The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Endothelial Cells Promote the Colorectal Cancer Stem Cell Phenotype through a Soluble Form of Jagged-1
Open accessAbstract
SUMMARY We report a paracrine effect whereby endothelial cells (ECs) promote the cancer stem cell (CSC) phenotype of human colorectal cancer (CRC) cells. We showed that, without direct cell-cell contact, ECs secrete factors that promoted the CSC phenotype in CRC cells via Notch activation. In human CRC specimens, CD133 and Notch intracellular domain-positive cells co-localized with CRC cells in perivascular regions. An EC-derived, soluble form of Jagged-1, via ADAM17 proteolytic activity, led to Notch activation in CRC cells in a paracrine manner; these effects were blocked by immunodepletion of Jagged-1 in EC conditioned medium or blockade of ADAM17 activity. ECs play an active role in promoting Notch signaling and the CSC phenotype by secreting soluble Jagged-1.
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Metadata
- Authors
- Lu, J., Ye, X., Fan, F., Xia, L., Bhattacharya, R., Bellister, S., Tozzi, F., Sceusi, E., Zhou, Y., Tachibana, I., Maru, D. M., Hawke, D. H., Rak, J., Mani, S. A., Zweidler-McKay, P., & Ellis, L. M.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2013-02
- Volume
- 23
- Issue
- 2
- Pages
- 171-185
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2036797607
- Cited by
- 447
- References
- 45
- FWCI
- 21.98
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lu, J., Ye, X., Fan, F., Xia, L., Bhattacharya, R., Bellister, S., Tozzi, F., Sceusi, E., Zhou, Y., Tachibana, I., Maru, D. M., Hawke, D. H., Rak, J., Mani, S. A., Zweidler-McKay, P., & Ellis, L. M. (2013). Endothelial Cells Promote the Colorectal Cancer Stem Cell Phenotype through a Soluble Form of Jagged-1. Cancer Cell. https://doi.org/10.1016/j.ccr.2012.12.021
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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