The DOI matches its Crossref record.
MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer
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“Hypoxia increases the deoxycytidine triphosphate (dCTP) level through the pentose phosphate pathway (PPP) via glucose metabolism and results in resistance to gemcitabine, a dCTP analog87.”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [87]
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Mevalonate Biosynthesis is a Metabolic Vulnerability of Gemcitabine-resistant Pancreatic Cancer
Michels, A. K., Calderon, S. E., Nghiem, E., Zimmer, E., Santana, L. S., Singh, R., Eiseler, T., Allgöwer, C., Tong, G., Wu, S., et al. (2026) · Gastroenterology · doi:10.1053/j.gastro.2026.09.027
Metadata
- Authors
- Shukla, S. K., Purohit, V., Mehla, K., Gunda, V., Chaika, N. V., Vernucci, E., King, R. J., Abrego, J., Goode, G. D., Dasgupta, A., Illies, A. L., Gebregiworgis, T., Dai, B., Augustine, J. J., Murthy, D., Attri, K. S., Mashadova, O., Grandgenett, P. M., Powers, R., Ly, Q. P., Lazenby, A. J., Grem, J. L., Yu, F., Matés, J. M., Asara, J. M., Kim, J.-W., Hankins, J. H., Weekes, C., Hollingsworth, M. A., Serkova, N. J., Sasson, A. R., Fleming, J. B., Oliveto, J. M., Lyssiotis, C. A., Cantley, L. C., Berim, L., & Singh, P. K.
- Affiliations
- Nebraska Medical Center (US)
- Corresponding author
- Singh, Pankaj K.
- ORCID
- Shukla, Surendra K.
- Purohit, Vinee
- Mehla, Kamiya
- Gunda, Venugopal
- Chaika, Nina V.
- Vernucci, Enza
- King, Ryan J.
- Abrego, Jaime
- Dasgupta, Aneesha
- Gebregiworgis, Teklab
- Dai, Bingbing
- Murthy, Divya
- Attri, Kuldeep S.
- Mashadova, Oksana
- Grandgenett, Paul M.
- Powers, Robert
- Ly, Quan P.
- Grem, Jean L.
- Matés, José M.
- Asara, John M.
- Kim, Jung-whan
- Weekes, Colin
- Hollingsworth, Michael A.
- Serkova, Natalie J.
- Fleming, Jason B.
- Lyssiotis, Costas A.
- Cantley, Lewis C.
- Singh, Pankaj K.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2017-09
- Volume
- 32
- Issue
- 3
- Pages
- 392
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2783642736
- Cited by
- 98
- References
- 0
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 8 · 2023: 11 · 2022: 11 · 2021: 18 · 2020: 22 · 2019: 13 · 2018: 6
- FWCI
- 3.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- MUC1, HIF-1α, signaling crosstalk, gemcitabine resistance, pancreatic cancer, glycolysis, de novo pyrimidine biosynthesis, chemoresistance
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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