The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Rapid Chemotherapy-Induced Acute Endothelial Progenitor Cell Mobilization: Implications for Antiangiogenic Drugs as Chemosensitizing Agents
Open accessAbstract
SUMMARY Several hypotheses have been proposed to explain how antiangiogenic drugs enhance the treatment efficacy of cytotoxic chemotherapy including impairing the ability of chemotherapy-responsive tumors to regrow after therapy. With respect to the latter, we show that certain chemotherapy drugs, e.g. paclitaxel, can rapidly induce pro-angiogenic bone marrow derived circulating endothelial cell (CEP) mobilization, and subsequent tumor homing, whereas others, e.g. gemcitabine, did not. Acute CEP mobilization was mediated, at least in part, by systemic induction of SDF-1α and could be prevented by various procedures such as treatment with anti-VEGFR2 blocking antibodies or by paclitaxel treatment in CEP-deficient Id-mutant mice, both of which resulted in enhanced anti-tumor effects mediated by paclitaxel, but not gemcitabine.
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A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis
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Microenvironmental regulation of therapeutic response in cancer
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Metadata
- Authors
- Shaked, Y., Henke, E., Roodhart, J. M. L., Mancuso, P., Langenberg, M. H. G., Colleoni, M., Daenen, L. G., Man, S., Xu, P., Emmenegger, U., Tang, T., Zhu, Z., Witte, L., Strieter, R. M., Bertolini, F., Voest, E. E., Benezra, R., & Kerbel, R. S.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 14
- Issue
- 3
- Pages
- 263-273
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2009337734
- Cited by
- 440
- References
- 45
- FWCI
- 16.01
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Shaked, Y., Henke, E., Roodhart, J. M. L., Mancuso, P., Langenberg, M. H. G., Colleoni, M., Daenen, L. G., Man, S., Xu, P., Emmenegger, U., Tang, T., Zhu, Z., Witte, L., Strieter, R. M., Bertolini, F., Voest, E. E., Benezra, R., & Kerbel, R. S. (2008). Rapid Chemotherapy-Induced Acute Endothelial Progenitor Cell Mobilization: Implications for Antiangiogenic Drugs as Chemosensitizing Agents. Cancer Cell. https://doi.org/10.1016/j.ccr.2008.08.001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
