The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Genomic Evolution of Breast Cancer Metastasis and Relapse
Open accessAbstract
Patterns of genomic evolution between primary and metastatic breast cancer have not been studied in large numbers, despite patients with metastatic breast cancer having dismal survival. We sequenced whole genomes or a panel of 365 genes on 299 samples from 170 patients with locally relapsed or metastatic breast cancer. Several lines of analysis indicate that clones seeding metastasis or relapse disseminate late from primary tumors, but continue to acquire mutations, mostly accessing the same mutational processes active in the primary tumor. Most distant metastases acquired driver mutations not seen in the primary tumor, drawing from a wider repertoire of cancer genes than early drivers. These include a number of clinically actionable alterations and mutations inactivating SWI-SNF and JAK2-STAT3 pathways.
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Cites
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“, 2015), and a pan-cancermetastasis study (Zehir et al., 2017), where mutations in these same genes are also acquired late in disease evolution.”
BackgroundInfluentialMutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma
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Cited by
Harbeck, N., Penault-Llorca, F., Cortes, J., Gnant, M., Houssami, N., Poortmans, P., Ruddy, K., Tsang, J., & Cardoso, F. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0111-2 · Cited by 3,024
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The evolutionary history of 2,658 cancers
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Metadata
- Authors
- Yates, L. R., Knappskog, S., Wedge, D., Farmery, J. H. R., Gonzalez, S., Martincorena, I., Alexandrov, L. B., Van Loo, P., Haugland, H. K., Lilleng, P. K., Gundem, G., Gerstung, M., Pappaemmanuil, E., Gazinska, P., Bhosle, S. G., Jones, D., Raine, K., Mudie, L., Latimer, C., Sawyer, E., Desmedt, C., Sotiriou, C., Stratton, M. R., Sieuwerts, A. M., Lynch, A. G., Martens, J. W., Richardson, A. L., Tutt, A., Lønning, P. E., & Campbell, P. J.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2017-08
- Volume
- 32
- Issue
- 2
- Pages
- 169-184.e7
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2746672093
- Cited by
- 665
- References
- 58
- FWCI
- 20.63
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Yates, L. R., Knappskog, S., Wedge, D., Farmery, J. H. R., Gonzalez, S., Martincorena, I., Alexandrov, L. B., Van Loo, P., Haugland, H. K., Lilleng, P. K., Gundem, G., Gerstung, M., Pappaemmanuil, E., Gazinska, P., Bhosle, S. G., Jones, D., Raine, K., Mudie, L., Latimer, C., . . . Campbell, P. J. (2017). Genomic Evolution of Breast Cancer Metastasis and Relapse. Cancer Cell. https://doi.org/10.1016/j.ccell.2017.07.005
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
