Hematopoietic Progenitor Kinase1 (HPK1) Mediates T Cell Dysfunction and Is a Druggable Target for T Cell-Based Immunotherapies

Si, Jingwen, Shi, Xiangjun, Sun, Shuhao, Zou, Bin, Li, Yaopeng, An, Dongjie, Lin, Xingyu, Gao, Yan, Long, Fei, Pang, Bo, Liu, Xing, Liu, Tian, Chi, Wenna, Chen, Ligong, Dimitrov, Dimiter S., Sun, Yan, Du, Xinru, Yin, Wen, Gao, Guangxun, Min, Junxia, Wei, Lai, Liao, Xuebin·2020·Cancer Cell
DOI 10.1016/j.ccell.2020.08.001

Cited by (214)

Items 201–214 of 214

  1. BindingDB Entry 50021897: Discovery of an Exceptionally Orally Bioavailable and Potent HPK1 PROTAC with Enhancement of Antitumor Efficacy of Anti-PD-L1 Therapy.
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  2. BindingDB Entry 50020901: Discovery of 5-aminopyrido[2,3-d]pyrimidin-7(8H)-one derivatives as new hematopoietic progenitor kinase 1 (HPK1) inhibitors.
    BindingDB · 2025 · UC San Diego
  3. BindingDB Entry 50022994: Discovery of Novel PROTAC-Based HPK1 Degraders with High Potency and Selectivity for Cancer Immunotherapy.
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  4. BindingDB Entry 50013789: Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds.
    BindingDB · 2022 · UC San Diego
  5. BindingDB Entry 50020545: Design, Synthesis, and Pharmacological Evaluation of Isoindoline Analogues as New HPK1 Inhibitors.
    BindingDB · 2024 · UC San Diego
  6. BindingDB Entry 50022957: Discovery of 1(2H)-phthalazinone and 1(2H)-isoquinolinone derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors.
    BindingDB · 2026 · UC San Diego
  7. BindingDB Entry 50012716: Identification of Potent Reverse Indazole Inhibitors for HPK1.
    BindingDB · 2022 · UC San Diego
  8. BindingDB Entry 50019356: Discovery of 7H-Pyrrolo[2,3-d]pyrimidine Derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors.
    BindingDB · 2024 · UC San Diego
  9. BindingDB Entry 50019406: Discovery of quinazoline HPK1 inhibitors with high cellular potency.
    BindingDB · 2024 · UC San Diego
  10. BindingDB Entry 50023115: Design, Synthesis, and biological evaluation of 7H-Pyrrolo[2,3-d]pyrimidines as potent HPK1 kinase inhibitors.
    BindingDB · 2026 · UC San Diego
  11. BindingDB Entry 50023752: Structure-Guided Optimization of 2-Aminoquinazoline Hematopoietic Progenitor Kinase 1 Inhibitors for Improved Oral Bioavailability and Synergistic Antitumor Immunity.
    BindingDB · 2026 · UC San Diego
  12. BindingDB Entry 50022713: Discovery of Pyridine-2-Carboxamides Derivatives as Potent and Selective HPK1 Inhibitors for the Treatment of Cancer.
    BindingDB · 2026 · UC San Diego
  13. BindingDB Entry 50018195: Potent and Selective Biaryl Amide Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1).
    BindingDB · 2024 · UC San Diego
  14. Discovery of a Novel Pyrido[2,1- h ]pteridin-6-one Derivative as a Potent and Orally Bioavailable HPK1 Inhibitor
    Yun Wu, Chenliang Shi, Chao Wu, Ziping Qi, Rui Jin, Qingwang Liu, Qianmao Liang, Aoli Wang, Wenchao Wang, Beilei Wang et al. · 2026 · Journal of Medicinal Chemistry