Mad2 Is a Critical Mediator of the Chromosome Instability Observed upon Rb and p53 Pathway Inhibition
Schvartzman, Juan-Manuel, Duijf, Pascal H.G., Sotillo, Rocio, Coker, Courtney, Benezra, Robert·2011·Cancer Cell
Cited by (183)
Items 101–183 of 183
- Translocation Breakpoints Preferentially Occur in Euchromatin and Acrocentric ChromosomesCheng‐Yu Lin, Ankit Shukla, John P. Grady, J. Lynn Fink, Eloise V. Dray, Pascal H. G. Duijf · 2018 · Cancers
- Genome-Wide Profiling of Pluripotent Cells Reveals a Unique Molecular Signature of Human Embryonic Germ CellsNikta Pashai, Haiping Hao, Angelo Homayoun All, Siddharth S. Gupta, Raghothama Chaerkady, Alejandro De Los Angeles, John D. Gearhart, Candace L. Kerr · 2012 · PLoS ONE
- BUB3, beyond the Simple Role of PartnerPatrícia M. A. Silva, Hassan Bousbaa · 2022 · Pharmaceutics
- Loss of RanGAP1 drives chromosome instability and rapid tumorigenesis of osteosarcomaYan Gong, Shitian Zou, Daizhao Deng, Liang Wang, Hongling Hu, Zeyou Qiu, Tiantian Wei, Panpan Yang, Jielong Zhou, Yu Zhang et al. · 2023 · Developmental Cell
- HPMA–Copolymer Nanocarrier Targets Tumor-Associated Macrophages in Primary and Metastatic Breast CancerMelissa N. Zimel, Chloe B. Horowitz, Vinagolu K. Rajasekhar, Alexander B. Christ, Xin Wei, Jianbo Wu, Paulina M. Wojnarowicz, Dong Wang, Steven R. Goldring, P. Edward Purdue et al. · 2017 · Molecular Cancer Therapeutics
- p53 Is Not Required for High CIN to Induce Tumor SuppressionLaura Hrycyniak, Jun Wan, Sean D. Ryan, Charanjeet Kaur, Ruth Sullivan, Avtar Roopra, Beth A. A. Weaver · 2020 · Molecular Cancer Research
- Histone code reader SPIN1 is a promising target of cancer therapyDi Li, Jihua Guo, Rong Jia · 2021 · Biochimie
- Developmental Acquisition of p53 FunctionsSushil Kumar Jaiswal, Sonam Raj, Melvin Depamphilis · 2021 · Genes
- Replication Stress and Mitotic Dysfunction in Cells Expressing Simian Virus 40 Large T AntigenLiang Hu, Harilaos Filippakis, Haomin Huang, Tim J. Yen, Ole V. Gjoerup · 2013 · Journal of Virology
- WT1 interacts with MAD2 and regulates mitotic checkpoint functionJayasha Shandilya, Eneda Toska, Derek J. Richard, Kathryn F. Medler, Stefan G. E. Roberts · 2014 · Nature Communications
- Bioinformatics Analysis and Validation Identify CDK1 and MAD2L1 as Prognostic Markers of RhabdomyosarcomaSuying Lü, Chengtao Sun, Huimou Chen, Chao Zhang, Wěi Li, Liu-Hong Wu, Jia Zhu, Feifei Sun, Junting Huang, Juan Wang et al. · 2020 · Cancer Management and Research
- Aurea Mediocritas: The Importance of a Balanced GenomeGianluca Varetti, David S. Pellman, David J. Gordon · 2014 · Cold Spring Harbor Perspectives in Biology
- Transcriptional Dynamics of Immortalized Human Mesenchymal Stem Cells during TransformationMasao Takeuchi, Atsunori Higashino, Kikuko Takeuchi, Yutaro Hori, Kazuko Koshiba‐Takeuchi, Hatsune Makino, Yoko Monobe, Marina Kishida, Jun Adachi, Jun Takeuchi et al. · 2015 · PLoS ONE
- Genomic instability and proliferation/survival pathways in RB1-deficient malignanciesLara Pappas, Xiaoliang Leon Xu, David H. Abramson, Suresh C. Jhanwar · 2017 · Advances in Biological Regulation
- The association between MAD2 and prognosis in cancer: a systematic review and meta-analysesTara Byrne, Helen G. Coleman, Janine A Cooper, Wilson Glenn McCluggage, Amanda H McCann, Fiona M. Furlong · 2017 · Oncotarget
- Disruption of CDK-resistant chromatin association by pRB causes DNA damage, mitotic errors, and reduces Condensin II recruitmentCharles A. Ishak, Courtney H. Coschi, Michael V. Roes, Frederick A. Dick · 2017 · Cell Cycle
- SAPCD2 promotes neuroblastoma progression by altering the subcellular distribution of E2F7Zi-Mu Zhang, Haibo Cao, Zhiheng Li, Ran Zhuo, Yanfang Tao, Xiaolu Li, Gen Lin Li, Xinmei Liao, Fang Fang, Yi Xie et al. · 2022 · Cell Death and Disease
- Combined TRIP13 and Aurora Kinase Inhibition Induces Apoptosis in Human Papillomavirus–Driven CancersSoma Ghosh, Tuhina Mazumdar, Wei Dong Xu, Reid Trenton Powell, CLIFFORD C. STEPHAN, Li Shen, Pooja Anil Shah, Curtis R. Pickering, Jeffery N. Myers, Jing Wang et al. · 2022 · Clinical Cancer Research
- Nuclear envelope protein lamin B receptor protects the genome from chromosomal instability and tumorigenesisShalaka Patil, Shruti Deshpande, Kundan Sengupta · 2022 · Human Molecular Genetics
- Expression of the mitotic-arrest deficiency 2 is associated with chemotherapy resistance in ovarian serous adenocarcinomaYUSUKE NAKANO, TOSHIYUKI SUMI, MASATOMO TERAMAE, Masanari Morishita, Takeshi Fukuda, Hiroyuki Terada, Hiroyuki Yoshida, YOSHINARI MATSUMOTO, Tomoyo Yasui, Osamu Ishiko · 2012 · Oncology Reports
- MYCN-mediated overexpression of mitotic spindle regulatory genes and loss of p53-p21 function jointly support the survival of tetraploid neuroblastoma cellsSina Gogolin, Richa Batra, Nathalie Harder, Volker Ehemann, Tobias Paffhausen, Nicolle Diessl, Vitaliya Sagulenko, Axel Benner, Stephan Gade, Ingo J. A. Nolte et al. · 2012 · Cancer Letters
- Mechanical stress during confined migration causes aberrant mitoses and c-MYC amplificationGiulia Bastianello, Gururaj Rao Kidiyoor, Conor Lowndes, Qingsen Li, Raoul J.P. Bonnal, Jeffrey Godwin, Fabio Iannelli, Lorenzo Drufuca, Ramona Bason, Fabrizio Orsenigo et al. · 2024 · Proceedings of the National Academy of Sciences
- Kinetochore Malfunction in Human PathologiesBas de Wolf, Geert J.P.L. Kops · 2017 · Advances in experimental medicine and biology
- Stranglehold on the spindle assembly checkpoint: the human papillomavirus E2 protein provokes BUBR1-dependent aneuploidyChye Ling Tan, Sébastien Teissier, Jayantha Gunaratne, Ling Shih Quek, Sophie Bellanger · 2015 · Cell Cycle
- Spotlite: Web Application and Augmented Algorithms for Predicting Co-Complexed Proteins from Affinity Purification – Mass Spectrometry DataDennis Goldfarb, Bridgid E. Hast, Wei William Wang, Michael B. Major · 2014 · Journal of Proteome Research
- Clinical Implications of Chromosomal Instability (CIN) and Kinetochore Abnormalities in Breast CancersIoannis A. Voutsadakis · 2019 · Molecular Diagnosis & Therapy
- Reduced MAD2 levels dampen apoptotic response to non-exchange sex chromosomes and lead to sperm aneuploidyImrul Faisal, Liisa Kauppi · 2017 · Development
- Chromosome 17 centromere amplification and chromosomal instability (CIN) in breast cancer: Pathogenic and therapeutic implicationsIoannis A. Voutsadakis · 2019 · Neoplasma
- Unbalanced replication as a major source of genetic instability in cancer cells.Daniel Corcos · 2012 · PubMed Central
- Anti-proliferative, pro-apototic and anti-migratory properties of HDAC inhibitor PXD-101 on osteosarcoma cell linesMichela Rossi, Viviana De Martino, Laura Di Giuseppe, Giulia Battafarano, Jacopo Di Gregorio, Sara Terreri, Francesco Marampon, Salvatore Minisola, Andrea Del Fattore · 2022 · Archives of Biochemistry and Biophysics
- Contribution of BubR1 to oxidative stress‐induced aneuploidy in p53‐deficient cellsAyae Ikawa‐Yoshida, Koji Ando, Eiji Oki, Hiroshi Saeki, Ryuichi Kumashiro, Kenji Taketani, Satoshi Ida, Eriko Tokunaga, Hiroyuki Kitao, Masaru Morita et al. · 2013 · Cancer Medicine
- Coordinated regulation of p31Cometand Mad2 expression is required for cellular proliferationDipali A. Date, Amy C Burrows, Monica Venere, Mark W. Jackson, Matthew K. Summers · 2013 · Cell Cycle
- MAD2 Expression in Ovarian Carcinoma: Different Expression Patterns and Levels among Various Types of Ovarian Carcinoma and Its Prognostic Significance in High-Grade Serous CarcinomaPo Eun Park, Ji Yun Jeong, Sunzoo Kim, Ji Young Park · 2013 · Journal of Pathology and Translational Medicine
- The RB protein: more than a sentry of cell cycle entryPulari U. Thangavelu, Cheng‐Yu Lin, Farzaneh Forouz, Kozo Tanaka, Eloise V. Dray, Pascal H. G. Duijf · 2025 · Trends in Molecular Medicine
- Hepatocellular Carcinoma: Current Therapeutic Algorithm for Localized and Advanced DiseaseAnju Jose, Maria Grazia Bavetta, Erika Martinelli, F. Bronte, Emilio Francesco Giunta, Kanjoormana Aryan Manu · 2022 · Journal of Oncology
- Interaction between RB protein and Nu MA is required for proper alignment of spindle microtubulesChiharu Uchida, Takayuki Hattori, Hirotaka Takahashi, Naoki Yamamoto, Masatoshi Kitagawa, Yoichi Taya · 2013 · Genes to Cells
- Kinetochore-associated protein 1 promotes the invasion and tumorigenicity of cervical cancer cells via matrix metalloproteinase-2 and matrix metalloproteinase-9Caimei Wang, Yiyuan Wang, Congrong Liu, Xiaoyu Meng, Zhongxia Hang · 2022 · Bioengineered
- Tumorigenicity analysis of heterogeneous dental stem cells and its self-modification for chromosome instabilityZhaosong Meng, Guoqing Chen, Jinlong Chen, Bo Yang, Mei Yu, Lian Feng, Zongting Jiang, Weihua Guo, Weidong Tian · 2015 · Cell Cycle
- University of Veterinary Medicine HannoverKarina Komm · 2010
- RB loss sensitizes cells to replication-associated DNA damage after PARP inhibition by trappingLuis Gregory Zamalloa, Margaret Pruitt, Nicole M. Hermance, Himabindu Gali, Rachel Litman Flynn, Amity L. Manning · 2023 · Life Science Alliance
- BRCA1 and MAD2 Are Coexpressed and Are Prognostic Indicators in Tubo-ovarian High-Grade Serous CarcinomaTara Byrne, Laura Nelson, James Beirne, Daniel Sharpe, Jennifer E. Quinn, Wilson Glenn McCluggage, Tracy Robson, Fiona M. Furlong · 2018 · International Journal of Gynecological Cancer
- Targeting TRIP13 for overcoming anticancer drug resistance (Review)Liwen Zhao, Siyu Ye, Shengnan Jing, Yong‐Jing Gao, Tianzhen He · 2023 · Oncology Reports
- DNA aneuploidy‐specific therapy for head and neck squamous cell carcinomaJorge García Martínez, Cristina García–Inclán, Carlos Suárez, José Luís Llorente, Mario A. J. A. Hermsen · 2014 · Head & Neck
- Retinal horizontal cells lackingRb1sustain persistent DNA damage and survive as polyploid giant cellsStacy L. Donovan, Joseph C. Corbo · 2012 · Molecular Biology of the Cell
- Biallelic MAD2L1BP (p31comet) mutation is associated with mosaic aneuploidy and juvenile granulosa cell tumorsGhada M. H. Abdel‐Salam, Susanne Hellmuth, Elise Gradhand, Stephan Käseberg, Jennifer Winter, Ann-Sophie Pabst, Maha Mohamed Eid, Holger Thiele, Peter Nürnberg, Birgit Susanne Budde et al. · 2023 · JCI Insight
- Downregulation of Mad2 and BubR1 increase the malignant potential and nocodazole resistance by compromising spindle assembly checkpoint signaling pathway in cervical carcinogenesisLi Wang, Jian Wang, Yubiao Jin, Jun Zheng, Yongbin Yang, Xiaowei Xi · 2019 · Journal of obstetrics and gynaecology research
- Genomic and transcriptomic profiling of combined small-cell lung cancer through microdissection: unveiling the transformational pathway of mixed subtypeWenjuan Ma, Ting Zhou, Mengmeng Song, Jiaqing Liu, Gang Chen, Jianhua Zhan, Liyan Ji, Fan Luo, Xuan Gao, Pansong Li et al. · 2024 · Journal of Translational Medicine
- Identification of targetable vulnerabilities of PLK1-overexpressing cancers by synthetic dosage lethalityChelsea E. Cunningham, Frederick S. Vizeacoumar, Yue Zhang, Liliia Kyrylenko, Simon Both, Vincent Maranda, He Dong, Jared D. W. Price, Peng Gao, Konrad Wagner et al. · 2025 · Cell Genomics
- Simultaneous reduction of MAD2 and BUBR1 expression induces mitotic spindle alterations associated with p53 dependent cell cycle arrest and deathLaura Lentini, Desirèe Piscitello, Lorena Veneziano, Aldo Di Leonardo · 2014 · Cell Biology International
- Molecular characterization of an MLL1 fusion and its role in chromosomal instabilitySreejit Parameswaran, Frederick S. Vizeacoumar, Kalpana Kalyanasundaram Bhanumathy, Fujun Qin, Md. Fahmid Islam, Behzad M. Toosi, Chelsea E. Cunningham, Darrell D. Mousseau, Maruti Uppalapati, Peter C. Stirling et al. · 2018 · Molecular Oncology
- MAD2L1 supports MYC-driven liver carcinogenesis in mice and predicts poor prognosis in human hepatocarcinomaXinjun Lu, Ya Zhang, Jiahao Xue, Matthias Evert, Diego Francesco Calvisi, Xin Chen, Xue Wang · 2024 · Toxicological Sciences
- The dynamics of signal amplification by macromolecular assemblies for the control of chromosome segregationSemin Lee, Víctor M. Bolaños-García · 2014 · Frontiers in Physiology
- Deficiency of PTEN leads to aberrant chromosome segregation through downregulation of MAD2Zhuo Sun, Jinqi Lu, Muyu Wu, Mingyan Li, Lu Bai, Zhenduo Shi, Lin Hao, Yongping Wu · 2019 · Molecular Medicine Reports
- BCR-ABL Hits at Mitosis; Implications for Chromosomal Instability, Aneuploidy and Therapeutic StrategyKatarzyna Piwocka, Kamila Wolanin, Monika Kusio-Kobiałka, Paulina Podszywalow‐Bartnicka · 2011 · InTech eBooks
- RB loss sensitizes cells to replication-associated DNA damage by PARP inhibitionLuis Gregory Zamalloa, Margaret Pruitt, Nicole M. Hermance, Himabindu Gali, Rachel Litman Flynn, Amity L. Manning · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Structure–Biological Function Relationship Extended to Mitotic Arrest-Deficient 2-Like Protein Mad2 Native and Mutants-New Opportunity for Genetic Disorder ControlSperanța Avram, Adina Luminita Milac, Maria Mernea, Dan Florin Mihailescu, Mihai V. Putz, Cătălin Buiu · 2014 · International Journal of Molecular Sciences
- Chromosomal Instability: Mad2 beyond the Spindle CheckpointEdward R. Ballister, Michael A. Lampson · 2012 · Current Biology
- Phosphorylation of MAD2 at Ser195 Promotes Spindle Checkpoint Defects and Sensitizes Cancer Cells to Radiotherapy in ATM Deficient CellsYang Wang, Tianyu Yu, Yi Han, Yazhi He, Yiran Song, Leiming Guo, Liwei An, Chunying Yang, Feng Wang · 2022 · Frontiers in Cell and Developmental Biology
- TSG101 depletion dysregulates mitochondria and PML NBs, triggering MAD2-overexpressing interphase cell death (MOID) through AIFM1-PML-DAXX pathwayYohei Niikura, Yao Xi, Rui Xu, Shengnan Chen, Jiezhu Fang, Xiang Duan, Guoli Zhong, Guoli Zhong, Zhifei He, Yan Guo et al. · 2024 · Cell Death and Disease
- Improving the Outcomes: Developing Cancer TherapeuticsNalân Utku · 2011 · Future Oncology
- 'Exploring aneuploidy: the significance of chromosomal imbalance' review seriesAndrew Jon Holland, Don W. Cleveland · 2012
- Mitosis: Chromosome Segregation and StabilityHatim M. Mustaly, Neil J. Ganem · 2015 · Wiley eBooks
- Chromosomal instability by mutations in a novel specificity factor of the minor spliceosomeBas de Wolf, Ali Oghabian, Maureen V. Akinyi, Sandra Hanks, Eelco C. Tromer, Jolien J. E. van Hooff, Lisa van Voorthuijsen, Laura E. van Rooijen, Jens Verbeeren, Esther C. H. Uijttewaal et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Transient tetraploidy as a route to chromosomal instabilityAnastasiya A. Kuznetsova · 2013 · Elektronische Hochschulschriften der LMU München (Ludwig-Maximilians-Universität München)
- Aneuploidy and Protein Homeostatic ImbalanceYun‐Chi Tang · 2015 · Wiley eBooks
- Integrins in Tumorigenesis and Cancer Cell InvasionGunilla Högnäs · 2013 · UTUPub (University of Turku)
- Inhibitor of the spindle assembly checkpoint surpasses apoptosis sensitizer in synergy with taxanesTeng-Long Han, Zhixin Jiang, Yuntian Li, Deng-Shan Wu, Jun Ji, Lin Tao Hu, Bin Hu, Hang Sha · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
- Mosaic Variegated AneuploidyBas de Wolf · 2020 · Utrecht University Repository (Utrecht University)
- Generation of a New Model for RB1-deficient Pineoblastoma and Lysosome-based TherapyEu Ddeum Chung · 2019 · TSpace (University of Toronto)
- Genetics of RetinoblastomaPradeep Sagar, Mahesh Palanivelu Shanmugam · 2022 · Springer eBooks
- Faculty Opinions recommendation of Mad2 overexpression uncovers a critical role for TRIP13 in mitotic exit.Hiroyuki Yamano · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- La proteína MAD2 como posible biomarcador diagnóstico en cáncerDaniela Galindo Alcázar · 2021
- Data from Combined TRIP13 and Aurora Kinase Inhibition Induces Apoptosis in Human Papillomavirus–Driven CancersSoma Ghosh, Tuhina Mazumdar, Wei Dong Xu, Reid Trenton Powell, CLIFFORD C. STEPHAN, Li Shen, Pooja Anil Shah, Curtis R. Pickering, Jeffery N. Myers, Jing Wang et al. · 2023
- Data from p53 Is Not Required for High CIN to Induce Tumor SuppressionLaura C. Funk, Jun Wan, Sean D. Ryan, Charanjeet Kaur, Ruth Sullivan, Avtar Roopra, Beth A. A. Weaver · 2023
- Germ cell tumor treatment resistance and liquid biopsy-based microRNA biomarkersDennis M. Timmerman · 2024 · Utrecht University Repository (Utrecht University)
- Additional file 1 of Genomic and transcriptomic profiling of combined small-cell lung cancer through microdissection: unveiling the transformational pathway of mixed subtypeMa, Wenjuan, Zhou, Ting, Song, Mengmeng, Liu, Jiaqing, Chen, Gang, Jianhua Zhan, Ji, Liyan, Fan Luo, Gao, Xuan, Pansong Li et al. · 2024 · Figshare
- Additional file 2 of Genomic and transcriptomic profiling of combined small-cell lung cancer through microdissection: unveiling the transformational pathway of mixed subtypeMa, Wenjuan, Zhou, Ting, Song, Mengmeng, Liu, Jiaqing, Chen, Gang, Jianhua Zhan, Ji, Liyan, Fan Luo, Gao, Xuan, Pansong Li et al. · 2024 · Figshare
- Influence of centrosome amplification on the response to chemotherapy in epithelial ovarian cancerGiulia Fantozzi · 2023 · theses.fr (ABES)
- Robust Estimation of Population Attributable Fractions in the Presence of Multiple Ordered MediatorsHan-Chi Peng, Woojoo Lee, An‐Shun Tai · 2026 · Statistics in Medicine
- CXCL8 expression, inflammatory biomarkers, and TP53 intronic polymorphisms in canine transmissible venereal tumorCarlos Mario González-Zambrano, Fernando Carmona Dinau, Eliana Hurtado Celis, Luis Maurício Montoya Flórez, João Pessoa Araújo, Luı́s Fernando Barbisan, Francisco Pedraza Ordóñez, Rogério Antônio de Oliveira, Luciane Alarcão Dias‐Melicio, Noeme Sousa Rocha · 2026 · Veterinary Immunology and Immunopathology
- Novel insights into retinoblastoma: From oncogenic circuitry to precision diagnosis and eye-preserving therapiesMin Zhou, Jieling Tang, Xuyang Wen, Jie Yang, Martine Johanna Jager, Jiayan Fan, Renbing Jia, Peiwei Chai, Xianqun Fan · 2026 · Progress in Retinal and Eye Research
- SCN1A regulates the cell cycle of mesenchymal stromal cells through APC/C-mediated CCNA2 degradationHiroki Kato, M. Zakaria, Soichiro Sonoda, Yukari Kyumoto‐Nakamura, Takayoshi Yamaza · 2026 · Biochemical and Biophysical Research Communications
- Physiological Response of Human Cells to Aneuploidy - Transcriptome Studies and Cellular AssaysMilena Dürrbaum · 2012 · MPG.PuRe (Max Planck Society)