The DOI matches its Crossref record; 215 of the 215 references it cites were found in a registry or an index.
The Varied Roles of Notch in Cancer
Open accessAbstract
Notch receptors influence cellular behavior by participating in a seemingly simple signaling pathway, but outcomes produced by Notch signaling are remarkably varied depending on signal dose and cell context. Here, after briefly reviewing new insights into physiologic mechanisms of Notch signaling in healthy tissues and defects in Notch signaling that contribute to congenital disorders and viral infection, we discuss the varied roles of Notch in cancer, focusing on cell autonomous activities that may be either oncogenic or tumor suppressive.
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Cites
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Notch1 mutations drive clonal expansion in normal esophageal epithelium but impair tumor growth
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Metadata
- Authors
- Aster, J. C., Pear, W. S., & Blacklow, S. C.
- Venue
- Annual Review of Pathology: Mechanisms of Disease
- Publisher
- Annual Reviews
- Published
- 2017-01-24
- Volume
- 12
- Issue
- 1
- Pages
- 245-275
- ISSN
- 1553-4006 (ISSN-L)
- 1553-4014
- OpenAlex
- W2419558864
- Cited by
- 710
- References
- 215
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Aster, J. C., Pear, W. S., & Blacklow, S. C. (2017). The Varied Roles of Notch in Cancer. Annual Review of Pathology: Mechanisms of Disease. https://doi.org/10.1146/annurev-pathol-052016-100127
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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