The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.
An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer
Open accessAbstract
Loss of MHC class I (MHC-I) antigen presentation in cancer cells can elicit immunotherapy resistance. A genome-wide CRISPR/Cas9 screen identified an evolutionarily conserved function of polycomb repressive complex 2 (PRC2) that mediates coordinated transcriptional silencing of the MHC-I antigen processing pathway (MHC-I APP), promoting evasion of T cell-mediated immunity. MHC-I APP gene promoters in MHC-I low cancers harbor bivalent activating H3K4me3 and repressive H3K27me3 histone modifications, silencing basal MHC-I expression and restricting cytokine-induced upregulation. Bivalent chromatin at MHC-I APP genes is a normal developmental process active in embryonic stem cells and maintained during neural progenitor differentiation. This physiological MHC-I silencing highlights a conserved mechanism by which cancers arising from these primitive tissues exploit PRC2 activity to enable immune evasion.
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Citations
Cites
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Cited by
Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation
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Metadata
- Authors
- Burr, M. L., Sparbier, C. E., Chan, K. L., Chan, Y.-C., Kersbergen, A., Lam, E. Y. N., Azidis-Yates, E., Vassiliadis, D., Bell, C. C., Gilan, O., Jackson, S., Tan, L., Wong, S. Q., Hollizeck, S., Michalak, E. M., Siddle, H. V., McCabe, M. T., Prinjha, R. K., Guerra, G. R., Solomon, B. J., Sandhu, S., Dawson, S.-J., Beavis, P. A., Tothill, R. W., Cullinane, C., Lehner, P. J., Sutherland, K. D., & Dawson, M. A.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2019-10
- Volume
- 36
- Issue
- 4
- Pages
- 385-401.e8
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2970548174
- Cited by
- 649
- References
- 77
- FWCI
- 18.33
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer. https://app.cochat.ai/papers/10.1016/j.ccell.2019.08.008
- The paper
- Burr, M. L., Sparbier, C. E., Chan, K. L., Chan, Y.-C., Kersbergen, A., Lam, E. Y. N., Azidis-Yates, E., Vassiliadis, D., Bell, C. C., Gilan, O., Jackson, S., Tan, L., Wong, S. Q., Hollizeck, S., Michalak, E. M., Siddle, H. V., McCabe, M. T., Prinjha, R. K., Guerra, G. R., . . . Dawson, M. A. (2019). An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer. Cancer Cell. https://doi.org/10.1016/j.ccell.2019.08.008
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
