The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Androgen Receptor Gene Expression in Prostate Cancer Is Directly Suppressed by the Androgen Receptor Through Recruitment of Lysine-Specific Demethylase 1
Open accessAbstract
SUMMARY Androgen receptor (AR) is reactivated in castration resistant prostate cancer (CRPC) through mechanisms including marked increases in AR gene expression. We identify an enhancer in the AR second intron contributing to increased AR expression at low androgen levels in CRPC. Moreover, at increased androgen levels the AR binds this site and represses AR gene expression through recruitment of lysine specific demethylase 1 (LSD1) and H3K4me1,2 demethylation. AR similarly represses expression of multiple genes mediating androgen synthesis, DNA synthesis and proliferation, while stimulating genes mediating lipid and protein biosynthesis. Androgen levels in CRPC appear adequate to stimulate AR activity on enhancer elements, but not suppressor elements, resulting in increased expression of AR and AR repressed genes that contribute to cellular proliferation.
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Cites
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
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LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription
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Self-citationAndrogen Receptor Regulates a Distinct Transcription Program in Androgen-Independent Prostate Cancer
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Cited by
Emerging mechanisms of resistance to androgen receptor inhibitors in prostate cancer
Watson, P. A., Arora, V. K., & Sawyers, C. L. (2015) · Nature Reviews Cancer · doi:10.1038/nrc4016 · Cited by 1,536
Targeted protein degradation by PROTACs
Neklesa, T. K., Winkler, J. D., & Crews, C. M. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.02.027 · Cited by 599
Androgen insensitivity syndrome
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Metadata
- Authors
- Cai, C., He, H. H., Chen, S., Coleman, I., Wang, H., Fang, Z., Chen, S., Nelson, P. S., Liu, X. S., Brown, M., & Balk, S. P.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 20
- Issue
- 4
- Pages
- 457-471
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2041034966
- Cited by
- 454
- References
- 38
- FWCI
- 24.74
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Androgen Receptor Gene Expression in Prostate Cancer Is Directly Suppressed by the Androgen Receptor Through Recruitment of Lysine-Specific Demethylase 1. https://app.cochat.ai/papers/10.1016/j.ccr.2011.09.001
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- Cai, C., He, H. H., Chen, S., Coleman, I., Wang, H., Fang, Z., Chen, S., Nelson, P. S., Liu, X. S., Brown, M., & Balk, S. P. (2011). Androgen Receptor Gene Expression in Prostate Cancer Is Directly Suppressed by the Androgen Receptor Through Recruitment of Lysine-Specific Demethylase 1. Cancer Cell. https://doi.org/10.1016/j.ccr.2011.09.001
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