Good Guy in Bad Company: How STRNs Convert PP2A into an Oncoprotein
Open accessAbstract
Certain Protein Phosphatase 2A (PP2A) complexes are human tumor suppressors. In contrast, a paper in this issue of Cancer Cell and two other recent studies demonstrate that PP2A-STRN3/4 complexes inactivate Hippo tumor suppressor pathway, resulting in YAP activation and tumorigenesis. Furthermore, this new oncogenic phosphatase mechanism may be druggable.
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Cites
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STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells
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Self-citationStructural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A
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Self-citationThe Hippo pathway as an antitumor target: time to focus on
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Self-citationThe STRIPAK complex is required for radial sorting and laminin receptor expression in Schwann cells
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- Authors
- Kurppa, K. J., & Westermarck, J.
- Affiliations
- University of Turku (FI)
- Åbo Akademi University (FI)
- Corresponding author
- Westermarck, Jukka
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2020-07
- Volume
- 38
- Issue
- 1
- Pages
- 20-22
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W3043613640
- Cited by
- 12
- References
- 10
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 2
- FWCI
- 1.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- protein phosphatase 2A, Hippo signaling pathway, YAP activation, tumor suppressor inactivation, carcinogenesis, phosphatase inhibitors
- MeSH terms
- Hippo Signaling Pathway, Autoantigens, Calmodulin-Binding Proteins, Humans, Membrane Proteins, Nerve Tissue Proteins, Stomach Neoplasms, Oncogene Proteins, Protein Serine-Threonine Kinases, Protein Phosphatase 2
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