Intertumoral Heterogeneity within Medulloblastoma Subgroups

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Items 601–700 of 1,000

1. Low Expression of the NRP1 Gene Is Associated with Shorter Overall Survival in Patients with Sonic Hedgehog and Group 3 Medulloblastoma
   Moisés Augusto de Araújo, Osvaldo Malafaia, Jurandir Marcondes Ribas-Filho, Lívia Fratini, Rafael Roesler, Gustavo Rassier Isolan · 2023 · International Journal of Molecular Sciences
2. Phenotypic switching as a non-genetic mechanism of resistance predicts antibody therapy regimens
   Jiawei Zhou, Can Liu, Yu Tang, Zhongbo Li, Yanguang Cao · 2024 · iScience
3. MYC-dependent upregulation of the de novo serine and glycine synthesis pathway is a targetable metabolic vulnerability in group 3 medulloblastoma
   Magretta Adiamah, Bethany Poole, Janet C. Lindsey, Sarah E. Kohe, Alaide Morcavallo, Florence Burté, Rebecca M. Hill, Helen Blair, Dean Thompson, Mankaran Singh et al. · 2024 · Neuro-Oncology
4. Developmental Origins and Oncogenesis in Medulloblastoma
   Karrie Mei Yee Kiang, Yogesh K.H. Wong, Soma Sengupta, Martine F. Roussel, Qing Richard Lu · 2025 · Annual Review of Neuroscience
5. Profiling tumour-infiltrating immune cells in a large paediatric medulloblastoma cohort: a retrospective analysis
   Mingze Chen, Xiangjun Shi, Yi Wang, Jiao Zhang, Jirong Guo, Xiuchen Guan, Yu Ling Sun, Wenhao Wu, Chunde Li, Yongji Tian et al. · 2025 · EBioMedicine
6. BCOR Internal Tandem Duplication Expression in Neural Stem Cells Promotes Growth, Invasion, and Expression of PRC2 Targets
   Satoshi Nakata, Ming Yuan, Jeffrey A. Rubens, Ulf D. Kahlert, Jarek Maciaczyk, Eric H. Raabe, Charles G. Eberhart · 2021 · International Journal of Molecular Sciences
7. SOX9 Defines Distinct Populations of Cells in SHH Medulloblastoma but Is Not Required for Math1-Driven Tumor Formation
   Christelle Adolphe, Amanda Millar, Marija Kojic, Deborah Sim Barkauskas, Anders Sundström, Fredrik J. Swartling, Soroor Hediyeh-zadeh, Chin Wee Tan, Melissa J. Davis, Laura A. Genovesi et al. · 2021 · Molecular Cancer Research
8. mTORC1 promotes malignant large cell/anaplastic histology and is a targetable vulnerability in SHH-TP53 mutant medulloblastoma
   Valentina Conti, Manuela Cominelli, Valentina Pieri, Alberto Luigi Gallotti, Ilaria Pagano, Matteo Zanella, Stefania Mazzoleni, Flavia Pivetta, Monica Patanè, Giulia Maria Scotti et al. · 2021 · JCI Insight
9. CD155 is a putative therapeutic target in medulloblastoma
   Sean Li, Roger E. McLendon, Eric W. Sankey, Reb Kornahrens, Anne-Marie Lyne, Florence M.G. Cavalli, Zachary P. McKay, James E. Herndon, Marc Remke, Daniel J. Picard et al. · 2022 · Clinical & Translational Oncology
10. Risk prediction in early childhood sonic hedgehog medulloblastoma treated with radiation-avoiding chemotherapy: Evidence for more than 2 subgroups
    Svenja Tonn, Andrey Korshunov, Denise Obrecht, Martin Sill, Michael Spohn, Katja von Hoff, Till Milde, Torsten Pietsch, Tobias Goschzik, Brigitte Bison et al. · 2023 · Neuro-Oncology
11. Clinical, Histological, and Molecular Prognostic Factors in Childhood Medulloblastoma: Where Do We Stand?
    Charikleia Ntenti, Konstantinos Lallas, Georgios Papazisis · 2023 · Diagnostics
12. Cross-species analysis of SHH medulloblastoma models reveals significant inhibitory effects of trametinib on tumor progression
    Stephanie Borlase, Alexandria DeCarlo, Ludivine Coudière-Morrison, Lisa Liang, Christopher J. Porter, Vijay Ramaswamy, Tamra E. Werbowetski‐Ogilvie · 2023 · Cell Death Discovery
13. Exploring Lin28 proteins: Unravelling structure and functions with emphasis on nervous system malignancies
    Ahmed Maklad, Mohammed Sedeeq, Kai Man Chan, Nuri Gueven, Iman Azimi · 2023 · Life Sciences
14. A therapeutically targetable positive feedback loop between lnc-HLX-2-7, HLX, and MYC that promotes group 3 medulloblastoma
    Keisuke Katsushima, Kandarp Joshi, Menglang Yuan, Brigette Romero, Mona Batish, Stacie L. Stapleton, George I. Jallo, Elayaraja Kolanthai, Sudipta Seal, Olivier Saulnier et al. · 2024 · Cell Reports
15. Loss of AMPKα2 Impairs Hedgehog-Driven Medulloblastoma Tumorigenesis
    Honglai Zhang, Rork D. Kuick, Sung Soo Park, Claire Peabody, Justin G. Yoon, Ester Calvo Fernández, Junying Wang, Dafydd G. Thomas, Benoı̂t Viollet, Ken Inoki et al. · 2018 · International Journal of Molecular Sciences
16. Establishment and Culture of Patient-Derived Primary Medulloblastoma Cell Lines
    Sara Badodi, Silvia Marino, Loredana Guglielmi · 2018 · Methods in molecular biology
17. MEMRI‐based imaging pipeline for guiding preclinical studies in mouse models of sporadic medulloblastoma
    Harikrishna Rallapalli, I‐Li Tan, Eugenia Volkova, Alexandre Wojcinski, Benjamin C Darwin, Jason P. Lerch, Alexandra L. Joyner, Daniel H. Turnbull · 2019 · Magnetic Resonance in Medicine
18. Identification and Functional Characterization of Novel MYC-Regulated Long Noncoding RNAs in Group 3 Medulloblastoma
    Jessica N. Rea, Annamaria Carissimo, Daniela Trisciuoglio, Barbara Illi, Daniel J. Picard, Marc Remke, Pietro Laneve, Elisa Caffarelli · 2021 · Cancers
19. Identification of a glioma functional network from gene fitness data using machine learning
    Chunxiang Xiang, Xiguo Liu, Daquan Zhou, Yi Zhou, Xu Wang, Feng Chen · 2022 · Journal of Cellular and Molecular Medicine
20. Identification of PBK as a hub gene and potential therapeutic target for medulloblastoma
    Yu‐Hao Deng, Huantao Wen, Hanjie Yang, Zhengqiang Zhu, Qiongzhen Huang, Yue-Wei Bi, Pengfei Wang, Ming Zhou, Jianwei Guan, Wangming Zhang et al. · 2022 · Oncology Reports
21. Sonic hedgehog signaling: Alternative splicing and pathogenic role in medulloblastoma
    Meiyu Qu, Qiangqiang He, Jiahao Luo, Tingyu Shen, Ruibo Gao, Yana Xu, Chengyun Xu, Muhammad Qasim Barkat, Linghui Zeng, Ximei Wu · 2022 · Genes & Diseases
22. STAT3 Inhibition Attenuates MYC Expression by Modulating Co-Activator Recruitment and Suppresses Medulloblastoma Tumor Growth by Augmenting Cisplatin Efficacy In Vivo
    Kyle Rohrer, Heyu Song, Anum Akbar, Yingling Chen, Suravi Pramanik, Phillip J. Wilder, Erin M. McIntyre, Nagendra K. Chaturvedi, Kishor K. Bhakat, Angie Rizzino et al. · 2023 · Cancers
23. Malignant Brain Tumours in Children : Present and Future Perspectives
    James T. Rutka · 2018 · Journal of Korean Neurosurgical Society
24. Sox2+ cells in Sonic Hedgehog-subtype medulloblastoma resist p53-mediated cell-cycle arrest response and drive therapy-induced recurrence
    Daniel M. Treisman, Yinghua Li, Brianna R. Pierce, Chaoyang Li, Andrew P. Chervenak, Gerald J. Tomasek, Guillermina Lozano, Xiaoyan Zheng, Marcel Kool, Yuan Zhu · 2019 · Neuro-Oncology Advances
25. Texture Analysis of T1-Weighted Contrast-Enhanced Magnetic Resonance Imaging Potentially Predicts Outcomes of Patients with Non–Wingless-Type/Non–Sonic Hedgehog Medulloblastoma
    Jiaqi Li, Chaoyue Chen, Rao Fu, Yang Zhang, Yimeng Fan, Jianguo Xu, Ying Cen · 2019 · World Neurosurgery
26. FHOD3 promotes carcinogenesis by regulating RhoA/ROCK1/LIMK1 signaling pathway in medulloblastoma
    J. Yu, Wei Shi, Rui Zhao, W. Shen, Haifengqing Li · 2020 · Clinical & Translational Oncology
27. Loss of 5-Hydroxymethylcytosine as an Epigenetic Signature That Correlates With Poor Outcomes in Patients With Medulloblastoma
    Fu Qiang Zhao, Zhiwei Zhang, Jing Zhang, Shun Zhang, Heng Zhang, Chi Zhao, Yang Chen, Lin Luo, Wei‐Min Tong, Chunde Li et al. · 2021 · Frontiers in Oncology
28. Novel Molecular Hallmarks of Group 3 Medulloblastoma by Single-Cell Transcriptomics
    Chaoying Qin, Yimin Pan, Yuzhe Li, Yue Li, Wenyong Long, Qing Liu · 2021 · Frontiers in Oncology
29. Identification of ITPR1 as a Hub Gene of Group 3 Medulloblastoma and Coregulated Genes with Potential Prognostic Values
    Pablo Shimaoka Chagas, Graziella Ribeiro de Sousa, Luciana Chain Veronez, Andrea Martins-da-Silva, Carolina Alves Pereira Corrêa, Gustavo Alencastro Veiga Cruzeiro, Luís Fernando Peinado Nagano, Rosane Gomes de Paula Queiróz, Suely Kazue Nagahashi Marie, Sílvia Regina Brandalise et al. · 2021 · Journal of Molecular Neuroscience
30. The role of methylation profiling in histologically diagnosed neurocytoma: a case series
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31. Immunohistochemical detection of ALK protein identifies APC mutated medulloblastoma and differentiates the WNT-activated medulloblastoma from other types of posterior fossa childhood tumors
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32. The mammalian Hedgehog pathway is modulated by ANP32 proteins
    Anna Hupfer, Anna I. Brichkina, Till Adhikary, Matthias Lauth · 2021 · Biochemical and Biophysical Research Communications
33. Stem-Like Cell Populations, p53-Pathway Activation and Mechanisms of Recurrence in Sonic Hedgehog Medulloblastoma
    Daniel M. Treisman, Yinghua Li, Yuan Zhu · 2021 · NeuroMolecular Medicine
34. Sonic hedgehog medulloblastomas are dependent on Netrin-1 for survival
    Julie Talbot, Joanna Fombonne, Jacob Torrejon-Diaz, Benjamin R. Babcock, Leon McSwain, Nicolas Rama, Ludovica Lospinoso Severini, Emma Bonerandi, Véronique Marsaud, Flavia Bernardi et al. · 2025 · Nature Communications
35. Integrated transcriptomic landscape of medulloblastoma and ependymoma reveals novel tumor subtype-specific biology
    Sonali Arora, Nicholas Nuechterlein, Matt Jensen, Gregory Glatzer, Philipp Sievers, Srinidhi Varadharajan, Andrey Korshunov, Felix Sahm, Stephen C. Mack, Michael D. Taylor et al. · 2025 · Neuro-Oncology
36. Preclinical assessment of checkpoint blockade combined with DNA methyltransferase inhibition in high-risk pediatric brain tumors reveals limited therapeutic synergy
    Deepak Kumar Mishra, Shelli M. Morris, Dean Popovski, Emily J Girard, Andrew Bondoc, Shiva Senthil Kumar, Augusto Faria Andrade, Xiaoting Zhu, Fupan Yao, Mi‐Youn Brusniak et al. · 2025 · Neuro-Oncology Advances
37. Multiomic integration reveals tumoral heterogeneity of lipid dependence within lethal group 3 medulloblastoma
    Flavia Bernardi, Jacob Torrejon-Diaz, Irene Basili, Randy Van Ommeren, Véronique Marsaud, Hua Yu, Julie Talbot, Judith Souphron, Émilie Indersie, Antoine Forget et al. · 2026 · Cancer Cell
38. Conventional Therapies Deplete Brain-Infiltrating Adaptive Immune Cells in a Mouse Model of Group 3 Medulloblastoma Implicating Myeloid Cells as Favorable Immunotherapy Targets
    Zahra Abbas, Courtney George, Mathew Ancliffe, Meegan Howlett, Anya C. Jones, Mani Kuchibhotla, Robert J. Wechsler‐Reya, Nicholas G. Gottardo, Raelene Endersby · 2022 · Frontiers in Immunology
39. Clinical and Molecular Features in Medulloblastomas Subtypes in Children in a Cohort in Taiwan
    Kuo-Sheng Wu, Shian‐Ying Sung, Man‐Hsu Huang, Yu‐Ling Lin, Che‐Chang Chang, Chia‐Lang Fang, Tai‐Tong Wong, Hsin‐Hung Chen, Min‐Lan Tsai · 2022 · Cancers
40. Sex differences in methylation profiles are apparent in medulloblastoma, particularly among SHH tumors
    Rachel M. Moss, Natali Sorajja, Lauren J. Mills, Christopher L. Moertel, Thanh T. Hoang, Logan G. Spector, David A. Largaespada, Lindsay A. Williams · 2023 · Frontiers in Oncology
41. Molecular and functional profiling of chemotolerant cells unveils nucleoside metabolism-dependent vulnerabilities in medulloblastoma
    Elena Mariotto, Elena Rampazzo, Roberta Bortolozzi, Fatlum Rruga, Ilaria Zeni, Lorenzo Manfreda, Chiara Marchioro, Martina Canton, Alice Cani, Ruben Magni et al. · 2023 · Acta Neuropathologica Communications
42. Marinopyrrole derivative MP1 as a novel anti-cancer agent in group 3 MYC-amplified Medulloblastoma
    Donald W. Coulter, Yashpal Singh Chhonker, Devendra Kumar, Varun Kesherwani, Wafaa N. Aldhafiri, Erin M. McIntyre, Gracey R. Alexander, Sutapa Ray, Shantaram S. Joshi, Rongshi Li et al. · 2024 · Journal of Experimental & Clinical Cancer Research
43. Medulloblastoma and other neoplasms in patients with heterozygous germline SUFU variants: A scoping review
    Stephanie G. Lee, D. Gareth Evans, Maddie Stephen, Rachel Goren, Melissa L. Bondy, Steven N. Goodman · 2024 · American Journal of Medical Genetics Part A
44. The pivotal role of irradiation‐induced apoptosis in the pathogenesis and therapy of medulloblastoma
    Seidu A. Richard · 2024 · Cancer Reports
45. LOXL1-AS1 contributes to metastasis in sonic-hedgehog medulloblastoma by promoting cancer stem-like phenotypes
    Anh Duy Do, Kuo-Sheng Wu, Shing-Shung Chu, Le Hien Giang, Yu‐Ling Lin, Che‐Chang Chang, Tai‐Tong Wong, Chia‐Ling Hsieh, Shian‐Ying Sung · 2024 · Journal of Experimental & Clinical Cancer Research
46. Machine learning approaches for multiomics data analysis
    Aimen Firdous, Sameen Firdous, Aarif Ali, Bisma Nisar, Hilal Ahmad, Gowhar Iqbal, Sheikh Bilal Ahmad · 2024 · Elsevier eBooks
47. High Expression of GABAA Receptor β Subunit Genes Is Associated with Longer Overall Survival in Medulloblastoma
    Jander Moreira Monteiro, Matheus Dalmolin, Marcelo A. C. Fernandes, Jaqueline Isadora Reis Ramos, Carmen Austrália Paredes Marcondes Ribas, Fernando Issamu Tabushi, Rafael Roesler, Gustavo Rassier Isolan · 2024 · Brain Sciences
48. Therapeutic radiation drives leptomeningeal dissemination of medulloblastoma through an innate immune process
    Carolina Nör, Kaitlin Kharas, Alex Rasnitsyn, Maria Claudia Vladoiu, Nam Woo Cho, Jacob S. Young, Felipe Nör, Ncedile Mankahla, Joonas A. Haapasalo, Kristiina Nordfors et al. · 2025 · Developmental Cell
49. Y-Box Binding Protein-1: A Neglected Target in Pediatric Brain Tumors?
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50. Multi-omics analysis of intertumoral heterogeneity within medulloblastoma uncharted-pathway subtypes
    Zhicen Li, Yifan Wei, Yanqiu Shao, Lei Tang, Jian Feng Gong · 2021 · Brain Tumor Pathology
51. Single nCounter assay for prediction of MYCN amplification and molecular classification of medulloblastomas: a multicentric study
    Daniel Antunes Moreno, Luciane Sussuchi da Silva, Maicon Fernando Zanon, Murilo Bonatelli, Flávia Escremim de Paula, Marcus De Medeiros Matsushita, Gustavo Ramos Teixeira, Iara Viana Vidigal Santana, Fabiano Pinto Saggioro, Luciano Neder et al. · 2022 · Journal of Neuro-Oncology
52. Utility of multimodality molecular profiling for pediatric patients with central nervous system tumors
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53. Inhibiting ALK2/ALK3 Signaling to Differentiate and Chemo-Sensitize Medulloblastoma
    Doria Filipponi, Marina Pagnuzzi‐Boncompagni, Gilles Pagès · 2022 · Cancers
54. Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma
    Kameda-Smith, Michelle M., Zhu, Helen, Luo, En-Ching, Suk, Yujin, Xella, Agata, Yee, Brian, Chokshi, Chirayu, Xing, Sansi, Tan, Frederick, Fox, Raymond G. et al. · 2022 · Nature Communications
55. YB1 modulates the DNA damage response in medulloblastoma
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56. Questions and answers in the management of children with medulloblastoma over the time. How did we get here? A systematic review
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57. High frequency of WNT-activated medulloblastomas with CTNNB1 wild type suggests a higher proportion of hereditary cases in a Latin-Iberian population
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58. Overcoming the limits of pediatric brain tumor radiotherapy: The use of preclinical 3D models
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59. Trimethylation of H3K27 during human cerebellar development in relation to medulloblastoma
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60. Medulloblastoma in infants: the never-ending challenge
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61. Centromere-associated protein E expresses a novel mRNA isoform in acute lymphoblastic leukemia.
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62. Nuclear Receptor Binding Protein 2 Is Downregulated in Medulloblastoma, and Reduces Tumor Cell Survival upon Overexpression
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63. Activated leukocyte cell adhesion molecule expression correlates with the WNT subgroup in medulloblastoma and is involved in regulating tumor cell proliferation and invasion
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64. High expression of Toll-like receptor 7 is a survival factor in pediatric medulloblastoma
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65. LIN28 expression and function in medulloblastoma
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66. Medulloblastoma in adults: evaluation of the Dutch society for neuro-oncology treatment protocol
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67. New research directions in medulloblastoma
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68. Differences in RNA and microRNA Expression Between PTCH1- and SUFU-mutated Medulloblastoma
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69. Calcium Signalling in Medulloblastoma: An In Silico Analysis of the Expression of Calcium Regulating Genes in Patient Samples
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70. Multiomic Medulloblastomas
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72. HIF-1 inactivation empowers HIF-2 to drive hypoxia adaptation in aggressive forms of medulloblastoma
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73. Targeting synthetic lethality between non-homologous end joining and radiation in very-high-risk medulloblastoma
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79. High-throughput neural stem cell-based drug screening identifies S6K1 inhibition as a selective vulnerability in sonic hedgehog-medulloblastoma
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80. DHODH Inhibition Suppresses MYC and Inhibits the Growth of Medulloblastoma in a Novel In Vivo Zebrafish Model
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81. Salvage therapies for first relapse of SHH medulloblastoma in early childhood
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82. In vitro Modeling of Embryonal Tumors
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83. Cancer Stem Cells, not Bulk Tumor Cells, Determine Mechanisms of Resistance to SMO Inhibitors
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86. The Role of the Dysregulation of Long Non-Coding and Circular RNA Expression in Medulloblastoma: A Systematic Review
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88. Bioinformatic Strategies for the Genomic and Epigenomic Characterization of Brain Tumors
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89. Cancer cell stemness, responses to experimental genotoxic treatments, cytomegalovirus protein expression and DNA replication stress in pediatric medulloblastomas
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90. Using Pharmacology to Squeeze the Life Out of Childhood Leukemia, and Potential Strategies to Achieve Breakthroughs in Medulloblastoma Treatment
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92. Gene Expression Signatures Identify Biologically Homogenous Subgroups of Grade 2 Meningiomas
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93. Effects of different molecular subtypes and tumor biology on the prognosis of medulloblastoma
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94. Identification of Let-7 miRNA Activity as a Prognostic Biomarker of SHH Medulloblastoma
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95. A novel finding of an IDH2 mutation in an interesting adult Sonic Hedgehog mutated medulloblastoma
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96. GLI3 Is Associated With Neuronal Differentiation in SHH-Activated and WNT-Activated Medulloblastoma
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