The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Mutant p53 Prolongs NF-κB Activation and Promotes Chronic Inflammation and Inflammation-Associated Colorectal Cancer
Open accessAbstract
Summary The tumor suppressor p53 is frequently mutated in human cancer. Common mutant p53 (mutp53) isoforms can actively promote cancer through gain-of-function (GOF) mechanisms. We report that mutp53 prolongs TNF-α-induced NF-κB activation in cultured cells and intestinal organoid cultures. Remarkably, when exposed to dextran sulfate sodium (DSS), mice harboring a germline p53 mutation develop severe chronic inflammation and persistent tissue damage, and are highly prone to inflammation-associated colon cancer. This mutp53 GOF is manifested by rapid onset of flat dysplastic lesions that progress to invasive carcinoma with mutp53 accumulation and augmented NF-κB activation, faithfully recapitulating features frequently observed in human colitis-associated colorectal cancer (CAC). These findings might explain the early appearance of p53 mutations in human CAC.
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Metadata
- Authors
- Cooks, T., Pateras, I. S., Tarcic, O., Solomon, H., Schetter, A. J., Wilder, S., Lozano, G., Pikarsky, E., Forshew, T., Rozenfeld, N., Harpaz, N., Itzkowitz, S., Harris, C. C., Rotter, V., Gorgoulis, V. G., & Oren, M.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2013-05
- Volume
- 23
- Issue
- 5
- Pages
- 634-646
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W1987912339
- Cited by
- 466
- References
- 11
- FWCI
- 18.81
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Cooks, T., Pateras, I. S., Tarcic, O., Solomon, H., Schetter, A. J., Wilder, S., Lozano, G., Pikarsky, E., Forshew, T., Rozenfeld, N., Harpaz, N., Itzkowitz, S., Harris, C. C., Rotter, V., Gorgoulis, V. G., & Oren, M. (2013). Mutant p53 Prolongs NF-κB Activation and Promotes Chronic Inflammation and Inflammation-Associated Colorectal Cancer. Cancer Cell. https://doi.org/10.1016/j.ccr.2013.03.022
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