Adult Congenital Heart Disease
Abstract
This article reviews the changing epidemiology of congenital heart disease summarizing its impact on the demographics of the congenital heart disease population and the progress made in order to improve outcomes in this patient population. Birth prevalence of congenital heart disease can be modified by many factors. As a result of decreasing mortality and increasing survival in all forms of congenital heart disease, the median age of patients has increased and adults now compose two-thirds of patients with congenital heart disease. Disease burden and resulting health services utilization increase significantly across the lifespan. Bridging the gap between policy and quality of care can be improved by referral to specialized adult congenital heart disease centers and planning delivery of specialized services that are commensurate with population needs, program accreditation criteria and certified training of designated workforce.
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The survival of children with the most critical forms of congenital heart disease requiring neonatal open-heart surgery has increased enormously over the last few decades.
“The survival of children with the most critical forms of congenital heart disease (CHD) requiring neonatal openheart surgery has increased enormously over the last few decades. 1”
From Perioperative neonatal brain injury is associated with worse school-age neurodevelopment in children with critical congenital heart disease (2018) · cites this paper as [1]
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Durán, A. C., Fernández, B., Fernández, M. C., López‐García, A., Arqué, J. M., & Sans-Coma, V. (2011) · Journal of Comparative Pathology · doi:10.1016/j.jcpa.2011.03.017 · Cited by 3 · see citing works
Environmental changes surrounding congenital heart disease
Choi, E. (2023) · Korean Journal of Pediatrics · doi:10.3345/cep.2022.00976 · Cited by 2 · see citing works
Changing Epidemiology of Congenital Heart Disease
Dray, E. M., & Marelli, A. J. (2016) · Congenital heart disease in adolescents and adults · doi:10.1007/978-3-319-31139-5_1 · Cited by 2 · see citing works
Self-citationAdults With Congenital Heart Disease
Marelli, A. J., Gatzoulis, M. Α., & Webb, G. D. (2017) · Elsevier eBooks · doi:10.1016/b978-0-7020-6929-1.00001-0 · Cited by 2 · see citing works
Self-citationDisparities in disease burden of congenital heart disease among 150,488 individuals in Western China
Wang, J., Bai, Y., Zhou, H., & Liu, J. (2025) · Scientific Reports · doi:10.1038/s41598-025-91256-w · Cited by 1 · see citing works
Dawkins, J. D., Cedars, A. M., & SCHUSSLER, J. M. (2019) · Clinical Case Reports · doi:10.1002/ccr3.1962 · Cited by 1 · see citing works
Pollmann, K., Murthi, S. R., Kračun, D., Schwarzmayr, T., Petry, A., Cleuziou, J., Hörer, J., Klop, M., Ewert, P., Görlach, A., et al. (2021) · Cardiovascular Diagnosis and Therapy · doi:10.21037/cdt-20-894 · Cited by 1 · see citing works
Editorial Commentary: Looking beyond the heart in adult congenital heart disease
Bouma, B. J., & Postma, A. V. (2016) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2016.05.002
The Patient with Congenital Cardiac Disease
Mauriat, P., & Assy, J. (2017) · Springer eBooks · doi:10.1007/978-3-319-60804-4_5
Zaban, N. B., Przybylowski, L. F., & Schamberger, M. S. (2019) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2019.05.015
Taranto, L. M., & Rhee, E. K. (2021) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000938
Risk of abnormal outcomes based on basic and advanced MRI measurements
Ahtam, B., Solti, M., & Grant, P. E. (2021) · Advances in magnetic resonance technology and applications · doi:10.1016/b978-0-12-816633-8.00020-x
Cohen, S., & Marelli, A. J. (2023) · Springer eBooks · doi:10.1007/978-1-4471-4999-6_181-2
Self-citationTREATMENT OF PULMONARY ARTERIAL HYPERTENSION ASSOCIATED WITH CONGENITAL HEART DEFECTS
Vasilyeva, L. I., & Kalashnykova, O. S. (2024) · Art of Medicine · doi:10.21802/artm.2024.3.31.207
Variability in technical fee billing for cardiac CT across congenital cardiac centers
Barfuss, S. B., Ballard, C., Marullo, B., Zimmerli, J., Linscott, L. L., Coonradt, C., & Han, B. (2025) · Journal of cardiovascular computed tomography · doi:10.1016/j.jcct.2024.12.089
Sloan, B., Nguyen, K., Hamlin, S., & Zeigler, S. (2025) · Cureus · doi:10.7759/cureus.93368
Assessing Genetic Testing in Adult Congenital Heart Disease: Current State and Patient Perspectives
Onorato, A. C., Klinkebiel, K., Levenseller, R., Chaudhari, B. P., Kistler, I. S., Vannatta, K. A., Gosselin, R., Texter, K. M., Garg, V., & Mah, M. L. (2026) · Circulation Genomic and Precision Medicine · doi:10.1161/circgen.125.005527
- Authors
- Mazor Dray, E., & Marelli, A. J.
- Affiliations
- McGill University Health Centre (CA)
- Corresponding author
- Marelli, Ariane J.
- ORCID
- Marelli, Ariane J.
- Venue
- Cardiology Clinics
- Publisher
- Elsevier BV
- Published
- 2015-11
- Volume
- 33
- Issue
- 4
- Pages
- 503-512
- ISSN
- 0733-8651 (ISSN-L)
- OpenAlex
- W1799523503
- Cited by
- 52
- References
- 52
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 7 · 2020: 5 · 2019: 5 · 2018: 7 · 2017: 5 · 2016: 8
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cardiology Clinics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cardiovascular and Diving-Related Complications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- adult congenital heart disease, birth prevalence, disease burden, health care utilization, patient survival, specialized care centers, employee training, quality of care, health policy
- MeSH terms
- Adult, Cardiac Care Facilities, Female, Health Services Needs and Demand, Heart Defects, Congenital, Humans, Male, Quality of Health Care, Referral and Consultation, Cost of Illness
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