Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

Mitsuishi, Yoichiro, Taguchi, Keiko, Kawatani, Yukie, Shibata, Tatsuhiro, Nukiwa, Toshihiro, Aburatani, Hiroyuki, Yamamoto, Masayuki, Motohashi, Hozumi·2012·Cancer Cell

DOI 10.1016/j.ccr.2012.05.016

Cited by (1,000)

Items 401–500 of 1,000

Clinical Implications of KEAP1-NFE2L2 Mutations in NSCLC
Jessica A. Hellyer, Sukhmani Kaur Padda, Maximilian Diehn, Heather A. Wakelee · 2020 · Journal of Thoracic Oncology
Metformin sensitizes endometrial cancer cells to chemotherapy through IDH1-induced Nrf2 expression via an epigenetic mechanism
Mingzhu Bai, Linlin Yang, Hong Liao, Xiaoyan Liang, Bingying Xie, Ji Xiong, Xiang Tao, Xiong Chen, Yali Cheng, Xiaojun Chen et al. · 2018 · Oncogene
Generation of a New Model Rat: Nrf2 Knockout Rats Are Sensitive to Aflatoxin B 1 Toxicity
Keiko Taguchi, Misaki Takaku, Patricia A. Egner, Masanobu Morita, Takehito Kaneko, Tomoji Mashimo, Thomas W. Kensler, Masayuki P. Yamamoto · 2016 · Toxicological Sciences
Beyond antioxidant genes in the ancient Nrf2 regulatory network
Lacher, Sarah E., Lee, Joslynn S., Wang, Xuting, Campbell, Michelle R., Bell, Douglas A., Slattery, Matthew · 2015 · Free Radical Biology and Medicine
Therapeutic Targeting of Mitochondrial One-Carbon Metabolism in Cancer
Aamod S. Dekhne, Zhanjun Hou, Aleem Gangjee, Larry H. Matherly · 2020 · Molecular Cancer Therapeutics
Glycolytic genes are targets of the nuclear receptor Ad4BP/SF-1
Takashi Baba, Hiroyuki Otake, Tetsuya Sato, Kanako Miyabayashi, Yurina Shishido, Chia‐Yih Wang, Yuichi Shima, Hiroshi Kimurâ, Mikako Yagi, Yasuhiro Ishihara et al. · 2014 · Nature Communications
The role of Nrf2-Keap1 axis in colorectal cancer, progression, and chemoresistance
Mohammad Reza Sadeghi, Farhad Jeddi, Narges Soozangar, Mohammad Hossein Somi, Nasser Samadi · 2017 · Tumor Biology
Cysteine transporter SLC3A1 promotes breast cancer tumorigenesis
Yang Zi Jiang, Yuan Cao, Yongbin Wang, Wei Li, Xinyi Liu, Yixuan Lv, Xiaoling Li, Jun Mi · 2017 · Theranostics
Mitochondria: The metabolic switch of cellular oncogenic transformation
Tan, Yan Qin, Zhang, Xi, Zhang, Shuwei, Zhu, Tao, Garg, Manoj, Lobie, Peter E., Pandey, Vijay · 2021 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
The Regulation of NRF2 by Nutrient-Responsive Signaling and Its Role in Anabolic Cancer Metabolism
Sae Bom Lee, Brianna N. Sellers, Gina M. DeNicola · 2017 · Antioxidants and Redox Signaling
Keap1 mutation renders lung adenocarcinomas dependent on Slc33a1
Rodrigo Romero, Francisco J. Sánchez Rivera, Peter M.K. Westcott, Kim L. Mercer, Arjun J. Bhutkar, Alexander Muir, Tania J González-Robles, Swanny Lamboy Rodríguez, Laura Z. Liao, Sheng Rong Ng et al. · 2020 · Nature Cancer
The role of Nrf2 in acute kidney injury: Novel molecular mechanisms and therapeutic approaches
Wei Wei, Ning Ma, Xiaoye Fan, Qinlei Yu, Xinxin Ci · 2020 · Free Radical Biology and Medicine
Nrf2 as a regulator of energy metabolism and mitochondrial function
Alina Yu. Luchkova, Ana Mata, Susana Cadenas · 2024 · FEBS Letters
Non-electrophilic modulators of the canonical Keap1/Nrf2 pathway
Benjamin G. Richardson, Atul D. Jain, Thomas E. Speltz, Terry W. Moore · 2015 · Bioorganic & Medicinal Chemistry Letters
Keap1/Nrf2 pathway in the frontiers of cancer and non-cancer cell metabolism
Dionysios V. Chartoumpekis, Nobunao Wakabayashi, Thomas W. Kensler · 2015 · Biochemical Society Transactions
Naringenin ameliorates progression of endometriosis by modulating Nrf2/Keap1/HO1 axis and inducing apoptosis in rats
Radhika Kapoor, Vijay Kumar Sirohi, Kanchan Gupta, Anila Dwivedi · 2019 · The Journal of Nutritional Biochemistry
KEAP1-Mutant NSCLC: The Catastrophic Failure of a Cell-Protecting Hub
Stefano Scalera, Marco Mazzotta, Clelia Cortile, Eriseld Krasniqi, Ruggero D. Maria, Federico Cappuzzo, Gennaro Ciliberto, Marcello Maugeri‐Saccà · 2022 · Journal of Thoracic Oncology
Sirtuin5 protects colorectal cancer from DNA damage by keeping nucleotide availability
Hao-Lian Wang, Yan Chen, Yun-Qian Wang, Juan Tan, Juan Tan, Qianqian Liu, Chun-Min Li, Xuemei Tong, Qin‐Yan Gao, Jie Hong et al. · 2022 · Nature Communications
Battles against aberrant KEAP1-NRF2 signaling in lung cancer: intertwined metabolic and immune networks
Ke Xu, Jie Ma, Sean R. R. Hall, Ren‐Wang Peng, Haitang Yang, Feng Yao · 2023 · Theranostics
Cis-element architecture of Nrf2–sMaf heterodimer binding sites and its relation to diseases
Akihito Otsuki, Masayuki P. Yamamoto · 2019 · Archives of Pharmacal Research
Roles of the KEAP1-NRF2 system in mammalian skin exposed to UV radiation
Ikehata, Hironobu, Yamamoto, Masayuki · 2018 · Toxicology and Applied Pharmacology
Macrophages sensing oxidized DAMPs reprogram their metabolism to support redox homeostasis and inflammation through a TLR2-Syk-ceramide dependent mechanism
Vlad Serbulea, Clint M. Upchurch, Katelyn W. Ahern, Gael F. P. Bories, Paxton E. Voigt, Dory E. DeWeese, Akshaya K. Meher, Thurl E. Harris, Norbert Leitinger · 2017 · Molecular Metabolism
Crosstalk between Nrf2 signaling and mitochondrial function in Parkinson's disease
Navneet Ammal Kaidery, Manuj Ahuja, Bobby Thomas · 2019 · Molecular and Cellular Neuroscience
Role of Nrf2 Signaling Cascade in Breast Cancer: Strategies and Treatment
Hitesh Kumar, Rachna M. Kumar, Devanjali Bhattacharjee, Preethi Somanna, Vikas Kumar Jain · 2022 · Frontiers in Pharmacology
Signaling Pathways Regulating Redox Balance in Cancer Metabolism
Maria Chiara De Santis, Paolo Ettore Porporato, Miriam Martini, Andrea Morandi · 2018 · Frontiers in Oncology
Transcriptional activation of antioxidant gene expression by Nrf2 protects against mitochondrial dysfunction and neuronal death associated with acute and chronic neurodegeneration
Molly J. Goodfellow, Apurva Borcar, Julie L. Proctor, Tiffany Greco, Robert E. Rosenthal, Gary M. Fiskum · 2020 · Experimental Neurology
ROS-associated immune response and metabolism: a mechanistic approach with implication of various diseases
Sharmistha Banerjee, Sumit Ghosh, Ankita Mandal, Noyel Ghosh, Parames Chandra Sil · 2020 · Archives of Toxicology
Activated PKB/GSK-3β synergizes with PKC-δ signaling in attenuating myocardial ischemia/reperfusion injury via potentiation of NRF2 activity: Therapeutic efficacy of dihydrotanshinone-I
Hao Zeng, Lingling Wang, Jiawei Zhang, Ting Shuang Pan, Yinghua Yu, Jingxia Lu, Ping Zhou, Hua Qiang Yang, Ping Li · 2020 · Acta Pharmaceutica Sinica B
KEAP1 deficiency drives glucose dependency and sensitizes lung cancer cells and tumors to GLUT inhibition
Pranavi Koppula, Kellen L. Olszewski, Yilei Zhang, Lavanya Kondiparthi, Xiaoguang Liu, Guang Lei, Molina Das, Bingliang Fang, Masha V. Poyurovsky, Boyi Gan · 2021 · iScience
Nanomaterials‐Induced Redox Imbalance: Challenged and Opportunities for Nanomaterials in Cancer Therapy
Xumeng Wu, Ziqi Zhou, Kai Li, Shaoqin Liu · 2024 · Advanced Science
The Impact of miRNA-Based Molecular Diagnostics and Treatment of NRF2-Stabilized Tumors
Shinsuke Yamamoto, Jun Inoue, Tatsuyuki Kawano, Ken‐ichi Kozaki, Ken Omura, Johji Inazawa · 2013 · Molecular Cancer Research
Dengue Virus Targets Nrf2 for NS2B3-Mediated Degradation Leading to Enhanced Oxidative Stress and Viral Replication
Matteo Ferrari, Alessandra Zevini, Enrico Palermo, Michela Muscolini, Magdalini Alexandridi, Marilena Paola Etna, Eliana Marina Coccia, Ana Fernández-Sesma, Carolyn B. Coyne, Donna D. Zhang et al. · 2020 · Journal of Virology
Deregulated transcription factors in cancer cell metabolisms and reprogramming
Rajni Kant, Rajesh Manne, Mohammad Anas, Vasudevarao Penugurti, Tingjin Chen, Bo‐Syong Pan, Che-Chia Hsu, Hui‐Kuan Lin · 2022 · Seminars in Cancer Biology
Contribution of NRF2 to sulfur metabolism and mitochondrial activity
Md. Morshedul Alam, Akihiro Kishino, Eunkyu Sung, Hiroki Sekine, Takaaki Abe, Shohei Murakami, Takaaki Akaike, Hozumi Motohashi · 2023 · Redox Biology
NRF2 Activation Impairs Quiescence and Bone Marrow Reconstitution Capacity of Hematopoietic Stem Cells
Shohei Murakami, Takuma Suzuki, Hideo Harigae, Paul‐Henri Roméo, Masayuki P. Yamamoto, Hozumi Motohashi · 2017 · Molecular and Cellular Biology
COVID-19: Proposing a Ketone-Based Metabolic Therapy as a Treatment to Blunt the Cytokine Storm
Patrick C. Bradshaw, William A. Seeds, Alexandra C. Miller, Vikrant R. Mahajan, William M. Curtis · 2020 · Oxidative Medicine and Cellular Longevity
Nrf2 Mediates Metabolic Reprogramming in Non-Small Cell Lung Cancer
Jiangang Zhao, Lin Xu, Di Meng, Liping Zeng, Runzhou Zhuang, Sha Huang, Wang Lv, Jian Hu · 2020 · Frontiers in Oncology
Nrf2 overexpression rescues the RPE in mouse models of retinitis pigmentosa
David M. Wu, Xuke Ji, Maryna V. Ivanchenko, Michelle Chung, Mary E. Piper, Parimal C. Rana, Sean K. Wang, Yunlu Xue, Emma R. West, Sophia R. Zhao et al. · 2021 · JCI Insight
Mitochondrial ROS driven by NOX4 upregulation promotes hepatocellular carcinoma cell survival after incomplete radiofrequency ablation by inducing of mitophagy via Nrf2/PINK1
Chao Peng, Xi Li, Feng Ao, Ting Li, Jingpei Guo, Junfeng Liu, Xiaoting Zhang, Jinyan Gu, Junjie Mao, Bin Zhou · 2023 · Journal of Translational Medicine
Disruption of KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex components by multiple genetic mechanisms: Association with poor prognosis in head and neck cancer
Victor D. Martínez, Emily A. Vucic, Kelsie L. Thu, Larissa A. Pikor, Stephen C. Lam, Wan L. Lam · 2014 · Head & Neck
Halofuginone inhibits colorectal cancer growth through suppression of Akt/mTORC1 signaling and glucose metabolism
Guoqing Chen, Chengfang Tang, Xiaoke Shi, Chengyuan Lin, Sarwat Fatima, Xiaohua Pan, Dajian Yang, Ge Zhang, Aiping Lü, Shuhai Lin et al. · 2015 · Oncotarget
The Protective Effect of Melatonin on Neural Stem Cell against LPS-Induced Inflammation
Juhyun Song, So Mang Kang, Kyoung Min Lee, Jong Eun Lee · 2015 · BioMed Research International
The PARP Enzyme Family and the Hallmarks of Cancer Part 1. Cell Intrinsic Hallmarks
Máté Ágoston Demény, László Virág · 2021 · Cancers
Nonalcoholic steatohepatitis and mechanisms by which it is ameliorated by activation of the CNC-bZIP transcription factor Nrf2
Boushra Bathish, Holly Robertson, John Francis Dillon, Albena T. Dinkova‐Kostova, John D. Hayes · 2022 · Free Radical Biology and Medicine
An insight into role of amino acids as antioxidants via NRF2 activation
Melford Chuka Egbujor, Olugbemi Tope Olaniyan, Chigbundu N. Emeruwa, Sarmistha Saha, Luciano Saso, Paolo Tucci · 2024 · Amino Acids
Altered Nrf2 Signaling Mediates Hypoglycemia-Induced Blood–Brain Barrier Endothelial Dysfunction In Vitro
Ravi Kiran Sajja, Kayla N. Green, Luca Cucullo · 2015 · PLoS ONE
Roles of Keap1–Nrf2 System in Upper Aerodigestive Tract Carcinogenesis
Akira Ohkoshi, Takafumi Suzuki, Masao Ono, Toshimitsu Kobayashi, Masayuki P. Yamamoto · 2012 · Cancer Prevention Research
NRF2 SUMOylation promotes de novo serine synthesis and maintains HCC tumorigenesis
Haoyan Guo, Jiaqian Xu, Quan Zheng, Jianli He, Wei Zhou, Kezhou Wang, Xian Huang, Qiuju Fan, Jiao Ma, Jinke Cheng et al. · 2019 · Cancer Letters
Functional Gene Knockout of NRF2 Increases Chemosensitivity of Human Lung Cancer A549 Cells In Vitro and in a Xenograft Mouse Model
Pawel A. Bialk, Yichen Wang, Kelly H. Banas, Eric Brian Kmiec · 2018 · Molecular Therapy — Oncolytics
Mutant p53 and Cellular Stress Pathways: A Criminal Alliance That Promotes Cancer Progression
Gabriella D’Orazi, Mara Cirone · 2019 · Cancers
Nrf2 deficiency decreases NADPH from impaired IDH shuttle and pentose phosphate pathway in retinal pigmented epithelial cells to magnify oxidative stress‐induced mitochondrial dysfunction
Marisol Cano, Sayantan Datta, Lei Wang, Tongyun Liu, Miguel Flores‐Bellver, Mira M. Sachdeva, Debasish Sinha, James T. Handa · 2021 · Aging Cell
NRF2 and Mitochondrial Function in Cancer and Cancer Stem Cells
Emiliano Panieri, Sónia Pinho, Gonçalo J. M. Afonso, Paulo Jorge Oliveira, Teresa Cunha‐Oliveira, Luciano Saso · 2022 · Cells
p62 bodies: Phase separation, NRF2 activation, and selective autophagic degradation
Masaaki Komatsu · 2022 · IUBMB Life
Research progress on Sirtuins (SIRTs) family modulators
Mingkai Chen, Junfei Tan, Zihan Jin, Tingting Jiang, Jiabiao Wu, Xiaolong Yu · 2024 · Biomedicine & Pharmacotherapy
Dissection of the role of p62/Sqstm1 in activation of Nrf2 during xenophagy
Ryosuke Ishimura, Keiji Tanaka, Masaaki Komatsu · 2014 · FEBS Letters
l -cysteine reversibly inhibits glucose-induced biphasic insulin secretion and ATP production by inactivating PKM2
Daiki Nakatsu, Yuta Horiuchi, Fumi Kano, Yoshiyuki Noguchi, Taichi Sugawara, Iseki Takamoto, Naoto Kubota, Takashi Kadowaki, Masayuki Murata · 2015 · Proceedings of the National Academy of Sciences
Nrf2 inhibition sensitizes breast cancer stem cells to ionizing radiation via suppressing DNA repair
Shenghui Qin, Xiaoyuan He, Houmin Lin, Bradley A. Schulte, Mingfeng Zhao, Kenneth D. Tew, Gavin Y. Wang · 2021 · Free Radical Biology and Medicine
The role of transketolase in human cancer progression and therapy
Shiming Hao, Qingfei Meng, Huihui Sun, Yunkuo Li, Yao Li, Liting Gu, Bin Liu, Yanghe Zhang, Honglan Zhou, Zhixiang Xu et al. · 2022 · Biomedicine & Pharmacotherapy
In vivo delivery of transcription factors with multifunctional oligonucleotides
Kunwoo Lee, Mohammad A. Rafi, Xiaojian Wang · 2015 · Nature Materials
Nrf2: bane or blessing in cancer?
Mingjun Xiang, Akhileshwar Namani, ShiJun Wu, XiaoLi Wang · 2014 · Journal of Cancer Research and Clinical Oncology
Lipid mediators involved in the oxidative stress and antioxidant defence of human lung cancer cells
Agnieszka Gęgotek, Jacek Nikliński, Neven Žarković, Kamelija Žarković, Georg Waeg, Wojciech Łuczaj, Radosław Charkiewicz, Elźbieta Skrzydlewska · 2016 · Redox Biology
Role of Nuclear Factor Erythroid 2-Related Factor 2 in Diabetic Nephropathy
Wenpeng Cui, Xu Min, Xiaohong Xu, Bing Du, Ping Luo · 2017 · Journal of Diabetes Research
Activity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity
Asad Jan, Brandon Jansonius, Alberto Delaidelli, Forum Bhanshali, Yi Andy An, Nelson Ferreira, Lisa M. Smits, Gian Luca Negri, Jens Christian Schwamborn, Poul Henning Jensen et al. · 2018 · Acta Neuropathologica Communications
The NAD+ Salvage Pathway Supports PHGDH-Driven Serine Biosynthesis
John Patrick Murphy, Michael Giacomantonio, João A. Paulo, Robert A. Everley, Barry E. Kennedy, Gopal P. Pathak, Derek R. Clements, Youra Kim, Cathleen Dai, Tanveer Sharif et al. · 2018 · Cell Reports
Differential Impact of Flavonoids on Redox Modulation, Bioenergetics, and Cell Signaling in Normal and Tumor Cells: A Comprehensive Review
Asimina Kerimi, Gary Williamson · 2017 · Antioxidants and Redox Signaling
Impaired Nrf2 regulation of mitochondrial biogenesis in rostral ventrolateral medulla on hypertension induced by systemic inflammation
Kay L. H. Wu, Chih‐Wei Wu, Yung‐Mei Chao, Chun‐Ying Hung, Julie Y.H. Chan · 2016 · Free Radical Biology and Medicine
Pan-cancer transcriptomic analysis associates long non-coding RNAs with key mutational driver events
Arghavan Ashouri, Volkan I. Sayin, Jimmy Van den Eynden, Simranjit X. Singh, Thales Y. Papagiannakopoulos, Erik Larsson · 2016 · Nature Communications
Nrf2‐Mediated Metabolic Reprogramming in Cancer
Yanyang Wang, Juan Chen, Xiaoming Liu, Ren Zhao, Hong Zhe · 2018 · Oxidative Medicine and Cellular Longevity
The Pleiotropic Role of the KEAP1/NRF2 Pathway in Cancer
Warren Wu, Thales Y. Papagiannakopoulos · 2020 · Annual Review of Cancer Biology
Targeted Anti-Mitochondrial Therapy: The Future of Oncology
Farzad Taghizadeh‐Hesary, Babak Behnam, Hassan Akbari, Moslem Bahadori · 2022 · Genes
Targeting NRF2–KEAP1 axis by Omega-3 fatty acids and their derivatives: Emerging opportunities against aging and diseases
Sergio Davinelli, Alessandro Medoro, Mariano Intrieri, Luciano Saso, Giovanni Scapagnini, Jing Kang · 2022 · Free Radical Biology and Medicine
Emerging roles of Nrf2 signal in non-small cell lung cancer
Yijun Tian, Qian Liu, Xuelian He, Xun Yuan, Yuan Chen, Qian Chu, Kongming Wu · 2016 · Journal of Hematology & Oncology
Activation of the Dickkopf1-CKAP4 pathway is associated with poor prognosis of esophageal cancer and anti-CKAP4 antibody may be a new therapeutic drug
Naoki Shinno, Hirokazu Kimura, Ryota Sada, Shuji Takiguchi, Masaki Mori, Katsumi Fumoto, Yuichiro� Doki, Akira Kikuchi · 2018 · Oncogene
Functional Role of NRF2 in Cervical Carcinogenesis
Junqi Ma, Tuersun Hatila, Shu-juan Jiao, Zheng Jian-He, xiao Jing-Bao, Ayshamgul Hasim · 2015 · PLoS ONE
Activation of apoptosis in NAF-1-deficient human epithelial breast cancer cells
Sarah H. Holt, Merav Darash‐Yahana, Yang Sung Sohn, Luhua Song, Ola Karmi, Sagi Tamir, Dorit Michaeli, Yuting Luo, Mark L. Paddock, Patricia Ann Jennings et al. · 2015 · Journal of Cell Science
Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism
Johannes Meiser, Sylvie Delcambre, André Wegner, Christian Jäger, Jenny Ghelfi, Aymeric Fouquier d’Hérouël, Xingchen Dong, Daniel Weindl, Constantin Stautner, Yannic Nonnenmacher et al. · 2016 · Neurobiology of Disease
Phytosomal Curcumin Elicits Anti-tumor Properties Through Suppression of Angiogenesis, Cell Proliferation and Induction of Oxidative Stress in Colorectal Cancer
Reyhaneh Moradi‐Marjaneh, Seyed Mahdi Hassanian, Farzad Rahmani, Seyed Hamid Aghaee‐Bakhtiari, Amir Avan, Majid Khazaei · 2019 · Current Pharmaceutical Design · Retracted
Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer
Christopher R. Silvers, Hiroshi Miyamoto, Edward M. Messing · 2017 · Oncotarget
Positive Aspects of Oxidative Stress at Different Levels of the Human Body: A Review
George Jîtcă, Bianca Eugenia Ősz, Amelia Tero-Vescan, Amalia Miklos, Carmen-Maria Rusz, Mădălina-Georgiana Bătrînu, Camil-Eugen Vari · 2022 · Antioxidants
Nrf2 regulates glucose uptake and metabolism in neurons and astrocytes
Noemí Esteras, Thomas S. Blacker, Evgeny Zherebtsov, Olga A. Stelmashchuk, Ying Zhang, W. Christian Wigley, Michael R. Duchen, Albena T. Dinkova‐Kostova, Andrey Y. Abramov · 2023 · Redox Biology
Targeting fatty acid oxidation enhances response to HER2-targeted therapy
Ipshita Nandi, Linjia Ji, Harvey W. Smith, Daina Zofija Avizonis, Vasilios Papavasiliou, Cynthia A. Lavoie, Alain Pacis, Sherif Samer Attalla, Virginie Sanguin‐Gendreau, William J. Muller · 2024 · Nature Communications
Mutant KRAS associated malic enzyme 1 expression is a predictive marker for radiation therapy response in non-small cell lung cancer
Gaurab Chakrabarti · 2015 · Radiation Oncology
WNT-3A Regulates an Axin1/NRF2 Complex That Regulates Antioxidant Metabolism in Hepatocytes
Patricia Rada, Ana Isabel Rojo, Anika Offergeld, Gui Jie Feng, Juan Pedro Velasco-Martin, José Manuel González‐Sancho, Ángela M. Valverde, Trevor C. Dale, Javier Regadera, Antonio Cuadrado · 2014 · Antioxidants and Redox Signaling
Inhibition of Glucose-6-Phosphate Dehydrogenase Reverses Cisplatin Resistance in Lung Cancer Cells via the Redox System
Weipeng Hong, Peiheng Cai, Chuncao Xu, Di Cao, Wei‐Bang Yu, Zhongxiang Zhao, Min Huang, Jing Jin · 2018 · Frontiers in Pharmacology
Metabolic reprogramming sustains cancer cell survival following extracellular matrix detachment
Hitoshi Endo, Satoshi Owada, Yutaka Inagaki, Yukari Shida, Masayuki Tatemichi · 2020 · Redox Biology
Biological effects of corosolic acid as an anti-inflammatory, anti-metabolic syndrome and anti-neoplasic natural compound.
Jin-Wei Zhao, Hong Zhou, Yanan An, Keshu Shen, L. Yu · 2020 · Oncology Letters
Autophagy in liver diseases
Elias Kouroumalis, Argryro Voumvouraki, Aikaterini Augoustaki, Dimitrios N. Samonakis · 2021 · World Journal of Hepatology
Nrf2 induces fibroblast growth factor 21 in diabetic mice
Yuki Furusawa, Akira Uruno, Yoko Yagishita, Chika Higashi, Masayuki P. Yamamoto · 2014 · Genes to Cells
Natural Compounds as Regulators of the Cancer Cell Metabolism
Claudia Cerella, Flavia Radogna, Mario A. Dicato, Marc F. Diederich · 2013 · International Journal of Cell Biology
Glutathionyl systems and metabolic dysfunction in obesity
Matthew J. Picklo, Eric K. Long, Emilie E. Vomhof‐DeKrey · 2015 · Nutrition Reviews
Histone chaperone FACT complex mediates oxidative stress response to promote liver cancer progression
Jialing Shen, Mengnuo Chen, Derek Lee, Cheuk‐Ting Law, Lai Wei, Felice Ho‐Ching Tsang, Don Wai‐Ching Chin, Carol Lai‐Hung Cheng, Joyce Man‐Fong Lee, Irene Oi‐Lin Ng et al. · 2019 · Gut
Exosomal Nrf2: From anti-oxidant and anti-inflammation response to wound healing and tissue regeneration in aged-related diseases
Houman Kahroba, Yasamin Davatgaran Taghipour · 2020 · Biochimie
NRF2 in Viral Infection
Angela Herengt, Jacob Thyrsted, Christian Kanstrup Holm · 2021 · Antioxidants
G6PD-mediated increase in de novo NADP + biosynthesis promotes antioxidant defense and tumor metastasis
Yang Zhang, Yi Xu, Wenyun Lu, Jinyang Li, Sixiang Yu, Eric J. Brown, Ben Z. Stanger, Joshua D. Rabinowitz, Xiaolu Yang · 2022 · Science Advances
Thyroid hormone inhibits hepatocellular carcinoma progression via induction of differentiation and metabolic reprogramming
Kowalik, Marta Anna, Puliga, Elisabetta, Cabras, Lavinia, Sulas, Pia, Petrelli, Annalisa, Perra, Andrea, Ledda-Columbano, Giovanna Maria, Morandi, Andrea, Merlin, Simone, Orrù, Claudia et al. · 2020 · Journal of Hepatology
Overview of Cancer Metabolism and Signaling Transduction
Heesuk Chae, Seong‐Tshool Hong · 2022 · International Journal of Molecular Sciences
The Crosstalk between Nrf2 and TGF-β1 in the Epithelial-Mesenchymal Transition of Pancreatic Duct Epithelial Cells
Sarah Arfmann-Knübel, Birte Struck, Geeske Genrich, Ole Helm, Bence Sipos, Susanne Sebens, H. Schäfer · 2015 · PLoS ONE
The Metabolic Heterogeneity and Flexibility of Cancer Stem Cells
Atsushi Tanabe, Hiroeki Sahara · 2020 · Cancers
Overview of redox regulation by Keap1–Nrf2 system in toxicology and cancer
Mikiko Suzuki, Akihito Otsuki, Nadine Keleku-Lukwete, Masayuki P. Yamamoto · 2016 · Current Opinion in Toxicology
NFE2L2/NRF2 Activity Is Linked to Mitochondria and AMP-Activated Protein Kinase Signaling in Cancers Through miR-181c/Mitochondria-Encoded Cytochrome c Oxidase Regulation
Kyeong-Ah Jung, Sujin Lee, Mi‐Kyoung Kwak · 2017 · Antioxidants and Redox Signaling