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The transcription factor MEF/ELF4 regulates the quiescence of primitive hematopoietic cells

Lacorazza, H. Daniel, Yamada, Takeshi, Liu, Yan, Miyata, Yasuhiko, Sivina, Mariela, Nunes, Juliana, Nimer, Stephen D.·2006·Cancer Cell
DOI 10.1016/j.ccr.2006.02.017
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Abstract

The transcriptional circuitry that regulates the quiescence of hematopoietic stem cells is largely unknown. We report that the transcription factor known as MEF (or ELF4), which is targeted by the t(X;21)(q26;q22) in acute myelogenous leukemia, regulates the proliferation of primitive hematopoietic progenitor cells at steady state, controlling their quiescence. Mef null HSCs display increased residence in G0 with reduced 5-bromodeoxyuridine incorporation in vivo and impaired cytokine-driven proliferation in vitro. Due to their increased HSC quiescence, Mef null mice are relatively resistant to the myelosuppressive effects of chemotherapy and radiation. Thus, MEF plays an important role in the decision of stem/primitive progenitor cells to divide or remain quiescent by regulating their entry to the cell cycle.

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Cited by

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Metadata

Authors
Lacorazza, H. D., Yamada, T., Liu, Y., Miyata, Y., Sivina, M., Nunes, J., & Nimer, S. D.
Venue
Cancer Cell
Publisher
Elsevier BV
Published
2006-03
Volume
9
Issue
3
Pages
175-187
ISSN
1535-6108
DOI
10.1016/j.ccr.2006.02.017
Cited by
141
References
2
Language
en
Licence

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