Cell of Origin of Small Cell Lung Cancer: Inactivation of Trp53 and Rb1 in Distinct Cell Types of Adult Mouse Lung

Generalized lacZ expression with the ROSA26 Cre reporter strain

Soriano, P. (1999) · Nature Genetics · doi:10.1038/5007 · Cited by 5,237 · see citing works

A global double-fluorescent Cre reporter mouse

Muzumdar, M. D., Tasic, B., Miyamichi, K., Li, L., & Luo, L. (2007) · genesis · doi:10.1002/dvg.20335 · Cited by 3,491 · see citing works

Identification of Bronchioalveolar Stem Cells in Normal Lung and Lung Cancer

Kim, C. F. B., Jackson, E. L., Woolfenden, A. E., Lawrence, S., Babar, I., Vogel, S., Crowley, D. G., Bronson, R. T., & Jacks, T. (2005) · Cell · doi:10.1016/j.cell.2005.03.032 · Cited by 2,196 · see citing works

Basal cells as stem cells of the mouse trachea and human airway epithelium

Rock, J. R., Onaitis, M. W., Rawlins, E. L., Lu, Y., Clark, C. P., Xue, Y., Randell, S. H., & Hogan, B. L. M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906850106 · Cited by 1,568 · see citing works

Cells of origin in cancer

Visvader, J. (2011) · Nature · doi:10.1038/nature09781 · Cited by 1,509 · see citing works

Annual Report to the Nation on the Status of Cancer, 1975–2005, Featuring Trends in Lung Cancer, Tobacco Use, and Tobacco Control

Jemal, A., Thun, M. J., Ries, L. A. G., Howe, H. L., Weir, H. K., Ward, E., Wu, X., Eheman, C. R., Anderson, R. N., Ajani, U. A., et al. (2008) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djn389 · Cited by 946 · see citing works

The Role of Scgb1a1+ Clara Cells in the Long-Term Maintenance and Repair of Lung Airway, but Not Alveolar, Epithelium

Rawlins, E. L., Okubo, T., Xue, Y., Brass, D. M., Auten, R. L., Hasegawa, H., Wang, F., & Hogan, B. L. M. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.04.002 · Cited by 855 · see citing works

A luminal epithelial stem cell that is a cell of origin for prostate cancer

Wang, X., Julio, M. K., Economides, K. D., Walker, D., Yu, H., Halili, M. V., Hu, Y.-P., Price, S. M., Abate-Shen, C. T., & Shen, M. M. (2009) · Nature · doi:10.1038/nature08361 · Cited by 734 · see citing works

Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling

Rock, J. R., Randell, S. H., & Hogan, B. L. M. (2010) · Disease Models & Mechanisms · doi:10.1242/dmm.006031 · Cited by 724 · see citing works

The type 2 cell as progenitor of alveolar epithelial regeneration. A cytodynamic study in mice after exposure to oxygen.

Adamson, I. Y. R., & Bowden, D. H. (1974) · PubMed · Cited by 713 · see citing works

Pathology of lung cancer

Travis, W. D. (2002) · Clinics in Chest Medicine · doi:10.1016/s0272-5231(03)00061-3 · Cited by 655 · see citing works

Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model

Meuwissen, R., Linn, S. C., Linnoila, R. I., Zevenhoven, J., Mooi, W. J., & Berns, A. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00220-4 · Cited by 643 · see citing works

Transformation of alveolar Type 2 cells to Type 1 cells following exposure to NO2

Evans, M. J., Cabral, L. J., Stephens, R. J., & Freeman, G. (1975) · Experimental and Molecular Pathology · doi:10.1016/0014-4800(75)90059-3 · Cited by 587 · see citing works

Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context

Guerra, C. E., Mijimolle, N., Dhawahir, A., Dubus, P. R., Barradas, M., Serrano, M., Campuzano, V., & Barbacid, M. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00191-0 · Cited by 566 · see citing works

Terminal Bronchioles Harbor a Unique Airway Stem Cell Population That Localizes to the Bronchoalveolar Duct Junction

Giangreco, A., Reynolds, S. D., & Stripp, B. R. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64169-7 · Cited by 544 · see citing works

Early restriction of peripheral and proximal cell lineages during formation of the lung

Perl, A. T., Wert, S. E., Nagy, A., Lobe, C. G., & Whitsett, J. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152238499 · Cited by 525 · see citing works

Small-cell lung cancer

Jackman, D. M., & Johnson, B. E. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67569-1 · Cited by 504 · see citing works

Neuroepithelial Bodies of Pulmonary Airways Serve as a Reservoir of Progenitor Cells Capable of Epithelial Regeneration

Reynolds, S. D., Giangreco, A., Power, J. H. T., & Stripp, B. R. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64727-x · Cited by 449 · see citing works

Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells

O’Gorman, S., Dagenais, N., Qian, M., & Marchuk, Y. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14602 · Cited by 436 · see citing works

Molecular genetics of small cell lung carcinoma

Wistuba, I. I., Gazdar, A. F., & Minna, J. D. (2001) · Seminars in Oncology · doi:10.1016/s0093-7754(01)90072-7 · Cited by 421 · see citing works

Stem cells and breast cancer: A field in transit

Smalley, M. J., & Ashworth, A. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1212 · Cited by 380 · see citing works

The Id2+ distal tip lung epithelium contains individual multipotent embryonic progenitor cells

Rawlins, E. L., Clark, C. P., Xue, Y., & Hogan, B. L. M. (2009) · Development · doi:10.1242/dev.037317 · Cited by 371 · see citing works

A Functional Role for Tumor Cell Heterogeneity in a Mouse Model of Small Cell Lung Cancer

Calbó, J., van Montfort, E. H. N., Proost, N., van Drunen, E., Beverloo, H. B., Meuwissen, R. L. J., & Berns, A. J. M. (2011) · Cancer Cell · doi:10.1016/j.ccr.2010.12.021 · Cited by 366 · see citing works

A highly efficient ligand‐regulated Cre recombinase mouse line shows that LoxP recombination is position dependent

Vooijs, M., Jonkers, J., & Berns, A. J. M. (2001) · EMBO Reports · doi:10.1093/embo-reports/kve064 · Cited by 354 · see citing works

Context-Dependent Transformation of Adult Pancreatic Cells by Oncogenic K-Ras

Friedlander, S., Chu, G. C., Snyder, E. L., Girnius, N., Dibelius, G., Crowley, D. G., Vasile, E., DePinho, R. A., & Jacks, T. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.09.027 · Cited by 338 · see citing works

Molecular Genetics of Lung Cancer

Sekido, Y., Fong, K. M., & Minna, J. D. (2003) · Annual Review of Medicine · doi:10.1146/annurev.med.54.101601.152202 · Cited by 318 · see citing works

Rb regulates fate choice and lineage commitment in vivo

Calo, E., Quintero-Estades, J. A., Danielian, P. S., Nedelcu, S., Berman, S. D., & Lees, J. A. (2010) · Nature · doi:10.1038/nature09264 · Cited by 313 · see citing works

Mouse models for human lung cancerPreprint

Meuwissen, R. L. J., & Berns, A. J. M. (2005) · Genes & Development · doi:10.1101/gad.1284505 · Cited by 301 · see citing works

Conditional Clara cell ablation reveals a self-renewing progenitor function of pulmonary neuroendocrine cells

Reynolds, S. D., Hong, K. U., Giangreco, A., Mango, G. W., Guron, C., Morimoto, Y., & Stripp, B. R. (2000) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2000.278.6.l1256 · Cited by 238 · see citing works

Conditional gene expression in the respiratory epithelium of the mouse

Perl, A.-K. T., Tichelaar, J., & Whitsett, J. (2002) · Transgenic research · doi:10.1023/a:1013986627504 · Cited by 237 · see citing works

Lung Cancer and Lung Stem Cells

Giangreco, A., Groot, K. R., & Janes, S. M. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200607-984pp · Cited by 170 · see citing works

cis-acting elements that confer lung epithelial cell expression of the CC10 gene.

Stripp, B. R., Sawaya, P. L., Luse, D. S., Wikenheiser‐Brokamp, K. A., Wert, S. E., Huffman, J. A., Lattier, D. L., Singh, G., Katyal, S. L., & Whitsett, J. A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42098-4 · Cited by 142 · see citing works

Constitutive achaete-scute homologue-1 promotes airway dysplasia and lung neuroendocrine tumors in transgenic mice.

Linnoila, R. I., Zhao, B., DeMayo, J. L., Nelkin, B. D., Baylin, S. B., DeMayo, F. J., & Ball, D. W. (2000) · PubMed · Cited by 125 · see citing works

Embryonic mouse lung epithelial progenitor cells co-express immunohistochemical markers of diverse mature cell lineages.

Wuenschell, C. W., Sunday, M. E., Singh, G., Minoo, P., Slavkin, H. C., & Warburton, D. (1996) · Journal of Histochemistry & Cytochemistry · doi:10.1177/44.2.8609367 · Cited by 109 · see citing works

Structure and expression of the pulmonary surfactant protein SP-C gene in the mouse.

Glasser, S. W., Korfhagen, T. R., Bruno, M. D., Dey, C. R., & Whitsett, J. A. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45836-x · Cited by 105 · see citing works

Cell proliferation contributes to PNEC hyperplasia after acute airway injury

Stevens, T. P., McBride, J. T., Peake, J. L., Pinkerton, K. E., & Stripp, B. R. (1997) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1997.272.3.l486 · Cited by 95 · see citing works

Rb family proteins differentially regulate distinct cell lineages during epithelial development

Wikenheiser‐Brokamp, K. A. (2004) · Development · doi:10.1242/dev.01232 · Cited by 90 · see citing works

Conditional Expression of Genes in the Respiratory Epithelium in Transgenic Mice

Perl, A. T., Zhang, L., & Whitsett, J. A. (2008) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2008-0011ed · Cited by 81 · see citing works

Functional Live Cell Imaging of the Pulmonary Neuroepithelial Body Microenvironment

Proost, I. D., Pintelon, I., Brouns, I., Kroese, A. B. A., Riccardi, D., Kemp, P. J., Timmermans, J., & Adriaensen, D. (2008) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2008-0011oc · Cited by 61 · see citing works

Cloning and Characterization of the Mouse Clara Cell-Specific 10-kDa Protein Gene: Comparison of the 5′-Flanking Region with the Human, Rat, and Rabbit Gene

Ray, M. K., Magdaleno, S. M., O’Malley, B. W., & DeMayo, F. J. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.2455 · Cited by 48 · see citing works

Genotype-Phenotype Relationships in a Mouse Model for Human Small-Cell Lung CancerPreprint

Calbó, J., Meuwissen, R. L. J., van Montfort, E. H. N., van Tellingen, O., & Berns, A. J. M. (2005) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2005.70.026 · Cited by 43 · see citing works

Expression of v-Ha-ras driven by the calcitonin/calcitonin gene-related peptide promoter: a novel transgenic murine model for medullary thyroid carcinoma

Johnston, D., Hatzis, D., & Sunday, M. E. (1998) · Oncogene · doi:10.1038/sj.onc.1201478 · Cited by 36 · see citing works

Calcitonin driven v-Ha-ras induces multilineage pulmonary epithelial hyperplasias and neoplasms

Sunday, M. E., Haley, K. J., Sikorski, K. A., Graham, S. A., Emanuel, R. L., Zhang, F., Mu, Q., Shahsafaei, A., & Hatzis, D. (1999) · Oncogene · doi:10.1038/sj.onc.1202810 · Cited by 34 · see citing works

SV40 T antigen transforms calcitonin cells of the thyroid but not CGRP-containing neurons in transgenic mice.

Baetscher, M., Schmidt, E. V., Shimizu, A., Leder, P., & Fishman, M. C. (1991) · PubMed · Cited by 28 · see citing works

The murine SP-C promoter directs type II cell-specific expression in transgenic mice

Glasser, S. W., Eszterhas, S. K., Detmer, E. A., Maxfield, M. D., & Korfhagen, T. R. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00250.2004 · Cited by 27 · see citing works

Loss of the LIM domain protein Lmo4 in the mammary gland during pregnancy impedes lobuloalveolar development

Sum, E. Y. M., Shackleton, M. J., Hahm, K., Thomas, R. M., O’Reilly, L. A., Wagner, K., Lindeman, G. J., & Visvader, J. E. (2005) · Oncogene · doi:10.1038/sj.onc.1208638 · Cited by 27 · see citing works

Non-small-cell lung cancers: a heterogeneous set of diseases

Chen, Z., Brainson, C. F., Hammerman, P. S., Kim, C. F., & Wong, K. (2014) · Nature reviews. Cancer · doi:10.1038/nrc3775 · Cited by 1,936 · see citing works

Small-cell lung cancer

Rudin, C. M., Brambilla, E. M., Finn, C. F., & Sage, J. (2021) · Nature Reviews Disease Primers · doi:10.1038/s41572-020-00235-0 · Cited by 1,632 · see citing works

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer

Peifer, M., Fernandez‐Cuesta, L., Sos, M. L., George, J., Seidel, D., Kasper, L. H., Plenker, D., Leenders, F., Sun, R., Zander, T., et al. (2012) · Nature Genetics · doi:10.1038/ng.2396 · Cited by 1,390 · see citing works

Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data

Rudin, C. M., Poirier, J. T., Byers, L. A., Dive, C., Dowlati, A., George, J., Heymach, J. V., Johnson, J. E. B., Lehman, J. M., MacPherson, D. P., et al. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0133-9 · Cited by 1,251 · see citing works

Cancer stem cells—Origins and biomarkers: Perspectives for targeted personalized therapies

Walcher, L., Kistenmacher, A.-K., Suo, H., Kitte, R., Dluczek, S., Strauß, A., Blaudszun, A.-R., Yevsa, T., Fricke, S., & Kossatz-Boehlert, U. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01280 · Cited by 1,007 · see citing works

Transformation from non-small-cell lung cancer to small-cell lung cancer: molecular drivers and cells of origin

Oser, M. G., Niederst, M. J., Sequist, L. V. D., & Engelman, J. A. (2015) · The Lancet Oncology · doi:10.1016/s1470-2045(14)71180-5 · Cited by 939 · see citing works

Progress and prospects of early detection in lung cancer

Knight, S., Crosbie, P. A. J., Balata, H., Chudziak, J., Hussell, T., & Dive, C. (2017) · Open Biology · doi:10.1098/rsob.170070 · Cited by 945 · see citing works

Small-cell lung cancer: what we know, what we need to know and the path forward

Gazdar, A. F., Bunn, P. A., & Minna, J. D. (2017) · Nature reviews. Cancer · doi:10.1038/nrc.2017.87 · Cited by 897 · see citing works

The great escape: tumour cell plasticity in resistance to targeted therapy

Boumahdi, S., & de Sauvage, F. J. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0044-1 · Cited by 759 · see citing works

Lineage Tracing

Kretzschmar, K., & Watt, F. M. (2012) · Cell · doi:10.1016/j.cell.2012.01.002 · Cited by 719 · see citing works

An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer

Burr, M. L., Sparbier, C. E., Chan, K. L., Chan, Y.-C., Kersbergen, A. J., Lam, E. Y. N., Azidis-Yates, E., Vassiliadis, D., Bell, C. C., Gilan, O., et al. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.08.008 · Cited by 656 · see citing works

Non-genetic mechanisms of therapeutic resistance in cancer

Marine, J., Dawson, S., & Dawson, M. A. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-020-00302-4 · Cited by 658 · see citing works

A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo

Saunders, L. R., Bankovich, A. J., Anderson, W. C., Aujay, M. A., Bheddah, S., Black, K., Desai, R. C., Escarpe, P. A., Hampl, J., Laysang, A., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aac9459 · Cited by 600 · see citing works

MYC Drives Progression of Small Cell Lung Cancer to a Variant Neuroendocrine Subtype with Vulnerability to Aurora Kinase Inhibition

Mollaoglu, G., Guthrie, M. R., Böhm, S., Brägelmann, J., Can, İ., Ballieu, P. M., Marx, A., George, J., Heinen, C., Chalishazar, M. D., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2016.12.005 · Cited by 594 · see citing works

MYC Drives Temporal Evolution of Small Cell Lung Cancer Subtypes by Reprogramming Neuroendocrine Fate

Ireland, A. S., Micinski, A. M., Kastner, D. W., Guo, B., Wait, S. J., Spainhower, K. B., Conley, C. C., Chen, O. S., Guthrie, M. R., Soltero, D., et al. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.05.001 · Cited by 506 · see citing works

ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs

Borromeo, M. D., Savage, T. K., Kollipara, R. K., He, M. Y., Augustyn, A., Osborne, J. K., Girard, L., Minna, J. D., Gazdar, A. F., Cobb, M. H., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.06.081 · Cited by 502 · see citing works

Genetically engineered mouse models in oncology research and cancer medicine

Kersten, K., de Visser, K. E., van Miltenburg, M. H., & Jonkers, J. (2017) · EMBO Molecular Medicine · doi:10.15252/emmm.201606857 · Cited by 502 · see citing works

Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer

Lim, J. S., Ibaseta, A., Fischer, M. M., Cancilla, B., O’Young, G., Cristea, S., Luca, V. C., Yang, D., Jahchan, N. S., Hamard, C., et al. (2017) · Nature · doi:10.1038/nature22323 · Cited by 482 · see citing works

Mechanisms of resistance to EGFR-targeted drugs: lung cancer

Morgillo, F., Della Corte, C. M., Fasano, M., & Ciardiello, F. (2016) · ESMO Open · doi:10.1136/esmoopen-2016-000060 · Cited by 476 · see citing works

Reproducible copy number variation patterns among single circulating tumor cells of lung cancer patients

Ni, X., Zhuo, M., Su, Z., Duan, J., Gao, Y., Wang, Z., Zong, C., Bai, H., Chapman, A. R., Zhao, J., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1320659110 · Cited by 454 · see citing works

CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer

Weiskopf, K., Jahchan, N. S., Schnorr, P. J., Cristea, S., Ring, A. M., Maute, R. L., Volkmer, A. K., Volkmer, J.-P., Liu, J., Lim, J. S., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci81603 · Cited by 441 · see citing works

Targeting Transcriptional Addictions in Small Cell Lung Cancer with a Covalent CDK7 Inhibitor

Christensen, C. L., Kwiatkowski, N. P., Abraham, B. J., Carretero, J., Al‐Shahrour, F., Zhang, T., Chipumuro, E., Herter-Sprie, G. S., Akbay, E. A., Altabef, A. B., et al. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.10.019 · Cited by 440 · see citing works

Emergence of a High-Plasticity Cell State during Lung Cancer Evolution

Marjanovic, N. D., Hofree, M., Chan, J. E., Canner, D. A., Wu, K., Trakala, M., Hartmann, G. G., Smith, O. C. G., Kim, J. Y., Evans, K. V., et al. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.06.012 · Cited by 388 · see citing works

N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells

Lee, J. K., Phillips, J. W., Smith, B. A., Park, J. W., Stoyanova, T. I., McCaffrey, E., Baertsch, R., Sokolov, A., Meyerowitz, J., Mathis, C., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.03.001 · Cited by 410 · see citing works

Lung Cancers: Molecular Characterization, Clonal Heterogeneity and Evolution, and Cancer Stem Cells

Testa, U., Castelli, G., & Pelosi, E. (2018) · Cancers · doi:10.3390/cancers10080248 · Cited by 406 · see citing works

Unravelling the complexity of metastasis — molecular understanding and targeted therapies

Sethi, N. S., & Kang, Y. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3125 · Cited by 396 · see citing works

Integrating genetic and non-genetic determinants of cancer evolution by single-cell multi-omics

Nam, A. S., Chaligné, R., & Landau, D. A. (2020) · Nature Reviews Genetics · doi:10.1038/s41576-020-0265-5 · Cited by 381 · see citing works

Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors

George, J., Walter, V., Peifer, M., Alexandrov, L. B., Seidel, D., Leenders, F., Maas, L., Müller, C., Dahmen, I., Delhomme, T. M., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03099-x · Cited by 379 · see citing works

Clinical insights into small cell lung cancer: Tumor heterogeneity, diagnosis, therapy, and future directions

Megyesfalvi, Z., Gay, C. M., Popper, H., Pirker, R., Ostoros, G., Heeke, S., Lang, C., Höetzenecker, K., Solta, A., Boettiger, K., et al. (2023) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21785 · Cited by 390 · see citing works

New Strategies in Overcoming Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Lung Cancer

Oxnard, G. R., Arcila, M. E., Chmielecki, J., Ladanyi, M., Miller, V. A., & Pao, W. J. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-2571 · Cited by 355 · see citing works

Rb Loss Is Characteristic of Prostatic Small Cell Neuroendocrine Carcinoma

Tan, H., Sood, A., Rahimi, H. A., Wang, W., Gupta, N., Hicks, J. L., Mosier, S. L., Gocke, C. D., Epstein, J. I., Netto, G. J., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-1982 · Cited by 344 · see citing works

Role of KEAP1 / NRF2 and TP53 Mutations in Lung Squamous Cell Carcinoma Development and Radiation Resistance

Jeong, Y., Hoang, N. T., Lovejoy, A. F., Stehr, H., Newman, A. M., Gentles, A. J., Kong, W. W., Truong, D., Martin, S. A., Chaudhuri, A. A., et al. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0127 · Cited by 348 · see citing works

A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma

Tammela, T., Rivera, F. J. S., Cetinbas, N. M., Wu, K., Joshi, N. S., Helenius, K. P., Park, Y., Azimi, R., Kerper, N. R., Wesselhoeft, R. A., et al. (2017) · Nature · doi:10.1038/nature22334 · Cited by 338 · see citing works

Development of Immunotherapy Combination Strategies in Cancer

Yap, T. A., Parkes, E. E., Peng, W., Moyers, J. T., Curran, M. A., & Tawbi, H. A. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-1209 · Cited by 336 · see citing works

Functional characterization of pulmonary neuroendocrine cells in lung development, injury, and tumorigenesis

Song, H., Yao, E., Lin, C., Gacayan, R., Chen, M.-H., & Chuang, P. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1207238109 · Cited by 313 · see citing works

Cellular and functional heterogeneity of the airway epithelium

Davis, J. D., & Wypych, T. P. (2021) · Mucosal Immunology · doi:10.1038/s41385-020-00370-7 · Cited by 306 · see citing works

Unique genetic profiles from cerebrospinal fluid cell-free DNA in leptomeningeal metastases of EGFR-mutant non-small-cell lung cancer: a new medium of liquid biopsy

Li, Y. S., Jiang, B., Yang, J., Zhang, X. C., Zhang, Z., Ye, J. Y., Zhong, W., Tu, H., Chen, H. J., Wang, Z., et al. (2018) · Annals of Oncology · doi:10.1093/annonc/mdy009 · Cited by 299 · see citing works

Genetic and Clonal Dissection of Murine Small Cell Lung Carcinoma Progression by Genome Sequencing

McFadden, D. G., Papagiannakopoulos, T. Y., Taylor-Weiner, A. N., Stewart, C., Carter, S. L., Cibulskis, K., Bhutkar, A. J., McKenna, A., Dooley, A. L., Vernon, A. N., et al. (2014) · Cell · doi:10.1016/j.cell.2014.02.031 · Cited by 289 · see citing works

Tracing the cellular origin of cancer

Blanpain, C. (2013) · Nature Cell Biology · doi:10.1038/ncb2657 · Cited by 275 · see citing works

Clinical Implications of Genomic Discoveries in Lung Cancer

Swanton, C., & Govindan, R. (2016) · New England Journal of Medicine · doi:10.1056/nejmra1504688 · Cited by 271 · see citing works

Multiple cells-of-origin of mutant K-Ras–induced mouse lung adenocarcinoma

Sutherland, K. D., Song, J., Kwon, M. C., Proost, N., Zevenhoven, J., & Berns, A. J. M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1319963111 · Cited by 267 · see citing works

Pancreatic cancer modeling using retrograde viral vector delivery and in vivo CRISPR/Cas9-mediated somatic genome editingPreprint

Chiou, S., Winters, I. P., Wang, J., Naranjo, S., Dudgeon, C., Tamburini, F. B., Brady Jennifer, J., Yang, D., Grüner, B. M., Chuang, C.-H., et al. (2015) · Genes & Development · doi:10.1101/gad.264861.115 · Cited by 267 · see citing works

Stem Cell Factor SOX2 Confers Ferroptosis Resistance in Lung Cancer via Upregulation of SLC7A11

Wang, X., Chen, Y., Wang, X., Tian, H., Wang, Y., Jin, J., Shan, Z., Liu, Y., Cai, Z., Tong, X., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-21-0567 · Cited by 265 · see citing works

Origins, genetic landscape, and emerging therapies of small cell lung cancerPreprint

Semenova, E. A., Nagel, R., & Berns, A. J. M. (2015) · Genes & Development · doi:10.1101/gad.263145.115 · Cited by 247 · see citing works

A crucial requirement for Hedgehog signaling in small cell lung cancer

Park, K.-S., Martelotto, L. G., Peifer, M., Sos, M. L., Karnezis, A. N., Mahjoub, M. R., Bernard, K., Conklin, J. F., Szczepny, A., Yuan, J., et al. (2011) · Nature Medicine · doi:10.1038/nm.2473 · Cited by 247 · see citing works

SOX2 Is the Determining Oncogenic Switch in Promoting Lung Squamous Cell Carcinoma from Different Cells of Origin

Ferone, G., Song, J., Sutherland, K. D., Bhaskaran, R., Monkhorst, K., Lambooij, J.-P., Proost, N., Gargiulo, G., & Berns, A. J. M. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.09.001 · Cited by 244 · see citing works

Building a lineage from single cells: genetic techniques for cell lineage tracking

Woodworth, M. B., Girskis, K. M., & Walsh, C. A. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2016.159 · Cited by 236 · see citing works

Small Cell Lung Cancer: Will Recent Progress Lead to Improved Outcomes?

Pietanza, M. C., Byers, L. A., Minna, J. D., & Rudin, C. M. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-2958 · Cited by 228 · see citing works

Characterization of the cell of origin for small cell lung cancer

Park, K.-S., Liang, M., Raiser, D. M., Zamponi, R., Roach, R. R., Curtis, S. J., Walton, Z. E., Schaffer, B. E., Roake, C. M., Zmoos, A., et al. (2011) · Cell Cycle · doi:10.4161/cc.10.16.17012 · Cited by 225 · see citing works

Rare Pulmonary Neuroendocrine Cells Are Stem Cells Regulated by Rb, p53, and Notch

Ouadah, Y., Rojas, E., Riordan, D. P., Capostagno, S., Kuo, C. S., & Krasnow, M. A. (2019) · Cell · doi:10.1016/j.cell.2019.09.010 · Cited by 219 · see citing works

Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma

LaFave, L. M., Kartha, V. K., Ma, S., Meli, K., Priore, I. S. D., Lareau, C. A., Naranjo, S., Westcott, P. M. K., Duarte, F. M., Sankar, V., et al. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.06.006 · Cited by 207 · see citing works

New clinical trial design in precision medicine: discovery, development and direction

Duan, X.-P., Qin, B., Jiao, X., Liu, K., Wang, Z., & Zang, Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01760-0 · Cited by 217 · see citing works

Cells of origin of lung cancers: lessons from mouse studiesPreprint

Ferone, G., Lee, M. C., Sage, J., & Berns, A. J. M. (2020) · Genes & Development · doi:10.1101/gad.338228.120 · Cited by 192 · see citing works

Crebbp Loss Drives Small Cell Lung Cancer and Increases Sensitivity to HDAC Inhibition

Jia, D., Augert, A., Kim, D. W., Eastwood, E., Wu, N., Ibrahim, A. H., Kim, K., Dunn, C. T., Pillai, S. P. S., Gazdar, A. F., et al. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-0385 · Cited by 195 · see citing works

Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers

Huang, F., Ni, M., Chalishazar, M. D., Huffman, K. E., Kim, J., Cai, L., Shi, X., Cai, F., Zacharias, L. G., Ireland, A. S., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.06.005 · Cited by 186 · see citing works

Novel therapeutic targets on the horizon for lung cancer

Tan, W.-L., Jain, A., Takano, A. M., Newell, E. W., Iyer, N. G., Lim, W., Tan, E.-H., Zhai, W., Hillmer, A. M., Tam, W. L., et al. (2016) · The Lancet Oncology · doi:10.1016/s1470-2045(16)30123-1 · Cited by 184 · see citing works

Modeling Pathogenesis of Primary Liver Cancer in Lineage-Specific Mouse Cell Types

Holczbauer, Á., Factor, V. M., Andersen, J. B., Marquardt, J. U., Kleiner, D. E., Raggi, C., Kitade, M., Seo, D., Akita, H., Durkin, M. E., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.03.013 · Cited by 182 · see citing works

Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes?

Bunn, P. A., Minna, J. D., Augustyn, A., Gazdar, A. F., Ouadah, Y., Krasnow, M. A., Berns, A. J. M., Brambilla, E. M., Rekhtman, N., Massion, P. P., et al. (2016) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2016.01.012 · Cited by 180 · see citing works

Molecular and cellular biology of neuroendocrine lung tumors: Evidence for separate biological entities

Swarts, D. R. A., Ramaekers, F. C. S., & Speel, E. M. (2012) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2012.05.001 · Cited by 179 · see citing works

NOTCH , ASCL1 , p53 and RB alterations define an alternative pathway driving neuroendocrine and small cell lung carcinomas

Meder, L., König, K., Ozretić, L., Schultheis, A. M., Ueckeroth, F., Ade, C. P., Albus, K., Boehm, D., Rommerscheidt‐Fuss, U., Florin, A., et al. (2015) · International Journal of Cancer · doi:10.1002/ijc.29835 · Cited by 179 · see citing works

PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer

Sato, T., Kaneda, A., Tsuji, S., Isagawa, T., Yamamoto, S., Fujita, T., Yamanaka, R., Tanaka, Y., Nukiwa, T., Márquez, V. E., et al. (2013) · Scientific Reports · doi:10.1038/srep01911 · Cited by 177 · see citing works

A framework for identification of actionable cancer genome dependencies in small cell lung cancer

Sos, M. L., Dietlein, F., Peifer, M., Schöttle, J., Balke‐Want, H., Müller, C., Koker, M., Richters, A., Heynck, S., Malchers, F., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1207310109 · Cited by 179 · see citing works

Prostate cancer originating in basal cells progresses to adenocarcinoma propagated by luminal-like cells

Stoyanova, T., Cooper, A. R., Drake, J., Liu, X., Armstrong, A., Pienta, K., Zhang, H., Kohn, D., Huang, J.-T., Witte, O., et al. (2013) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1320565110 · Cited by 170 · see citing works

Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity

Pearson, J. D., Huang, K., Pacal, M., McCurdy, S. R., Lü, S., Aubry, A., Yu, T., Wadosky, K. M., Zhang, L., Wang, T., et al. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.06.016 · Cited by 172 · see citing works

New Approaches to SCLC Therapy: From the Laboratory to the Clinic

Poirier, J. T., George, J., Owonikoko, T. K., Berns, A. J. M., Brambilla, E. M., Byers, L. A., Carbone, D. P., Chen, H. J., Christensen, C. L., Dive, C., et al. (2020) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2020.01.016 · Cited by 173 · see citing works

A biobank of small cell lung cancer CDX models elucidates inter- and intratumoral phenotypic heterogeneity

Simpson, K., Stoney, R., Frese, K. K., Simms, N., Rowe, W., Pearce, S. P., Humphrey, S., Booth, L., Morgan, D., Dynowski, M., et al. (2020) · Nature Cancer · doi:10.1038/s43018-020-0046-2 · Cited by 173 · see citing works

LKB1 Inactivation Elicits a Redox Imbalance to Modulate Non-small Cell Lung Cancer Plasticity and Therapeutic Response

Li, F., Han, X., Li, F., Wang, R., Wang, H., Gao, Y., Wang, X., Fang, Z., Zhang, W., Yao, S., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.04.001 · Cited by 169 · see citing works

MAX Inactivation in Small Cell Lung Cancer Disrupts MYC–SWI/SNF Programs and Is Synthetic Lethal with BRG1

Romero, O. A., Torres-Diz, M., Pros, E., Savola, S. P., Gómez, A., Morán, S., Sáez, C., Iwakawa, R., Villanueva, A., Montuenga, L. M., et al. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0799 · Cited by 164 · see citing works

Intertumoral Heterogeneity in SCLC Is Influenced by the Cell Type of Origin

Yang, D., Denny, S. K., Greenside, P., Chaikovsky, A. C., Brady Jennifer, J., Ouadah, Y., Granja, J. M., Jahchan, N. S., Lim, J. S., Kwok, S., et al. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-0987 · Cited by 158 · see citing works

The Transcriptional and Epigenetic Landscape of Cancer Cell Lineage Plasticity

Davies, A., Zoubeidi, A., Beltran, H., & Selth, L. A. (2023) · Cancer Discovery · doi:10.1158/2159-8290.cd-23-0225 · Cited by 155 · see citing works

Mouse models for lung cancer

Kwon, M.-C., & Berns, A. J. M. (2013) · Molecular Oncology · doi:10.1016/j.molonc.2013.02.010 · Cited by 145 · see citing works

Single-cell transcriptomic profiling reveals the tumor heterogeneity of small-cell lung cancer

Tian, Y., Li, Q., Yang, Z., Zhang, S., Xu, J., Wang, Z., Bai, H., Duan, J., Zheng, B. J., Li, W., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01150-4 · Cited by 151 · see citing works

Exposure to secondhand tobacco smoke and lung cancer by histological type: A pooled analysis of the International Lung Cancer Consortium (ILCCO)

Kim, C. H., Lee, Y.-C. A., Hung, R. J., McNallan, S. R., Coté, M. L., Lim, W., Chang, S., Kim, J. H., Ugolini, D., Chen, Y., et al. (2014) · International Journal of Cancer · doi:10.1002/ijc.28835 · Cited by 147 · see citing works

Impact of risk factors on early cancer evolution

Weeden, C. E., Hill, W., Lim, E. L., Gronroos, E. C., & Swanton, C. (2023) · Cell · doi:10.1016/j.cell.2023.03.013 · Cited by 143 · see citing works

Identification of DHODH as a therapeutic target in small cell lung cancer

Li, L., Ng, S. R., Colón, C. I., Drapkin, B. J., Hsu, P. P., Li, Z., Nabel, C. S., Lewis, C. A., Romero, R., Mercer, K. L., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aaw7852 · Cited by 141 · see citing works

Adaptation or selection—mechanisms of castration-resistant prostate cancer

Zong, Y., & Goldstein, A. S. (2012) · Nature Reviews Urology · doi:10.1038/nrurol.2012.237 · Cited by 133 · see citing works

The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesisPreprint

Oser, M. G., Sabet, A. H., Gao, W., Chakraborty, A. A., Schinzel, A. C., Jennings, R. B., Fonseca, R., Bonal, D. M., Booker, M. A., Flaifel, A., et al. (2019) · Genes & Development · doi:10.1101/gad.328336.119 · Cited by 134 · see citing works

Formation of a Neurosensory Organ by Epithelial Cell Slithering

Kuo, C. S., & Krasnow, M. A. (2015) · Cell · doi:10.1016/j.cell.2015.09.021 · Cited by 133 · see citing works

PTEN Is a Potent Suppressor of Small Cell Lung Cancer

Cui, M., Augert, A., Rongione, M. A., Conkrite, K. L., Parazzoli, S. D., Nikitin, A. Y., Ingolia, N. T., & MacPherson, D. P. (2014) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-13-0554 · Cited by 131 · see citing works

Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer

Faber, A. C., Farago, A. F., Costa, C., Dastur, A., Gomez-Caraballo, M., Robbins, R., Wagner, B. L., Rideout, W. M., Jakubik, C. T., Ham, J., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1411848112 · Cited by 127 · see citing works

Recent advances and contraversies on the role of pulmonary neuroepithelial bodies as airway sensors

Cutz, E., Pan, J., Yeger, H., Domnik, N. J., & Fisher, J. T. (2012) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2012.09.003 · Cited by 130 · see citing works

A Braf kinase-inactive mutant induces lung adenocarcinoma

Nieto, P., Ambrogio, C., Esteban-Burgos, L., Goméz-López, G., Blasco, M. T., Yao, Z., Marais, R., Rosen, N. X., Chiarle, R., Pisano, D. G., et al. (2017) · Nature · doi:10.1038/nature23297 · Cited by 130 · see citing works

The Comparative Pathology of Genetically Engineered Mouse Models for Neuroendocrine Carcinomas of the Lung

Gazdar, A. F., Savage, T. K., Johnson, J. E. B., Berns, A. J. M., Sage, J., Linnoila, R. I., MacPherson, D. P., McFadden, D. G., Farago, A. F., Jacks, T., et al. (2015) · Journal of Thoracic Oncology · doi:10.1097/jto.0000000000000459 · Cited by 121 · see citing works

Small cell lung cancer transformation: From pathogenesis to treatment

Yin, X., Li, Y., Wang, H., Jia, T., Wang, E., Luo, Y., Wei, Y., Qin, Z., & Ma, X. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.03.006 · Cited by 120 · see citing works

Polycomb-mediated silencing in neuroendocrine prostate cancer

Clermont, P., Lin, D., Crea, F., Wu, R. C., Xue, H., Wang, Y., Thu, K. L., Lam, W. L., Collins, C. C., Wang, Y. Z., et al. (2015) · Clinical Epigenetics · doi:10.1186/s13148-015-0074-4 · Cited by 115 · see citing works

A Human Adult Stem Cell Signature Marks Aggressive Variants across Epithelial Cancers

Smith, B. A., Balanis, N. G., Nanjundiah, A., Sheu, K. M., Tsai, B. L., Zhang, Q., Park, J. W., Thompson, M. J., Huang, J., Witte, O. N., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.08.062 · Cited by 114 · see citing works

Pulmonary neuroendocrine cells: physiology, tissue homeostasis and disease

Noguchi, M., Furukawa, K. T., & Morimoto, M. (2020) · Disease Models & Mechanisms · doi:10.1242/dmm.046920 · Cited by 115 · see citing works

Distinct initiating events underpin the immune and metabolic heterogeneity of KRAS-mutant lung adenocarcinoma

Best, S. A., Ding, S., Kersbergen, A., Dong, X., Song, J.-Y., Xie, Y., Reljic, B., Li, K., Vince, J. E., Rathi, V., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12164-y · Cited by 108 · see citing works

Systems-level network modeling of Small Cell Lung Cancer subtypes identifies master regulators and destabilizers

Wooten, D. J., Groves, S. M., Tyson, D. R., Liu, Q., Lim, J. S., Albert, R., Lopez, C. F., Sage, J., & Quaranta, V. (2019) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1007343 · Cited by 114 · see citing works

WNT signaling – lung cancer is no exception

Rapp, J., Járomi, L., Kvell, K., Miskei, G., & Pongracz, J. E. (2017) · Respiratory Research · doi:10.1186/s12931-017-0650-6 · Cited by 113 · see citing works

Acquired resistance to targeted therapies in NSCLC: Updates and evolving insights

Meador, C. B., & Hata, A. N. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107522 · Cited by 115 · see citing works

Lineage-specific intolerance to oncogenic drivers restricts histological transformation

Gardner, E. E., Earlie, E. M., Li, K., Thomas, J., Hubisz, M. J., Stein, B. D., Zhang, C., Cantley, L. C., Laughney, A. M., & VARMUS, H. E. (2024) · Science · doi:10.1126/science.adj1415 · Cited by 115 · see citing works

Development and Regeneration of Sox2+ Endoderm Progenitors Are Regulated by a HDAC1/2-Bmp4/Rb1 Regulatory Pathway

Wang, Y., Tian, Y., Morley, M. P., Lu, M. M., DeMayo, F. J., Olson, E. N., & Morrisey, E. E. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.01.012 · Cited by 111 · see citing works

EZH2 promotes progression of small cell lung cancer by suppressing the TGF-β-Smad-ASCL1 pathway

Murai, F., Koinuma, D., Shinozaki‐Ushiku, A., Fukayama, M., Miyaozono, K., & Ehata, S. (2015) · Cell Discovery · doi:10.1038/celldisc.2015.26 · Cited by 109 · see citing works

Generation of pulmonary neuroendocrine cells and SCLC-like tumors from human embryonic stem cells

Chen, H. J., Poran, A., Unni, A. M., Huang, S. X. L., Elemento, O., Snoeck, H., & VARMUS, H. E. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20181155 · Cited by 102 · see citing works

Cellular and molecular biology of small cell lung cancer: an overview.

Karachaliou, N., Pilotto, S., Lazzari, C., Bria, E., de Marinis, F., & Rosell, R. (2016) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2218-6751.2016.01.02 · Cited by 96 · see citing works

Genetic requirement forMycland efficacy of RNA Pol I inhibition in mouse models of small cell lung cancerPreprint

Kim, D. W., Wu, N., Kim, Y., Cheng, P. F., Basom, R., Kim, D., Dunn, C. T., Lee, A. Y., Kim, K., Lee, C. S., et al. (2016) · Genes & Development · doi:10.1101/gad.279307.116 · Cited by 96 · see citing works

The DNA methylation landscape of small cell lung cancer suggests a differentiation defect of neuroendocrine cells

Kalari, S. K., Jung, M., Kernstine, K. H., Takahashi, T., & Pfeifer, G. P. (2012) · Oncogene · doi:10.1038/onc.2012.362 · Cited by 95 · see citing works

MYCN drives chemoresistance in small cell lung cancer while USP7 inhibition can restore chemosensitivityPreprint

Grunblatt, E., Wu, N., Zhang, H., Liu, X., Norton, J. P., Ohol, Y. M., Leger, P. R., Hiatt, J. B., Eastwood, E., Thomas, R., et al. (2020) · Genes & Development · doi:10.1101/gad.340133.120 · Cited by 95 · see citing works

Cell-autonomous immune gene expression is repressed in pulmonary neuroendocrine cells and small cell lung cancer

Cai, L., Liu, H., Huang, F., Fujimoto, J., Girard, L., Chen, J., Li, Y., Zhang, Y.-A., Deb, D., Stastny, V., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-01842-7 · Cited by 93 · see citing works

Abstract SY10-02: Mouse models for (non) small cell lung cancer: Heterogeneity and cell of origin

Berns, A. J. M., Sutherland, K., Kwon, M. C., Proost, N., & Calbó, J. (2012) · Cancer Research · doi:10.1158/1538-7445.am2012-sy10-02

Abstract IA21: Tumor heterogeneity and cell-of-origin of mouse small cell and non-small cell lung cancer

Berns, A. J. M. (2014) · Molecular Cancer Research · doi:10.1158/1557-3125.modorg-ia21

Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model

Meuwissen, R., Linn, S. C., Linnoila, R. I., Zevenhoven, J., Mooi, W. J., & Berns, A. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00220-4 · Cited by 643 · see citing works

Characterization of the cell of origin for small cell lung cancer

Park, K.-S., Liang, M., Raiser, D. M., Zamponi, R., Roach, R. R., Curtis, S. J., Walton, Z. E., Schaffer, B. E., Roake, C. M., Zmoos, A., et al. (2011) · Cell Cycle · doi:10.4161/cc.10.16.17012 · Cited by 225 · see citing works

Small Cell Lung Cancer: Significance of RB Alterations and TTF-1 Expression in its Carcinogenesis, Phenotype, and Biology

Kitamura, H., Yazawa, T., Sato, H., Okudela, K., & Shimoyamada, H. (2009) · Endocrine Pathology · doi:10.1007/s12022-009-9072-4 · Cited by 50 · see citing works