Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming
Mitsuishi, Yoichiro, Taguchi, Keiko, Kawatani, Yukie, Shibata, Tatsuhiro, Nukiwa, Toshihiro, Aburatani, Hiroyuki, Yamamoto, Masayuki, Motohashi, Hozumi·2012·Cancer Cell
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- The flavonoid Astragalin shows anti‐tumor activity and inhibits PI3K/AKT signaling in gastric cancerZhongqing Wang, Jian Lv, Xiufang Li, Qing Lin · 2021 · Chemical Biology & Drug Design
- Newly synthesized chitosan-nanoparticles attenuate carbendazim hepatorenal toxicity in rats via activation of Nrf2/HO1 signalling pathwayElshazly Mo, Yasmin A. Ebedy, Marwa A. Ibrahim, Khaled Y. Farroh, Eman Ibrahim Hassanen · 2022 · Scientific Reports
- Nrf2 is essential for timely M phase entry of replicating hepatocytes during liver regenerationYuhong Zou, Min Hu, Joonyong Lee, Shashank Manohar Nambiar, Veronica Garcia, Qi Bao, Jefferson Y. Chan, Guoli Dai · 2014 · American Journal of Physiology-Gastrointestinal and Liver Physiology
- Prominent Steatosis with Hypermetabolism of the Cell Line Permissive for Years of Infection with Hepatitis C VirusKazuo Sugiyama, Hirotoshi Ebinuma, Nobuhiro Nakamoto, Noriko Sakasegawa, Yuko Murakami, Po–Sung Chu, Shingo Usui∥, Yuka Ishibashi∥, Yuko Wakayama, Nobuhito Taniki et al. · 2014 · PLoS ONE
- Acute kidney injury to chronic kidney disease transitionSarah A. Strausser, Daisuke Nakano, Tomokazu Souma · 2018 · Current Opinion in Nephrology & Hypertension
- Assessing the protective effect of rosiglitazone against electronic cigarette/tobacco smoke-induced blood–brain barrier impairmentFarzane Sivandzade, Luca Cucullo · 2019 · BMC Neuroscience
- Impacts of NRF2 activation in non–small‐cell lung cancer cell lines on extracellular metabolitesDaisuke Saigusa, Ikuko N. Motoike, Sakae Saito, Michael Zorzi, Yuichi Aoki, Hiroshi Kitamura, Mikiko Suzuki, Fumiki Katsuoka, Hirofumi Ishii, Kengo Kinoshita et al. · 2019 · Cancer Science
- NRF2 and Key Transcriptional Targets in Melanoma Redox ManipulationEvan L. Carpenter, Alyssa L. Becker, Arup K. Indra · 2022 · Cancers
- Potential role of molecular hydrogen therapy on oxidative stress and redox signaling in chronic kidney diseaseCai‐Mei Zheng, Yi‐Chou Hou, Min-Tser Liao, Kuo‐Wang Tsai, Wan‐Chung Hu, Chien-Chih Yeh, Kuo‐Cheng Lu · 2024 · Biomedicine & Pharmacotherapy
- 17β-Estradiol Ameliorates Light-Induced Retinal Damage in Sprague–Dawley Rats by Reducing Oxidative StressShaolan Wang, Baoying Wang, Yan Feng · 2014 · Journal of Molecular Neuroscience
- Nrf2 deficiency leads to behavioral, neurochemical and transcriptional changes in miceHiroyuki Muramatsu, Fumiki Katsuoka, Katsuo Toide, Yusuke I. Shimizu, Shoji Furusako, Masayuki P. Yamamoto · 2013 · Genes to Cells
- Oncogenic transformation of mesenchymal stem cells decreases Nrf2 expression favoring in vivo tumor growth and poorer survivalJuan Manuel Funes, Stephen R Henderson, Rachel Kaufman, James M. Flanagan, Mathew P. Robson, Barbara R. Pedley, Salvador Moncada, Chris Boshoff · 2014 · Molecular Cancer
- Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and DiseaseSentiljana Gumeni, Ioannis P. Trougakos · 2016 · Oxidative Medicine and Cellular Longevity
- The novel Nrf2 inducer TFM-735 ameliorates experimental autoimmune encephalomyelitis in miceChika Higashi, Atsuko Kawaji, N Tsuda, Makiko Hayashi, Ryota Saito, Yoko Yagishita, Takafumi Suzuki, Akira Uruno, Masaki Nakamura, Kazunari Nakao et al. · 2017 · European Journal of Pharmacology
- Nrf2 promotes oesophageal cancer cell proliferation via metabolic reprogramming and detoxification of reactive oxygen speciesYuki Kitano, Yoshifumi Baba, Shigeki Nakagawa, Keisuke Miyake, Masaaki Iwatsuki, Takatsugu Ishimoto, Yo‐ichi Yamashita, Naoya Yoshida, Masayuki Watanabe, Mitsuyoshi Nakao et al. · 2017 · The Journal of Pathology
- Loss of NRF2 function exacerbates the pathophysiology of sickle cell disease in a transgenic mouse modelXingguo Zhu, Caixia Xi, Bobby Thomas, Betty S. Pace · 2017 · Blood
- Nrf2 and Keap1 abnormalities in esophageal squamous cell carcinoma and association with the effect of chemoradiotherapyJingze Zhang, Qinghua Jiao, Li Kong, Jing Yu, Aiju Fang, Minghuan Li, Jinming Yu · 2018 · Thoracic Cancer
- Reasonably activating Nrf2: A long-term, effective and controllable strategy for neurodegenerative diseasesQi Li, Shuaishuai Xing, Ying Chen, Qinghong Liao, Qihang Li, Yang Liu, Siyu He, Feng Feng, Yao Chen, Jie Zhang et al. · 2019 · European Journal of Medicinal Chemistry
- How DNA methylation affects the Warburg effectXingxin Zhu, Zefeng Xuan, Jun Chen, Zequn Li, Shusen Zheng, Penghong Song · 2020 · International Journal of Biological Sciences
- Conflicting metabolic alterations in cancer stem cells and regulation by the stromal nicheTadahito Yasuda, Takatsugu Ishimoto, Hideo Baba · 2021 · Regenerative Therapy
- The multifaceted role of NRF2 in cancer progression and cancer stem cells maintenanceBo-Hyun Choi, Jin Myung Kim, Mi‐Kyoung Kwak · 2021 · Archives of Pharmacal Research
- Skeletal muscle-specific Keap1 disruption modulates fatty acid utilization and enhances exercise capacity in female miceTakahiro Onoki, Yoshihiro Izumi, Masatomo Takahashi, Shohei Murakami, Daisuke Matsumaru, Nao Ohta, Sisca Meida Wati, Nozomi Hatanaka, Fumiki Katsuoka, Mitsuharu Okutsu et al. · 2021 · Redox Biology
- A PTEN variant uncouples longevity from impaired fitness in Caenorhabditis elegans with reduced insulin/IGF-1 signalingHae‐Eun H. Park, Wooseon Hwang, Seokjin Ham, Eunah Kim, Özlem Altıntaş, Sang‐Soon Park, Heehwa G. Son, Yujin Lee, Dong-Yeop Lee, Won Do Heo et al. · 2021 · Nature Communications
- Targeting the redox imbalance in mitochondria: A novel mode for cancer therapyShalini Mani, Geeta Swargiary, Stephen John Ralph · 2021 · Mitochondrion
- Switching of Redox Signaling by Prdx6 Expression Decides Cellular Fate by Hormetic Phenomena Involving Nrf2 and Reactive Oxygen SpeciesBhavana Chhunchha, Eri Kubo, Dhirendra P. Singh · 2022 · Cells
- Association of nanoparticles and Nrf2 with various oxidative stress-mediated diseasesRekha Thiruvengadam, Baskar Venkidasamy, Ramkumar Samynathan, Govindasamy Rajakumar, Muthu Thiruvengadam, Jin Hee Kim · 2023 · Chemico-Biological Interactions
- Continuous activation of Nrf2 and its target antioxidant enzymes leads to arsenite-induced malignant transformation of human bronchial epithelial cellsYang Xu, Dapeng Wang, Yuan Ma, Xiguo Xu, Zhen Hua Zhu, Xiaojuan Wang, Hanyi Deng, Chunchun Li, Min Chen, Jian Tong et al. · 2015 · Toxicology and Applied Pharmacology
- Heme oxygenase-1: an emerging therapeutic target to curb cardiac pathologyGábor Czibik, Geneviève Dérumeaux, Daigo Sawaki, Guro Valen, Roberto Motterlini · 2014 · Basic Research in Cardiology
- Silencing Nrf2 impairs glioma cell proliferation via AMPK-activated mTOR inhibitionYue Jia, Handong Wang, Qiang Wang, Hui Ding, Heming Wu, Hao Pan · 2015 · Biochemical and Biophysical Research Communications
- Soluble factors from stellate cells induce pancreatic cancer cell proliferation via Nrf2-activated metabolic reprogramming and ROS detoxificationYuan Seng Wu, Chung Yeng Looi, Kavita S. Subramaniam, Atsushi Masamune, Ivy Chung · 2016 · Oncotarget
- Growth and stress response mechanisms underlying post-feeding regenerative organ growth in the Burmese pythonAudra L. Andrew, Blair W. Perry, Daren C. Card, Drew R. Schield, Robert P. Ruggiero, Suzanne E. McGaugh, Amit Choudhary, Stephen M. Secor, Todd A. Castoe · 2017 · BMC Genomics
- Molecular Mechanisms Underlying Hepatocellular Carcinoma Induction by Aberrant NRF2 Activation-Mediated Transcription Networks: Interaction of NRF2-KEAP1 Controls the Fate of HepatocarcinogenesisEffi Haque, M. Rezaul Karim, Aamir Salam Teeli, Magdalena Śmiech, Paweł Leszczyński, Dawid Winiarczyk, Emil D. Parvanov, Atanas G. Atanasov, Hiroaki Taniguchi · 2020 · International Journal of Molecular Sciences
- High NRF2 Levels Correlate with Poor Prognosis in Colorectal Cancer Patients and with Sensitivity to the Kinase Inhibitor AT9283 In VitroLaura Torrente, Gunjit Maan, Asma O.M. Rezig, Jean A. Quinn, Angus W. Jackson, Andrea Grilli, Laura Casares, Ying Zhang, Evgeny Kulesskiy, Jani Saarela et al. · 2020 · Biomolecules
- IKKα inactivation promotes Kras-initiated lung adenocarcinoma development through disrupting major redox regulatory pathwaysNa‐Young Song, Feng Zhu, Zining Wang, Jami Willette‐Brown, Sichuan Xi, Zhonghe Sun, Ling Su, Xiaolin Wu, Buyong Ma, Ruth Nussinov et al. · 2018 · Proceedings of the National Academy of Sciences
- Metabolic Adaptation-Mediated Cancer Survival and Progression in Oxidative StressYongquan Tang, Zhe Zhang, Yan Chen, Siyuan Qin, Li Zhou, Wei Gao, Zhisen Shen · 2022 · Antioxidants
- Dysregulated anti-oxidant signalling and compromised mitochondrial integrity negatively influence regulatory T cell function and viability in liver diseaseTrishan Vaikunthanathan, Emmanuelle Landmann, Diana Marin-Correa, Marco Romano, Silvia Cellone Trevelin, Qi Peng, Elena Crespo, Mauro Corrado, Juan José Lozano, Erika L. Pearce et al. · 2023 · EBioMedicine
- Loss of Notch1-dependent p21Waf1/Cip1expression influences the Notch1 outcome in tumorigenesisSamantha Cialfi, Rocco Palermo, Sonia Manca, Carlo De Blasio, Paula Vargas Romero, Saula Checquolo, Diana Bellavia, Daniela Uccelletti, Michele Saliola, Angelo D’Alessandro et al. · 2014 · Cell Cycle
- Renal cell carcinoma: translational aspects of metabolism and therapeutic consequencesOscar C. Y. Yang, Patrick Henry Maxwell, Patrick J. Pollard · 2013 · Kidney International
- ZNF32 protects against oxidative stress-induced apoptosis by modulating C1QBP transcriptionKai Li, Bo Gao, Jun Li, Hai‐Ning Chen, Yanyan Li, Yuyan Wei, Di Gong, Junping Gao, Jie Zhang, Weiwei Tan et al. · 2015 · Oncotarget
- Genetic inactivation of Nrf2 prevents clonal expansion of initiated cells in a nutritional model of rat hepatocarcinogenesisClaudia Orrù, Marta Szydlowska, Keiko Taguchi, Patrizia Zavattari, Andrea Perra, Masayuki P. Yamamoto, Amedeo Columbano · 2018 · Journal of Hepatology
- Absence of TXNIP in Humans Leads to Lactic Acidosis and Low Serum Methionine Linked to Deficient Respiration on PyruvateYurika Katsu-Jiménez, Carmela Vazquez‐Calvo, Camilla Maffezzini, Maria Halldin, Xiaoxiao Peng, Christoph Freyer, Anna Wredenberg, Alfredo Giménez-Cassina, Anna Wedell, Elias S.J. Arnér · 2019 · Diabetes
- Mitochondrial biology in airway pathogenesis and the role of NRF2Hye‐Youn Cho, Steven R. Kleeberger · 2019 · Archives of Pharmacal Research
- Discovering functional evolutionary dependencies in human cancersMarco Mina, Arvind Iyer, Daniele Tavernari, Franck Raynaud, Giovanni Ciriello · 2020 · Nature Genetics
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- Major ginsenosides from Panax ginseng promote aerobic cellular respiration and SIRT1-mediated mitochondrial biosynthesis in cardiomyocytes and neuronsQingxia Huang, Tingting Lou, Jing Lü, Manying Wang, Xuenan Chen, Linyuan Xue, Xiaolei Tang, Wenxiu Qi, Zepeng Zhang, Hang Su et al. · 2022 · Journal of Ginseng Research
- Emerging Role of NRF2 Signaling in Cancer Stem Cell PhenotypeSteffanus Pranoto Hallis, Jin Myung Kim, Mi‐Kyoung Kwak · 2023 · Molecules and Cells
- PI3Kγ maintains the self-renewal of acute myeloid leukemia stem cells by regulating the pentose phosphate pathwayHao Gu, Chiqi Chen, Zhi-Shuai Hou, Xiadi He, Shaozhen Xie, Jing Ni, Changli Qian, Xin Cheng, Tao Jiang, Ce Yang et al. · 2024 · Blood
- Role of Nrf2 in Cancer Photodynamic Therapy: Regulation of Human ABC Transporter ABCG2Toshihisa Ishikawa, Yoshinaga Kajimoto, Wei Yan Sun, Hiroshi Nakagawa, Yutaka Inoue, Yoji Ikegami, Shin‐Ichi Miyatake, Toshihiko Kuroiwa · 2013 · Journal of Pharmaceutical Sciences
- Nrf2 inhibition sensitizes cholangiocarcinoma cells to cytotoxic and antiproliferative activities of chemotherapeutic agentsPapavee Samatiwat, Auemduan Prawan, Laddawan Senggunprai, Upa Kukongviriyapan, Veerapol Kukongviriyapan · 2016 · Tumor Biology
- Novel Grb14-Mediated Cross Talk between Insulin and p62/Nrf2 Pathways Regulates Liver Lipogenesis and Selective Insulin ResistanceLucie Popineau, Lucille Morzyglod, Nadège Carré, Michèle Caüzac, Pascale Bossard, Carina Prip‐Buus, Véronique Lenoir, Bruno Ragazzon, Véronique Fauveau, Lorenne Robert et al. · 2016 · Molecular and Cellular Biology
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- Keap1-Nrf2 System Plays an Important Role in Invariant Natural Killer T Cell Development and HomeostasisKalyani Pyaram, Ajay Kumar, Yeung‐Hyen Kim, Sanjeev Noel, Sekhar P. Reddy, Hamid Rabb, Cheong‐Hee Chang · 2019 · Cell Reports
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- Genome-wide global identification of NRF2 binding sites in A549 non-small cell lung cancer cells by ChIP-Seq reveals NRF2 regulation of genes involved in focal adhesion pathwaysAkhileshwar Namani, Kaihua Liu, Shengcun Wang, Xihang Zhou, Yijiao Liao, Hongyan Wang, Xiu Jun Wang, Xiuwen Tang · 2019 · Aging
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