The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Increased Vascular Permeability in the Bone Marrow Microenvironment Contributes to Disease Progression and Drug Response in Acute Myeloid Leukemia
Open accessAbstract
The biological and clinical behaviors of hematological malignancies can be influenced by the active crosstalk with an altered bone marrow (BM) microenvironment. In the present study, we provide a detailed picture of the BM vasculature in acute myeloid leukemia using intravital two-photon microscopy. We found several abnormalities in the vascular architecture and function in patient-derived xenografts (PDX), such as vascular leakiness and increased hypoxia. Transcriptomic analysis in endothelial cells identified nitric oxide (NO) as major mediator of this phenotype in PDX and in patient-derived biopsies. Moreover, induction chemotherapy failing to restore normal vasculature was associated with a poor prognosis. Inhibition of NO production reduced vascular permeability, preserved normal hematopoietic stem cell function, and improved treatment response in PDX.
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BackgroundMolecular mechanisms and clinical applications of angiogenesis
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Cancer cells compress intratumour vessels
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Neural regulation of bone and bone marrow
Maryanovich, M., Takeishi, S., & Frenette, P. S. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a031344 · Cited by 114
Tissue-resident macrophages promote early dissemination of multiple myeloma via IL-6 and TNFα
Akhmetzyanova, I., Aaron, T., Galbo, P., Tikhonova, A., Dolgalev, I., Tanaka, M., Aifantis, I., Zheng, D., Zang, X., & Fooksman, D. (2021) · Blood Advances · doi:10.1182/bloodadvances.2021005327 · Cited by 39
Metadata
- Authors
- Passaro, D., Di Tullio, A., Abarrategi, A., Rouault-Pierre, K., Foster, K., Ariza-McNaughton, L., Montaner, B., Chakravarty, P., Bhaw, L., Diana, G., Lassailly, F., Gribben, J., & Bonnet, D.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2017-09
- Volume
- 32
- Issue
- 3
- Pages
- 324-341.e6
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2750755858
- Cited by
- 258
- References
- 10
- FWCI
- 18.64
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Passaro, D., Di Tullio, A., Abarrategi, A., Rouault-Pierre, K., Foster, K., Ariza-McNaughton, L., Montaner, B., Chakravarty, P., Bhaw, L., Diana, G., Lassailly, F., Gribben, J., & Bonnet, D. (2017). Increased Vascular Permeability in the Bone Marrow Microenvironment Contributes to Disease Progression and Drug Response in Acute Myeloid Leukemia. Cancer Cell. https://doi.org/10.1016/j.ccell.2017.08.001
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
