Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

Mitsuishi, Yoichiro, Taguchi, Keiko, Kawatani, Yukie, Shibata, Tatsuhiro, Nukiwa, Toshihiro, Aburatani, Hiroyuki, Yamamoto, Masayuki, Motohashi, Hozumi·2012·Cancer Cell

Cited by (1,000)

Items 601–700 of 1,000

  1. Nrf2 Regulates β-Cell Mass by Suppressing β-Cell Death and Promoting β-Cell Proliferation
    Sharon Baumel-Alterzon, Liora S. Katz, Gabriel Brill, Clairete Jean-Pierre, Yansui Li, Isabelle Tse, Shyam S. Biswal, Adolfo Garcı́a-Ocaña, Donald K. Scott · 2022 · Diabetes
  2. The Tumor Suppressor Kinase LKB1: Metabolic Nexus
    Mohammed Bourouh, Paola A. Marignani · 2022 · Frontiers in Cell and Developmental Biology
  3. Atherosclerosis, Diabetes Mellitus, and Cancer: Common Epidemiology, Shared Mechanisms, and Future Management
    Vasiliki K. Katsi, Ilias P. Papakonstantinou, Konstantinos P Tsioufis · 2023 · International Journal of Molecular Sciences
  4. Kaposi's Sarcoma-Associated Herpesvirus Induces Nrf2 Activation in Latently Infected Endothelial Cells through SQSTM1 Phosphorylation and Interaction with Polyubiquitinated Keap1
    Olsi Gjyshi, Stephanie Flaherty, Mohanan Valiya Veettil, Karen E. Johnson, Bala Chandran, Virginie Bottero · 2014 · Journal of Virology
  5. Global metabolomic profiling of uterine leiomyomas
    Hanna-Riikka Heinonen, Miika M. Mehine, Netta Mäkinen, Annukka M. Pasanen, Esa Pitkänen, Auli Karhu, Nanna S. Sarvilinna, Jari Sjöberg, Oskari Heikinheimo, Ralf C. Bützow et al. · 2017 · British Journal of Cancer
  6. Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Inhibition: An Emerging Strategy in Cancer Therapy
    Zhengyu Jiang, Mengchen Lu, Qidong You · 2018 · Journal of Medicinal Chemistry
  7. The flavonoid Astragalin shows anti‐tumor activity and inhibits PI3K/AKT signaling in gastric cancer
    Zhongqing Wang, Jian Lv, Xiufang Li, Qing Lin · 2021 · Chemical Biology & Drug Design
  8. Newly synthesized chitosan-nanoparticles attenuate carbendazim hepatorenal toxicity in rats via activation of Nrf2/HO1 signalling pathway
    Elshazly Mo, Yasmin A. Ebedy, Marwa A. Ibrahim, Khaled Y. Farroh, Eman Ibrahim Hassanen · 2022 · Scientific Reports
  9. Nrf2 is essential for timely M phase entry of replicating hepatocytes during liver regeneration
    Yuhong Zou, Min Hu, Joonyong Lee, Shashank Manohar Nambiar, Veronica Garcia, Qi Bao, Jefferson Y. Chan, Guoli Dai · 2014 · American Journal of Physiology-Gastrointestinal and Liver Physiology
  10. Prominent Steatosis with Hypermetabolism of the Cell Line Permissive for Years of Infection with Hepatitis C Virus
    Kazuo Sugiyama, Hirotoshi Ebinuma, Nobuhiro Nakamoto, Noriko Sakasegawa, Yuko Murakami, Po–Sung Chu, Shingo Usui∥, Yuka Ishibashi∥, Yuko Wakayama, Nobuhito Taniki et al. · 2014 · PLoS ONE
  11. Acute kidney injury to chronic kidney disease transition
    Sarah A. Strausser, Daisuke Nakano, Tomokazu Souma · 2018 · Current Opinion in Nephrology & Hypertension
  12. Assessing the protective effect of rosiglitazone against electronic cigarette/tobacco smoke-induced blood–brain barrier impairment
    Farzane Sivandzade, Luca Cucullo · 2019 · BMC Neuroscience
  13. Impacts of NRF2 activation in non–small‐cell lung cancer cell lines on extracellular metabolites
    Daisuke Saigusa, Ikuko N. Motoike, Sakae Saito, Michael Zorzi, Yuichi Aoki, Hiroshi Kitamura, Mikiko Suzuki, Fumiki Katsuoka, Hirofumi Ishii, Kengo Kinoshita et al. · 2019 · Cancer Science
  14. NRF2 and Key Transcriptional Targets in Melanoma Redox Manipulation
    Evan L. Carpenter, Alyssa L. Becker, Arup K. Indra · 2022 · Cancers
  15. Potential role of molecular hydrogen therapy on oxidative stress and redox signaling in chronic kidney disease
    Cai‐Mei Zheng, Yi‐Chou Hou, Min-Tser Liao, Kuo‐Wang Tsai, Wan‐Chung Hu, Chien-Chih Yeh, Kuo‐Cheng Lu · 2024 · Biomedicine & Pharmacotherapy
  16. 17β-Estradiol Ameliorates Light-Induced Retinal Damage in Sprague–Dawley Rats by Reducing Oxidative Stress
    Shaolan Wang, Baoying Wang, Yan Feng · 2014 · Journal of Molecular Neuroscience
  17. Nrf2 deficiency leads to behavioral, neurochemical and transcriptional changes in mice
    Hiroyuki Muramatsu, Fumiki Katsuoka, Katsuo Toide, Yusuke I. Shimizu, Shoji Furusako, Masayuki P. Yamamoto · 2013 · Genes to Cells
  18. Oncogenic transformation of mesenchymal stem cells decreases Nrf2 expression favoring in vivo tumor growth and poorer survival
    Juan Manuel Funes, Stephen R Henderson, Rachel Kaufman, James M. Flanagan, Mathew P. Robson, Barbara R. Pedley, Salvador Moncada, Chris Boshoff · 2014 · Molecular Cancer
  19. Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and Disease
    Sentiljana Gumeni, Ioannis P. Trougakos · 2016 · Oxidative Medicine and Cellular Longevity
  20. The novel Nrf2 inducer TFM-735 ameliorates experimental autoimmune encephalomyelitis in mice
    Chika Higashi, Atsuko Kawaji, N Tsuda, Makiko Hayashi, Ryota Saito, Yoko Yagishita, Takafumi Suzuki, Akira Uruno, Masaki Nakamura, Kazunari Nakao et al. · 2017 · European Journal of Pharmacology
  21. Nrf2 promotes oesophageal cancer cell proliferation via metabolic reprogramming and detoxification of reactive oxygen species
    Yuki Kitano, Yoshifumi Baba, Shigeki Nakagawa, Keisuke Miyake, Masaaki Iwatsuki, Takatsugu Ishimoto, Yo‐ichi Yamashita, Naoya Yoshida, Masayuki Watanabe, Mitsuyoshi Nakao et al. · 2017 · The Journal of Pathology
  22. Loss of NRF2 function exacerbates the pathophysiology of sickle cell disease in a transgenic mouse model
    Xingguo Zhu, Caixia Xi, Bobby Thomas, Betty S. Pace · 2017 · Blood
  23. Nrf2 and Keap1 abnormalities in esophageal squamous cell carcinoma and association with the effect of chemoradiotherapy
    Jingze Zhang, Qinghua Jiao, Li Kong, Jing Yu, Aiju Fang, Minghuan Li, Jinming Yu · 2018 · Thoracic Cancer
  24. Reasonably activating Nrf2: A long-term, effective and controllable strategy for neurodegenerative diseases
    Qi Li, Shuaishuai Xing, Ying Chen, Qinghong Liao, Qihang Li, Yang Liu, Siyu He, Feng Feng, Yao Chen, Jie Zhang et al. · 2019 · European Journal of Medicinal Chemistry
  25. How DNA methylation affects the Warburg effect
    Xingxin Zhu, Zefeng Xuan, Jun Chen, Zequn Li, Shusen Zheng, Penghong Song · 2020 · International Journal of Biological Sciences
  26. Conflicting metabolic alterations in cancer stem cells and regulation by the stromal niche
    Tadahito Yasuda, Takatsugu Ishimoto, Hideo Baba · 2021 · Regenerative Therapy
  27. The multifaceted role of NRF2 in cancer progression and cancer stem cells maintenance
    Bo-Hyun Choi, Jin Myung Kim, Mi‐Kyoung Kwak · 2021 · Archives of Pharmacal Research
  28. Skeletal muscle-specific Keap1 disruption modulates fatty acid utilization and enhances exercise capacity in female mice
    Takahiro Onoki, Yoshihiro Izumi, Masatomo Takahashi, Shohei Murakami, Daisuke Matsumaru, Nao Ohta, Sisca Meida Wati, Nozomi Hatanaka, Fumiki Katsuoka, Mitsuharu Okutsu et al. · 2021 · Redox Biology
  29. A PTEN variant uncouples longevity from impaired fitness in Caenorhabditis elegans with reduced insulin/IGF-1 signaling
    Hae‐Eun H. Park, Wooseon Hwang, Seokjin Ham, Eunah Kim, Özlem Altıntaş, Sang‐Soon Park, Heehwa G. Son, Yujin Lee, Dong-Yeop Lee, Won Do Heo et al. · 2021 · Nature Communications
  30. Targeting the redox imbalance in mitochondria: A novel mode for cancer therapy
    Shalini Mani, Geeta Swargiary, Stephen John Ralph · 2021 · Mitochondrion
  31. Switching of Redox Signaling by Prdx6 Expression Decides Cellular Fate by Hormetic Phenomena Involving Nrf2 and Reactive Oxygen Species
    Bhavana Chhunchha, Eri Kubo, Dhirendra P. Singh · 2022 · Cells
  32. Association of nanoparticles and Nrf2 with various oxidative stress-mediated diseases
    Rekha Thiruvengadam, Baskar Venkidasamy, Ramkumar Samynathan, Govindasamy Rajakumar, Muthu Thiruvengadam, Jin Hee Kim · 2023 · Chemico-Biological Interactions
  33. Continuous activation of Nrf2 and its target antioxidant enzymes leads to arsenite-induced malignant transformation of human bronchial epithelial cells
    Yang Xu, Dapeng Wang, Yuan Ma, Xiguo Xu, Zhen Hua Zhu, Xiaojuan Wang, Hanyi Deng, Chunchun Li, Min Chen, Jian Tong et al. · 2015 · Toxicology and Applied Pharmacology
  34. Heme oxygenase-1: an emerging therapeutic target to curb cardiac pathology
    Gábor Czibik, Geneviève Dérumeaux, Daigo Sawaki, Guro Valen, Roberto Motterlini · 2014 · Basic Research in Cardiology
  35. Silencing Nrf2 impairs glioma cell proliferation via AMPK-activated mTOR inhibition
    Yue Jia, Handong Wang, Qiang Wang, Hui Ding, Heming Wu, Hao Pan · 2015 · Biochemical and Biophysical Research Communications
  36. Soluble factors from stellate cells induce pancreatic cancer cell proliferation via Nrf2-activated metabolic reprogramming and ROS detoxification
    Yuan Seng Wu, Chung Yeng Looi, Kavita S. Subramaniam, Atsushi Masamune, Ivy Chung · 2016 · Oncotarget
  37. Growth and stress response mechanisms underlying post-feeding regenerative organ growth in the Burmese python
    Audra L. Andrew, Blair W. Perry, Daren C. Card, Drew R. Schield, Robert P. Ruggiero, Suzanne E. McGaugh, Amit Choudhary, Stephen M. Secor, Todd A. Castoe · 2017 · BMC Genomics
  38. Molecular Mechanisms Underlying Hepatocellular Carcinoma Induction by Aberrant NRF2 Activation-Mediated Transcription Networks: Interaction of NRF2-KEAP1 Controls the Fate of Hepatocarcinogenesis
    Effi Haque, M. Rezaul Karim, Aamir Salam Teeli, Magdalena Śmiech, Paweł Leszczyński, Dawid Winiarczyk, Emil D. Parvanov, Atanas G. Atanasov, Hiroaki Taniguchi · 2020 · International Journal of Molecular Sciences
  39. High NRF2 Levels Correlate with Poor Prognosis in Colorectal Cancer Patients and with Sensitivity to the Kinase Inhibitor AT9283 In Vitro
    Laura Torrente, Gunjit Maan, Asma O.M. Rezig, Jean A. Quinn, Angus W. Jackson, Andrea Grilli, Laura Casares, Ying Zhang, Evgeny Kulesskiy, Jani Saarela et al. · 2020 · Biomolecules
  40. IKKα inactivation promotes Kras-initiated lung adenocarcinoma development through disrupting major redox regulatory pathways
    Na‐Young Song, Feng Zhu, Zining Wang, Jami Willette‐Brown, Sichuan Xi, Zhonghe Sun, Ling Su, Xiaolin Wu, Buyong Ma, Ruth Nussinov et al. · 2018 · Proceedings of the National Academy of Sciences
  41. Metabolic Adaptation-Mediated Cancer Survival and Progression in Oxidative Stress
    Yongquan Tang, Zhe Zhang, Yan Chen, Siyuan Qin, Li Zhou, Wei Gao, Zhisen Shen · 2022 · Antioxidants
  42. Dysregulated anti-oxidant signalling and compromised mitochondrial integrity negatively influence regulatory T cell function and viability in liver disease
    Trishan Vaikunthanathan, Emmanuelle Landmann, Diana Marin-Correa, Marco Romano, Silvia Cellone Trevelin, Qi Peng, Elena Crespo, Mauro Corrado, Juan José Lozano, Erika L. Pearce et al. · 2023 · EBioMedicine
  43. Loss of Notch1-dependent p21Waf1/Cip1expression influences the Notch1 outcome in tumorigenesis
    Samantha Cialfi, Rocco Palermo, Sonia Manca, Carlo De Blasio, Paula Vargas Romero, Saula Checquolo, Diana Bellavia, Daniela Uccelletti, Michele Saliola, Angelo D’Alessandro et al. · 2014 · Cell Cycle
  44. Renal cell carcinoma: translational aspects of metabolism and therapeutic consequences
    Oscar C. Y. Yang, Patrick Henry Maxwell, Patrick J. Pollard · 2013 · Kidney International
  45. ZNF32 protects against oxidative stress-induced apoptosis by modulating C1QBP transcription
    Kai Li, Bo Gao, Jun Li, Hai‐Ning Chen, Yanyan Li, Yuyan Wei, Di Gong, Junping Gao, Jie Zhang, Weiwei Tan et al. · 2015 · Oncotarget
  46. Genetic inactivation of Nrf2 prevents clonal expansion of initiated cells in a nutritional model of rat hepatocarcinogenesis
    Claudia Orrù, Marta Szydlowska, Keiko Taguchi, Patrizia Zavattari, Andrea Perra, Masayuki P. Yamamoto, Amedeo Columbano · 2018 · Journal of Hepatology
  47. Absence of TXNIP in Humans Leads to Lactic Acidosis and Low Serum Methionine Linked to Deficient Respiration on Pyruvate
    Yurika Katsu-Jiménez, Carmela Vazquez‐Calvo, Camilla Maffezzini, Maria Halldin, Xiaoxiao Peng, Christoph Freyer, Anna Wredenberg, Alfredo Giménez-Cassina, Anna Wedell, Elias S.J. Arnér · 2019 · Diabetes
  48. Mitochondrial biology in airway pathogenesis and the role of NRF2
    Hye‐Youn Cho, Steven R. Kleeberger · 2019 · Archives of Pharmacal Research
  49. Discovering functional evolutionary dependencies in human cancers
    Marco Mina, Arvind Iyer, Daniele Tavernari, Franck Raynaud, Giovanni Ciriello · 2020 · Nature Genetics
  50. Sestrin2 as a potential therapeutic target for cardiovascular diseases
    Anbo Gao, Feng Li, Qun Zhou, Linxi Chen · 2020 · Pharmacological Research
  51. Major ginsenosides from Panax ginseng promote aerobic cellular respiration and SIRT1-mediated mitochondrial biosynthesis in cardiomyocytes and neurons
    Qingxia Huang, Tingting Lou, Jing Lü, Manying Wang, Xuenan Chen, Linyuan Xue, Xiaolei Tang, Wenxiu Qi, Zepeng Zhang, Hang Su et al. · 2022 · Journal of Ginseng Research
  52. Emerging Role of NRF2 Signaling in Cancer Stem Cell Phenotype
    Steffanus Pranoto Hallis, Jin Myung Kim, Mi‐Kyoung Kwak · 2023 · Molecules and Cells
  53. PI3Kγ maintains the self-renewal of acute myeloid leukemia stem cells by regulating the pentose phosphate pathway
    Hao Gu, Chiqi Chen, Zhi-Shuai Hou, Xiadi He, Shaozhen Xie, Jing Ni, Changli Qian, Xin Cheng, Tao Jiang, Ce Yang et al. · 2024 · Blood
  54. Role of Nrf2 in Cancer Photodynamic Therapy: Regulation of Human ABC Transporter ABCG2
    Toshihisa Ishikawa, Yoshinaga Kajimoto, Wei Yan Sun, Hiroshi Nakagawa, Yutaka Inoue, Yoji Ikegami, Shin‐Ichi Miyatake, Toshihiko Kuroiwa · 2013 · Journal of Pharmaceutical Sciences
  55. Nrf2 inhibition sensitizes cholangiocarcinoma cells to cytotoxic and antiproliferative activities of chemotherapeutic agents
    Papavee Samatiwat, Auemduan Prawan, Laddawan Senggunprai, Upa Kukongviriyapan, Veerapol Kukongviriyapan · 2016 · Tumor Biology
  56. Novel Grb14-Mediated Cross Talk between Insulin and p62/Nrf2 Pathways Regulates Liver Lipogenesis and Selective Insulin Resistance
    Lucie Popineau, Lucille Morzyglod, Nadège Carré, Michèle Caüzac, Pascale Bossard, Carina Prip‐Buus, Véronique Lenoir, Bruno Ragazzon, Véronique Fauveau, Lorenne Robert et al. · 2016 · Molecular and Cellular Biology
  57. Activation of Nrf2 Is Required for Normal and ChREBPα-Augmented Glucose-Stimulated β-Cell Proliferation
    Anil T. Kumar, Liora S. Katz, Anna M. Schulz, Mi-Sung Kim, Lee B. Honig, Lucy Qian Li, Bennett Davenport, Dirk Homann, Adolfo Garcı́a-Ocaña, Mark A. Herman et al. · 2018 · Diabetes
  58. Ad4BP/SF-1 regulates cholesterol synthesis to boost the production of steroids
    Takashi Baba, Hiroyuki Otake, Miki Inoue, Tetsuya Sato, Yasuhiro Ishihara, Ju-Yeon Moon, Megumi Tsuchiya, Kanako Miyabayashi, Hidesato Ogawa, Yuichi Shima et al. · 2018 · Communications Biology
  59. Keap1-Nrf2 System Plays an Important Role in Invariant Natural Killer T Cell Development and Homeostasis
    Kalyani Pyaram, Ajay Kumar, Yeung‐Hyen Kim, Sanjeev Noel, Sekhar P. Reddy, Hamid Rabb, Cheong‐Hee Chang · 2019 · Cell Reports
  60. Transcription factor NRF2 uses the Hippo pathway effector TAZ to induce tumorigenesis in glioblastomas
    Maribel Escoll, Diego Lastra, Marta Pajares, Natalia Robledinos-Antón, Ana Isabel Rojo, Raquel Fernández-Ginés, Marta Mendiola, Virginia Martínez-Marín, I. Esteban, Pilar López‐Larrubia et al. · 2020 · Redox Biology
  61. Antiproliferative Activity of Ursolic Acid in MDA-MB-231 Human Breast Cancer Cells through Nrf2 Pathway Regulation
    Xi Zhang, Tong Li, Er Sheng Gong, Rui Hai Liu · 2020 · Journal of Agricultural and Food Chemistry
  62. Integrative analyses of gene expression and chemosensitivity of patient-derived ovarian cancer spheroids link G6PD-driven redox metabolism to cisplatin chemoresistance
    Kaoru Yamawaki, Yutaro Mori, Hiroaki Sakai, Yusuke Kanda, Daisuke Shiokawa, Haruka Ueda, Tatsuya Ishiguro, Kosuke Yoshihara, Kazunori Nagasaka, Takashi Onda et al. · 2021 · Cancer Letters
  63. HIPK2 in cancer biology and therapy: Recent findings and future perspectives
    Andrea Conte, Valeria Valente, Simona Paladino, Giovanna Maria Pierantoni · 2022 · Cellular Signalling
  64. Effect of Zearalenone-Induced Ferroptosis on Mice Spermatogenesis
    Yajing Li, Zhendong Zhu, Haixiang Cui · 2022 · Animals
  65. The nuclear factor erythroid 2-related factor 2/p53 axis in breast cancer
    Hadi Fakheri, Mir Amirhossein Sajadi, Ahmad Afrashteh, Wenbiao Ma, Lei Xia, Mohammad Valilo · 2023 · Biochemia Medica
  66. NRF2 activation in the heart induces glucose metabolic reprogramming and reduces cardiac dysfunction via upregulation of the pentose phosphate pathway
    Anna Zoccarato, Ioannis Smyrnias, Christina Maria Reumiller, Anne Dragøy Hafstad, Mei Chong, Daniel A. Richards, Célio X.C. Santos, Asjad Visnagri, Sharwari Verma, Daniel I. Bromage et al. · 2024 · Cardiovascular Research
  67. Diminished stress resistance and defective adaptive homeostasis in age-related diseases
    Naomi Lomeli, Daniela Annenelie Bota, Kelvin J.A. Davies · 2017 · Clinical Science
  68. dCK negatively regulates the NRF 2/ ARE axis and ROS production in pancreatic cancer
    Qiangsheng Hu, Yi Qin, Jinfeng Xiang, Wensheng Liu, Wenyan Xu, Qiqing Sun, Shunrong Ji, Jiang Liu, Zheng Zhang, Quanxing Ni et al. · 2018 · Cell Proliferation
  69. Antioxidants as a Double-Edged Sword in the Treatment of Cancer
    Majid Asadi-Samani, Najmeh Kaffash Farkhad, Mohammad‐Reza Mahmoudian‐Sani, Hedayatollah Shirzad · 2019 · IntechOpen eBooks
  70. Repurposing drugs as pro‐oxidant redox modifiers to eliminate cancer stem cells and improve the treatment of advanced stage cancers
    Stephen John Ralph, Sam Nozuhur, Reem Ali ALHulais, Sara Rodríguez‐Enríquez, Rafael Moreno‐Sánchez · 2019 · Medicinal Research Reviews
  71. Activation of the Melanocortin-1 Receptor by NDP-MSH Attenuates Oxidative Stress and Neuronal Apoptosis through PI3K/Akt/Nrf2 Pathway after Intracerebral Hemorrhage in Mice
    Siming Fu, Xu Luo, Xuan Wu, Tongyu Zhang, Linggui Gu, Yiying Wang, Meng Gao, Yuan Zeng Cheng, Zongyi Xie · 2020 · Oxidative Medicine and Cellular Longevity
  72. Nrf2 Activation: Involvement in Central Nervous System Traumatic Injuries. A Promising Therapeutic Target of Natural Compounds
    Serena Silvestro, Emanuela Mazzon · 2022 · International Journal of Molecular Sciences
  73. Rexinoid inhibits Nrf2-mediated transcription through retinoid X receptor alpha
    Jiaguo Wu, Hongyan Wang, Xiuwen Tang · 2014 · Biochemical and Biophysical Research Communications
  74. Camptothecin Sensitizes Hepatocellular Carcinoma Cells to Sorafenib- Induced Ferroptosis Via Suppression of Nrf2
    Ahmed S. Elkateb, Shahira Nofal, Sahar Abd El-mohsen Ali, Hanaa B. Atya · 2023 · Inflammation
  75. Electrophilic metabolites targeting the KEAP1/NRF2 partnership
    Albena T. Dinkova‐Kostova, Henriikka Hakomäki, Anna–Liisa Levonen · 2024 · Current Opinion in Chemical Biology
  76. Role of the transcription factor NRF2 in maintaining the integrity of the Blood-Brain Barrier
    Eduardo Cazalla, Antonio Cuadrado, Ángel J. García‐Yagüe · 2024 · Fluids and Barriers of the CNS
  77. Naringenin Attenuates H2O2-Induced Mitochondrial Dysfunction by an Nrf2-Dependent Mechanism in SH-SY5Y Cells
    Marcos Roberto de Oliveira, Flávia Bittencourt Brasil, Cláudia Marlise Balbinotti Andrade · 2017 · Neurochemical Research
  78. Genome-wide global identification of NRF2 binding sites in A549 non-small cell lung cancer cells by ChIP-Seq reveals NRF2 regulation of genes involved in focal adhesion pathways
    Akhileshwar Namani, Kaihua Liu, Shengcun Wang, Xihang Zhou, Yijiao Liao, Hongyan Wang, Xiu Jun Wang, Xiuwen Tang · 2019 · Aging
  79. Arginine methylation of ribose-5-phosphate isomerase A senses glucose to promote human colorectal cancer cell survival
    Jizheng Guo, Qixiang Zhang, Ying Su, Xiaochen Lu, Yiping Wang, Miao Yin, Weiguo Hu, Wenyu Wen, Qun‐Ying Lei · 2020 · Science China Life Sciences
  80. Acute hypoxia effects on Keap1/Nrf2 (Mafs)-GST pathway related oxidative metabolism in muscle of Japanese flounder (Paralichthys olivaceus)
    Binghua Liu, Haishen Wen, Xiaohui Li, Jun Yang, Guangling Li, Meizhao Zhang, Jifang Li, Feng He · 2021 · The Science of The Total Environment
  81. Role of CD133/NRF2 Axis in the Development of Colon Cancer Stem Cell-Like Properties
    Jimin Park, Seung Ki Kim, Steffanus Pranoto Hallis · 2022 · Frontiers in Oncology
  82. The Role of Sulfhydryl Reactivity of Small Molecules for the Activation of the KEAP1/NRF2 Pathway and the Heat Shock Response
    Albena T. Dinkova‐Kostova · 2012 · Scientifica
  83. Oncogenic KRAS triggers metabolic reprogramming in pancreatic ductal adenocarcinoma
    Xuqing Shen, Ningning Niu, Jing Xue · 2022 · Journal of Translational Internal Medicine
  84. Redox Dysregulation in the Tumor Microenvironment Contributes to Cancer Metastasis
    Wanning Liu, Boda Wang, Mingzhen Zhou, Dan Liu, Fulin Chen, Xiaodi Zhao, Yuanyuan Lu · 2023 · Antioxidants and Redox Signaling
  85. NF-E2-related factor 2 promotes compensatory liver hypertrophy after portal vein branch ligation in mice
    Keiichi Shirasaki, Keiko Taguchi, Michiaki Unno, Hozumi Motohashi, Masayuki P. Yamamoto · 2014 · Hepatology
  86. Hexokinase 2 and nuclear factor erythroid 2–related factor 2 transcriptionally coactivate xanthine oxidoreductase expression in stressed glioma cells
    Touseef Sheikh, Piyushi Gupta, Pruthvi Gowda, Shruti Patrick, Ellora Sen · 2018 · Journal of Biological Chemistry
  87. Multi-omics analysis: Repeated exposure of a 3D bronchial tissue culture to whole-cigarette smoke.
    S. Ishikawa, K. Matsumura, N. Kitamura, Y. Takanami, S. Ito · 2019 · Toxicology in Vitro
  88. Nrf2 Activator RS9 Suppresses Pathological Ocular Angiogenesis and Hyperpermeability
    Shinsuke Nakamura, Tetsuro Noguchi, Yuki Inoue, Shuji Sakurai, Anri Nishinaka, Yoshifumi Hida, Tomomi Masuda, Yasuhiro Nakagami, Naoto Horai, Hideshi Tsusaki et al. · 2019 · Investigative Ophthalmology & Visual Science
  89. SLC25A32 sustains cancer cell proliferation by regulating flavin adenine nucleotide (FAD) metabolism
    Valeria Santoro, Ilya Kovalenko, Kim Vriens, Stefan Christen, Andreas Bernthaler, Andrea Haegebarth, Sarah‐Maria Fendt, Sven Christian · 2020 · Oncotarget
  90. Molecular mechanisms and systemic targeting of NRF2 dysregulation in cancer
    Jong-Su Kang, Le Ba Nam, Ok-Kyung Yoo, Young‐Sam Keum · 2020 · Biochemical Pharmacology
  91. The PIK3CA-E545K-SIRT4 signaling axis reduces radiosensitivity by promoting glutamine metabolism in cervical cancer
    Wei Jiang, Xueyan Ouyang, Zhaodong Ji, Wanling Shi, Yutuan Wu, Qianlan Yao, Yi Wang, Wentao Yang, Libing Xiang, Huijuan Yang · 2023 · Cancer Letters
  92. A Somatic Mutation of the KEAP1 Gene in Malignant Melanoma Is Involved in Aberrant NRF2 Activation and an Increase in Intrinsic Drug Resistance
    Shinpei Miura, Masahiko Shibazaki, Shuya Kasai, Shinji Yasuhira, Ayano Watanabe, Tsuyoshi Inoue, Yuich Kageshita, Kanako Tsunoda, Kazuhiro Takahashi, Toshihide Akasaka et al. · 2013 · Journal of Investigative Dermatology
  93. Dual pharmacological inhibition of glutathione and thioredoxin systems synergizes to kill colorectal carcinoma stem cells
    Genki Tanaka, Ken-ichi Inoue, Takayuki Shimizu, Kazumi Akimoto, Keiichi Kubota · 2016 · Cancer Medicine
  94. Carnosine Prevents Type 2 Diabetes-Induced Osteoarthritis Through the ROS/NF-κB Pathway
    Yue Yang, Yang Wang, Yawei Kong, Xiaoning Zhang, He Zhang, Yi Gang, Lunhao Bai · 2018 · Frontiers in Pharmacology
  95. CD26/DPP4 as a Therapeutic Target in Nonalcoholic Steatohepatitis Associated Hepatocellular Carcinoma
    Sohji Nishina, Keisuke Hino · 2022 · Cancers
  96. Influence of intermittent fasting on autophagy in the liver
    Yanan Ma, Xuemei Jiang, Wei Tang, Peipei Song · 2023 · BioScience Trends
  97. Aqueous extract of Cortex Dictamni protects H9c2 cardiomyocytes from hypoxia/reoxygenation-induced oxidative stress and apoptosis by PI3K/Akt signaling pathway
    Li Lin, Yunfeng Zhou, Yanlin Li, Lili Wang, Lan Sun, Lidong Zhou, Hiderori Arai, Yun Qi, Xu Yang · 2017 · Biomedicine & Pharmacotherapy
  98. Antioxidant effects of sulforaphane in human HepG2 cells and immortalised hepatocytes
    Peng Liu, Wei Wang, JONATHAN C. Y. TANG, Richard Peter Bowater, Yongping Bao · 2019 · Food and Chemical Toxicology
  99. The β -TrCP-Mediated Pathway Cooperates with the Keap1-Mediated Pathway in Nrf2 Degradation In Vivo
    Ayumi Kuga, Kouhei Tsuchida, Harit Panda, Makoto Horiuchi, Akihito Otsuki, Keiko Taguchi, Fumiki Katsuoka, Mikiko Suzuki, Masayuki P. Yamamoto · 2022 · Molecular and Cellular Biology
  100. Cystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation
    Haoran Zhu, Keefe T. Chan, Xinran Huang, Carmelo Cerra, Shaun Blake, Anna Trigos, Dovile Anderson, Darren J. Creek, David Peter De Souza, Xi Wang et al. · 2022 · eLife