Cited by 344Prostate Cancer Treatment and ResearchHER2/EGFR in Cancer ResearchEstrogen and related hormone effects

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HER2/neu kinase-dependent modulation of androgen receptor function through effects on DNA binding and stability.

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Mellinghoff, Ingo K., Vivanco, Igor, Kwon, Andrew, Tran, Chris, Wongvipat, John, Sawyers, Charles L.·2004·Cancer Cell

DOI 10.1016/j.ccr.2004.09.031

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Abstract

Given the role of the EGFR/HER2 family of tyrosine kinases in breast cancer, we dissected the molecular basis of EGFR/HER2 kinase signaling in prostate cancer. Using the small molecule dual EGFR/HER2 inhibitor PKI-166, we show that the biologic effects of EGFR/HER-2 pathway inhibition are caused by reduced AR transcriptional activity. Additional genetic and pharmacologic experiments show that this modulation of AR function is mediated by the HER2/ERBB3 pathway, not by EGFR. This HER2/ERBB3 signal stabilizes AR protein levels and optimizes binding of AR to promoter/enhancer regions of androgen-regulated genes. Surprisingly, the downstream signaling pathway responsible for these effects appears to involve kinases other than Akt. These data suggest that the HER2/ERBB3 pathway is a critical target in hormone-refractory prostate cancer.

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Authors: Mellinghoff, I. K., Vivanco, I., Kwon, A., Tran, C., Wongvipat, J., & Sawyers, C. L.
Affiliations: University of California, Los Angeles (US)
Howard Hughes Medical Institute (US)
Corresponding author: Sawyers, Charles L.
ORCID: Mellinghoff, Ingo K.
Vivanco, Igor
Sawyers, Charles L.
Venue: Cancer Cell
Publisher: Elsevier BV
Published: 2004-11
Volume: 6
Issue: 5
Pages: 517-527
ISSN: 1535-6108 (ISSN-L)
DOI: 10.1016/j.ccr.2004.09.031
OpenAlex: W2077863736
Cited by: 344
References: 80
Citations by year: 2026: 2 · 2025: 3 · 2024: 6 · 2023: 15 · 2022: 6 · 2021: 10 · 2020: 10 · 2019: 6 · 2018: 10 · 2017: 15 · 2016: 16 · 2015: 17 · 2014: 17 · 2013: 20 · 2012: 23
FWCI: 19.11
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3180 d)
Locations: Cancer Cell (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
Health Sciences › Medicine › Oncology › HER2/EGFR in Cancer Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Keywords: HER2/neu, androgen receptor, HER3, prostate cancer, castration-resistant prostate cancer, protein stability, DNA binding, transcriptional activity, Akt-independent signaling, tyrosine kinase inhibitors
MeSH terms: Animals, Chlorocebus aethiops, DNA, Neoplasm, Humans, Male, Prostatic Neoplasms, Proto-Oncogene Proteins, Pyrimidines, Pyrroles, Receptors, Androgen, Transfection, Tumor Cells, Cultured, Signal Transduction, Protein Serine-Threonine Kinases, Receptor, ErbB-2, Erb-b2 Receptor Tyrosine Kinases, COS Cells, RNA, Small Interfering, Proto-Oncogene Proteins c-akt, ErbB Receptors

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HER2/neu kinase-dependent modulation of androgen receptor function through effects on DNA binding and stability.

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