Oncogenic collagen I homotrimers from cancer cells bind to α3β1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer

STAR: ultrafast universal RNA-seq aligner

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The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data

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Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

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Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms

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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

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Spatial reconstruction of single-cell gene expression data

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Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients

Gopalakrishnan, V., Spencer, C. N., Nezi, L., Reuben, A., Andrews, M. C., Karpinets, T. V., Prieto, P. A., Vicente, D., Hoffman, K., Wei, S. C., et al. (2018) · Science · doi:10.1126/science.aan4236 · Cited by 4,812

Commensal Bifidobacterium promotes antitumor immunity and facilitates anti–PD-L1 efficacy

Sivan, A., Corrales, L., Hubert, N., Williams, J. B., Aquino-Michaels, K., Earley, Z. M., Benyamin, F. W., Man Lei, Y., Jabri, B., Alegre, M.-L., et al. (2015) · Science · doi:10.1126/science.aac4255 · Cited by 3,888

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

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The Role of the Tumor Microenvironment in Pancreatic Ductal Adenocarcinoma: Recent Advancements and Emerging Therapeutic Strategies

Glapiński, F., Zając, W., Fudalej, M. M., Deptała, A., Czerw, A. I., Sygit, K., Kozłowski, R., & Badowska-Kozakiewicz, A. M. (2025) · Cancers · doi:10.3390/cancers17101599 · Cited by 15

Small Leucine-Rich Proteoglycan PODNL1 Identified as a Potential Tumor Matrix-Mediated Biomarker for Prognosis and Immunotherapy in a Pan-Cancer Setting

Dai, G., Sun, Y., Wei, R., & Xi, L. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45070386 · Cited by 13

Co-Delivery of Gemcitabine and Honokiol by Lipid Bilayer-Coated Mesoporous Silica Nanoparticles Enhances Pancreatic Cancer Therapy via Targeting Depletion of Tumor Stroma

Liu, D., Wang, L., Li, H., Li, D., Zhou, J., Wang, J., Zhang, Q., & Cai, D. (2024) · Molecules · doi:10.3390/molecules29030675 · Cited by 13

Inflammation, microbiota, and pancreatic cancer

Chen, X., Sun, F., Wang, X., Feng, X., Aref, A. R., Tian, Y., Ashrafizadeh, M., & Wu, D. (2025) · Cancer Cell International · doi:10.1186/s12935-025-03673-6 · Cited by 15

ITGA3–MET interaction promotes papillary thyroid cancer progression via ERK and PI3K/AKT pathways

Lan, Y., Liu, D., Liang, B., Song, X., Xie, L., Peng, H., Guo, H., Hong, C., Weng, X., Wei, X., et al. (2025) · Annals of Medicine · doi:10.1080/07853890.2025.2483379 · Cited by 15

Heterocellular crosstalk and architecture of the pancreatic tumour microenvironment

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Longitudinal Intravascular Antibody Labeling Identified Regulatory T Cell Recruitment as a Therapeutic Target in a Mouse Model of Lung Cancer

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Coating Dormant Collagenase‐Producing Bacteria with Metal‐Anesthetic Networks for Precision Tumor Therapy

Han, Q., Yang, F., Chen, M., Zhang, M., Wang, L., Wang, H., Liu, J., & Cao, Z. (2024) · Advanced Science · doi:10.1002/advs.202407402 · Cited by 12

Pancreatic ductal adenocarcinoma cells reshape the immune microenvironment: Molecular mechanisms and therapeutic targets

Zhao, Y., Qin, C., Chen, L., Li, Z., Zhao, B., Li, T., Zhang, X., & Wang, W. (2024) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2024.189183 · Cited by 14

Precision Spatial Control of Tumor‐Stroma Interactions in Cancer Models via 3D Bioprinting for Advanced Research and Therapy

Li, Y., Cui, H., & Cui, H. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202503391 · Cited by 15

STAT3–mediated up-regulation of DAB2 via SRC-YAP1 signaling axis promotes Helicobacter pylori-driven gastric tumorigenesis

Duan, Y., Kong, P., Huang, M., Yan, Y., Dou, Y., Huang, B., Guo, J., Kang, W., Zhu, C., Wang, Y., et al. (2024) · Biomarker Research · doi:10.1186/s40364-024-00577-x · Cited by 11

Microbes in the tumor microenvironment: New additions to break the tumor immunotherapy dilemma

Zhou, L., Fan, S., Zhang, W., Wang, D., & Tang, D. (2024) · Microbiological Research · doi:10.1016/j.micres.2024.127777 · Cited by 12

Col1A1 as a new decoder of clinical features and immune microenvironment in ovarian cancer

Xiao, X., Long, F., Yu, S., Wu, W., Nie, D., Ren, X., Li, W., Wang, X., Yu, L., Wang, P., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1496090 · Cited by 15

Collagen dynamics in the breast cancer tumor microenvironment and therapeutic perspectives

Wu, D., Liu, L., Ying, J., Qian, Z., You, Y., Ning, X., Zhang, F., Wang, Y., & Zhang, Y. (2025) · Discover Oncology · doi:10.1007/s12672-025-04182-8 · Cited by 13

Decoding collagen cues: the interplay of integrins and discoidin domain receptors in health and disease

Trono, P., Masi, I., Ottavi, F., & Rosanò, L. (2026) · Journal of Biomedical Science · doi:10.1186/s12929-025-01211-0 · Cited by 13

Collagenase-Functionalized Liposomes Overcome Stromal Barriers in Pancreatic Cancer

Hwang, J.-E., Jeon, M., Yim, H., Park, J., Kim, H., Lee, S., Park, H., Lee, J. K., & Im, H. (2026) · ACS Nano · doi:10.1021/acsnano.5c20618 · Cited by 12

SIN3B Loss Heats up Cold Tumor Microenvironment to Boost Immunotherapy in Pancreatic Cancer

Zhang, Z., Tang, Y., Wang, Y., Xu, J., Yang, X., Liu, M., Mazzone, M., Niu, N., Sun, Y., Tang, Y., et al. (2024) · Advanced Science · doi:10.1002/advs.202402244 · Cited by 11

Comprehensive retrospect and future perspective on bacteriophage and cancer

Liping, Z., Sheng, Y., Wu, Y., Yifei, S., Jiaqun, H., Xiaojian, Y., Han, S., & Jing, Z. (2024) · Virology Journal · doi:10.1186/s12985-024-02553-1 · Cited by 10

The Immune–Genomics of Cholangiocarcinoma: A Biological Footprint to Develop Novel Immunotherapies

Cammarota, A., Balsano, R., Pressiani, T., Bozzarelli, S., Rimassa, L., & Lleò, A. (2025) · Cancers · doi:10.3390/cancers17020272 · Cited by 11

Circulating collagen type I fragments as specific biomarkers of cardiovascular outcome risk: Where are the opportunities?

Martin, E. M., Chang, J., González, A., & Genovese, F. (2025) · Matrix Biology · doi:10.1016/j.matbio.2025.03.001 · Cited by 9

Integrated analysis of single-cell and bulk transcriptomes uncovers clinically relevant molecular subtypes in human prostate cancer

Ding, T., He, L., Lin, G.-W., Xu, L., Zhu, Y., Wang, X., Liu, X., Guo, J., Lei, F., Zuo, Z., et al. (2025) · Chinese Journal of Cancer Research · doi:10.21147/j.issn.1000-9604.2025.01.07 · Cited by 10

The role of various collagen types in tumor biology: a review

Zhou, Y., Jiang, Z., Cao, L., & Yang, J. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1549797 · Cited by 12

DKK1-SE recruits AP1 to activate the target gene DKK1 thereby promoting pancreatic cancer progression

Shao, L., Yu, H., Wang, M., Chen, L., Ji, B., Wu, T. Q., Teng, X., Su, M., Han, X., Shi, W., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06915-z · Cited by 9

Benign non-immune cells in tumor microenvironment

Liu, S., Liu, C., He, Y., & Li, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1561577 · Cited by 9

ECM, integrins, and DDRs: A nexus of cancer progression, therapy, and future directions

Azim, M. A., & Martino, J. S. D. (2025) · Matrix Biology · doi:10.1016/j.matbio.2025.04.002 · Cited by 9

Elucidating the tumor microenvironment interactions in breast, cervical, and ovarian cancer through single-cell RNA sequencing

Zhu, X., Zhang, L., Yu, X., Yan, P., Zhang, X., Zhao, Y., Wang, D., & Yang, X. (2025) · Scientific Reports · doi:10.1038/s41598-025-03017-4 · Cited by 9

What does it take to be a collagen receptor?

Farndale, R. W., Sonnenberg, A., DiPersio, C. M., Eble, J. A., Heino, J., & Gullberg, D. (2022) · Matrix Biology · doi:10.1016/j.matbio.2022.12.004 · Cited by 9

Dual Recombinase–Based Mouse Models Help Decipher Cancer Biology and Targets for Therapy

Šket, T., Falcomatà, C., & Saur, D. (2023) · Cancer Research · doi:10.1158/0008-5472.can-22-2119 · Cited by 9

The Prospect of Harnessing the Microbiome to Improve Immunotherapeutic Response in Pancreatic Cancer

Rogers, S. C., Charles, A. M., & Thomas, R. M. (2023) · Cancers · doi:10.3390/cancers15245708 · Cited by 9

Identification of molecular subtypes and diagnostic model in clear cell renal cell carcinoma based on collagen-related genes may predict the response of immunotherapy

Hong, Y., Lv, Z., Xing, Z., Xu, H., Chand, H., Wang, J., & Li, Y. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1325447 · Cited by 8

Loss of p53 and SMAD4 induces adenosquamous subtype pancreatic cancer in the absence of an oncogenic KRAS mutation

Yang, D., Sun, X., Moniruzzaman, R., Wang, H., Citu, C., Zhao, Z., Wistuba, I. I., Wang, H., Maitra, A., & Chen, Y. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101711 · Cited by 7

A 3D Self-Assembly Platform Integrating Decellularized Matrix Recapitulates In Vivo Tumor Phenotypes and Heterogeneity

Buckenmeyer, M. J., Brooks, E. A., Taylor, M. S., Orenuga, I. K., Yang, L., Holewinski, R. J., Meyer, T. J., Galloux, M., Garmendia‐Cedillos, M., Pohida, T. J., et al. (2025) · Cancer Research · doi:10.1158/0008-5472.can-24-1954 · Cited by 9

Transcriptome-wide analysis reveals potential roles of CFD and ANGPTL4 in fibroblasts regulating B cell lineage for extracellular matrix-driven clustering and novel avenues for immunotherapy in breast cancer

Wang, H., Zhu, Y.-N., Zhang, S., Liu, K., Huang, R., Li, Z., Lan, M., & Li, Y. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01237-y · Cited by 9

The potential application of stroma modulation in targeting tumor cells: Focus on pancreatic cancer and breast cancer models

Roscigno, G., Jacobs, S., Toledo, B., Borea, R., Russo, G., Pepe, F., Serrano, M. J., Calabrò, V., Troncone, G., Giovannoni, R., et al. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.05.003 · Cited by 9

Spatial transcriptomics profiling of gallbladder adenocarcinoma: a detailed two-case study of progression from precursor lesions to cancer

Pirenne, S., Manzano‐Núñez, F., Loriot, A. E., Cordi, S., Desmet, L., Aydın, S., Hubert, C., Toffoli, S., Limaye, N., Sempoux, C. L., et al. (2024) · BMC Cancer · doi:10.1186/s12885-024-12770-0 · Cited by 8

RBM39 promotes hepatocarcinogenesis by regulating RFX1’s alternative splicing and subsequent activation of integrin signaling pathway

Zhang, B., Zhou, Y., Xu, X., Xu, G., Wu, Z., Wu, Q., Zeng, Q., Yang, J., Lv, T., & Yang, J. (2025) · Oncogene · doi:10.1038/s41388-025-03327-x · Cited by 8

High serum levels of the C-propetide of type V collagen (PRO-C5) are prognostic for short overall survival in patients with pancreatic ductal adenocarcinoma

Nissen, N. I., Johansen, A. Z., Chen, I. M., Jensen, C., Madsen, E. A., Hansen, C. P., Thorlacius‐Ussing, J., Karsdal, M. A., Johansen, J. S., Diab, H. M. H., et al. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1158058 · Cited by 9

Mouse Models to Evaluate the Functional Role of the Tumor Microenvironment in Cancer Progression and Therapy ResponsesPreprint

McAndrews, K. M., Mahadevan, K. K., & Kalluri, R. (2024) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041411 · Cited by 8

Alterations of the bile microbiome is associated with progression-free survival in pancreatic ductal adenocarcinoma patients

Jiang, H., Tian, Y., Xu, L., Chen, X., Huang, Y., Wu, J., Wang, T., Liu, T., Wu, X., Ye, C., et al. (2024) · BMC Microbiology · doi:10.1186/s12866-024-03371-9 · Cited by 7

Association of tumor microbiome with survival in resected early-stage PDAC

Meng, Y., Wang, C., Usyk, M., Kwak, S., Peng, C., Hu, K. S., Oberstein, P. E., Krogsgaard, M., Li, H., Hayes, R. B., et al. (2025) · mSystems · doi:10.1128/msystems.01229-24 · Cited by 8

The Crucial Nexus: Unveiling the Role of Collagen in Cancer Progression

Reeva, H., Mahesh, G., Manjunath, U., Selvamurugan, N., & Mohankumar, D. (2025) · Seminars in Oncology · doi:10.1016/j.seminoncol.2025.152346 · Cited by 7

New trend in molecular diagnostics: Insights from the tumor microenvironment

Fan, B., Zhang, J., Li, C., & Zhang, X. (2025) · Interdisciplinary medicine · doi:10.1002/inmd.70048 · Cited by 9

The hexosamine biosynthetic pathway drives tumor immune evasion via translational control of PD-L1 at the elongation level

Liu, B., Wu, Y., Xiang, A.-Y., Yu, Y., Song, S., Zhang, Y., Gu, J., Lu, H., Xu, P., Liu, F., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116249 · Cited by 7

Tumor microenvironment subtyping in pancreatic ductal adenocarcinoma: New avenues for personalized therapeutic strategies

Srinivasan, D., Gout, J., Kleger, A., & Roger, É. (2025) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2025.115697 · Cited by 7

Top advances of the year: Pancreatic cancer

Warren, E. A. K., Lesinski, G. B., & Maithel, S. K. (2023) · Cancer · doi:10.1002/cncr.35031 · Cited by 7

Vdelta1 T cells are more resistant than Vdelta2 T cells to the immunosuppressive properties of galectin-3

Schadeck, J., Oberg, H., Peipp, M., Hedemann, N., Schamel, W. W. A., Bauerschlag, D., & Wesch, D. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1286097 · Cited by 7

Profiling of collagen and extracellular matrix deposition from cell culture using in vitro ExtraCellular matrix mass spectrometry imaging (ivECM-MSI)

Zambrzycki, S. C., Saberi, S., Biggs, R. M., Eskandari, N., Delisi, D., Taylor, H. B., Mehta, A. S., Drake, R. R., Gentile, S., Bradshaw, A. D., et al. (2024) · Matrix Biology Plus · doi:10.1016/j.mbplus.2024.100161 · Cited by 8

Distinct small molecule inhibitors of Kras specifically prime CTLA4 blockade therapy to transcriptionally reprogram Tregs and overcome resistance to suppress pancreas cancerPreprint

Mahadevan, K. K., Maldonado, A. S., Li, B., Bickert, A. A., Perdyan, A., Kumbhar, S. V., Piya, S., Sockwell, A. M., Morse, S. J., Arian, K. A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.28.640711 · Cited by 7

CAFomics: convergence to translation for precision stroma approaches

McCabe, I. C., Peng, X. L., Kearney, J. F., & Yeh, J. J. (2024) · Carcinogenesis · doi:10.1093/carcin/bgae063 · Cited by 6

The histological growth patterns in liver metastases from colorectal cancer display differences in lymphoid, myeloid, and mesenchymal cells

Garcia‐Vicién, G., Ruíz, N., Micke, P., Ruffinelli, J. C., Mils, K., Bañuls, M., Molina, N. M., Pardo, M. A., Lladó, L., Mezheyeuski, A., et al. (2024) · MedComm · doi:10.1002/mco2.70000 · Cited by 7

ANGPTL3 promotes colorectal carcinoma progression and metastasis through regulating COL1A2 transcription via interacting with integrin αVβ3

Chen, Z., Zhenxing, L., Cai, T., Yang, X. X., Jie, H., Xiao, W. L., Zheng, X., Liu, H., Huang, L., Xiong, L., et al. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.218150 · Cited by 7

ECM-responsive nanomedicine to enhance immunotherapy in pancreatic cancer

Li, L., Wen, J., Xu, H., Yu, H., Bai, X. L., & Zhang, Y. (2025) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2025.115356 · Cited by 7

Integrated multiomics revealed adenosine signaling predict immunotherapy response and regulate tumor ecosystem of melanoma

Xu, Y., Lau, P., Chen, X., Zhao, S., He, Y., Jiang, Z., Chen, X., Zhang, G., & Liu, H. (2024) · Human Genomics · doi:10.1186/s40246-024-00651-3 · Cited by 6

Systematic multiomics analysis and in vitro experiments suggest that ITGA5 could serve as a promising therapeutic target for ccRCC

Che, X., Tian, X., Wang, Z., Zhu, S., Ye, S., Wang, Y., Chen, Y., Huang, Y., Anwaier, A., Yao, P., et al. (2024) · Cancer Cell International · doi:10.1186/s12935-024-03546-4 · Cited by 6

Comprehensive analysis of the critical role of the epithelial mesenchymal transition subtype - TAGLN-positive fibroblasts in colorectal cancer progression and immunosuppression

Zhang, J., Jin, X., Hou, Y., Gu, B., Li, H., Yi, L., Wu, W., & Hu, S. (2025) · Cell & Bioscience · doi:10.1186/s13578-025-01405-x · Cited by 6

P4HA1 mediates YAP hydroxylation and accelerates collagen synthesis in temozolomide-resistant glioblastoma

Li, X., Yu, G., Zhong, X., Zhong, J., Chen, X., Chen, Q., Xue, J., Xi, Y., Zhang, X., Ling, Y., et al. (2025) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003679 · Cited by 9

Targets in the Tumour Matrisome to Promote Cancer Therapy Response

Jalil, S. M. A., Henry, J. C., & Cameron, A. J. M. (2024) · Cancers · doi:10.3390/cancers16101847 · Cited by 8

pH-responsive morphological transition: Peptide amphiphile-based nanovehicles inhibit drug efflux and modulate cancer-associated fibroblasts to combat bladder cancer

Huang, H., Bao, L., Yu, Z., Du, Y., Liu, J., Liu, P., Yang, W., & Bai, J. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.160271 · Cited by 5

Machine Learning-Enhanced Single-Particle Tracking for Rapid Screening of Tumor Immunomodulatory Drugs

Chen, H., Wang, L., Zhang, S.-Y., Liu, Y., Liu, S., & Wang, Z. (2025) · ACS Nano · doi:10.1021/acsnano.5c06795 · Cited by 5

Strategic modulation of the gastrointestinal microbiome to enhance pancreatic cancer immunotherapy

Jagwani, S., Musumeci, L., Flores, L., Mackenzie, G. G., & Amiji, M. M. (2025) · Drug Discovery Today · doi:10.1016/j.drudis.2025.104528 · Cited by 6

The tumor microbiome and cancer immunotherapy: A systematic review of a new frontier beyond the gut

Barjij, I., & Meliani, M. (2025) · Bulletin du Cancer · doi:10.1016/j.bulcan.2025.09.006 · Cited by 5

The Mclust Analysis of Tumor Budding Unveils the Role of the Collagen Family in Cervical Cancer Progression

Lee, E., Le, T. M., Chong, G. O., Cho, J., & Park, J. Y. (2024) · Life · doi:10.3390/life14081004 · Cited by 5

COL3A1high cancer-associated fibroblasts orchestrate metabolic and immune microenvironments to confer chemoresistance in breast cancer

Jiang, P., Li, X., Wang, Z., Li, S., Huang, Y., Li, Y.-X., Chen, Y., & Sun, X. (2026) · npj Precision Oncology · doi:10.1038/s41698-026-01338-9 · Cited by 4

The role of thrombospondin-1 in dermatological conditions

Chen, L.-S., Zheng, B., Zhao, C.-Y., He, C., & Xing-hua, G. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1724955 · Cited by 4

Untangling the tumorigenic role of homotrimeric collagen I

Jørgensen, C. (2022) · Cancer Cell · doi:10.1016/j.ccell.2022.07.007 · Cited by 4

Establishment of homotrimer collagen type I signature and its association with clinical manifestation and tertiary lymphoid structures formation in liver cancer

Shen, X., Chen, Z.-C., Wang, X., Wang, X., Xie, S., Zheng, X., Yang, L., & Lu, L. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e31320 · Cited by 4

Global Literature Analysis of Tumor Organoid and Tumor-on-Chip Research

Shoji, J., Davis, R. P., Mummery, C. L., & Krauss, S. J. K. (2025) · Cancers · doi:10.3390/cancers17010108 · Cited by 4

De Novo Design of Specific Heterotrimeric Collagen‐Like Peptides via Genetic Algorithm

Bui, T. H., Adetunji, O., Cole, C. C., Yu, L. T., Peterson, C. M., & Hartgerink, J. D. (2025) · Advanced Science · doi:10.1002/advs.202502377 · Cited by 4

Hpv-driven rewiring of the tumor immune microenvironment through single-cell profiling informs prognosis and therapy in HNSCC

Li, Y., Kou, Q., Zheng, C., Nov, P., Wang, C., Ni, P., Li, L., Zhang, Y., Wang, D., Prasai, A., et al. (2025) · Oral Oncology · doi:10.1016/j.oraloncology.2025.107789 · Cited by 4

Favorable histo-molecular remodeling of pancreatic ductal adenocarcinoma after neoadjuvant FOLFIRINOX followed by high-dose stereotactic body radiotherapy

Bouchart, C., Senar, O. A., Navez, J., Verset, L., Boisson, A., Hein, M., Stosic, K., Quertinmont, E., Tafciu, V., Zhao, S., et al. (2026) · British Journal of Cancer · doi:10.1038/s41416-025-03274-0 · Cited by 4

Collagen Mechanics

Szarek, P., & Ruberti, J. W. (2026) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-032-05273-5_10 · Cited by 4

Crosstalk Between Intratumoral Microbes and Tumor Immunity: Implications for Tumor Therapy

Li, F., Qiao, L., Liang, X., Zhang, Y., Liang, N., Xie, J., Deng, G., Hao, Y., Hu, P., Wu, X., et al. (2026) · Cancer Medicine · doi:10.1002/cam4.71575 · Cited by 4

A pan-cancer single-cell transcriptomic atlas of human bone metastases

Wang, S., Ma, F., Wang, D., Yu, Q., Zheng, H., Chen, Z., Zhao, S., Xu, L., Ye, Q., Tan, Y., et al. (2026) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.102583 · Cited by 7

Acquired resistance of cancer therapies: Mechanisms and perspectives

Wang, M., Zhai, X., Li, J., Chen, J., Gai, X., Liu, X., Liu, Y., Zhou, Q., & Chen, C. (2026) · Chinese Medical Journal · doi:10.1097/cm9.0000000000004048 · Cited by 5

Oncogenic Kras targeting with MRTX1133 or Daraxonrasib specifically synergize with anti-CTLA4 to promote anti-tumor immunity in pancreatic cancer

Mahadevan, K. K., Maldonado, A. S., Li, B., Bickert, A. A., Perdyan, A., Kumbhar, S. V., Piya, S., Sockwell, A. M., Morse, S. J., Arian, K. A., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-75960-3 · Cited by 12

Identification of fibronectin type III domain containing 3B as a potential prognostic and therapeutic target for pancreatic cancer: a preliminary analysis

Wang, Y., Kong, Y., Yang, Q., Zhong, C., & Zhou, D. (2024) · European journal of medical research · doi:10.1186/s40001-024-01823-6 · Cited by 4

Integrin α2 in the microenvironment and the tumor compartment of digestive (gastrointestinal) cancers: emerging regulators and therapeutic opportunities

Liu, T., Gu, Y., Zhang, Y., & Li, Y. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1439709 · Cited by 4

Systematic pan-cancer analysis of the potential tumor diagnosis and prognosis biomarker P4HA3

Wu, Y., Zhang, B., Nong, J., Alarcón, R., Guo, W., Liu, Y., Zhao, S., & Wei, R. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1045061 · Cited by 4

Mechanical cues of extracellular matrix determine tumor innervationPreprint

Jiang, S., Zhang, S., Cai, Z., Yu, M., Li, H., Jiang, L., Cai, S., Zhu, Y., Wang, H., Huo, R., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.25.586535 · Cited by 4

Collagen-disrupting attIL12 TIL therapy boosts deep T cell infiltration via dual signaling activation and CCKAR reduction in sarcomas

Hu, J., Singh, H., Jin, Y., Zhang, W., Wang, J., Xia, X., Somaiah, N., Gorlick, R. G., & Li, S. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2507542122 · Cited by 4

Microenvironment of Solid Tumors

Korneenko, T. V., Pestov, N. B., Shakhparonov, M. I., & Barlev, N. A. (2025) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl36940 · Cited by 3

A 3D Bioprinted Pancreatic Cancer Model Using Collagen-Gelatin Methacrylamide-Alginate Bioinks to Mimic the Desmoplastic Microenvironment

Gato-Diaz, U., Blanco-Garcia, S., Peixoto, D., Concheiro, Á., Alvarez‐Lorenzo, C., & Blanco‐Fernandez, B. (2025) · Biomacromolecules · doi:10.1021/acs.biomac.5c00450 · Cited by 4

Collagen Signaling via DDR1 Exacerbates Barriers to Macromolecular Drug Delivery in a 3D Model of Pancreatic Cancer Fibrosis

Ohira, M., Kitamura, M., Iwasaki, H., Ohta‐Okano, H., Tsujii, H., Nakamura, R., Nakazawa, T., Nishiguchi, A., Yamamoto, M., Osada, K., et al. (2025) · Small · doi:10.1002/smll.202506926 · Cited by 4

Collagen and Its Roles in the Tumor Immune Microenvironment: Structure, Function, and Therapeutic Potential

Zhang, Y. N., Wang, W. N., Liu, G. Q., Wang, L. N., Zhang, X., Mei, J., & Yang, K. N. (2025) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl45052 · Cited by 3

Tumor microenvironment and mechanotransduction pathways: Novel targets and new directions for cancer therapy

Zhang, X., Sun, J., Li, Z., & Wang, S. (2026) · Mechanobiology in Medicine · doi:10.1016/j.mbm.2026.100189 · Cited by 3

Tumor cell-derived HSP47 promotes pancreatic Cancer metastasis via Homotrimeric collagen-mediated M2 macrophage polarization

Ling, X., Zhang, Y., Zhu, L., Xu, Z., Bao, Y., Lin, H., Wu, J., Shi, J., Liu, L., & Dong, Q. (2026) · Cellular Signalling · doi:10.1016/j.cellsig.2026.112589 · Cited by 3

Collagen Lattice Model, Populated with Heterogeneous Cancer-Associated Fibroblasts, Facilitates Advanced Reconstruction of Pancreatic Cancer Microenvironment

Song, X., Nihashi, Y., Imai, Y., Mori, N., Kagaya, N., Suenaga, H., Shin‐ya, K., Yamamoto, M., Setoyama, D., Kunisaki, Y., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25073740 · Cited by 3

A two-step dance commits collagen to folding

Brodsky, B., & Persikov, A. V. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2422338121 · Cited by 3

Supramolecular Assembly of Collagen-Mimetic Peptide D-Periodic Fibrils and Nanoassemblies

Cole, C. C., Kreutzberger, M. A. B., Klein, K., Cahue, K. A., Pogostin, B. H., Farsheed, A. C., Swain, J. W. R., Bui, T. H., Dey, A., Makhoul, J. T., et al. (2026) · Biomacromolecules · doi:10.1021/acs.biomac.6c00345 · Cited by 3

Nidogen-2 (NID2) is a Key Factor in Collagen Causing Poor Response to Immunotherapy in Melanoma

Sha, Y., Mao, A.-Q., Liu, Y., Li, J.-P., Gong, Y.-T., Xiao, D., Huang, J., Gao, Y., Wu, M.-Y., & Shen, H. (2023) · Pharmacogenomics and Personalized Medicine · doi:10.2147/pgpm.s399886 · Cited by 3

The molecular classification of cancer-associated fibroblasts on a pan-cancer single-cell transcriptional profilingPreprint

Chen, B., Chan, W. N., Xie, F., Mui, C. W., Cheung, A. H. K., liu, X., Lung, R. W. M., Chow, C., Zhang, Z., Shi, S., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-2412848/v1 · Cited by 3

Cirrhotic-extracellular matrix attenuates aPD-1 treatment response by initiating immunosuppressive neutrophil extracellular traps formation in hepatocellular carcinomaPreprint

Shen, X., Xie, S., Zou, T., Hu, B., Xu, J., Zhen, X., Xu, Y., Wang, X., Wang, H., Wang, S., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-2908133/v1 · Cited by 3

Isolation of type I collagen homotrimer from human placenta with LC–MS monitoring of the α1(I)/α2(I) chain ratio

Taga, Y., Kiriyama-Tanaka, T., & Mizuno, K. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.128301 · Cited by 2

High levels of fibrotic tumor components are associated with recurrence and intratumoral immune status in advanced colorectal cancer patients

Dorjkhorloo, G., Shiraishi, T., Erkhem‐Ochir, B., Sohda, M., Okami, H., Yamaguchi, A., Shioi, I., Komine, C., Nakazawa, N., Shibasaki, Y., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-80489-w · Cited by 4

Cancer‑associated fibroblasts in human malignancies, with a particular emphasis on sarcomas (Review)

Benešová, I., Kalkusova, K., Kwon, Y., Táborská, P., Stakheev, D., Krausová, K., Smetanová, J., Ozaniak, A., Bartůňková, J., Smrž, D., et al. (2025) · International Journal of Oncology · doi:10.3892/ijo.2025.5785 · Cited by 3

The microbiome shaping cancer development, progression, and therapeutic response

Salihoğlu, R. (2025) · Physiological Genomics · doi:10.1152/physiolgenomics.00091.2025 · Cited by 3

Integrative Multi‐Omics Analysis Uncovers Immunological Phenotypes Predictive of Combinatorial Immunotherapy Response in Gastric Cancer

Wang, J., Zhang, W., Zhang, J., Zhao, C., Zhang, W., Fang, M., Chen, F., Wu, Z., Xu, X., Yu, Z., et al. (2025) · Advanced Science · doi:10.1002/advs.202514482 · Cited by 6

Functionalized collagen-based biomaterials via self-assembly: implications for gastrointestinal health

Qin, M., He, Y., He, Y., Wu, Y., Liu, Q., Guan, Y., Yang, L., & Guo, J. (2025) · Collagen and Leather · doi:10.1186/s42825-025-00217-6 · Cited by 2

Mapping the knowledge landscape: a bibliometric analysis of gut microbiota in cancer immunotherapy with implications for clinical translation

Su, P., Tao, Y., Wang, A., & Xiao, Y. (2025) · International Journal of Surgery · doi:10.1097/js9.0000000000004476 · Cited by 3

Inhibiting the Secreted RGDKGE Collagen Peptide Selectively Controls CD8+ T-Cell Migration on Denatured Collagen-IV and Enhances Their Accumulation in Tumors

Han, X., Caron, J. M., & Brooks, P. C. (2026) · American Journal Of Pathology · doi:10.1016/j.ajpath.2025.09.008 · Cited by 2

Type I collagen homotrimers: A potential cancer‐specific interventional target

Zhou, Y., Zhang, L., Xie, J., & Han, J. (2022) · MedComm – Oncology · doi:10.1002/mog2.16 · Cited by 1

Untangling the tumorigenic role of homotrimeric collagen I

Jørgensen, C. (2022) · Cancer Cell · doi:10.1016/j.ccell.2022.07.007 · Cited by 4

Collagen I Homotrimers Promote PDAC Growth and Impact Immunity

(2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-rw2022-138 · Cited by 2

Abstract 4589: Deciphering collagen-responsive mechanism in pancreatic tumor progression and immunology at single-cell resolution

Chen, Y. (2023) · Cancer Research · doi:10.1158/1538-7445.am2023-4589

Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer

Chen, Y., Kim, J., Yang, S., Wang, H., Wu, C.-J., Sugimoto, H., LeBleu, V. S., & Kalluri, R. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.02.007 · Cited by 566