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Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model
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“Finally, the regulated feedback by miR-26a and miR-26b might be important not only in neurons, but for proliferation/differentiation events in general, as both family members have been implicated with differentiation of other cell types, stemness, and cancer (Wong and Tellam 2008;Huse et al. 2009;Kota et al. 2009;Ma et al. 2010).”
From Intronic miR-26b controls neuronal differentiation by repressing its host transcript,ctdsp2 (2012) · cites this paper as Kota et al. 2009
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Combinatorial microRNA target predictions
Krek, A., Grün, D., Poy, M. N., Wolf, R., Rosenberg, L., Epstein, E. J., MacMenamin, P., da Piedade, I., Gunsalus, K. C., Stoffel, M., et al. (2005) · Nature Genetics · doi:10.1038/ng1536 · Cited by 4,603
Silencing of microRNAs in vivo with ‘antagomirs’
Krützfeldt, J., Rajewsky, N., Braich, R., Rajeev, K. G., Tuschl, T., Manoharan, M., & Stoffel, M. (2005) · Nature · doi:10.1038/nature04303 · Cited by 3,949
A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing
Landgraf, P., Rusu, M., Sheridan, R., Sewer, A., Iovino, N., Aravin, A., Pfeffer, S., Rice, A., Kamphorst, A. O., Landthaler, M., et al. (2007) · Cell · doi:10.1016/j.cell.2007.04.040 · Cited by 3,626
The impact of microRNAs on protein output
Baek, D., Villén, J., Shin, C., Camargo, F. D., Gygi, S. P., & Bartel, D. P. (2008) · Nature · doi:10.1038/nature07242 · Cited by 3,592
Widespread changes in protein synthesis induced by microRNAs
Selbach, M., Schwanhäusser, B., Thierfelder, N., Fang, Z., Khanin, R., & Rajewsky, N. (2008) · Nature · doi:10.1038/nature07228 · Cited by 3,429 · cited 2×
“miRNAs potently influence cellular behavior through the regulation of extensive gene expression networks (Baek et al., 2008; Selbach et al., 2008).”
A microRNA component of the p53 tumour suppressor network
He, L., He, X., Lim, L. P., de Stanchina, E., Xuan, Z., Liang, Y., Xue, W., Zender, L., Magnus, J., Ridzon, D., et al. (2007) · Nature · doi:10.1038/nature05939 · Cited by 2,692
Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis
Maguire, A. M., Simonelli, F., Pierce, E. A., Pugh, E. N., Mingozzi, F., Bennicelli, J., Banfi, S., Marshall, K. A., Testa, F., Surace, E. M., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0802315 · Cited by 2,145
Control of translation and mRNA degradation by miRNAs and siRNAs: Table 1.
Valencia-Sanchez, M. A., Liu, J., Hannon, G. J., & Parker, R. (2006) · Genes & Development · doi:10.1101/gad.1399806 · Cited by 2,060
Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis
Chang, T.-C., Wentzel, E. A., Kent, O. A., Ramachandran, K., Mullendore, M., Lee, K. H., Feldmann, G., Yamakuchi, M., Ferlito, M., Lowenstein, C. J., et al. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.05.010 · Cited by 2,010
Self-citationFatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways
Grimm, D., Streetz, K. L., Jopling, C. L., Storm, T. A., Pandey, K., Davis, C. R., Marion, P., Salazar, F., & Kay, M. A. (2006) · Nature · doi:10.1038/nature04791 · Cited by 1,677
Flagged first, then by citations
Research works printed but not linked: 52
- Alexander, 2008, Potential of AAV vectors in the treatment of metabolic disease, Gene Ther., 15, 831, 10.1038/gt.2008.64 · DOI
- Beer, 2004, Developmental context determines latency of MYC-induced tumorigenesis, PLoS Biol., 2, e332, 10.1371/journal.pbio.0020332 · DOI
- Betel, 2008, The microRNA.org resource: targets and expression, Nucleic Acids Res., 36, D149, 10.1093/nar/gkm995 · DOI
- Bommer, 2007, p53-Mediated activation of miRNA34 candidate tumor-suppressor genes, Curr. Biol., 17, 1298, 10.1016/j.cub.2007.06.068 · DOI
- Calin, 2006, MicroRNA signatures in human cancers, Nat. Rev. Cancer, 6, 857, 10.1038/nrc1997 · DOI
- Calin, 2004, Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers, Proc. Natl. Acad. Sci. USA, 101, 2999, 10.1073/pnas.0307323101 · DOI
- Carter, 2005, Adeno-associated virus vectors in clinical trials, Hum. Gene Ther., 16, 541, 10.1089/hum.2005.16.541 · DOI
- Chang, 2008, Widespread microRNA repression by Myc contributes to tumorigenesis, Nat. Genet., 40, 43, 10.1038/ng.2007.30 · DOI
- de Fougerolles, 2007, Interfering with disease: a progress report on siRNA-based therapeutics, Nat. Rev. Drug Discov., 6, 443, 10.1038/nrd2310 · DOI
- Elmen, 2008, LNA-mediated microRNA silencing in non-human primates, Nature, 452, 896, 10.1038/nature06783 · DOI · Paper page
- Esau, 2006, miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting, Cell Metab., 3, 87, 10.1016/j.cmet.2006.01.005 · DOI · Paper page
- Esquela-Kerscher, 2008, The let-7 microRNA reduces tumor growth in mouse models of lung cancer, Cell Cycle, 7, 759, 10.4161/cc.7.6.5834 · DOI
- Felsher, 1999, Reversible tumorigenesis by MYC in hematopoietic lineages, Mol. Cell, 4, 199, 10.1016/S1097-2765(00)80367-6 · DOI
- Gao, 2002, Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy, Proc. Natl. Acad. Sci. USA, 99, 11854, 10.1073/pnas.182412299 · DOI · Paper page
- Gaur, 2007, Characterization of microRNA expression levels and their biological correlates in human cancer cell lines, Cancer Res., 67, 2456, 10.1158/0008-5472.CAN-06-2698 · DOI · Paper page
- Giering, 2008, Expression of shRNA from a tissue-specific pol II promoter is an effective and safe RNAi therapeutic, Mol. Ther., 16, 1630, 10.1038/mt.2008.144 · DOI
- Grimm, 2007, RNAi and Gene Therapy: a mutual attraction, Hematology (Am Soc Hematol Educ Program), 2007, 473, 10.1182/asheducation-2007.1.473 · DOI
- Grimson, 2007, MicroRNA targeting specificity in mammals: determinants beyond seed pairing, Mol. Cell, 27, 91, 10.1016/j.molcel.2007.06.017 · DOI · Paper page
- He, 2007, microRNAs join the p53 network–another piece in the tumour-suppression puzzle, Nat. Rev. Cancer, 7, 819, 10.1038/nrc2232 · DOI
- Hwang, 2007, A hexanucleotide element directs microRNA nuclear import, Science, 315, 97, 10.1126/science.1136235 · DOI
- Johnson, 2005, RAS is regulated by the let-7 microRNA family, Cell, 120, 635, 10.1016/j.cell.2005.01.014 · DOI
- Kashuba, 2004, RBSP3 (HYA22) is a tumor suppressor gene implicated in major epithelial malignancies, Proc. Natl. Acad. Sci. USA, 101, 4906, 10.1073/pnas.0401238101 · DOI
- Kato, 2008, microRNAs: small molecules with big roles—C. elegans to human cancer, Biol. Cell, 100, 71, 10.1042/BC20070078 · DOI
- Kim, 2005, MicroRNA biogenesis: coordinated cropping and dicing, Nat. Rev. Mol. Cell Biol., 6, 376, 10.1038/nrm1644 · DOI · Paper page
- Kloosterman, 2006, The diverse functions of microRNAs in animal development and disease, Dev. Cell, 11, 441, 10.1016/j.devcel.2006.09.009 · DOI · Paper page
- Kumar, 2008, Suppression of non-small cell lung tumor development by the let-7 microRNA family, Proc. Natl. Acad. Sci. USA, 105, 3903, 10.1073/pnas.0712321105 · DOI
- Kumar, 2007, Impaired microRNA processing enhances cellular transformation and tumorigenesis, Nat. Genet., 39, 673, 10.1038/ng2003 · DOI
- Love, 2008, Not miR-ly small RNAs: big potential for microRNAs in therapy, J. Allergy Clin. Immunol., 121, 309, 10.1016/j.jaci.2007.12.1167 · DOI
- Lu, 2005, MicroRNA expression profiles classify human cancers, Nature, 435, 834, 10.1038/nature03702 · DOI
- Lujambio, 2007, CpG island hypermethylation of tumor suppressor microRNAs in human cancer, Cell Cycle, 6, 1455, 10.4161/cc.6.12.4408 · DOI
- McBride, 2008, Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: implications for the therapeutic development of RNAi, Proc. Natl. Acad. Sci. USA, 105, 5868, 10.1073/pnas.0801775105 · DOI
- McCarty, 2008, Self-complementary AAV vectors; advances and applications, Mol. Ther., 16, 1648, 10.1038/mt.2008.171 · DOI · Paper page
- Nakai, 2005, Unrestricted hepatocyte transduction with adeno-associated virus serotype 8 vectors in mice, J. Virol., 79, 214, 10.1128/JVI.79.1.214-224.2005 · DOI
- O'Donnell, 2005, c-Myc-regulated microRNAs modulate E2F1 expression, Nature, 435, 839, 10.1038/nature03677 · DOI · Paper page
- Park, 2008, Cancer gene therapy using adeno-associated virus vectors, Front. Biosci., 13, 2653, 10.2741/2872 · DOI
- Pathak, 2008, Nano-vectors for efficient liver specific gene transfer, Int. J. Nanomedicine, 3, 31
- Peng, 2000, Transduction of hepatocellular carcinoma (HCC) using recombinant adeno-associated virus (rAAV): in vitro and in vivo effects of genotoxic agents, J. Hepatol., 32, 975, 10.1016/S0168-8278(00)80102-6 · DOI
- Raver-Shapira, 2007, Transcriptional activation of miR-34a contributes to p53-mediated apoptosis, Mol. Cell, 26, 731, 10.1016/j.molcel.2007.05.017 · DOI
- Roberts, 2008, Sorafenib in liver cancer–just the beginning, N. Engl. J. Med., 359, 420, 10.1056/NEJMe0802241 · DOI
- Rodino-Klapac, 2007, A translational approach for limb vascular delivery of the micro-dystrophin gene without high volume or high pressure for treatment of Duchenne muscular dystrophy, J. Transl. Med., 5, 45, 10.1186/1479-5876-5-45 · DOI
- Shen, 2008, A novel and effective hepatocyte growth factor kringle 1 domain and p53 cocktail viral gene therapy for the treatment of hepatocellular carcinoma, Cancer Lett., 272, 268, 10.1016/j.canlet.2008.03.064 · DOI
- Stenvang, 2008, The utility of LNA in microRNA-based cancer diagnostics and therapeutics, Semin. Cancer Biol., 18, 89, 10.1016/j.semcancer.2008.01.004 · DOI
- Tarasov, 2007, Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest, Cell Cycle, 6, 1586, 10.4161/cc.6.13.4436 · DOI
- Thorgeirsson, 2002, Molecular pathogenesis of human hepatocellular carcinoma, Nat. Genet., 31, 339, 10.1038/ng0802-339 · DOI
- Ventura, 2009, MicroRNAs and cancer: short RNAs go a long way, Cell, 136, 586, 10.1016/j.cell.2009.02.005 · DOI
- Vermeulen, 2003, The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer, Cell Prolif., 36, 131, 10.1046/j.1365-2184.2003.00266.x · DOI
- Visone, 2007, Specific microRNAs are downregulated in human thyroid anaplastic carcinomas, Oncogene, 26, 7590, 10.1038/sj.onc.1210564 · DOI
- Wakabayashi-Ito, 1994, Characterization of the regulatory elements in the promoter of the human elongation factor-1 alpha gene, J. Biol. Chem., 269, 29831, 10.1016/S0021-9258(18)43956-7 · DOI
- Wang, 2003, Rapid and highly efficient transduction by double-stranded adeno-associated virus vectors in vitro and in vivo, Gene Ther., 10, 2105, 10.1038/sj.gt.3302133 · DOI · Paper page
- Wienholds, 2005, MicroRNA expression in zebrafish embryonic development, Science, 309, 310, 10.1126/science.1114519 · DOI · Paper page
- Xi, 2006, Differentially regulated micro-RNAs and actively translated messenger RNA transcripts by tumor suppressor p53 in colon cancer, Clin. Cancer Res., 12, 2014, 10.1158/1078-0432.CCR-05-1853 · DOI
- Zhang, 2006, microRNAs exhibit high frequency genomic alterations in human cancer, Proc. Natl. Acad. Sci. USA, 103, 9136, 10.1073/pnas.0508889103 · DOI
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MicroRNA therapeutics: towards a new era for the management of cancer and other diseases
Rupaimoole, R., & Slack, F. J. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.246 · Cited by 4,741
Dang, C. V. (2012) · Cell · doi:10.1016/j.cell.2012.03.003 · Cited by 3,390
EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer
Singh, A., & Settleman, J. (2010) · Oncogene · doi:10.1038/onc.2010.215 · Cited by 2,545
The role of non-coding RNAs in oncology
Slack, F. J., & Chinnaiyan, A. M. (2019) · Cell · doi:10.1016/j.cell.2019.10.017 · Cited by 1,619
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Metadata
- Authors
- Kota, J., Chivukula, R. R., O'Donnell, K. A., Wentzel, E. A., Montgomery, C. L., Hwang, H.-W., Chang, T.-C., Vivekanandan, P., Torbenson, M., Clark, K. R., Mendell, J. R., & Mendell, J. T.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2009-06
- Volume
- 137
- Issue
- 6
- Pages
- 1005-1017
- ISSN
- 0092-8674
- PMC
- PMC2722880
- Cited by
- 1,452
- References
- 13
- Language
- en
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