A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network

Cited by (198)

Items 101–198 of 198

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  3. Allosteric Interactions by p53 mRNA Govern HDM2 E3 Ubiquitin Ligase Specificity under Different Conditions
    Ixaura Medina‐Medina, Paola García-Beltrán, Ignacio de la Mora-de la Mora, Jesús Oria‐Hernández, Guy Millot, Robin Fåhræus, Horacio Reyes‐Vivas, José G. Sampedro, Vanesa Olivares‐Illana · 2016 · Molecular and Cellular Biology
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    Dading Huang, Yifei Qi, Jianing Song, John Z. H. Zhang · 2018 · Journal of Computational Chemistry
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  10. Targeting MDM4 Splicing in Cancers
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  11. The proline rich domain of p53 is dispensable for MGMT-dependent DNA repair and cell survival following alkylation damage
    Katherine Baran, Mao Yang, Christopher P. Dillon, Leona D. Samson, Douglas R. Green · 2017 · Cell Death and Differentiation
  12. Is there a biological plausability for p53 codon 72 polymorphism influence on cervical cancer development?
    Hugo Manuel Lopes de Sousa, Alexandra M. Santos, Daniela Pinto, Rui Medeiros · 2011 · Acta Médica Portuguesa
  13. Identification of a Novel Isoform of iASPP and its Interaction with p53
    Xinwei Zhang, Shiyong Diao, Qing Rao, Haiyan Xing, Hang Liu, Xiaolong Liao, Min Wang, Jianxiang Wang · 2007 · Journal of Molecular Biology
  14. The expression of MDM2, MDM4, p53 and p21 in myeloid neoplasms and the effect of MDM2/MDM4 dual inhibitor
    Mohammad Reza Eskandari, Yang Shi, John Liu, Joseph M. Albanese, Swati Goel, Amit K. Verma, Yanhua Wang · 2020 · Leukemia & lymphoma/Leukemia and lymphoma
  15. An observational study on the expression levels of MDM2 and MDMX proteins, and associated effects on P53 in a series of human liposarcomas
    Nader Touqan, Christine P. Diggle, Edlo T Verghese, Sarah Perry, Kieran J. Horgan, William Merchant, Rashida Anwar, Alexander F. Markham, Ian Carr, Rajgopal Achuthan · 2013 · BMC Clinical Pathology
  16. Inhibition of Mdmx (Mdm4) in vivo induces anti-obesity effects
    Ning Kon, Donglai Wang, Tongyuan Li, Le Jiang, Li Qiang, Wei Gu · 2018 · Oncotarget
  17. Downregulation of Mdm2 and Mdm4 enhances viral gene expression during adenovirus infection
    Heng Yang, Zhi‐Ming Zheng, Lisa Zhao, Qiang Li, Daiqing Liao · 2012 · Cell Cycle
  18. Activation of p53 following ionizing radiation, but not other stressors, is dependent on the proline-rich domain (PRD)
    Hamish G. Campbell, Reena Mehta, Axel A. Neumann, Carlos Rubio‐Terres, Margaret A. Baird, Tania L. Slatter, Antony W. Braithwaite · 2012 · Oncogene
  19. Ubiquitination of MDM2 modulated by Epstein-Barr virus encoded latent membrane protein 1
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  20. Biophysical investigation of the dual binding surfaces of human transcription factors FOXO4 and p53
    Jinwoo Kim, Dabin Ahn, Chin‐Ju Park · 2021 · FEBS Journal
  21. Induction of p53 expression and apoptosis by a recombinant dual-target MDM2/MDMX inhibitory protein in wild-type p53 breast cancer cells
    QIAN-QIAN GENG, DAN-FENG DONG, NAN-ZHENG CHEN, YIN-YING WU, En Xiao Li, Jie Wang, Shaomeng Wang · 2013 · International Journal of Oncology
  22. The TP53 fertility network
    Diego D’Ávila Paskulin, Vanessa Rodrigues Paixão‐Côrtes, Pierre L. Hainaut, María Cátira Bortolini, Patrícia Ashton‐Prolla · 2012 · Genetics and Molecular Biology
  23. Mdm4 loss in mice expressing a p53 hypomorph alters tumor spectrum without improving survival
    M Fang, Iva Simeonova, Boris Bardot, Vincent Lejour, Sara Jaber, Rachida Bouarich-Bourimi, Aurélie Morin, Franck Toledo · 2013 · Oncogene
  24. The breast of parous women without cancer has a different genomic profile compared to those with cancer
    Irma H. Russo, Fathima S. Sheriff, Peter Morrison, Patrícia A. Russo, Rebecca Heulings, José Russo, Daniel Mailo, Gabriela Balogh · 2007 · International Journal of Oncology
  25. A p53-regulated apoptotic gene signature predicts treatment response and outcome in pediatric acute lymphoblastic leukemia
    Russell O. Bainer, Matthew R. Trendowski, Cheng Cheng, Deqing Pei, Wenjian Yang, Steven W. Paugh, Kathleen H. Goss, Andrew D. Skol, Paul Pavlidis, Ching‐Hon Pui et al. · 2017 · Cancer Management and Research
  26. The MDMX Acidic Domain Uses Allovalency to Bind Both p53 and MDMX
    Malissa J. Fenton, Wade M. Borcherds, Lihong Chen, Asokan Anbanandam, Robin Levy, Jiandong Chen, Gary W. Daughdrill · 2022 · Journal of Molecular Biology
  27. BOP1 Knockdown Attenuates Neointimal Hyperplasia by Activating p53 and Inhibiting Nascent Protein Synthesis
    Fangyuan Jia, Qi Wu, Zhiwei Wang, Min Zhang, Shun Yuan, Yanjia Che, Bowen Li, Zhipeng Hu, Xiaoping Hu · 2021 · Oxidative Medicine and Cellular Longevity
  28. Analysis and Design of Piezoelectric Braille Display
    Pruittikorn Smithmaitrie · 2009 · InTech eBooks
  29. Mutant p53: evolving perspectives
    Gizem Efe, Katherine M. Cunningham, Anil K. Rustgi, Carol L. Prives, James J. Manfredi, Francisco J. Sánchez Rivera · 2025 · Genes & Development
  30. TP53/miR-129/MDM2/4/TP53 feedback loop modulates cell proliferation and apoptosis in retinoblastoma
    Xiaolei Yao, Hui Shen, Qinghua Peng, Jingsheng Yu · 2021 · Cell Cycle
  31. Serum Response Factor (SRF) Drives the Transcriptional Upregulation of the MDM4 Oncogene in HCC
    Rossella Pellegrino, Abhishek Thavamani, Diego Francesco Calvisi, Jan Budczies, Ariane Neumann, Robert Geffers, Jasmin Kroemer, Damaris Greule, Peter Schirmacher, Alfred Nordheim et al. · 2021 · Cancers
  32. Probing Difference in Binding Modes of Inhibitors to MDMX by Molecular Dynamics Simulations and Different Free Energy Methods
    Shuhua Shi, Shaolong Zhang, Qinggang Zhang · 2015 · PLoS ONE
  33. FLT3 inhibitors induce p53 instability, driven by STAT5/MDM2/p53 competitive interactions in acute myeloid leukemia
    Han Zhong Pei, Yao Guo, Yuming Zhao, Dengyang Zhang, Zhiguang Chang, Jingfeng Zhou, Suk‐Hwan Baek, Zhizhuang Joe Zhao, Chun Chen, Yun Chen · 2025 · Cancer Letters
  34. Bridged Analogues for p53-Dependent Cancer Therapy Obtained by S-Alkylation
    Ewa D. Micewicz, Shantanu K. Sharma, Alan J. Waring, Hai T. Luong, William H. McBride, Piotr P. Ruchala · 2015 · International Journal of Peptide Research and Therapeutics
  35. Do p53 stress responses impact organismal aging?
    Paul Hasty, Judith Campisi, Zelton Dave Sharp · 2016 · Translational Cancer Research
  36. Rapid identification of dual p53-MDM2/MDMX interaction inhibitors through virtual screening and hit-based substructure search
    Si Chen, Xiang Li, Weirong Yuan, Yan Zou, Zhongwu Guo, Yifeng Chai, Wuyuan Lu · 2017 · RSC Advances
  37. Mdm2 Plays a Positive Role as an Effector of p53-Dependent Responses
    Luciana E. Giono, James J. Manfredi · 2007 · Cell Cycle
  38. Multienzyme assembly of a p53 transcription complex
    Ted R. Hupp, Malcolm D. Walkinshaw · 2007 · Nature Structural & Molecular Biology
  39. Epigenetic regulation of melanoma tumor suppressor miRNA-124a.
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  40. The Trp53 delta proline (Trp53ΔP ) mouse exhibits increased genome instability and susceptibility to radiation-induced, but not spontaneous, tumor development
    Cassandra Adams, Jennifer S. Yu, Jian‐Hua Mao, Kuang‐Yu Jen, Sylvain V. Costes, Mark R. Wade, Jocelyn D. Shoemake, Olulanu H. Aina, Reyno Del Rosario, Phuong Thuy Menchavez et al. · 2015 · Molecular Carcinogenesis
  41. Réactivation de p53 dans les tumeurs : une stratégie antitumorale prometteuse
    Franck Toledo, Olivier Bluteau, Iva Simeonova · 2007 · médecine/sciences
  42. Tumor Suppressor Genes
    David Cosgrove, Ben Ho Park, Bert Vogelstein · 2017 · Wiley eBooks
  43. p53 sequence polymorphisms in late-stage leukemic Mytilus edulis are homologous with M. trossulus p53
    Ekaterina I. Vassilenko, Susan Anne Baldwin · 2013 · Marine Biology
  44. The multifunctional proline-rich domain of p53 tumor suppressor
    Yuesheng Zhang, Madhuri Dutta · 2025 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  45. Virtual Screening for DNA Repair Inhibitors
    Barakat, K., Jack A. Tuszyński · 2011 · InTech eBooks
  46. Oxidative Stress and Carcinogenesis
    Mohinder Bansal, Naveen Kaushal · 2014 · Springer eBooks
  47. SHORT REPORT Potential for treatment of liposarcomas with the MDM2 antagonist Nutlin-3A
    Erik B. Paulsen, Paul Noordhuis, Florence Pédeutour, Gunnar Sæter, Ola Myklebost · 2007
  48. Comprehensive computational analysis via Adverse Outcome Pathways and Aggregate Exposure Pathways in exploring synergistic effects from radon and tobacco smoke on lung cancer
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  49. Insights into the binding mechanisms of inhibitors of MDM2 based on molecular dynamics simulations and binding free energy calculations
    Pei Tang Zhao, Huali Cao, Yu Chen, Tong Zhu · 2019 · Chemical Physics Letters
  50. Isolation, characterization and functional analysis of full length p53 cDNA from Bubalus bubalis
    Minu Singh, Suruchi Aggarwal, Ashok Kumar Mohanty, Tapas K. Mukhopadhyay · 2015 · Gene
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  52. Assignment of the disordered, proline-rich N-terminal domain of the tumour suppressor p53 protein using 1HN and 1Hα-detected NMR measurements
    Fanni Sebák, Péter Ecsédi, László Nyitray, Andrea Bodor · 2023 · Biomolecular NMR Assignments
  53. Research Highlights: Highlights from the Latest Articles in Epigenomics
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  54. Mutant mice lacking alternatively spliced p53 isoforms unveil Ackr4 as a male-specific prognostic factor in Myc-driven B-cell lymphomas
    Anne Fajac, Iva Simeonova, Julia Leemput, Marc Gabriel, Aurélie Morin, Vincent Lejour, Annaïg Hamon, Jeanne Rakotopare, Wilhelm Vaysse-Zinkhöfer, Eliana Eldawra et al. · 2024 · eLife
  55. EEF1A2 inhibiert über eine PI3K/AKT/mTOR-abhängige Stabilisierung von MDM4 die p53-Funktion im Leberzellkarzinom
    Thomas Longerich · 2014 · Der Pathologe
  56. Characterization of the E3 Ubiquitin Ligase Pirh2
    Elizabeth Tai · 2010 · TSpace (University of Toronto)
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  58. P53, ROS: Redox Regulation Signaling, Metabolic Reprogramming, and Autophagy in Cancer
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    Sara Jaber, Eliana Eldawra, Jeanne Rakotopare, Iva Simeonova, Vincent Lejour, Marc Gabriel, Tatiana Cañeque, Vitalina Volochtchouk, Monika Licaj, Anne Fajac et al. · 2024 · eLife
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  61. Oncogenic and teratogenic effects of Trp53Y217C, an inflammation-prone mouse model of the human hotspot mutant TP53Y220C
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  62. p53: Point Mutations, SNPs and Cancer
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  63. The Genomic Basis of Breast Development and Differentiation
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  66. Role of TP53 Mutations in Cancer (An Overview)
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  67. Novel approaches to the treatment of high-grade sarcoma
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  89. Mutant mice lacking alternatively spliced p53 isoforms unveil Ackr4 as a male-specific prognostic factor in Myc-driven B-cell lymphomas
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  97. Conséquences pathologiques des dérégulations de la voie p53-DREAM : insuffisance médullaire, microcéphalie et cancer
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