The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Twist1-Induced Invadopodia Formation Promotes Tumor Metastasis
Open accessAbstract
Summary The Twist1 transcription factor is known to promote tumor metastasis and induce Epithelial-Mesenchymal Transition (EMT). Here, we report that Twist1 is capable of promoting the formation of invadopodia, specialized membrane protrusions for extracellular matrix degradation. Twist1 induces PDGFRα expression, which in turn activates Src, to promote invadopodia formation. We show that Twist1 and PDGFRα are central mediators of invadopodia formation in response to various EMT-inducing signals. Induction of PDGFRα and invadopodia is essential for Twist1 to promote tumor metastasis. Consistent with PDGFRα being a direct transcriptional target of Twist1, coexpression of Twist1 and PDGFRα predicts poor survival in breast tumor patients. Therefore, invadopodia-mediated matrix degradation is a key function of Twist1 in promoting tumor metastasis.
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Self-citationTwist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis
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Cited by
Regulatory networks defining EMT during cancer initiation and progression
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Guidelines and definitions for research on epithelial-mesenchymal transition
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Self-citationEpithelial Mesenchymal Transition in Tumor Metastasis
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Metadata
- Authors
- Eckert, M. A., Lwin, T. M., Chang, A. T., Kim, J., Danis, E., Ohno-Machado, L., & Yang, J.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 19
- Issue
- 3
- Pages
- 372-386
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2051940224
- Cited by
- 476
- References
- 37
- FWCI
- 19.44
- Type
- journal article
- Language
- en
- Open access
- bronze
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