Cited by 183Microtubule and mitosis dynamicsCancer-related Molecular PathwaysDNA Repair Mechanisms

Mad2 Is a Critical Mediator of the Chromosome Instability Observed upon Rb and p53 Pathway Inhibition

Open access
Schvartzman, Juan-Manuel, Duijf, Pascal H.G., Sotillo, Rocio, Coker, Courtney, Benezra, Robert·2011·Cancer Cell

Abstract

Multiple mechanisms have been proposed to explain how Rb and p53 tumor suppressor loss lead to chromosome instability (CIN). It was recently shown that Rb pathway inhibition causes overexpression of the mitotic checkpoint gene Mad2, but whether Mad2 overexpression is required to generate CIN in this context is unknown. Here, we show that CIN in cultured cells lacking Rb family proteins requires Mad2 upregulation and that this upregulation is also necessary for CIN and tumor progression in vivo. Mad2 is also repressed by p53 and its upregulation is required for CIN in a p53 mutant tumor model. These results demonstrate that Mad2 overexpression is a critical mediator of the CIN observed upon inactivation of two major tumor suppressor pathways.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.ccr.2011.04.017

Cites

52 of 52 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • RB is important for p53-dependent downregulation of multiple genes.

    “RB, too, is important for p53-dependent downregulation of multiple genes.100, 101, 102, 103”

    From Census and evaluation of p53 target genes (2017) · cites this paper as [102]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

2 of the 54 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. Sambrook J Russel D 2001 Molecular Cloning: A Laboratory Manual 3 CSHL Press

Cited by

Sorted by citations

Authors
Schvartzman, J.-M., Duijf, P. H. G., Sotillo, R., Coker, C., & Benezra, R.
Affiliations
Memorial Sloan Kettering Cancer Center (US)
Corresponding author
Benezra, Robert
Venue
Cancer Cell
Publisher
Elsevier BV
Published
2011-06
Volume
19
Issue
6
Pages
701-714
ISSN
1535-6108 (ISSN-L)
OpenAlex
W2021579554
Cited by
181
References
54
Citations by year
2026: 4 · 2025: 2 · 2024: 8 · 2023: 11 · 2022: 12 · 2021: 9 · 2020: 5 · 2019: 11 · 2018: 13 · 2017: 18 · 2016: 14 · 2015: 9 · 2014: 18 · 2013: 17 · 2012: 22
FWCI
9.80
Type
journal article
Language
en
Open access
Locations
  • Cancer Cell (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • QUT ePrints (Queensland University of Technology) (submittedVersion)
Funders
  • National Institutes of Health
  • Susan G. Komen for the Cure
  • Alex's Lemonade Stand Foundation for Childhood Cancer
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Keywords
Mad2, chromosomal instability, retinoblastoma protein, p53, tumor suppressor pathways, spindle assembly checkpoint, tumor progression
MeSH terms
Animals, Calcium-Binding Proteins, Female, Humans, Mammary Neoplasms, Experimental, Mice, Inbred C57BL, Repressor Proteins, Signal Transduction, Tumor Suppressor Protein p53, Retinoblastoma Protein, Cell Cycle Proteins, Chromosomal Instability, HCT116 Cells, Cell Proliferation, Cyclin-Dependent Kinase Inhibitor p21, Mice, Epithelial-Mesenchymal Transition, Mad2 Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review