The DOI matches its Crossref record; 202 of the 202 references it cites were found in a registry or an index.
T Cell Dysfunction in Cancer
Open accessAbstract
Therapeutic reinvigoration of tumor-specific T cells has greatly improved clinical outcome in cancer. Nevertheless, many patients still do not achieve durable benefit. Recent evidence from studies in murine and human cancer suggest that intratumoral T cells display a broad spectrum of (dys-)functional states, shaped by the multifaceted suppressive signals that occur within the tumor microenvironment. Here we discuss the current understanding of T cell dysfunction in cancer, the value of novel technologies to dissect such dysfunction at the single cell level, and how our emerging understanding of T cell dysfunction may be utilized to develop personalized strategies to restore antitumor immunity.
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1 retracted
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Cited by
Mao, X., Xu, J., Wang, W., Liang, C., Hua, J., Liu, J., Zhang, B., Meng, Q., Yu, X., & Shi, S. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01428-1 · Cited by 2,290
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Cytotoxic CD8+ T cells in cancer and cancer immunotherapy
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TOX is a critical regulator of tumour-specific T cell differentiation
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Metadata
- Authors
- Thommen, D. S., & Schumacher, T. N.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2018-04
- Volume
- 33
- Issue
- 4
- Pages
- 547-562
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2797429263
- Cited by
- 1,299
- References
- 202
- FWCI
- 37.33
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Thommen, D. S., & Schumacher, T. N. (2018). T Cell Dysfunction in Cancer. Cancer Cell. https://doi.org/10.1016/j.ccell.2018.03.012
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
