Cell of Origin of Small Cell Lung Cancer: Inactivation of Trp53 and Rb1 in Distinct Cell Types of Adult Mouse Lung

Sutherland, Kate D., Proost, Natalie, Brouns, Inge, Adriaensen, Dirk, Song, Ji-Ying, Berns, Anton·2011·Cancer Cell

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Items 101–200 of 538

  1. Neuronal activity-dependent mechanisms of small cell lung cancer pathogenesis
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  2. New molecular classification of large cell neuroendocrine carcinoma and small cell lung carcinoma with potential therapeutic impacts
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  4. Future Options of Molecular-Targeted Therapy in Small Cell Lung Cancer
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  5. Current knowledge of small cell lung cancer transformation from non-small cell lung cancer
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  6. Circulating tumor cells and CDX models as a tool for preclinical drug development
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  7. Co-expression network analysis identifies Spleen Tyrosine Kinase (SYK) as a candidate oncogenic driver in a subset of small-cell lung cancer
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  8. FoxA1 and FoxA2 drive gastric differentiation and suppress squamous identity in NKX2-1-negative lung cancer
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  9. Novel Hybrid Phenotype Revealed in Small Cell Lung Cancer by a Transcription Factor Network Model That Can Explain Tumor Heterogeneity
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  10. Lung Stem and Progenitor Cells in Tissue Homeostasis and Disease
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  11. Novel Transcriptional Targets of the SRY-HMG Box Transcription Factor SOX4 Link Its Expression to the Development of Small Cell Lung Cancer
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  12. Functional synapses between neurons and small cell lung cancer
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  13. RETRACTED ARTICLE: Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-δ
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  14. Understanding Lineage Plasticity as a Path to Targeted Therapy Failure in EGFR-Mutant Non-small Cell Lung Cancer
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  15. Harnessing Natural Killer Immunity in Metastatic SCLC
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  16. Advanced small cell lung cancer (SCLC): new challenges and new expectations
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  17. Lamin B1 loss promotes lung cancer development and metastasis by epigenetic derepression of RET
    Yanhan Jia, Joaquim S. L. Vong, Alina Asafova, Boyan K. Garvalov, Luca Caputo, Julio Cordero, Anshu Singh, Thomas Boettger, Stefan Günther, Ludger Fink et al. · 2019 · The Journal of Experimental Medicine
  18. Combined SCLC Clinical and Pathologic Characteristics
    Shahab Babakoohi, Pingfu Fu, Michael Yang, Philip Aaron Linden, Afshin Dowlati · 2012 · Clinical Lung Cancer
  19. Small cell lung cancer: Subtypes and therapeutic implications
    Walter Wang, Alyssa Shulman, Joseph M. Amann, David Paul Carbone, Philip N. Tsichlis · 2022 · Seminars in Cancer Biology
  20. MAX functions as a tumor suppressor and rewires metabolism in small cell lung cancer
    A. Augert, Haritha Mathsyaraja, A. Ibrahim, B. Freie, Michael Geuenich, Pei-Feng Cheng, Sydney P. Alibeckoff, N. Wu, J. Hiatt, Ryan S. Basom et al. · 2020 · Cancer Cell
  21. NFIB overexpression cooperates with Rb/p53 deletion to promote small cell lung cancer
    Nan Wu, Deshui Jia, Ali H. Ibrahim, Cindy J. Bachurski, Richard M. Gronostajski, David P MacPherson · 2016 · Oncotarget
  22. Killing SCLC: insights into how to target a shapeshifting tumor
    Kate D. Sutherland, Abbie S. Ireland, Trudy G. Oliver · 2022 · Genes & Development
  23. The a“MAZE”ing World of Lung-Specific Transgenic Mice
    Emma L. Rawlins, Anne‐Karina T. Perl · 2011 · American Journal of Respiratory Cell and Molecular Biology
  24. Cells of origin for cancer: an updated view from prostate cancer
    L. Xin · 2012 · Oncogene
  25. Mechanisms of acquired resistance to EGFR-tyrosine kinase inhibitor in Korean patients with lung cancer
    Wonjun Ji, Chang‐Min Choi, Jin Kyung Rho, Se Jin Jang, Young Soo Park, Sung‐Min Chun, Woo Sung Kim, Jung‐Shin Lee, Sang‐We Kim, Dae Ho Lee et al. · 2013 · BMC Cancer
  26. Dkk3 dependent transcriptional regulation controls age related skeletal muscle atrophy
    Yin, Jie, Yang, Lele, Xie, Yangli, Liu, Yan, Li, Sheng, Yang, Wenjun, Xu, Bo, Ji, Hongbin, Ding, Lianghua, Wang, Kun et al. · 2018 · Nature Communications
  27. Single-Cell Analysis of Circulating Tumor Cells: Why Heterogeneity Matters
    Su Bin Lim, Chwee Teck Lim, Wan‐Teck Lim · 2019 · Cancers
  28. Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes
    Dorit Hockman, Alan J. Burns, Gerhard Schlosser, Keith P. Gates, Benjamin Jevans, Alessandro Mongera, Shannon Fisher, Gökhan Ünlü, Ela W. Knapik, Charles K. Kaufman et al. · 2017 · eLife
  29. Cell of origin of lung cancer
    Mark W. Onaitis, Jennifer M. Hanna · 2013 · Journal of Carcinogenesis
  30. ASCL1 represses a SOX9 + neural crest stem-like state in small cell lung cancer
    Rachelle R. Olsen, Abbie S. Ireland, David W. Kastner, Sarah M. Groves, Kyle B. Spainhower, Karine Pozo, Demetra P. Kelenis, Christopher P. Whitney, Matthew R. Guthrie, Sarah J. Wait et al. · 2021 · Genes & Development
  31. Consider the lung as a sensory organ: A tip from pulmonary neuroendocrine cells
    Ankur Garg, Pengfei Sui, Jamie M. Verheyden, Lisa R. Young, Xin Sun · 2019 · Current topics in developmental biology/Current Topics in Developmental Biology
  32. Challenges of small cell lung cancer heterogeneity and phenotypic plasticity
    Kathryn Simpson, Dominic G. Rothwell, Fiona Helen Blackhall, Caroline Dive · 2025 · Nature reviews. Cancer
  33. Lineage factors and differentiation states in lung cancer progression
    William K.C. Cheung, Don X. Nguyen · 2015 · Oncogene
  34. Less Is More: Rare Pulmonary Neuroendocrine Cells Function as Critical Sensors in Lung
    Jinhao Xu, Haoze Vincent Yu, Xin Sun · 2020 · Developmental Cell
  35. Combined Small Cell Carcinoma of the Lung: Is It a Single Entity?
    Xiaoliang Zhao, Justine N. McCutcheon, Bhaskar Kallakury, Joeffrey J. Chahine, Drew W. Pratt, Mark A. Raffeld, Yulong Chen, Changli Wang, Giuseppe Giaccone · 2017 · Journal of Thoracic Oncology
  36. Archetype tasks link intratumoral heterogeneity to plasticity and cancer hallmarks in small cell lung cancer
    Sarah M. Groves, Geena V. Ildefonso, Caitlin O. McAtee, Patricia Midori Murobushi Ozawa, Abbie S. Ireland, Philip E. Stauffer, Perry T. Wasdin, Xiaomeng Huang, Yi Qiao, Jing Shan Lim et al. · 2022 · Cell Systems
  37. Diversity of Epithelial Stem Cell Types in Adult Lung
    Feng Li, Jinxi He, Jun Wei, William Chi Shing Cho, Xiaoming Liu · 2015 · Stem Cells International
  38. Organoid models in lung regeneration and cancer
    Jianhai Wang, Xianglu Li, Huaiyong Chen · 2020 · Cancer Letters
  39. Stemness and inducing differentiation of small cell lung cancer NCI-H446 cells
    Zhihui Zhang, Yifei Zhou, Hui Qian, Genbao Shao, Xiaodong Lü, Q Chen, Xiaochun Sun, D Chen, R Yin, Hua Ling Zhu et al. · 2013 · Cell Death and Disease
  40. Mechanisms of resistance to EGFR targeted therapies
    Gorjan Hrustanovic, Bianca J. Lee, Trever Grant Bivona · 2013 · Cancer Biology & Therapy
  41. Cell of Origin Links Histotype Spectrum to Immune Microenvironment Diversity in Non-small-Cell Lung Cancer Driven by Mutant Kras and Loss of Lkb1
    Ashwini Sakrepatna Nagaraj, Jenni Lahtela, Annabrita Hemmes, Teijo S. Pellinen, Sami Blom, Jennifer R. Devlin, Kaisa Salmenkivi, Olli Kallioniemi, Mikko Ilari Mäyränpää, Katja Maria Närhi et al. · 2017 · Cell Reports
  42. Resistance to EGFR inhibitors in non-small cell lung cancer: Clinical management and future perspectives
    Chiara Tomasello, Cinzia Baldessari, Martina Napolitano, Giulia Orsi, Giulia Grizzi, Federica Bertolini, Fausto Barbieri, Stefano Cascinu · 2018 · Critical Reviews in Oncology/Hematology
  43. Tumor Heterogeneity Underlies Differential Cisplatin Sensitivity in Mouse Models of Small-Cell Lung Cancer
    Franziska Böttger, Ekaterina A. Semenova, Ji‐Ying Song, Giustina Ferone, Jan van der Vliet, Miranda Cozijnsen, Rajith Bhaskaran, Lorenzo Bombardelli, Sander R. Piersma, Thang V. Pham et al. · 2019 · Cell Reports
  44. Advances in Small-Cell Lung Cancer (SCLC) Translational Research
    Benjamin Jacob Drapkin, Charles M. Rudin · 2020 · Cold Spring Harbor Perspectives in Medicine
  45. Transformation to Small Cell Lung Cancer of Pulmonary Adenocarcinoma: Clinicopathologic Analysis of Six Cases
    Soomin Ahn, Soo Hyun Hwang, Joungho Han, Yoon‐La Choi, Se‐Hoon Lee, Jin Seok Ahn, Keunchil Park, Myung‐Ju Ahn, Woong‐Yang Park · 2016 · Journal of Pathology and Translational Medicine
  46. Circulating Tumor DNA Profiling in Small-Cell Lung Cancer Identifies Potentially Targetable Alterations
    Siddhartha H. K. Devarakonda, Sumithra Sankararaman, Brett H. Herzog, Kathryn Ann Gold, Saiama Naheed Waqar, Jeffrey P. Ward, Victoria M. Raymond, Richard Burnham Lanman, Aadel A. Chaudhuri, Taofeek Kunle Owonikoko et al. · 2019 · Clinical Cancer Research
  47. Sphere Culture of Murine Lung Cancer Cell Lines Are Enriched with Cancer Initiating Cells
    Brian J. Morrison, Jason C. Steel, John Charles Morris · 2012 · PLoS ONE
  48. Intrinsic electrical activity drives small-cell lung cancer progression
    Paola Peinado, Marco Stazi, Claudio Ballabio, Michael-Bogdan Margineanu, Zhaoqi Li, Caterina I. Colón, Min‐Shu Hsieh, Shreoshi Pal Choudhuri, Victor Stastny, Seth Hamilton et al. · 2025 · Nature
  49. Neuroendocrinology of the lung revealed by single-cell RNA sequencing
    Christin S. Kuo, Spyros Darmanis, Alex Diaz de Arce, Yin Liu, Nicole Almanzar, Ting-Hsuan Wu, Stephen R. Quake, Mark A. Krasnow · 2022 · eLife
  50. Lung cancer stem cells: Molecular features and therapeutic targets
    Sandeep Singh, Srikumar Chellappan · 2013 · Molecular Aspects of Medicine
  51. Effective growth-suppressive activity of maternal embryonic leucine-zipper kinase (MELK) inhibitor against small cell lung cancer
    Hiroyuki Inoue, Taigo Kato, Sope Omowale Olugbile, Kenji Tamura, Suyoun Chung, Takashi Miyamoto, Yo Matsuo, Ravi Salgia, Yusuke Nakamura, Jae-Hyun Park · 2016 · Oncotarget
  52. ASCL1, NKX2-1, and PROX1 co-regulate subtype-specific genes in small-cell lung cancer
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  53. The Resistance to EGFR-TKIs in Non-Small Cell Lung Cancer: From Molecular Mechanisms to Clinical Application of New Therapeutic Strategies
    Carmelo Laface, Felicia Maria Maselli, Anna Natalizia Santoro, Maria Laura Iaia, Francesca Ambrogio, Marigia Laterza, Chiara Guarini, Pierluigi De Santis, Martina Perrone, Palma Fedele · 2023 · Pharmaceutics
  54. Genetically-engineered mouse models of small cell lung cancer: the next generation
    Matthew G. Oser, David P MacPherson, Trudy G. Oliver, Julien Sage, Kwon-Sik Park · 2024 · Oncogene
  55. Small cells – big issues: biological implications and preclinical advancements in small cell lung cancer
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  56. “Keaping” a lid on lung cancer: the Keap1-Nrf2 pathway
    Sarah A. Best, Kate D. Sutherland · 2018 · Cell Cycle
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  58. Human pluripotent stem cell‐derived lung organoids: Potential applications in development and disease modeling
    Lu Tian, Jinghui Gao, Irving M. Garcia, Huanhuan Joyce Chen, Alessandra Castaldi, Ya‐Wen Chen · 2020 · Wiley Interdisciplinary Reviews Developmental Biology
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  60. YAP silencing by RB1 mutation is essential for small-cell lung cancer metastasis
    ZhengMing Wu, Junhui Su, Fu-long Li, Tao Chen, Jaimie Mayner, Adam Jeffrey Engler, Shenghong Ma, Qingquan Li, Kun‐Liang Guan · 2023 · Nature Communications
  61. Signal control through Raf: in sickness and in health
    Jihan K. Osborne, Elma Zaganjor, Melanie H. Cobb · 2011 · Cell Research
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  65. Multi-omics profiling of primary small cell carcinoma of the esophagus reveals RB1 disruption and additional molecular subtypes
    Renda Li, Zhenlin Yang, Fei Shao, Hong Sheng Cheng, Yaru Wen, Sijin Sun, Wei Guo, Zitong Li, Fan Zhang, Liyan Xue et al. · 2021 · Nature Communications
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  67. Differential development of large-cell neuroendocrine or small-cell lung carcinoma upon inactivation of 4 tumor suppressor genes
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  69. Combined deletion of Bap1 , Nf2 , and Cdkn2ab causes rapid onset of malignant mesothelioma in mice
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  70. Basal cell of origin resolves neuroendocrine–tuft lineage plasticity in cancer
    Abbie S. Ireland, Daniel A Xie, Sarah B. Hawgood, Margaret W. Barbier, Lisa Y. Zuo, Benjamin E Hanna, Scarlett Lucas-Randolph, Darren R. Tyson, Benjamin L. Witt, Ramaswamy Govindan et al. · 2025 · Nature
  71. Lineage Tracing of Mammary Epithelial Cells Using Cell-Type-Specific Cre-Expressing Adenoviruses
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  72. Adult lung stem cells and their contribution to lung tumourigenesis
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  73. Biomarkers for small cell lung cancer: Neuroendocrine, epithelial and circulating tumour cells
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  74. Cellular Mechanisms Underlying Intertumoral Heterogeneity
    Kate D. Sutherland, Jane E. Visvader · 2015 · Trends in cancer
  75. MEN1 deficiency leads to neuroendocrine differentiation of lung cancer and disrupts the DNA damage response
    Huan Qiu, Bangming Jin, Zhanfeng Wang, Bin Xu, Qi‐Fan Zheng, Li Zhang, Ling-Yu Zhu, Shuang Shi, Jun-Bo Yuan, Xiao Lin et al. · 2020 · Nature Communications
  76. Small Cell Lung Cancer Transformation as a Mechanism of Resistance to PD-1 Therapy in KRAS-Mutant Lung Adenocarcinoma: A Report of Two Cases
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  77. Rlf–Mycl Gene Fusion Drives Tumorigenesis and Metastasis in a Mouse Model of Small Cell Lung Cancer
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  78. Comprehensive analysis of treatment modes and clinical outcomes of small cell lung cancer transformed from epidermal growth factor receptor mutant lung adenocarcinoma
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  79. Promoters of ASCL1‐ and NEUROD1‐dependent genes are specific targets of lurbinectedin in SCLC cells
    Federico Costanzo, Marta Martínez, Gema Santamaría Núñez, Juan Ignacio Díaz‐Hernandéz, Carlos Mario Genes Robles, Javier Díez Pérez, Emmanuel Compe, Roméo Ricci, Tsai‐Kun Li, Frédéric Coin et al. · 2022 · EMBO Molecular Medicine
  80. Poly(β-amino ester) Nanoparticle Delivery of TP53 Has Activity against Small Cell Lung Cancer In Vitro and In Vivo
    Chandrashekhar D. Kamat, Ron B. Shmueli, Nick Connis, Charles M. Rudin, Jordan J. Green, Christine L. Hann · 2013 · Molecular Cancer Therapeutics
  81. Cholinergic Targets in Lung Cancer
    Eliot R. Spindel · 2016 · Current Pharmaceutical Design
  82. Immunogenomic cancer evolution: A framework to understand cancer immunosuppression
    Shogo Kumagai, Yusaku Momoi, Hiroyoshi Nishikawa · 2025 · Science Immunology
  83. Mutationally Activated PIK3CAH1047R Cooperates with BRAFV600E to Promote Lung Cancer Progression
    Christy L. Trejo, Shon Green, Victoria L. Marsh, Eric Andrew Collisson, Gioia Iezza, Wayne Allen Phillips, Martin McMahon · 2013 · Cancer Research
  84. Emerging Biomarkers and the Changing Landscape of Small Cell Lung Cancer
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  85. Olfactory neuroblastoma mimics molecular heterogeneity and lineage trajectories of small-cell lung cancer
    John B. Finlay, Abbie S. Ireland, Sarah B. Hawgood, Tony Reyes, Tiffany Ko, Rachelle R. Olsen, Ralph Abi Hachem, David Woojin Jang, Diana Bell, Joseph Minhow Chan et al. · 2024 · Cancer Cell
  86. Upregulation of FGF9 in Lung Adenocarcinoma Transdifferentiation to Small Cell Lung Cancer
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  87. Recent advances in the molecular landscape of lung neuroendocrine tumors
    Giuseppe Pelosi, Fabrizio Bianchi, Paul M Hofman, Linda Pattini, Philipp Ströbel, Fiorella Calabrese, Salma Naheed, Chloe Holden, Judith Cave, Hanibal Bohnenberger et al. · 2019 · Expert Review of Molecular Diagnostics
  88. Notch Transduction in Non-Small Cell Lung Cancer
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  89. NeuroD1 regulation of migration accompanies the differential sensitivity of neuroendocrine carcinomas to TrkB inhibition
    Jihan K. Osborne, Jill E. Larsen, Joshua X. Gonzales, David S. Shames, Mitsuo Sato, Ignacio Ivan Wistuba, Luc Girard, John Dorrance Minna, Melanie H. Cobb · 2013 · Oncogenesis
  90. Distinct genetic alterations in small cell carcinoma from different anatomic sites
    Xiaoyong Zheng, Delong Liu, John T. Fallon, Minghao Zhong · 2015 · Experimental Hematology and Oncology
  91. SnapShot: Lung Cancer Models
    Anna F. Farago, Eric L. Snyder, Tyler Jacks · 2012 · Cell
  92. Whole exome sequencing (WES) analysis of transformed small cell lung cancer (SCLC) from lung adenocarcinoma (LUAD)
    Tongji Xie, Yan Li, Jianming Ying, Weijing Cai, Junling Li, Kye Young Lee, Biagio Ricciuti, Jose M. Pacheco, Puyuan Xing · 2020 · Translational Lung Cancer Research
  93. Transcriptional deregulation underlying the pathogenesis of small cell lung cancer
    Dong Wook Kim, Keun‐Cheol Kim, Kee‐Beom Kim, Colin T. Dunn, Kwon-Sik Park · 2018 · Translational Lung Cancer Research
  94. Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes
    Christina E. Sparbier, Andrea Gillespie, Juliana Gomez, Nishi Kumari, Ali Motazedian, Kah Lok Chan, Charles C. Bell, Omer Gilan, Yih-Chih Chan, Sarah Popp et al. · 2023 · Nature Cell Biology
  95. Lung Cancer Stem Cell: Fancy Conceptual Model of Tumor Biology or Cornerstone of a Forthcoming Therapeutic Breakthrough?
    Tony Sourisseau, Khaled Aref Hassan, Ignacio Ivan Wistuba, Frederique Madeleine Penault-Llorca, Julien Adam, Éric Deutsch, Jean‐Charles Soria · 2013 · Journal of Thoracic Oncology
  96. TOPK (T‐ LAK cell‐originated protein kinase) inhibitor exhibits growth suppressive effect on small cell lung cancer
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  97. SOX2 and Rb1 in esophageal small-cell carcinoma: their possible involvement in pathogenesis
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  99. Current and future therapies for small cell lung carcinoma
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  100. Context-Dependent Effects of Amplified MAPK Signaling during Lung Adenocarcinoma Initiation and Progression
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