The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Integrated Molecular and Clinical Analysis of 1,000 Pediatric Low-Grade Gliomas
Open accessAbstract
Summary Pediatric low-grade gliomas (pLGG) are frequently driven by genetic alterations in the RAS/MAPK pathway yet show unexplained variability in their clinical outcome. To address this, we characterized a cohort of >1,000 clinically annotated pLGG. 84% of cases harbored a driver alteration, while those without an identified alteration also often exhibited up-regulation of the RAS/MAPK pathway. pLGG could be broadly classified based on their alteration type. Rearrangement-driven tumors were diagnosed at a younger age, enriched for WHO grade I histology, infrequently progressed, and rarely resulted in death as compared to SNV-driven tumors. Further sub-classification of clinical-molecular correlates stratified pLGG into risk categories. These data highlight the biological and clinical differences between pLGG subtypes and opens avenues for future treatment refinement.
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The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary
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Self-citationANNOVAR: functional annotation of genetic variants from high-throughput sequencing data
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Self-citationAn Integrated Genomic Analysis of Human Glioblastoma Multiforme
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IDH1 and IDH2 Mutations in Gliomas
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Horbinski, C., Berger, T., Packer, R. J., & Wen, P. Y. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00679-w · Cited by 312
Metadata
- Authors
- Ryall, S., Zapotocky, M., Fukuoka, K., Nobre, L., Guerreiro Stucklin, A., Bennett, J., Siddaway, R., Li, C., Pajovic, S., Arnoldo, A., Kowalski, P. E., Johnson, M., Sheth, J., Lassaletta, A., Tatevossian, R. G., Orisme, W., Qaddoumi, I., Surrey, L. F., Li, M. M., Waanders, A. J., Gilheeney, S., Rosenblum, M., Bale, T., Tsang, D. S., Laperriere, N., Kulkarni, A., Ibrahim, G. M., Drake, J., Dirks, P., Taylor, M. D., Rutka, J. T., Laughlin, S., Shroff, M., Shago, M., Hazrati, L.-N., D'Arcy, C., Ramaswamy, V., Bartels, U., Huang, A., Bouffet, E., Karajannis, M. A., Santi, M., Ellison, D. W., Tabori, U., & Hawkins, C.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2020-04
- Volume
- 37
- Issue
- 4
- Pages
- 569-583.e5
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W3015449027
- Cited by
- 474
- References
- 59
- FWCI
- 26.67
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ryall, S., Zapotocky, M., Fukuoka, K., Nobre, L., Guerreiro Stucklin, A., Bennett, J., Siddaway, R., Li, C., Pajovic, S., Arnoldo, A., Kowalski, P. E., Johnson, M., Sheth, J., Lassaletta, A., Tatevossian, R. G., Orisme, W., Qaddoumi, I., Surrey, L. F., Li, M. M., . . . Hawkins, C. (2020). Integrated Molecular and Clinical Analysis of 1,000 Pediatric Low-Grade Gliomas. Cancer Cell. https://doi.org/10.1016/j.ccell.2020.03.011
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