The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Oxidative Damage Targets Complexes Containing DNA Methyltransferases, SIRT1, and Polycomb Members to Promoter CpG Islands
Open accessAbstract
SUMMARY Cancer cells simultaneously harbor global losses and gains in DNA methylation. We demonstrate that inducing cellular oxidative stress by treatment with hydrogen peroxide, recruits DNA methyltransferase 1 (DNMT1) to damaged chromatin. DNMT1 becomes part of a complex(es) containing DNMT3B and members of Polycomb Repressive Complex 4. Hydrogen peroxide treatment causes translocalization of these proteins from non-GC-rich to GC-rich areas. Key components are similarly enriched at gene promoters in an in vivo colitis model. While high expression genes enriched for members of the complex have histone mark and nascent transcription changes, CpG island-containing low expression genes gain promoter DNA methylation. Thus, oxidative damage induces formation and localization of a silencing complex that may explain cancer-specific aberrant DNA methylation and transcriptional silencing.
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Cites
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DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
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“In vitro we see an increase in DNA methylation that correlates with the low basal expression level of these genes, which harbor PcG complexes in embryonic stem and progenitor cells (Ohm et al., 2007; Schlesinger et al., 2007; Widschwendter et al., 2007).”
BackgroundInfluentialEpigenetic stem cell signature in cancer
Widschwendter, M., Fiegl, H., Egle, D., Mueller-Holzner, E., Spizzo, G., Marth, C., Weisenberger, D. J., Campan, M., Young, J., Jacobs, I., et al. (2007) · Nature Genetics · doi:10.1038/ng1941 · Cited by 1,143
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Self-citationCpG islands influence chromatin structure via the CpG-binding protein Cfp1
Thomson, J. P., Skene, P. J., Selfridge, J., Clouaire, T., Guy, J., Webb, S., Kerr, A. R. W., Deaton, A., Andrews, R., James, K. D., et al. (2010) · Nature · doi:10.1038/nature08924 · Cited by 625
Inhibition of SIRT1 Reactivates Silenced Cancer Genes without Loss of Promoter DNA Hypermethylation
Pruitt, K., Zinn, R. L., Ohm, J. E., McGarvey, K. M., Kang, S.-H. L., Watkins, D. N., Herman, J. G., & Baylin, S. B. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020040 · Cited by 387 · cited 1×
“(Pruitt et al., 2006) and has been implicated in DNA damage repair in both yeast and mammalian cells.”
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SIRT1 Regulates UV-Induced DNA Repair through Deacetylating XPA
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Cited by
Chiappinelli, K. B., Strissel, P. L., Desrichard, A., Li, H., Henke, C., Akman, B., Hein, A., Rote, N. S., Cope, L. M., Snyder, A., et al. (2015) · Cell · doi:10.1016/j.cell.2015.07.011 · Cited by 2,022
Self-citationThe role of ROS in tumour development and progression
Cheung, E. C., & Vousden, K. H. (2022) · Nature Reviews Cancer · doi:10.1038/s41568-021-00435-0 · Cited by 1,595
Epigenetic Determinants of Cancer
Baylin, S. B., & Jones, P. A. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a019505 · Cited by 1,226
Self-citationOxidative Stress in Human Pathology and Aging: Molecular Mechanisms and Perspectives
Hajam, Y. A., Rani, R., Ganie, S. Y., Sheikh, T. A., Javaid, D., Qadri, S. S., Pramodh, S., Alsulimani, A., Alkhanani, M. F., Harakeh, S., et al. (2022) · Cells · doi:10.3390/cells11030552 · Cited by 915
Cancer Epigenetics: Tumor Heterogeneity, Plasticity of Stem-like States, and Drug Resistance
Easwaran, H., Tsai, H.-C., & Baylin, S. B. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.05.015 · Cited by 915
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Metadata
- Authors
- O'Hagan, H. M., Wang, W., Sen, S., DeStefano Shields, C., Lee, S. S., Zhang, Y. W., Clements, E. G., Cai, Y., Van Neste, L., Easwaran, H., Casero, R. A., Sears, C. L., & Baylin, S. B.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 20
- Issue
- 5
- Pages
- 606-619
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2168889003
- Cited by
- 563
- References
- 10
- FWCI
- 12.34
- Type
- journal article
- Language
- en
- Open access
- bronze
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- O'Hagan, H. M., Wang, W., Sen, S., DeStefano Shields, C., Lee, S. S., Zhang, Y. W., Clements, E. G., Cai, Y., Van Neste, L., Easwaran, H., Casero, R. A., Sears, C. L., & Baylin, S. B. (2011). Oxidative Damage Targets Complexes Containing DNA Methyltransferases, SIRT1, and Polycomb Members to Promoter CpG Islands. Cancer Cell. https://doi.org/10.1016/j.ccr.2011.09.012
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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