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Cited by 887

The DOI matches its Crossref record; 131 of the 131 references it cites were found in a registry or an index.

Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma

Open access
Robertson, A. Gordon, Shih, Juliann, Yau, Christina, Gibb, Ewan A., Oba, Junna, Mungall, Karen L., Hess, Julian M., Uzunangelov, Vladislav, Walter, Vonn, Danilova, Ludmila, Lichtenberg, Tara M., Kucherlapati, Melanie, Kimes, Patrick K., Tang, Ming, Penson, Alexander, Babur, Ozgun, Akbani, Rehan, Bristow, Christopher A., Hoadley, Katherine A., Iype, Lisa, Chang, Matthew T., Abdel-Rahman, Mohamed H., Akbani, Rehan, Ally, Adrian, Auman, J. Todd, Babur, Ozgun, Balasundaram, Miruna, Balu, Saianand, Benz, Christopher, Beroukhim, Rameen, Birol, Inanc, Bodenheimer, Tom, Bowen, Jay, Bowlby, Reanne, Bristow, Christopher A., Brooks, Denise, Carlsen, Rebecca, Cebulla, Colleen M., Chang, Matthew T., Cherniack, Andrew D., Chin, Lynda, Cho, Juok, Chuah, Eric, Chudamani, Sudha, Cibulskis, Carrie, Cibulskis, Kristian, Cope, Leslie, Coupland, Sarah E., Danilova, Ludmila, Defreitas, Timothy, Demchok, John A., Desjardins, Laurence, Dhalla, Noreen, Esmaeli, Bita, Felau, Ina, Ferguson, Martin L., Frazer, Scott, Gabriel, Stacey B., Gastier-Foster, Julie M., Gehlenborg, Nils, Gerken, Mark, Gershenwald, Jeffrey E., Getz, Gad, Gibb, Ewan A., Griewank, Klaus G., Grimm, Elizabeth A., Hayes, D. Neil, Hegde, Apurva M., Heiman, David I., Helsel, Carmen, Hess, Julian M., Hoadley, Katherine A., Hobensack, Shital, Holt, Robert A., Hoyle, Alan P., Hu, Xin, Hutter, Carolyn M., Jager, Martine J., Jefferys, Stuart R., Jones, Corbin D., Jones, Steven J.M., Kandoth, Cyriac, Kasaian, Katayoon, Kim, Jaegil, Kimes, Patrick K., Kucherlapati, Melanie, Kucherlapati, Raju, Lander, Eric, Lawrence, Michael S., Lazar, Alexander J., Lee, Semin, Leraas, Kristen M., Lichtenberg, Tara M., Lin, Pei, Liu, Jia, Liu, Wenbin, Lolla, Laxmi, Lu, Yiling, Iype, Lisa, Ma, Yussanne, Mahadeshwar, Harshad S., Mariani, Odette, Marra, Marco A., Mayo, Michael, Meier, Sam, Meng, Shaowu, Meyerson, Matthew, Mieczkowski, Piotr A., Mills, Gordon B., Moore, Richard A., Mose, Lisle E., Mungall, Andrew J., Mungall, Karen L., Murray, Bradley A., Naresh, Rashi, Noble, Michael S., Oba, Junna, Pantazi, Angeliki, Parfenov, Michael, Park, Peter J., Parker, Joel S., Penson, Alexander, Perou, Charles M., Pihl, Todd, Pilarski, Robert, Protopopov, Alexei, Radenbaugh, Amie, Rai, Karan, Ramirez, Nilsa C., Ren, Xiaojia, Reynolds, Sheila M., Roach, Jeffrey, Robertson, A. Gordon, Roman-Roman, Sergio, Roszik, Jason, Sadeghi, Sara, Saksena, Gordon, Sastre, Xavier, Schadendorf, Dirk, Schein, Jacqueline E., Schoenfield, Lynn, Schumacher, Steven E., Seidman, Jonathan, Seth, Sahil, Sethi, Geetika, Sheth, Margi, Shi, Yan, Shields, Carol, Shih, Juliann, Shmulevich, Ilya, Simons, Janae V., Singh, Arun D., Sipahimalani, Payal, Skelly, Tara, Sofia, Heidi, Soloway, Matthew G., Song, Xingzhi, Stern, Marc-Henri, Stuart, Joshua, Sun, Qiang, Sun, Huandong, Tam, Angela, Tan, Donghui, Tang, Ming, Tang, Jiabin, Tarnuzzer, Roy, Taylor, Barry S., Thiessen, Nina, Thorsson, Vesteinn, Tse, Kane, Uzunangelov, Vladislav, Veluvolu, Umadevi, Verhaak, Roel G.W., Voet, Doug, Walter, Vonn, Wan, Yunhu, Wang, Zhining, Weinstein, John N., Wilkerson, Matthew D., Williams, Michelle D., Wise, Lisa, Woodman, Scott E., Wong, Tina, Wu, Ye, Yang, Liming, Yang, Lixing, Yau, Christina, Zenklusen, Jean C., Zhang, Jiashan, Zhang, Hailei, Zmuda, Erik, Cherniack, Andrew D., Benz, Christopher, Mills, Gordon B., Verhaak, Roel G.W., Griewank, Klaus G., Felau, Ina, Zenklusen, Jean C., Gershenwald, Jeffrey E., Schoenfield, Lynn, Lazar, Alexander J., Abdel-Rahman, Mohamed H., Roman-Roman, Sergio, Stern, Marc-Henri, Cebulla, Colleen M., Williams, Michelle D., Jager, Martine J., Coupland, Sarah E., Esmaeli, Bita, Kandoth, Cyriac, Woodman, Scott E.·2017·Cancer Cell
DOI 10.1016/j.ccell.2017.07.003
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Abstract

Comprehensive multiplatform analysis of 80 uveal melanomas (UM) identifies four molecularly distinct, clinically relevant subtypes: two associated with poor-prognosis monosomy 3 (M3) and two with better-prognosis disomy 3 (D3). We show that BAP1 loss follows M3 occurrence and correlates with a global DNA methylation state that is distinct from D3-UM. Poor-prognosis M3-UM divide into subsets with divergent genomic aberrations, transcriptional features, and clinical outcomes. We report change-of-function SRSF2 mutations. Within D3-UM, EIF1AX- and SRSF2/SF3B1-mutant tumors have distinct somatic copy number alterations and DNA methylation profiles, providing insight into the biology of these low- versus intermediate-risk clinical mutation subtypes.

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Authors
Robertson, A. G., Shih, J., Yau, C., Gibb, E. A., Oba, J., Mungall, K. L., Hess, J. M., Uzunangelov, V., Walter, V., Danilova, L., Lichtenberg, T. M., Kucherlapati, M., Kimes, P. K., Tang, M., Penson, A., Babur, O., Akbani, R., Bristow, C. A., Hoadley, K. A., Iype, L., Chang, M. T., Abdel-Rahman, M. H., Akbani, R., Ally, A., Auman, J. T., Babur, O., Balasundaram, M., Balu, S., Benz, C., Beroukhim, R., Birol, I., Bodenheimer, T., Bowen, J., Bowlby, R., Bristow, C. A., Brooks, D., Carlsen, R., Cebulla, C. M., Chang, M. T., Cherniack, A. D., Chin, L., Cho, J., Chuah, E., Chudamani, S., Cibulskis, C., Cibulskis, K., Cope, L., Coupland, S. E., Danilova, L., Defreitas, T., Demchok, J. A., Desjardins, L., Dhalla, N., Esmaeli, B., Felau, I., Ferguson, M. L., Frazer, S., Gabriel, S. B., Gastier-Foster, J. M., Gehlenborg, N., Gerken, M., Gershenwald, J. E., Getz, G., Gibb, E. A., Griewank, K. G., Grimm, E. A., Hayes, D. N., Hegde, A. M., Heiman, D. I., Helsel, C., Hess, J. M., Hoadley, K. A., Hobensack, S., Holt, R. A., Hoyle, A. P., Hu, X., Hutter, C. M., Jager, M. J., Jefferys, S. R., Jones, C. D., Jones, S. J. M., Kandoth, C., Kasaian, K., Kim, J., Kimes, P. K., Kucherlapati, M., Kucherlapati, R., Lander, E., Lawrence, M. S., Lazar, A. J., Lee, S., Leraas, K. M., Lichtenberg, T. M., Lin, P., Liu, J., Liu, W., Lolla, L., Lu, Y., Iype, L., Ma, Y., Mahadeshwar, H. S., Mariani, O., Marra, M. A., Mayo, M., Meier, S., Meng, S., Meyerson, M., Mieczkowski, P. A., Mills, G. B., Moore, R. A., Mose, L. E., Mungall, A. J., Mungall, K. L., Murray, B. A., Naresh, R., Noble, M. S., Oba, J., Pantazi, A., Parfenov, M., Park, P. J., Parker, J. S., Penson, A., Perou, C. M., Pihl, T., Pilarski, R., Protopopov, A., Radenbaugh, A., Rai, K., Ramirez, N. C., Ren, X., Reynolds, S. M., Roach, J., Robertson, A. G., Roman-Roman, S., Roszik, J., Sadeghi, S., Saksena, G., Sastre, X., Schadendorf, D., Schein, J. E., Schoenfield, L., Schumacher, S. E., Seidman, J., Seth, S., Sethi, G., Sheth, M., Shi, Y., Shields, C., Shih, J., Shmulevich, I., Simons, J. V., Singh, A. D., Sipahimalani, P., Skelly, T., Sofia, H., Soloway, M. G., Song, X., Stern, M.-H., Stuart, J., Sun, Q., Sun, H., Tam, A., Tan, D., Tang, M., Tang, J., Tarnuzzer, R., Taylor, B. S., Thiessen, N., Thorsson, V., Tse, K., Uzunangelov, V., Veluvolu, U., Verhaak, R. G. W., Voet, D., Walter, V., Wan, Y., Wang, Z., Weinstein, J. N., Wilkerson, M. D., Williams, M. D., Wise, L., Woodman, S. E., Wong, T., Wu, Y., Yang, L., Yang, L., Yau, C., Zenklusen, J. C., Zhang, J., Zhang, H., Zmuda, E., Cherniack, A. D., Benz, C., Mills, G. B., Verhaak, R. G. W., Griewank, K. G., Felau, I., Zenklusen, J. C., Gershenwald, J. E., Schoenfield, L., Lazar, A. J., Abdel-Rahman, M. H., Roman-Roman, S., Stern, M.-H., Cebulla, C. M., Williams, M. D., Jager, M. J., Coupland, S. E., Esmaeli, B., Kandoth, C., & Woodman, S. E.
Venue
Cancer Cell
Publisher
Elsevier BV
Published
2017-08
Volume
32
Issue
2
Pages
204-220.e15
ISSN
1535-6108 (ISSN-L)
DOI
10.1016/j.ccell.2017.07.003
OpenAlex
W2745658163
Cited by
887
References
131
FWCI
69.81
Type
journal article
Language
en
Open access
hybrid

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Robertson, A. G., Shih, J., Yau, C., Gibb, E. A., Oba, J., Mungall, K. L., Hess, J. M., Uzunangelov, V., Walter, V., Danilova, L., Lichtenberg, T. M., Kucherlapati, M., Kimes, P. K., Tang, M., Penson, A., Babur, O., Akbani, R., Bristow, C. A., Hoadley, K. A., . . . Woodman, S. E. (2017). Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma. Cancer Cell. https://doi.org/10.1016/j.ccell.2017.07.003

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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