Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth
Open accessAbstract
ErbB2 is a ligand-less member of the ErbB receptor family that functions as a coreceptor with EGFR, ErbB3, and ErbB4. Here, we describe an approach to target ErbB2's role as a coreceptor using a monoclonal antibody, 2C4, which sterically hinders ErbB2's recruitment into ErbB ligand complexes. Inhibition of ligand-dependent ErbB2 signaling by 2C4 occurs in both low- and high-ErbB2-expressing systems. Since the ErbB3 receptor contains an inactive tyrosine kinase domain, 2C4 is very effective in blocking heregulin-mediated ErbB3-ErbB2 signaling. We demonstrate that the in vitro and in vivo growth of several breast and prostate tumor models is inhibited by 2C4 treatment.
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It is likely that heregulin-driven tumors lacking HER2 amplification may benefit from HER2-directed therapies.
“It is likely that also heregulin-driven tumors lacking HER2 amplification may benefit from HER2-directed therapies [92, 95, 96]”
From Primary and acquired resistance to EGFR-targeted therapies in colorectal cancer: impact on future treatment strategies (2014) · cites this paper as [96]
Trastuzumab is unable to block ligand-induced HER2-containing heterodimers.
“This is consistent with data showing that trastuzumab is unable to block ligand-induced HER2-containing heterodimers (Agus et al., 2002).”
From ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics (2014) · cites this paper as Agus et al., 2002
Cites
Slamon, D. J., Clark, G. M., Wong, S. G., Levin, W. J., Ullrich, A., & McGuire, W. L. (1987) · Science · doi:10.1126/science.3798106 · Cited by 11,760 · see citing works
Slamon, D. J., Leyland-Jones, B., Shak, S., Fuchs, H., Paton, V., Bajamonde, A., Fleming, T., Eiermann, W., Wolter, J., Pegram, M., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103153441101 · Cited by 11,500 · see citing works
Untangling the ErbB signalling network
Yarden, Y., & Sliwkowski, M. X. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35052073 · Cited by 6,974 · see citing works
Self-citationReal time quantitative PCR.Preprint
Heid, C., Stevens, J., Livak, K. J., & Williams, P. (1996) · Genome Research · doi:10.1101/gr.6.10.986 · Cited by 6,180 · see citing works
Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets
Clynes, R. A., Towers, T. L., Presta, L. G., & Ravetch, J. V. (2000) · Nature Medicine · doi:10.1038/74704 · Cited by 2,768 · see citing works
Cobleigh, M., Vogel, C. L., Tripathy, D., Robert, N. J., Scholl, S., Fehrenbacher, L., Wolter, J. M., Paton, V. E., Shak, S., Lieberman, G., et al. (1999) · Journal of Clinical Oncology · doi:10.1200/jco.1999.17.9.2639 · Cited by 2,767 · see citing works
A novel method for real time quantitative RT-PCR.Preprint
Gibson, U. E., Heid, C., & Williams, P. M. (1996) · Genome Research · doi:10.1101/gr.6.10.995 · Cited by 2,090 · see citing works
Graus-Porta, D., Beerli, R. R., Daly, J. M., & Hynes, N. E. (1997) · The EMBO Journal · doi:10.1093/emboj/16.7.1647 · Cited by 1,593 · see citing works
The EGF receptor family as targets for cancer therapy
Mendelsohn, J. M., & Baselga, J. M. (2000) · Oncogene · doi:10.1038/sj.onc.1204082 · Cited by 1,341 · see citing works
Hidalgo, M., Siu, L. L., Nemunaitis, J., Rizzo, J., Hammond, L. A., Takimoto, C., Eckhardt, S. G., Tolcher, A., Britten, C. D., Denis, L., et al. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.13.3267 · Cited by 1,001 · see citing works
Baselga, J. M., Norton, L., Albanell, J., Kim, Y. M., & Mendelsohn, J. M. (1998) · PubMed · Cited by 996 · see citing works
Craft, N., Shostak, Y., Carey, M., & Sawyers, C. L. (1999) · Nature Medicine · doi:10.1038/6495 · Cited by 980 · see citing works
The Epidermal Growth Factor Receptor and Its Inhibition in Cancer Therapy
Woodburn, J. R. (1999) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(98)00045-x · Cited by 834 · see citing works
Wells, A. (1999) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(99)00015-1 · Cited by 819 · see citing works
Pinkas‐Kramarski, R., Soussan, L., Waterman, H., Levkowitz, G., Alroy, I., Klapper, L. N., Lavi, S., Seger, R., Ratzkin, B. J., Sela, M., et al. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00603.x · Cited by 770 · see citing works
Molina, M. A., Codony‐Servat, J., Albanell, J., Rojo, F., Arribas, J., & Baselga, J. M. (2001) · PubMed · Cited by 766 · see citing works
Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity.
Guy, P. M., Platko, J. V., Cantley, L. C., Cerione, R. A., & Carraway, K. L. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.17.8132 · Cited by 698 · see citing works
Pegram, M. D., Hsu, S., Lewis, G., Pietras, R. J., Beryt, M., Sliwkowski, M. X., Coombs, D., Baly, D. L., Kabbinavar, F. F., & Slamon, D. J. (1999) · Oncogene · doi:10.1038/sj.onc.1202526 · Cited by 693 · see citing works
Self-citationErbB‐2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer.
Karunagaran, D., Tzahar, E., Beerli, R. R., Chen, X., Graus-Porta, D., Ratzkin, B. J., Seger, R., Hynes, N. E., & Yarden, Y. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00356.x · Cited by 674 · see citing works
Nonclinical studies addressing the mechanism of action of trastuzumab (Herceptin).
Sliwkowski, M. X., Ja, L., Gd, L., Te, H., FENDLY, B. M., & Fox, J. A. (1999) · PubMed · Cited by 653 · see citing works
Self-citationCoexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin.
Sliwkowski, M. X., Schaefer, G., Akita, R. W., Lofgren, J. A., Fitzpatrick, V. D., Nuijens, A., FENDLY, B. M., Cerione, R. A., VANDLEN, R. L., & Carraway, K. L. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36676-0 · Cited by 644 · see citing works
Self-citationYeh, S., Lin, H., Kang, H., Thin, T. H., Lin, M., & Chang, C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5458 · Cited by 594 · see citing works
Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas.
Alimandi, M., Romano, A., Curia, M. C., Muraro, R., Fedi, P., Aaronson, S. A., Fiore, P. P. D., & Kraus, M. H. (1995) · PubMed · Cited by 548 · see citing works
Androgen Receptor Signaling in Androgen-Refractory Prostate Cancer
Grossmann, M. E., Huang, H., & Tindall, D. J. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.22.1687 · Cited by 548 · see citing works
Smart drugs: Tyrosine kinase inhibitors in cancer therapy
Shawver, L. K., Slamon, D. J., & Ullrich, A. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00039-9 · Cited by 524 · see citing works
ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor.
Soltoff, S. P., Carraway, K. L., Prigent, S. A., Gullick, W. G., & Cantley, L. C. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.6.3550 · Cited by 515 · see citing works
Wen, Y., Hu, M. C. ‐., Makino, K., Spohn, B., Bartholomeusz, G. A., Yan, D., & Hung, M. (2000) · PubMed · Cited by 461 · see citing works
Klapper, L. N., Glathe, S., Vaisman, N., Hynes, N. E., Andrews, G. C., Sela, M., & Yarden, Y. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.9.4995 · Cited by 455 · see citing works
Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential
Caltagirone, S., Rossi, C., Poggi, A., Ranelletti, F. O., Natali, P. G., Brunetti, M., Aiello, F. B., & Piantelli, M. (2000) · International Journal of Cancer · doi:10.1002/1097-0215(20000815)87:4 · Cited by 441 · see citing works
Lenferink, A. E. G., Pinkas‐Kramarski, R., van de Poll, M. L. M., van Vugt, M. J. H., Klapper, L. N., Tzahar, E., Waterman, H., Sela, M., van Zoelen, E. J. J., & Yarden, Y. (1998) · The EMBO Journal · doi:10.1093/emboj/17.12.3385 · Cited by 413 · see citing works
Heregulin‐dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3.
Wallasch, C., Weiss, F. U., Niederfellner, G., Jallal, B., Issing, W., & Ullrich, A. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00101.x · Cited by 406 · see citing works
FENDLY, B. M., Winget, M., Hudziak, R. M., Lipari, M. T., Napier, M. A., & Ullrich, A. (1990) · PubMed · Cited by 403 · see citing works
Arteaga, C. L. (2001) · PubMed · Cited by 397 · see citing works
Her-2-neu Expression and Progression Toward Androgen Independence in Human Prostate Cancer
Signoretti, S. (2000) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/92.23.1918 · Cited by 397 · see citing works
Pietras, R. J., Pegram, M. D., Finn, R. S., Maneval, D. A., & Slamon, D. J. (1998) · Oncogene · doi:10.1038/sj.onc.1202132 · Cited by 387 · see citing works
Binding specificities and affinities of egf domains for ErbB receptors
Jones, J. T., Akita, R. W., & Sliwkowski, M. X. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00283-5 · Cited by 387 · see citing works
Self-citationWorthylake, R. A., Opresko, L. K., & Wiley, H. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.13.8865 · Cited by 326 · see citing works
Cunha, G. R. (1994) · Cancer · doi:10.1002/1097-0142(19940801)74:3+ · Cited by 321 · see citing works
Beerli, R. R., & Hynes, N. E. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.11.6071 · Cited by 308 · see citing works
ZD1839 (???Iressa???)*,??? as an Anticancer Agent
Baselga, J., & Averbuch, S. D. (2000) · Drugs · doi:10.2165/00003495-200060001-00004 · Cited by 303 · see citing works
ErbB-1 and ErbB-2 Acquire Distinct Signaling Properties Dependent upon Their Dimerization Partner
Olayioye, M. A., Graus-Porta, D., Beerli, R. R., Rohrer, J., Gay, B., & Hynes, N. E. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.9.5042 · Cited by 262 · see citing works
Agus, D. B., Cordon‐Cardo, C., Fox, W., Drobnjak, M., Koff, A., Golde, D. W., & Scher, H. I. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.21.1869 · Cited by 248 · see citing works
Self-citation(1996) · PubMed · Cited by 238 · see citing works
CWR22: androgen-dependent xenograft model derived from a primary human prostatic carcinoma.
Wainstein, M. A., He, F., Robinson, D. R., Kung, H., Schwartz, S., Giaconia, J. M., Edgehouse, N. L., Pretlow, T. P., Bodner, D. R., & Kursh, E. D. (1994) · PubMed · Cited by 225 · see citing works
Scher, H. I., Sarkis, A. S., Reuter, V., Cohen, D., Netto, G. J., Petrylak, D. P., LIANES, P., FUKS, Z. Y., Mendelsohn, J. M., & Cordon‐Cardo, C. (1995) · PubMed · Cited by 214 · see citing works
Self-citationThe ErbB-2/HER2 oncogenic receptor of adenocarcinomas: from orphanhood to multiple stromal ligands
Tzahar, E. (1998) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(97)00032-2 · Cited by 192 · see citing works
Epidermal growth factor receptor
Jorissen, R. N., Walker, F., Pouliot, N., Garrett, T., Ward, C. W., & Burgess, A. W. (2003) · Elsevier eBooks · doi:10.1016/b978-012160281-9/50004-9 · Cited by 188 · see citing works
Kalmes, A., Vesti, B. R., Daum, G., Abraham, J. A., & Clowes, A. W. (2000) · Circulation Research · doi:10.1161/01.res.87.2.92 · Cited by 182 · see citing works
Beerli, R. R., Graus-Porta, D., Woods-Cook, K., Chen, X., Yarden, Y., & Hynes, N. E. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.12.6496 · Cited by 182 · see citing works
HER-2/neu (p185neu) protein expression in the natural or treated history of prostate cancer.
Osman, I., Scher, H. I., Drobnjak, M., Verbel, D., Morris, M. J., Agus, D. B., Ross, J. S., & Cordon‐Cardo, C. (2001) · PubMed · Cited by 161 · see citing works
Self-citationIntracellular expression of single chain antibodies reverts ErbB-2 transformation.
Beerli, R. R., Wels, W. S., & Hynes, N. E. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)51027-4 · Cited by 155 · see citing works
Agus, D. B., Scher, H. I., Higgins, B., Fox, W. D., Heller, G., Fazzari, M. J., Cordon‐Cardo, C., & Golde, D. W. (1999) · PubMed · Cited by 143 · see citing works
Self-citationLewis, G. D., Lofgren, J. A., McMurtrey, A. E., Nuijens, A., FENDLY, B. M., Bauer, K. D., & Sliwkowski, M. X. (1996) · PubMed · Cited by 140 · see citing works
Self-citationShi, Y., Brands, F., CHATTERJEE, S., Feng, A., Groshen, S. G., Schewe, J., Lieskovsky, G., & Côté, R. J. (2001) · The Journal of Urology · doi:10.1016/s0022-5347(05)65822-3 · Cited by 122 · see citing works
HER-2/neu gene amplification status in prostate cancer by fluorescence in situ hybridization
Ross, J. S., Sheehan, C., Hayner‐Buchan, A., Ambros, R. A., Kallakury, B., Kaufman, R. P., Fisher, H. A. �., & Muraca, P. J. (1997) · Human Pathology · doi:10.1016/s0046-8177(97)90157-x · Cited by 105 · see citing works
Schaefer, G., Fitzpatrick, V. D., & Sliwkowski, M. X. (1997) · Oncogene · doi:10.1038/sj.onc.1201317 · Cited by 104 · see citing works
Self-citationEGF receptor signaling in prostate morphogenesis and tumorigenesis.
Kim, H. G., Kassis, J. N., Souto, J. C. S., Turner, T., & Wells, A. H. (1999) · PubMed · doi:10.14670/hh-14.1175 · Cited by 100 · see citing works
Marte, B. M., Graus-Porta, D., Jeschke, M. G., Fabbro, D., Hynes, N. E., & Taverna, D. (1995) · PubMed · Cited by 98 · see citing works
Kelley, R. F., O'Connell, M. P., Carter, P. M., Presta, L. G., Eigenbrot, C. W., Covarrubias, M., Snedecor, B., Bourell, J. H., & Vetterlein, D. (1992) · Biochemistry · doi:10.1021/bi00139a003 · Cited by 96 · see citing works
Expression and Gene Copy Number Analysis of ERBB2 Oncogene in Prostate Cancer
Savinainen, K., Saramäki, O. R., Linja, M. J., Ola Bratt, A., Tammela, T. L. J., Isola, J. J., & Visakorpi, T. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64377-5 · Cited by 90 · see citing works
HER2 Protein Expression and Gene Amplification in Androgen-Independent Prostate Cancer
Reese, D., Small, E. J., Magrane, G., Waldman, F. M., Chew, K., & Sudilovsky, D. (2001) · American Journal of Clinical Pathology · doi:10.1309/vxkk-yvrh-9b11-ydpt · Cited by 79 · see citing works
Kallakury, B., Sheehan, C. E., Ambros, R. A., Fisher, H., Kaufman, R. P., Muraca, P. J., & Ross, J. S. (1998) · Journal of Clinical Oncology · doi:10.1200/jco.1998.16.4.1302 · Cited by 70 · see citing works
Tørring, N., Pe, J., Bs, S., & Nexø, E. (2000) · PubMed · Cited by 68 · see citing works
Fitzpatrick, V. D., Pisacane, P. I., VANDLEN, R. L., & Sliwkowski, M. X. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00737-6 · Cited by 67 · see citing works
Self-citationJones, J. T., Ballinger, M. D., Pisacane, P. I., Lofgren, J. A., Fitzpatrick, V. D., Fairbrother, W. J., Wells, J. A., & Sliwkowski, M. X. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.19.11667 · Cited by 57 · see citing works
Self-citationLw, C. (1993) · PubMed · Cited by 51 · see citing works
Adam, R. M., Borer, J. G., Williams, B. J., Eastham, J. A., Loughlin, K. R., & Freeman, M. R. (1999) · Endocrinology · doi:10.1210/endo.140.12.7221 · Cited by 49 · see citing works
A potential role for activated HER-2 in prostate cancer.
Agus, D. B., Akita, R. W., Fox, W. D., Lofgren, J. A., Higgins, B., Maiese, K., Scher, H. I., & Sliwkowski, M. X. (2000) · PubMed · Cited by 41 · see citing works
Self-citationHer-2/neu oncogene amplification in clinically localised prostate cancer
Oxley, J., Winkler, M. H., Gillatt, D. A., & Peat, D. (2002) · Journal of Clinical Pathology · doi:10.1136/jcp.55.2.118 · Cited by 40 · see citing works
Inhibitors of Tyrosine Kinases in the Treatment of Psoriasis
Ben‐Bassat, H., & Klein, B. (2000) · Current Pharmaceutical Design · doi:10.2174/1381612003400182 · Cited by 39 · see citing works
Stromal-epithelial interactions in breast cancer
Cullen, K. J., & Lippman, M. E. (1991) · Cancer treatment and research · doi:10.1007/978-1-4615-3500-3_20 · Cited by 31 · see citing works
Sadick, M. D., Sliwkowski, M. X., Nuijens, A., Bald, L. N., Chiang, N., Lofgren, J. A., & Wong, W. L. (1996) · Analytical Biochemistry · doi:10.1006/abio.1996.0114 · Cited by 26 · see citing works
Self-citationDuque, J. L. F., Adam, R. M., Mullen, J. S., Lin, J., Richie, J. P., & Freeman, M. R. (2001) · The Journal of Urology · doi:10.1097/00005392-200101000-00080 · Cited by 11 · see citing works
Flagged first, then by citations
10 of the 83 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
ERBB receptors and cancer: the complexity of targeted inhibitors
Hynes, N. E., & Lane, H. A. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1609 · Cited by 3,313 · see citing works
Pertuzumab plus Trastuzumab plus Docetaxel for Metastatic Breast Cancer
Baselga, J., Cortés, J., Kim, S.-B., Im, S.-A., Hegg, R., Im, Y.-H., Roman, L., Pedrini, J. L., Pienkowski, T., Knott, A., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1113216 · Cited by 2,532 · see citing works
Gianni, L., Pieńkowski, T., Im, Y., Roman, L., Tseng, L., Liu, M.-C., Lluch, A. M., Starosławska, E., de la Haba-Rodríguez, J., Im, S., et al. (2011) · The Lancet Oncology · doi:10.1016/s1470-2045(11)70336-9 · Cited by 2,387 · see citing works
Tyrosine Kinases as Targets for Cancer Therapy
Krause, D. S., & Etten, R. A. V. (2005) · New England Journal of Medicine · doi:10.1056/nejmra044389 · Cited by 1,376 · see citing works
The ErbB/HER family of protein-tyrosine kinases and cancer
Roskoski, R. J. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2013.11.002 · Cited by 1,365 · see citing works
Deconstructing the molecular portraits of breast cancer
Prat, A., & Perou, C. M. (2010) · Molecular Oncology · doi:10.1016/j.molonc.2010.11.003 · Cited by 1,345 · see citing works
The discovery of receptor tyrosine kinases: targets for cancer therapy
Gschwind, A., Fischer, O. M., & Ullrich, A. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1360 · Cited by 1,227 · see citing works
Targeting HER2-positive breast cancer: advances and future directions
Swain, S. M., Shastry, M., & Hamilton, E. (2023) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00579-0 · Cited by 1,160 · see citing works
Novel anticancer targets: revisiting ERBB2 and discovering ERBB3
Baselga, J. M., & Swain, S. M. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2656 · Cited by 1,144 · see citing works
Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex
Franklin, M. C., Carey, K. D., Vajdos, F. F., Leahy, D. J., de Vos, A. M., & Sliwkowski, M. X. (2004) · Cancer Cell · doi:10.1016/s1535-6108(04)00083-2 · Cited by 1,123 · see citing works
Self-citationStructural basis for inhibition of the epidermal growth factor receptor by cetuximab
Li, S., Schmitz, K. R., Jeffrey, P. D., Wiltzius, J. J. W., Kussie, P. H., & Ferguson, K. M. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.03.003 · Cited by 1,117 · see citing works
ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics
Arteaga, C. L., & Engelman, J. A. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.02.025 · Cited by 1,048 · see citing works
Scher, H. I., & Sawyers, C. L. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.03.4777 · Cited by 1,025 · see citing works
Self-citationSwain, S. M., Kim, S.-B., Cortés, J., Ro, J., Semiglazov, V., Campone, M., Ciruelos, E., Ferrero, J.-M., Schneeweiss, A., Knott, A., et al. (2013) · The Lancet Oncology · doi:10.1016/s1470-2045(13)70130-x · Cited by 1,006 · see citing works
Holbro, T., Beerli, R. R., Maurer, F., Koziczak, M., Barbas, C. F., & Hynes, N. E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1537685100 · Cited by 952 · see citing works
Mechanisms of Disease: understanding resistance to HER2-targeted therapy in human breast cancer
Nahta, R., Yu, D., Hung, M., Hortobágyi, G. N., & Esteva, F. J. (2006) · Nature Clinical Practice Oncology · doi:10.1038/ncponc0509 · Cited by 916 · see citing works
An Open-and-Shut Case? Recent Insights into the Activation of EGF/ErbB Receptors
Burgess, A. W., Cho, H., Eigenbrot, C. W., Ferguson, K. M., Garrett, T., Leahy, D. J., Lemmon, M. A., Sliwkowski, M. X., Ward, C. W., & Yokoyama, S. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00350-2 · Cited by 908 · see citing works
Self-citationTreatment of HER2-positive breast cancer: current status and future perspectives
Arteaga, C. L., Sliwkowski, M. X., Osborne, C. K., Perez, E. A., Puglisi, F., & Gianni, L. (2011) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2011.177 · Cited by 860 · see citing works
Self-citationJunttila, T. T., Akita, R. W., Parsons, K. L., Fields, C. T., Phillips, G. D. L., Friedman, L. S., Sampath, D., & Sliwkowski, M. X. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.03.020 · Cited by 829 · see citing works
Self-citationHER2-Low Breast Cancer: Pathological and Clinical Landscape
Tarantino, P., Hamilton, E. P., Tolaney, S. M., Cortés, J., Morganti, S., Ferraro, E., Marra, A., Viale, G., Trapani, D., Cardoso, F., et al. (2020) · Journal of Clinical Oncology · doi:10.1200/jco.19.02488 · Cited by 804 · see citing works
Nahta, R., Yuan, L. X. H., Zhang, B., Kobayashi, R., & Esteva, F. J. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3841 · Cited by 793 · see citing works
Deciphering breast cancer: from biology to the clinic
Nolan, E., Lindeman, G. J., & Visvader, J. E. (2023) · Cell · doi:10.1016/j.cell.2023.01.040 · Cited by 761 · see citing works
Critical Update and Emerging Trends in Epidermal Growth Factor Receptor Targeting in Cancer
Baselga, J. M., & Arteaga, C. L. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.11.890 · Cited by 721 · see citing works
Epidermal Growth Factor Receptor Targeting in Cancer
Mendelsohn, J. M., & Baselga, J. M. (2006) · Seminars in Oncology · doi:10.1053/j.seminoncol.2006.04.003 · Cited by 693 · see citing works
Baselga, J. M., Gelmon, K. A., Verma, S., Wardley, A. M., Conte, P., Miles, D. W., Bianchi, G., Cortés, J., McNally, V. A., Ross, G. A., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.24.2024 · Cited by 643 · see citing works
ErbB Receptors: Directing Key Signaling Networks Throughout Life
Holbro, T., & Hynes, N. E. (2004) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.44.101802.121440 · Cited by 642 · see citing works
A Central Role for HER3 in HER2 -Amplified Breast Cancer: Implications for Targeted Therapy
Lee-Hoeflich, S. T., Crocker, L., Yao, E. S., Pham, T. Q., Munroe, X., Hoeflich, K. P., Sliwkowski, M. X., & Stern, H. M. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0380 · Cited by 632 · see citing works
Self-citationValabrega, G., Montemurro, F., & Aglietta, M. (2007) · Annals of Oncology · doi:10.1093/annonc/mdl475 · Cited by 627 · see citing works
Scheuer, W., Friess, T., BURTSCHER, H. J., Bossenmaier, B., Endl, J., & Hasmann, M. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4597 · Cited by 624 · see citing works
Nahta, R., Hung, M., & Esteva, F. J. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3856 · Cited by 607 · see citing works
Sabbah, D. A., Hajjo, R., & Sweidan, K. (2020) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026620666200303123102 · Cited by 606 · see citing works
The role of HER2 in cancer therapy and targeted drug delivery
Tai, W., Mahato, R., & Cheng, K. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.04.009 · Cited by 557 · see citing works
Nagy, P., Friedländer, E., Tanner, M., Kapanen, A. I., Carraway, K. L., Isola, J. J., & Jovin, T. M. (2005) · Cancer Research · doi:10.1158/0008-5472.473.65.2 · Cited by 525 · see citing works
The HER2 Receptor in Breast Cancer: Pathophysiology, Clinical Use, and New Advances in Therapy
Mitri, Z. I., Constantine, T., & O'Regan, R. M. (2012) · Chemotherapy Research and Practice · doi:10.1155/2012/743193 · Cited by 520 · see citing works
Resistance to Trastuzumab in Breast Cancer
Pohlmann, P. R., Mayer, I. A., & Mernaugh, R. L. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-0636 · Cited by 506 · see citing works
Austin, C. D., Mazière, A. M. G. L. D., Pisacane, P. I., van Dijk, S., Eigenbrot, C. W., Sliwkowski, M. X., Klumperman, J., & Scheller, R. H. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-07-0591 · Cited by 498 · see citing works
Self-citationRitter, C. A., Perez-Torres, M., Rinehart, C., Guix, M., Dugger, T., Engelman, J. A., & Arteaga, C. L. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-0701 · Cited by 497 · see citing works
Spector, N. L., & Blackwell, K. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.22.1507 · Cited by 497 · see citing works
HER2-amplified breast cancer: mechanisms of trastuzumab resistance and novel targeted therapies
Gajria, D., & Chandarlapaty, S. (2011) · Expert Review of Anticancer Therapy · doi:10.1586/era.10.226 · Cited by 494 · see citing works
Wang, S. E., Narasanna, A., Pérez-Torres, M., Xiang, B., Wu, F. Y., Yang, S., Carpenter, G. F., Gazdar, A. F., Muthuswamy, S. K., & Arteaga, C. L. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.05.023 · Cited by 474 · see citing works
Herceptin: mechanisms of action and resistance
Nahta, R., & Esteva, F. J. (2005) · Cancer Letters · doi:10.1016/j.canlet.2005.01.041 · Cited by 446 · see citing works
The role of HER2, EGFR, and other receptor tyrosine kinases in breast cancer
Hsu, J. L., & Hung, M. (2016) · Cancer and Metastasis Reviews · doi:10.1007/s10555-016-9649-6 · Cited by 451 · see citing works
Chan, C., Li, C., Yang, W., Gao, Y., Lee, S.-W., Feng, Z., Huang, H.-Y., Tsai, K. K., Flores, L. G., Shao, Y., et al. (2012) · Cell · doi:10.1016/j.cell.2012.02.065 · Cited by 434 · see citing works
HER2 therapy: Molecular mechanisms of trastuzumab resistance
Nahta, R., & Esteva, F. J. (2006) · Breast Cancer Research · doi:10.1186/bcr1612 · Cited by 433 · see citing works
Punnoose, E. A., Atwal, S., Liu, W., Raja, R., Fine, B. M., Hughes, B. G. M., Hicks, R. J., Hampton, G. M., Amler, L. C., Pirzkall, A., et al. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-3148 · Cited by 415 · see citing works
Agus, D. B., Gordon, M. S., Taylor, C., Natale, R. B., Karlan, B. Y., Mendelson, D. S., Press, M. F., Allison, D. E., Sliwkowski, M. X., Lieberman, G., et al. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.03.184 · Cited by 390 · see citing works
Self-citationRexer, B. N., & Arteaga, C. L. (2012) · Critical Reviews™ in Oncogenesis · doi:10.1615/critrevoncog.v17.i1.20 · Cited by 372 · see citing works
Baselga, J. M., Cortés, J., Im, S., Clark, E., Ross, G. A., Kiermaier, A. C., & Swain, S. M. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2013.54.5384 · Cited by 364 · see citing works
Spatial regulation of receptor tyrosine kinases in development and cancer
Casaletto, J. B., & McClatchey, A. I. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3277 · Cited by 362 · see citing works
Schoeberl, B., Pace, E. A., Fitzgerald, J. B., Harms, B. D., Xu, L., Nie, L., Linggi, B. E., Kalra, A. V., Paragas, V. B., Bukhalid, R. A., et al. (2009) · Science Signaling · doi:10.1126/scisignal.2000352 · Cited by 358 · see citing works
Mellinghoff, I. K., Vivanco, I., Kwon, A., Tran, C., Wongvipat, J., & Sawyers, C. L. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.09.031 · Cited by 344 · see citing works
Schaefer, G., Haber, L., Crocker, L., Shia, S., Shao, L., Dowbenko, D. J., Tótpál, K., Wong, A., Lee, C. V., Stawicki, S. S., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.09.003 · Cited by 341 · see citing works
Self-citationTrastuzumab: triumphs and tribulations
Nahta, R., & Esteva, F. J. (2007) · Oncogene · doi:10.1038/sj.onc.1210379 · Cited by 336 · see citing works
O’Brien, N. A., Browne, B. C., Chow, L., Wang, Y., Ginther, C., Arboleda, J., Duffy, M. J., Crown, J. P., O’Donovan, N., & Slamon, D. J. (2010) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-1171 · Cited by 324 · see citing works
Adams, C. W., Allison, D. E., Flagella, K. M., Presta, L. G., Clarke, J. B., Dybdal, N. O., McKeever, K., & Sliwkowski, M. X. (2005) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-005-0058-x · Cited by 316 · see citing works
Self-citationCardiac Toxicity in Breast Cancer Survivors: Review of Potential Cardiac Problems
Bird, B., & Swain, S. M. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1033 · Cited by 306 · see citing works
Mechanisms for oncogenic activation of the epidermal growth factor receptor
Zandi, R., Larsen, A. B., Andersen, P., Stockhausen, M., & Poulsen, H. S. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.06.023 · Cited by 303 · see citing works
Antitumour immunity regulated by aberrant ERBB family signalling
Kumagai, S., Koyama, S., & Nishikawa, H. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-020-00322-0 · Cited by 279 · see citing works
Luen, S. J., Salgado, R., Fox, S. B., Savas, P. S., Eng‐Wong, J., Clark, E., Kiermaier, A. C., Swain, S. M., Baselga, J. M., Michiels, S., et al. (2016) · The Lancet Oncology · doi:10.1016/s1470-2045(16)30631-3 · Cited by 276 · see citing works
Rimawi, M. F., Mayer, I. A., Forero, A., Nanda, R., Goetz, M. P., Rodriguez, A. A., Pavlick, A. C., Wang, T., Hilsenbeck, S. G., Gutiérrez, C., et al. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.44.8027 · Cited by 274 · see citing works
Tanner, M., Kapanen, A. I., Junttila, T. T., Raheem, O., Grénman, S., Elo, J. P., Elenius, K., & Isola, J. J. (2004) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.1585.3.12 · Cited by 272 · see citing works
Gianni, L., Lladó, A., Bianchi, G., Cortés, J., Kellokumpu‐Lehtinen, P., Cameron, D., Miles, D. W., Salvagni, S., Wardley, A. M., Goeminne, J.-C., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.24.1661 · Cited by 262 · see citing works
Erjala, K., Sundvall, M., Junttila, T. T., Zhang, N., Savisalo, M., Mali, P., Kulmala, J. A. J., Pulkkinen, J. O., Grenman, R. A., & Elenius, K. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-2404 · Cited by 257 · see citing works
Xia, W., Gerard, C. M., Liu, L.-H., Baudson, N., Ory, T., & Spector, N. L. (2005) · Oncogene · doi:10.1038/sj.onc.1208774 · Cited by 258 · see citing works
Osborne, C., Wilson, P., & Tripathy, D. (2004) · The Oncologist · doi:10.1634/theoncologist.9-4-361 · Cited by 257 · see citing works
Gordon, M. S., Matei, D. E., Aghajanian, C. A., Matulonis, U. A., BREWER, M. A., Fleming, G. F., Hainsworth, J. D., García, A. A., Pegram, M. D., Schilder, R. J., et al. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2005.05.4221 · Cited by 252 · see citing works
Targeting HER1/EGFR: A molecular approach to cancer therapy
Arteaga, C. (2003) · Seminars in Oncology · doi:10.1016/s0093-7754(03)70010-4 · Cited by 250 · see citing works
Cortés, J., Fumoleau, P., Bianchi, G., Petrella, T. M., Gelmon, K. A., Pivot, X. B., Verma, S., Albanell, J., Conte, P., Lluch, A. M., et al. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.37.4207 · Cited by 250 · see citing works
Huang, X., Gao, L., Wang, S., McManaman, J. L., Thor, A. D., Yang, X.-H., Esteva, F. J., & Liu, B. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3321 · Cited by 244 · see citing works
The ERBB3 receptor in cancer and cancer gene therapy
Sithanandam, G., & Anderson, L. M. (2008) · Cancer Gene Therapy · doi:10.1038/cgt.2008.15 · Cited by 240 · see citing works
Trastuzumab Has Preferential Activity against Breast Cancers Driven by HER2 Homodimers
Ghosh, R., Narasanna, A., Wang, S. E., Liu, S., Chakrabarty, A., Balko, J. M., Gonzalez-Angulo, A. M., Mills, G. B., Penuel, E. M., Winslow, J. W., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-1872 · Cited by 228 · see citing works
Targeting FGFR4 Inhibits Hepatocellular Carcinoma in Preclinical Mouse Models
French, D., Lin, B. C., Wang, M.-T., Adams, C. W., Shek, T., Hötzel, K., Bolon, B., Ferrando, R., Blackmore, C., Schroeder, K., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036713 · Cited by 216 · see citing works
Drug delivery approaches for breast cancer
Singh, S. K., Singh, S., Lillard, J. W., & Singh, R. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s140325 · Cited by 220 · see citing works
Mechanism of Action of Anti-Her2 Monoclonal Antibodies: Scientific Update on Trastuzumab and 2c4
Albanell, J., Codony, J., Rovira, A., Mellado, B., & Gascón, P. (2003) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-0081-0_21 · Cited by 219 · see citing works
Ligand-induced ErbB receptor dimerization
Lemmon, M. A. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.10.024 · Cited by 216 · see citing works
Her2-positive breast cancer: Herceptin and beyond
Dean-Colomb, W. M., & Esteva, F. J. (2008) · European Journal of Cancer · doi:10.1016/j.ejca.2008.09.013 · Cited by 208 · see citing works
Epidermal Growth Factor Increases Coactivation of the Androgen Receptor in Recurrent Prostate Cancer
Gregory, C. W., Fei, X., Ponguta, L. A., He, B., Bill, H. M., French, F. S., & Wilson, E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m307649200 · Cited by 201 · see citing works
Molecular Pathways: HER3 Targeted Therapy
Gala, K. P., & Chandarlapaty, S. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-1549 · Cited by 197 · see citing works
Phillips, G. D. L., Fields, C. T., Li, G., Dowbenko, D. J., Schaefer, G., Miller, K. D., André, F., Burris, H. A., Albain, K. S., Harbeck, N., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-0358 · Cited by 198 · see citing works
Self-citationNami, B., Maadi, H., & Wang, Z. (2018) · Cancers · doi:10.3390/cancers10100342 · Cited by 192 · see citing works
Targeting the function of the HER2 oncogene in human cancer therapeutics
Moasser, M. M. (2007) · Oncogene · doi:10.1038/sj.onc.1210478 · Cited by 190 · see citing works
Chen, C. B., Chernis, G. A., Hoang, V. Q., & Landgraf, R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1332660100 · Cited by 190 · see citing works
HER2 Expression Beyond Breast Cancer: Therapeutic Implications for Gynecologic Malignancies
English, D. P.-G., Roque, D. M., & Santin, A. D. (2013) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-013-0024-9 · Cited by 188 · see citing works
Campbell, M. R., Amin, D. N., & Moasser, M. M. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1218 · Cited by 187 · see citing works
Arpino, G., Gutiérrez, C., Weiss, H. L., Rimawi, M. F., Massarweh, S. A., Bharwani, L. D., Placido, S. D., Osborne, C. K., & Schiff, R. (2007) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djk151 · Cited by 188 · see citing works
Makhija, S. K., Amler, L. C., Glenn, D., Ueland, F. R., Gold, M. A., Dizon, D. S., Paton, V. E., Lin, C., Januario, T., Ng, K., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.22.3354 · Cited by 186 · see citing works
Self-citationTargeting of erbB3 receptor to overcome resistance in cancer treatment
Ma, J., Lyu, H., Huang, J., & Liu, B. (2014) · Molecular Cancer · doi:10.1186/1476-4598-13-105 · Cited by 176 · see citing works
Resistance to HER2-directed antibodies and tyrosine kinase inhibitors
Garrett, J. T., & Arteaga, C. L. (2011) · Cancer Biology & Therapy · doi:10.4161/cbt.11.9.15045 · Cited by 179 · see citing works
HER-2-targeted therapy: lessons learned and future directions.
Nahta, R., & Esteva, F. J. (2003) · PubMed · Cited by 178 · see citing works
Ali, M. A., Mondal, K., Jiao, Y., Oren, S., Xu, Z., Sharma, A., & Dong, L. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b05648 · Cited by 177 · see citing works
Fuller, S. J., Sivarajah, K., & Sugden, P. H. (2008) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2008.02.278 · Cited by 175 · see citing works
HER3 signaling and targeted therapy in cancer
Mishra, R., Patel, H. M., Alanazi, S., Yuan, L., & Garrett, J. T. (2018) · Oncology Reviews · doi:10.4081/oncol.2018.355 · Cited by 175 · see citing works
Ben-Kasus, T., Schechter, B., Lavi, S., Yarden, Y., & Sela, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812059106 · Cited by 173 · see citing works
Mechanisms of action of therapeutic antibodies for cancer
Redman, J. M., Hill, E., Aldeghaither, D. S., & Weiner, L. M. (2015) · Molecular Immunology · doi:10.1016/j.molimm.2015.04.002 · Cited by 171 · see citing works
Monoclonal antibodies for the treatment of cancer
Shuptrine, C. W., Surana, R., & Weiner, L. M. (2012) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2011.12.009 · Cited by 172 · see citing works
The Mysterious Ways of ErbB2/HER2 Trafficking
Bertelsen, V., & Stang, E. (2014) · Membranes · doi:10.3390/membranes4030424 · Cited by 172 · see citing works
Molecular predictors of response to trastuzumab and lapatinib in breast cancer
Esteva, F. J., Yu, D., Hung, M., & Hortobágyi, G. N. (2009) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2009.216 · Cited by 168 · see citing works
Pertuzumab: new hope for patients with HER2-positive breast cancer
Capelán, M., Pugliano, L., de Azambuja, E., Bozovic, I., Saini, K. S., Sotiriou, C. P., Loi, S., & Piccart, M. J. (2012) · Annals of Oncology · doi:10.1093/annonc/mds328 · Cited by 167 · see citing works
Wang, S. E., Xiang, B., Guix, M., Olivares, M. G., Parker, J. S., Chung, C. H., Pandiella, A., & Arteaga, C. L. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00787-08 · Cited by 165 · see citing works
Swain, S. M., Ewer, M. S., Cortés, J., Amadori, D., Miles, D. W., Knott, A., Clark, E., Benyunes, M. C., Ross, G. A., & Baselga, J. M. (2013) · The Oncologist · doi:10.1634/theoncologist.2012-0448 · Cited by 163 · see citing works
- Authors
- Agus, D. B., Akita, R. W., Fox, W. D., Lewis, G. D., Higgins, B., Pisacane, P. I., Lofgren, J. A., Tindell, C., Evans, D. P., Maiese, K., Scher, H. I., & Sliwkowski, M. X.
- Affiliations
- Cedars-Sinai Medical Center (US)
- Genentech (US)
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Sliwkowski, Mark X
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2002-08
- Volume
- 2
- Issue
- 2
- Pages
- 127-137
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2014457594
- Cited by
- 873
- References
- 83
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 21 · 2023: 38 · 2022: 21 · 2021: 21 · 2020: 28 · 2019: 29 · 2018: 27 · 2017: 24 · 2016: 38 · 2015: 48 · 2014: 69 · 2013: 59 · 2012: 51
- FWCI
- 16.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- PepsiCo
- Topics
- Health Sciences › Medicine › Oncology › HER2/EGFR in Cancer Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Keywords
- ERBB2, HER2, HER3, neuregulin-1, ErbB receptor family, breast cancer, prostate cancer, tumor growth inhibition, tyrosine kinase inhibitors
- MeSH terms
- Androgens, Animals, Antibodies, Monoclonal, Antineoplastic Agents, Breast Neoplasms, Cell Division, Female, Humans, Ligands, Male, Neoplasm Transplantation, Prostatic Neoplasms, Protein Binding, RNA, Messenger, Time Factors, Transplantation, Heterologous, Tumor Cells, Cultured, Signal Transduction, Gene Expression Regulation, Neoplastic, Erb-b2 Receptor Tyrosine Kinases, Neuregulin-1, Receptor, ErbB-3, Mice
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