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Single-Cell Genomic Characterization Reveals the Cellular Reprogramming of the Gastric Tumor Microenvironment

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TIM-3 restrains anti-tumour immunity by regulating inflammasome activation

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Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence

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Remodeling of the immune and stromal cell compartment by PD-1 blockade in mismatch repair-deficient colorectal cancer

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Mapping the immune environment in clear cell renal carcinoma by single-cell genomics

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IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy

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PD1Hi CD8+ T cells correlate with exhausted signature and poor clinical outcome in hepatocellular carcinoma

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Targeting TREM2 on tumor-associated macrophages enhances immunotherapy

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Spatiotemporal Co-Dependency between Macrophages and Exhausted CD8 + T Cells in Cancer

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BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells

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Unraveling the crosstalk between melanoma and immune cells in the tumor microenvironment

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Treatment of Advanced Melanoma in 2020 and Beyond

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Principles and therapeutic applications of adaptive immunity

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Exhausted CD8+T Cells in the Tumor Immune Microenvironment: New Pathways to Therapy

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Glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in glioblastoma

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Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

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Mitochondrial dysfunction promotes the transition of precursor to terminally exhausted T cells through HIF-1α-mediated glycolytic reprogramming

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CD8 T-cell subsets: heterogeneity, functions, and therapeutic potential

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Epigenetic regulation of T cell exhaustion

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Early precursor T cells establish and propagate T cell exhaustion in chronic infection

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Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche

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SLC38A2 and glutamine signalling in cDC1s dictate anti-tumour immunity

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The β1-adrenergic receptor links sympathetic nerves to T cell exhaustion

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cGAS-STING–mediated DNA sensing maintains CD8 ⁺ T cell stemness and promotes antitumor T cell therapy

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Reversing T-cell Exhaustion in Cancer: Lessons Learned from PD-1/PD-L1 Immune Checkpoint Blockade

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IL-10-expressing CAR T cells resist dysfunction and mediate durable clearance of solid tumors and metastases

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VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance

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How chemokines organize the tumour microenvironment

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Conventional type I dendritic cells maintain a reservoir of proliferative tumor-antigen specific TCF-1+ CD8+ T cells in tumor-draining lymph nodes

Schenkel, J. M., Herbst, R. H., Canner, D. A., Li, A., Hillman, M., Shanahan, S.-L., Gibbons, G., Smith, O. C. G., Kim, J. Y., Westcott, P. M. K., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.08.026 · Cited by 287 · see citing works

LAG-3 and PD-1 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity

Andrews, L. P., Butler, S. C., Cui, J., Cillo, A. R., Cardello, C., Liu, C., Brunazzi, E. A., Baessler, A., Xie, B., Kunning, S. R., et al. (2024) · Cell · doi:10.1016/j.cell.2024.07.016 · Cited by 292 · see citing works

The loss of RNA N6-adenosine methyltransferase Mettl14 in tumor-associated macrophages promotes CD8+ T cell dysfunction and tumor growth

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PD-1-cis IL-2R agonism yields better effectors from stem-like CD8+ T cells

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Adverse Events Following Cancer Immunotherapy: Obstacles and Opportunities

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Immune mechanisms orchestrate tertiary lymphoid structures in tumors via cancer-associated fibroblasts

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Abstract 2701: Functionally specialized subsets of exhausted CD8+ T cells mediate tumor control and differentially respond to checkpoint blockade

Miller, B. C., Sen, D. R., Abosy, R. A., Bi, K., Virkud, Y. V., LaFleur, M. W., Yates, K. B., Lako, A., Felt, K. D., Naik, G. S., et al. (2019) · Immunology · doi:10.1158/1538-7445.sabcs18-2701

Abstract A83: Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

Miller, B. C., Sen, D. R., Abosy, R. A., Bi, K., Virkud, Y. V., LaFleur, M. W., Yates, K. B., Lako, A., Felt, K. D., Naik, G. S., et al. (2020) · Cancer Immunology Research · doi:10.1158/2326-6074.tumimm19-a83 · Cited by 3 · see citing works

Abstract A216: Functionally specialized subsets of exhausted CD8+ T-cells mediate tumor control and response to checkpoint blockade

Sen, D. R., Miller, B. C., Abosy, R. A., Bi, K., LaFleur, M. W., Yates, K. B., Lako, A., Felt, K. D., Naik, G. S., Manos, M. P., et al. (2019) · Cancer Immunology Research · doi:10.1158/2326-6074.cricimteatiaacr18-a216

Abstract 4683: Distinct subsets of dysfunctional CD8+ T cells underlie response to checkpoint blockade

Miller, B. C., Sen, D. R., Al-Abosy, R., Bi, K., Yates, K. B., Gjini, E., Felt, K. D., Manguso, R. T., Rodig, S. J., Sharpe, A. H., et al. (2018) · Cancer Research · doi:10.1158/1538-7445.am2018-4683

Chromatin State and Immunotherapy

Haining, W. N. (2018) · Blood · doi:10.1182/blood-2018-99-109432