Wahl, Geoffrey M.

Cysteine depletion induces pancreatic tumor ferroptosis in mice

Badgley, M. A., Kremer, D. M., Maurer, H. C., DelGiorno, K. E., Lee, H.-J., Purohit, V., Sagalovskiy, I. R., Ma, A., Kapilian, J., Firl, C. E. M., et al. (2020) · Science

Ferroptosis and cancer prognosisCell death mechanisms and regulation

Cited by 1,294

Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

Toledo, F., & Wahl, G. M. (2006) · Nature reviews. Cancer

Cancer-related Molecular PathwaysHeat shock proteins research

Cited by 1,286

MDM2, MDMX and p53 in oncogenesis and cancer therapy

Wade, M., Li, Y.-C., & Wahl, G. M. (2013) · Nature Reviews Cancer

Cancer-related Molecular PathwaysHeat shock proteins research

Cited by 1,279

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.

Di Leonardo, A., Linke, S. P., Clarkin, K., & Wahl, G. M. (1994) · Genes & Development

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 1,215

Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy

Sherman, M. H., Yu, R. T., Engle, D. D., Ding, N., Atkins, A. R., Tiriac, H., Collisson, E. A., Connor, F., Van Dyke, T., Kozlov, S., et al. (2014) · Cell

Pancreatic and Hepatic Oncology ResearchPancreatitis Pathology and Treatment

Cited by 1,158

Linking the p53 tumour suppressor pathway to somatic cell reprogramming

Kawamura, T., Suzuki, J., Wang, Y. V., Menendez, S., Morera, L. B., Raya, A., Wahl, G. M., & Belmonte, J. C. I. (2009) · Nature

Pluripotent Stem Cells ResearchDevelopmental Biology and Gene Regulation

Cited by 1,115

c-Myc Can Induce DNA Damage, Increase Reactive Oxygen Species, and Mitigate p53 Function

Vafa, O., Wade, M., Kern, S., Beeche, M., Pandita, T. K., Hampton, G. M., & Wahl, G. M. (2002) · Molecular Cell

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 876

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

Stommel, J. M., Marchenko, N. D., Jimenez, G. S., Moll, U. M., Hope, T. J., & Wahl, G. M. (1999) · The EMBO Journal

Cancer-related Molecular PathwaysNuclear Structure and Function

Cited by 738

The p53 orchestra: Mdm2 and Mdmx set the tone

Wade, M., Wang, Y. V., & Wahl, G. M. (2010) · Trends in Cell Biology

Cancer-related Molecular PathwaysHeat shock proteins research

Cited by 450

Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring

Shi, Y., Gao, W., Lytle, N. K., Huang, P., Yuan, X., Dann, A. M., Ridinger-Saison, M., DelGiorno, K. E., Antal, C. E., Liang, G., et al. (2019) · Nature

Pancreatic and Hepatic Oncology ResearchPancreatitis Pathology and Treatment

Cited by 431

Accelerated MDM2 auto‐degradation induced by DNA‐damage kinases is required for p53 activation

Stommel, J. M., & Wahl, G. M. (2004) · The EMBO Journal

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 386

Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest.

Huang, L. C., Clarkin, K. C., & Wahl, G. M. (1996) · Proceedings of the National Academy of Sciences

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 384

The evolution of diverse biological responses to DNA damage: insights from yeast and p53

Wahl, G. M., & Carr, A. M. (2001) · Nature Cell Biology

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 376

Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4

Marine, J.-C., Francoz, S., Maetens, M., Wahl, G., Toledo, F., & Lozano, G. (2006) · Cell Death & Differentiation

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 352

MDM2 and MDM4: p53 regulators as targets in anticancer therapy

Toledo, F., & Wahl, G. M. (2007) · The International Journal of Biochemistry & Cell Biology

Cancer-related Molecular PathwaysHeat shock proteins research

Cited by 261

A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network

Toledo, F., Krummel, K. A., Lee, C. J., Liu, C.-W., Rodewald, L.-W., Tang, M., & Wahl, G. M. (2006) · Cancer Cell

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 199

The C-terminal lysines fine-tune p53 stress responses in a mouse model, but are not required for stability control or transactivation

Krummel, K. A., Lee, C. J., Toledo, F., & Wahl, G. M. (2005) · Proceedings of the National Academy of Sciences

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 187

Derivatization of unprotected polynucleotides

Chu, B. C. F., Wahl, G. M., & Orgel, L. E. (1983) · Nucleic Acids Research

DNA and Nucleic Acid ChemistryOrganophosphorus compounds synthesis

Cited by 182

Targeting Mdm2 and Mdmx in cancer therapy: better living through medicinal chemistry?

Wade, M., & Wahl, G. M. (2009) · Molecular Cancer Research

Cancer-related Molecular PathwaysHeat shock proteins research

Cited by 170

Hdmx modulates the outcome of p53 activation in human tumor cells

Wade, M., Wong, E. T., Tang, M., Stommel, J. M., & Wahl, G. M. (2006) · Journal of Biological Chemistry

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 163

Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation

Wang, Y. V., Wade, M., Wong, E., Li, Y.-C., Rodewald, L. W., & Wahl, G. M. (2007) · Proceedings of the National Academy of Sciences

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 116

Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion

Khan, S. H., Moritsugu, J., & Wahl, G. M. (2000) · Proceedings of the National Academy of Sciences

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 103

Increased Radioresistance and Accelerated B Cell Lymphomas in Mice with Mdmx Mutations that Prevent Modifications by DNA-Damage-Activated Kinases

Wang, Y. V., Leblanc, M., Wade, M., Jochemsen, A. G., & Wahl, G. M. (2009) · Cancer Cell

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 79

Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity

Wang, Y. V., Leblanc, M., Fox, N., Mao, J.-H., Tinkum, K. L., Krummel, K., Engle, D., Piwnica-Worms, D., Piwnica-Worms, H., Balmain, A., et al. (2011) · Genes & Development

Hematopoietic Stem Cell TransplantationCancer-related Molecular Pathways

Cited by 53