Fleming, Jason B.

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

Son, J., Lyssiotis, C. A., Ying, H., Wang, X., Hua, S., Ligorio, M., Perera, R. M., Ferrone, C. R., Mullarky, E., Shyh-Chang, N., et al. (2013) · Nature

Cancer, Hypoxia, and MetabolismPancreatic and Hepatic Oncology Research

Cited by 1,990

Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine

Geller, L. T., Barzily-Rokni, M., Danino, T., Jonas, O. H., Shental, N., Nejman, D., Gavert, N., Zwang, Y., Cooper, Z. A., Shee, K., et al. (2017) · Science

Pancreatic and Hepatic Oncology ResearchBacterial Cancer Therapy

Cited by 1,817

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

Viale, A., Pettazzoni, P., Lyssiotis, C. A., Ying, H., Sánchez, N., Marchesini, M., Carugo, A., Green, T., Seth, S., Giuliani, V., et al. (2014) · Nature

Pancreatic and Hepatic Oncology ResearchCancer, Hypoxia, and Metabolism

Cited by 1,259

KrasG12D-Induced IKK2/β/NF-κB Activation by IL-1α and p62 Feedforward Loops Is Required for Development of Pancreatic Ductal Adenocarcinoma

Ling, J., Kang, Y., Zhao, R., Xia, Q., Lee, D.-F., Chang, Z., Li, J., Peng, B., Fleming, J. B., Wang, H., et al. (2012) · Cancer Cell

NF-κB Signaling PathwaysPancreatic and Hepatic Oncology Research

Cited by 513

Phase II Trial of Cetuximab, Gemcitabine, and Oxaliplatin Followed by Chemoradiation With Cetuximab for Locally Advanced (T4) Pancreatic Adenocarcinoma: Correlation of Smad4(Dpc4) Immunostaining With Pattern of Disease Progression

Crane, C. H., Varadhachary, G. R., Yordy, J. S., Staerkel, G. A., Javle, M. M., Safran, H., Haque, W., Hobbs, B. D., Krishnan, S., Fleming, J. B., et al. (2011) · Journal of Clinical Oncology

Pancreatic and Hepatic Oncology ResearchPancreatitis Pathology and Treatment

Cited by 288

Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer

Dey, P., Baddour, J., Muller, F., Wu, C. C., Wang, H., Liao, W.-T., Lan, Z., Chen, A., Gutschner, T., Kang, Y., et al. (2017) · Nature

Cancer, Hypoxia, and MetabolismPancreatic and Hepatic Oncology Research

Cited by 264

Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer

Yao, W., Rose, J. L., Wang, W., Seth, S., Jiang, H., Taguchi, A., Liu, J., Yan, L., Kapoor, A., Hou, P., et al. (2019) · Nature

Pancreatic and Hepatic Oncology ResearchProteoglycans and glycosaminoglycans research

Cited by 214

Transport properties of pancreatic cancer describe gemcitabine delivery and response

Koay, E. J., Truty, M. J., Cristini, V., Thomas, R. M., Chen, R., Chatterjee, D., Kang, Y., Bhosale, P. R., Tamm, E. P., Crane, C. H., et al. (2014) · Journal of Clinical Investigation

Pancreatic and Hepatic Oncology ResearchMRI in cancer diagnosis

Cited by 184

Molecular Consequences of Silencing Mutant K-ras in Pancreatic Cancer Cells: Justification for K-ras–Directed Therapy

Fleming, J. B., Shen, G.-L., Holloway, S. E., Davis, M., & Brekken, R. A. (2005) · Molecular Cancer Research

Pancreatic and Hepatic Oncology ResearchProtein Kinase Regulation and GTPase Signaling

Cited by 176

SMAD4 Gene Mutation Renders Pancreatic Cancer Resistance to Radiotherapy through Promotion of Autophagy

Wang, F., Xia, X., Yang, C., Shen, J., Mai, J., Kim, H.-C., Kirui, D., Kang, Y., Fleming, J. B., Koay, E. J., et al. (2018) · Clinical Cancer Research

Pancreatic and Hepatic Oncology ResearchTGF-β signaling in diseases

Cited by 160

Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer

Genovese, G., Carugo, A., Tepper, J., Robinson, F. S., Li, L., Svelto, M., Nezi, L., Corti, D., Minelli, R., Pettazzoni, P., et al. (2017) · Nature

Pancreatic and Hepatic Oncology ResearchCancer Cells and Metastasis

Cited by 131

Inhibition of discoidin domain Receptor 1 reduces collagen-mediated tumorigenicity in pancreatic ductal adenocarcinoma

Aguilera, K. Y., Huang, H., Du, W., Hagopian, M. M., Wang, Z., Hinz, S., Hwang, T. H., Wang, H., Fleming, J. B., Castrillon, D. H., et al. (2017) · Molecular Cancer Therapeutics

Pancreatic and Hepatic Oncology ResearchProtease and Inhibitor Mechanisms

Cited by 118

Association of clinical factors with a major pathologic response following preoperative therapy for pancreatic ductal adenocarcinoma

Cloyd, J. M., Wang, H., Egger, M. E., Tzeng, C.-W. D., Prakash, L. R., Maitra, A., Varadhachary, G. R., Shroff, R., Javle, M., Fogelman, D., et al. (2017) · JAMA Surgery

Pancreatic and Hepatic Oncology ResearchCholangiocarcinoma and Gallbladder Cancer Studies

Cited by 112

A Visually Apparent and Quantifiable CT Imaging Feature Identifies Biophysical Subtypes of Pancreatic Ductal Adenocarcinoma

Koay, E. J., Lee, Y., Cristini, V., Lowengrub, J. S., Kang, Y., Lucas, F. A. S., Hobbs, B. P., Ye, R., Elganainy, D., Almahariq, M., et al. (2018) · Clinical Cancer Research

Pancreatic and Hepatic Oncology ResearchRadiomics and Machine Learning in Medical Imaging

Cited by 110

MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer

Shukla, S. K., Purohit, V., Mehla, K., Gunda, V., Chaika, N. V., Vernucci, E., King, R. J., Abrego, J., Goode, G. D., Dasgupta, A., et al. (2017) · Cancer Cell

Cancer, Hypoxia, and MetabolismPancreatic and Hepatic Oncology Research

Cited by 98

Dual Farnesyl and Geranylgeranyl Transferase Inhibitor Thwarts Mutant KRAS-Driven Patient-Derived Pancreatic Tumors

Kazi, A., Xiang, S., Yang, H., Chen, L., Kennedy, P., Ayaz, M., Fletcher, S., Cummings, C., Lawrence, H. R., Beato, F., et al. (2019) · Clinical Cancer Research

Protein Kinase Regulation and GTPase SignalingPancreatic and Hepatic Oncology Research

Cited by 81

YAP1 oncogene is a context-specific driver for pancreatic ductal adenocarcinoma

Tu, B., Yao, J., Ferri-Borgogno, S., Zhao, J., Chen, S., Wang, Q., Yan, L., Zhou, X., Zhu, C., Bang, S., et al. (2019) · JCI Insight

Hippo pathway signaling and YAP/TAZPancreatic and Hepatic Oncology Research

Cited by 75

Clinical Calculator of Conditional Survival Estimates for Resected and Unresected Survivors of Pancreatic Cancer

Katz, M. H. G., Hu, C.-Y., Fleming, J. B., Pisters, P. W. T., Lee, J. E., & Chang, G. J. (2012) · Archives of Surgery

Pancreatic and Hepatic Oncology ResearchGlobal Cancer Incidence and Screening

Cited by 59

Targeting Glucose Metabolism Sensitizes Pancreatic Cancer to MEK Inhibition

Yan, L., Tu, B., Yao, J., Gong, J., Carugo, A., Bristow, C. A., Wang, Q., Zhu, C., Dai, B., Kang, Y., et al. (2021) · Cancer Research

Pancreatic and Hepatic Oncology ResearchCancer, Hypoxia, and Metabolism

Cited by 48

Imaging-based biomarkers: changes in the tumor interface of pancreatic ductal adenocarcinoma on computed tomography scans indicate response to cytotoxic therapy

Amer, A. M., Zaid, M., Chaudhury, B., Elganainy, D., Lee, Y., Wilke, C. T., Cloyd, J., Wang, H., Maitra, A., Wolff, R. A., et al. (2018) · Cancer

Pancreatic and Hepatic Oncology ResearchMRI in cancer diagnosis

Cited by 43

Outpatient virtual clinical encounters after complex surgery for cancer: a prospective pilot study of “TeleDischarge”

Katz, M. H. G., Slack, R., Bruno, M., McMillan, J., Fleming, J. B., Lee, J. E., Bednarski, B., Papadopoulos, J., & Matin, S. F. (2016) · Journal of Surgical Research

Telemedicine and Telehealth ImplementationEnhanced Recovery After Surgery

Cited by 27

Erratum: Corrigendum: Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

Son, J., Lyssiotis, C. A., Ying, H., Wang, X., Hua, S., Ligorio, M., Perera, R. M., Ferrone, C. R., Mullarky, E., Shyh-Chang, N., et al. (2013) · Nature

Cancer, Hypoxia, and MetabolismPancreatic and Hepatic Oncology Research

Cited by 10