA mutation clonality correlates with outcomes in taselisib + fulvestrant-treated ER+/HER2–, PIK3CA-mutated breast cancers
    Katherine E. Hutchinson, Jessica W. Chen, Heidi M. Savage, Thomas J. Stout, Frauke Schimmöller, Javier Cortés, Dent, Susan, Nadia Harbeck, William Jacot, Ian E. Krop et al. · 2023 · Figshare
  8. Additional file 8 of Integrated multi-omics analysis and machine learning developed a prognostic model based on mitochondrial function in a large multicenter cohort for Gastric Cancer
    Ma, Yimeng, Jin, Jingjing, Xue, Zixuan, Zhao, Jungang, Cai, Weiyang, Zhang, Wanli · 2024 · Figshare
  9. Additional file 1 of Body fatness and breast cancer risk in relation to phosphorylated mTOR expression in a sample of predominately Black women
    Cheng, Ting-Yuan David, Angela R. Omilian, Yao, Song, Zhang, Weizhou, Datta, Susmita, Bshara, Wiam, Ondracek, Rochelle Payne, Warren Davis, Song Liu, Hong, Chi-Chen et al. · 2021 · Figshare
  10. Additional file 1 of Novel cellular systems unveil mucosal melanoma initiating cells and a role for PI3K/Akt/mTOR pathway in mucosal melanoma fitness
    Matilde Monti, Benerini Gatta, Luisa, Bugatti, Mattia, Irene Pezzali, Sara Picinoli, Marcello Manfredi, Antonio Lavazza, Virginia Vita Vanella, Veronica De Giorgis, Lucia Zanatta et al. · 2024 · Figshare
  11. Additional file 8 of 2,6-DMBQ is a novel mTOR inhibitor that reduces gastric cancer growth in vitro and in vivo
    Xueyin Zu, Ma, Xiaoli, Xie, Xiaomeng, Lu, Bingbing, Kyle Vaughn Laster, Liu, Kangdong, Dong, Zigang, Kim, Dong Joon · 2020 · Figshare
  12. Additional file 14 of Integrated multi-omics analysis and machine learning developed a prognostic model based on mitochondrial function in a large multicenter cohort for Gastric Cancer
    Ma, Yimeng, Jin, Jingjing, Xue, Zixuan, Zhao, Jungang, Cai, Weiyang, Zhang, Wanli · 2024 · Figshare
  13. Additional file 5 of Novel cellular systems unveil mucosal melanoma initiating cells and a role for PI3K/Akt/mTOR pathway in mucosal melanoma fitness
    Matilde Monti, Benerini Gatta, Luisa, Bugatti, Mattia, Irene Pezzali, Sara Picinoli, Marcello Manfredi, Antonio Lavazza, Virginia Vita Vanella, Veronica De Giorgis, Lucia Zanatta et al. · 2024 · Figshare
  14. Additional file 4 of 2,6-DMBQ is a novel mTOR inhibitor that reduces gastric cancer growth in vitro and in vivo
    Xueyin Zu, Ma, Xiaoli, Xie, Xiaomeng, Lu, Bingbing, Kyle Vaughn Laster, Liu, Kangdong, Dong, Zigang, Kim, Dong Joon · 2020 · Figshare
  15. Unveiling bioactive compounds in kola nut seeds: GC-MS identification and computational analysis for anticancer potential
    Azzah Alshehri, Saleh O. S. Bahaffi, Mohd Rehan, Mohd Suhail, Ahmed Ibrahim Al-Asmari, Diaa T. A. Youssef, Alaa Khedr, Torki A. Zughaibi · 2026 · Frontiers in Nutrition
  16. Impact of PIK3CAH1047R Mutation on Glioblastoma Survival: Insights from a Preliminary Study
    Mistry Mittal, Shruti Patel, Hemang Patel, Trivedi Trupti I · 2026 · Gujarat Cancer Society Research Journal
  17. pKAKA: a protein language model for prioritizing kinase-disrupting variants in diseases.
    Jun-Teng Li, Hao-Yang Cheng, Zhuoran Liang, Jiamin Hu, Yi-Ting Chu, Ruoxi Cai, Bijin Cao, Ying Jin, Yutao Xie, Huai-Qiang Ju et al. · 2026 · Journal of genetics and genomics = Yi chuan xue bao
  18. The Role of Protein Kinases in the Management of Oncological Diseases by Acting on Ferroptotic Pathways
    Valentina Folgiero, Matteo Caforio · 2026 · International Journal of Molecular Sciences
  19. Inferring signaling pathway abnormalities from histopathological images via logic-constrained gene-pathway heterogeneous knowledge graph
    Yu Yu, Wen Shi, Xin Chen, Jinghui Feng, Simin Huang, Shixian Zeng, Xiaolin Bo, Jianing Xi · 2026 · npj Biomedical Innovations.
  20. Cartographie du phosphoprotéome régulé par les isoformes du PI3K de classe I dans le cancer du pancréas
    Célia Cintas · 2017 · theses.fr (ABES)
  21. Implication des enzymes de déubiquitination associés au protéasome dans la pathogénie du mélanome
    Robin Didier · 2018
  22. New Mechanism of Action of Rapalogs : Transcriptional Regulation of TRIB3 and Alteration of Pre-mRNA Splicing
    Bojana Stefanovska · 2019 · theses.fr (ABES)
  23. Exploring PI3K signalling dynamics in pancreatic cancer
    Carmen Fernanda Ramos Delgado · 2020 · theses.fr (ABES)
  24. Overcoming drug resistance in diffuse large b-cell lymphoma by targeting cell metabolism and the alternative NF-kB pathway
    Stéphanie Nuan-Aliman · 2021 · theses.fr (ABES)
  25. Characterizing and targeting the microenviromental changes in PIK3CA related overgrowth syndromes
    Ilaria Galasso · 2024
  26. Modulation of the PI3K/Akt signaling pathway by steroidal saponins: therapeutic implications in cancer
    Mohammad Bagher Majnooni, Maryam Naseri, Shayan Bakhshy-Chenary, Younes Zeinalii, Mahdis Azadi, Mohammad Hosein Farzaei, Sajad Fakhri, Syed Mustafa Ghanadian, Javier Echeverría · 2026 · Frontiers in Pharmacology
  27. Pan-cancer analysis reveals the prognostic and therapeutic relevance of MEX3A with a focus on chromophobe renal cell carcinoma
    Shuang Wang, Jiejun Zhang, Mengyu Zheng, Yi Feng, Tao Li · 2026 · Frontiers in Oncology
  28. Activation of the PI3K/AKT/mTOR signaling pathway in bladder cancer pathogenesis and its therapeutic significance
    Dereje E. Bogale · 2026 · Cancer Treatment and Research Communications
  29. Chromatin Landscape of Cancer Cell Lines Identifies Enhancer Subtypes
    M. Mattohti, E. Arslan, Ayush T. Raman, Christopher J. Terranova, Zhi-Yi Liu, Elias Orouji, Sanjana Srinivasan, V. Kochat, M. Tang, S. Amin et al. · 2026 · bioRxiv
  30. Single-Cell Analysis Reveals STARD10 as a Fatty Acid Metabolism Regulator of Breast Cancer Progression via the PI3K/Akt Pathway
    Yining Han, Jiacheng Fan, Yue Xi, Pengxiang Zhu, Qiyue Sun, Xiaofeng Li · 2026 · International Journal of Molecular Sciences
  31. TET1-mediated DNA demethylation and transcription activation of MRPS17 induces lung adenocarcinoma through PI3K-AKT-mTOR pathway
    Nan Zhou, Lei Song, Yang Wu, Ying Wei, Wenwen Zhang, Bingbing Wang, Yanbin Zhao, Yan Wang · 2026 · Journal of Molecular Histology
  32. An Evaluation of the Anti‐Cancer Effect of Phenylalanyl‐Tyrosine Dipeptide: Molecular Docking, Molecular Dynamics Simulation, Biological Activity‐Toxicity Predictions and In Vitro Studies
    Bilge Bıçak, Serda Kecel‐Gunduz, Gizem Akman · 2026 · Peptide Science
  33. PTEN homozygous deletion is a negative prognostic factor in tumor treating fields‐treated glioblastoma, IDH wildtype patients
    Jakob Nückles, Claudius Jelgersma, Christin Siewert, Brendan Osberg, Simone Schmid, Arend Koch, Eilís Pérez, Daniel Teichmann, Martin Misch, Anna-Gila Karbe et al. · 2026 · Brain Pathology
  34. Discovery of Tetrasubstituted Quinazolin-4(3 H )-ones as Wild-type-sparing, Highly Selective PI3KαH1047R Inhibitors
    Chun Chen, Ryan Holmes, Jack Carter, Soham Maity, Sarah B. Pawley, Nicholaas Stahl, Amy Crossan, Joseph D. Rager, Ashish Juvekar, Min Wang et al. · 2026 · Journal of Medicinal Chemistry
  35. Interpreting human genetic variation at atomic resolution
    Michael T. Zimmermann, Raul A. Urrutia · 2026 · Nature Genetics
  36. Deciphering the Medicinal Chemistry Aspects of Akt Inhibitors for the Management of Cancer: Structure–Activity Relationship Frameworks, Landscapes, and Optimization Approaches
    Mayur S. Dhangar, Mahesh B. Palkar · 2026 · Chemistry & Biodiversity
  37. COL10A1 at the crossroads of tumor signaling networks and environment remodeling
    Er Wei, Xiaoyue Guo, Kexin Wang, Wenqi Gu, Yang Zhang, Wang Xianli, Chuanyu Sun · 2026 · Pathology - Research and Practice
  38. The Transcription Factor PRDM15 Activates the PPP2R5C / PI3K ‐Akt Pathway to Promote Steroid Hormone Secretion in Goat Granulosa Cells
    Peng Wang, Senxuan Hou, Runqing Chi, Kai Liu, Xiaoyun He, Yuliang Wen, Yufang Liu, Mingxing Chu · 2026 · The FASEB Journal
  39. Low Expression of PINK1 Suppresses Mitophagy in Sonic Hedgehog–Driven Medulloblastoma in Association With Activation of the PI3K / AKT Signaling Pathway
    Qi Zhang, Hui Yang, Chao Hu, C. Zhang, Longtao He · 2026 · Microscopy Research and Technique
  40. Dysregulated AKT signaling reprograms osteosarcoma to drive selective reliance on EP300
    Ian Michael Delahunty, Stephanie Nance, Yang Zhang, François Lamoureux, Qi Liu, William C. Wright, Kristina Ritter, Noha A.M. Shendy, Bénédicte Brounais-Le Royer, Sandra J. Kietlinska et al. · 2026 · The Journal of Experimental Medicine
  41. Natural compounds targeting cancer-associated genes: Multi-omics mechanisms and therapeutic potential
    Thakur Prava Jyoti, Manisha Sharma, Karan Sidana, Sunanda Choudhary, Neeraj Choudhary, Dinesh Kumar, Pooja Shivappa · 2026 · Advances in Cancer Biology - Metastasis
  42. BindingDB Entry 50016411: Molecular design of dual inhibitors of PI3K and potential molecular target of cancer for its treatment: A review.
    BindingDB · 2023 · UC San Diego
  43. BindingDB Entry 50021993: Rational Design of a Novel 6H-Benzo[c]chromen Series as Selective PI3Kα Inhibitors.
    BindingDB · 2025 · UC San Diego
  44. BindingDB Entry 50015996: Discovery of 2-Methyl-2-(4-(2-methyl-8-(1
    BindingDB · 2023 · UC San Diego
  45. BindingDB Entry 50007976: Design, Synthesis, and Biological Evaluation of Imidazo[1,2-
    BindingDB · 2021 · UC San Diego