The DOI matches its Crossref record; 89 of the 89 references it cites were found in a registry or an index.
Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer
Open accessAbstract
SUMMARY Despite the development of second-generation antiandrogens, acquired resistance to hormone therapy remains a major challenge in treating advanced prostate cancer. We find that cancer-associated fibroblasts (CAFs) can promote antiandrogen resistance in mouse models and in prostate organoid cultures. We identify neuregulin 1 (NRG1) in CAF supernatant, which promotes resistance in tumor cells through activation of HER3. Pharmacological blockade of the NRG1/HER3 axis using clinical-grade blocking antibodies re-sensitizes tumors to hormone deprivation in vitro and in vivo. Furthermore, patients with castration-resistant prostate cancer with increased tumor NRG1 activity have an inferior response to second-generation antiandrogen therapy. This work reveals a paracrine mechanism of antiandrogen resistance in prostate cancer amenable to clinical testing using available targeted therapies.
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Metadata
- Authors
- Zhang, Z., Karthaus, W. R., Lee, Y. S., Gao, V. R., Wu, C., Russo, J. W., Liu, M., Mota, J. M., Abida, W., Linton, E., Lee, E., Barnes, S. D., Chen, H.-A., Mao, N., Wongvipat, J., Choi, D., Chen, X., Zhao, H., Manova-Todorova, K., de Stanchina, E., Taplin, M.-E., Balk, S. P., Rathkopf, D. E., Gopalan, A., Carver, B. S., Mu, P., Jiang, X., Watson, P. A., & Sawyers, C. L.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2020-08
- Volume
- 38
- Issue
- 2
- Pages
- 279-296.e9
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W3043502623
- Cited by
- 259
- References
- 89
- FWCI
- 16.62
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zhang, Z., Karthaus, W. R., Lee, Y. S., Gao, V. R., Wu, C., Russo, J. W., Liu, M., Mota, J. M., Abida, W., Linton, E., Lee, E., Barnes, S. D., Chen, H.-A., Mao, N., Wongvipat, J., Choi, D., Chen, X., Zhao, H., Manova-Todorova, K., . . . Sawyers, C. L. (2020). Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer. Cancer Cell. https://doi.org/10.1016/j.ccell.2020.06.005
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
