The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
RETRACTED: Coordinated Silencing of MYC-Mediated miR-29 by HDAC3 and EZH2 as a Therapeutic Target of Histone Modification in Aggressive B-Cell Lymphomas
Open accessAbstract
SUMMARY We investigated the transcriptional and epigenetic repression of miR-29 by Myc, HDAC3, and EZH2 in mantle cell lymphoma and other Myc-associated lymphomas. We demonstrate that miR-29 is repressed by Myc through a co-repressor complex with HDAC3 and EZH2. Myc contributes to EZH2 upregulation via repression of the EZH2 targeting miR-26a, and EZH2 induces Myc via inhibition of the Myc targeting miR-494 to create positive feedback. Combined inhibition of HDAC3 and EZH2 cooperatively disrupted the Myc-EZH2-miR-29 axis, resulting in restoration of miR-29 expression, down-regulation of miR-29 targeted genes, and lymphoma growth suppression in vitro and in vivo. These findings define a Myc-mediated miRNA repression mechanism, shed light on Myc lymphomagenesis mechanisms and reveals promising therapeutic targets for aggressive B-cell malignancies.
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Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model
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Widespread microRNA repression by Myc contributes to tumorigenesis
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Self-citationmir-29 regulates Mcl-1 protein expression and apoptosis
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Tcl1 Expression in Chronic Lymphocytic Leukemia Is Regulated by miR-29 and miR-181
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MYC stimulates EZH2 expression by repression of its negative regulator miR-26a
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Metadata
- Authors
- Zhang, X., Zhao, X., Fiskus, W., Lin, J., Lwin, T., Rao, R., Zhang, Y., Chan, J. C., Fu, K., Marquez, V. E., Chen-Kiang, S., Moscinski, L. C., Seto, E., Dalton, W. S., Wright, K. L., Sotomayor, E., Bhalla, K., & Tao, J.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 22
- Issue
- 4
- Pages
- 506-523
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W1971981721
- Cited by
- 276
- References
- 23
- FWCI
- 8.96
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- bronze
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- Zhang, X., Zhao, X., Fiskus, W., Lin, J., Lwin, T., Rao, R., Zhang, Y., Chan, J. C., Fu, K., Marquez, V. E., Chen-Kiang, S., Moscinski, L. C., Seto, E., Dalton, W. S., Wright, K. L., Sotomayor, E., Bhalla, K., & Tao, J. (2012). RETRACTED: Coordinated Silencing of MYC-Mediated miR-29 by HDAC3 and EZH2 as a Therapeutic Target of Histone Modification in Aggressive B-Cell Lymphomas. Cancer Cell. https://doi.org/10.1016/j.ccr.2012.09.003
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
