The first 30 years of p53: growing ever more complex.

WAF1, a potential mediator of p53 tumor suppression

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

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p53, guardian of the genome

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The retinoblastoma protein and cell cycle control

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In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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Mdm2 promotes the rapid degradation of p53

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Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

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The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

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Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

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Participation of p53 protein in the cellular response to DNA damage.

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Regulation of p53 stability by Mdm2

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Blinded by the Light: The Growing Complexity of p53

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

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A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

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A microRNA component of the p53 tumour suppressor network

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Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

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Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

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T antigen is bound to a host protein in SY40-transformed cells

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p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

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p63, a p53 Homolog at 3q27–29, Encodes Multiple Products with Transactivating, Death-Inducing, and Dominant-Negative Activities

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Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

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Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas

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Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis

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Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

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Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis

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The p53 proto-oncogene can act as a suppressor of transformation

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Definition of a consensus binding site for p53

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Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

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Restoration of p53 function leads to tumour regression in vivo

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Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

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The p53-mdm-2 autoregulatory feedback loop.

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Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

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p53 Has a Direct Apoptogenic Role at the Mitochondria

Mihara, M., Erster, S. H., Zaika, A. I., Petrenko, O., Chittenden, T. D., Pančoška, P., & Moll, U. M. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00050-9 · Cited by 1,771 · see citing works

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

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Monoallelically Expressed Gene Related to p53 at 1p36, a Region Frequently Deleted in Neuroblastoma and Other Human Cancers

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AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

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A novel form of Epstein-Barr virus latency in normal B cells in vivo

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Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19

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SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

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p53 mutant mice that display early ageing-associated phenotypes

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Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

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Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

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Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

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Transcriptional Activation of miR-34a Contributes to p53-Mediated Apoptosis

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Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

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DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA

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mdm2 expression is induced by wild type p53 activity.

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Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

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Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

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A Single Nucleotide Polymorphism in the MDM2 Promoter Attenuates the p53 Tumor Suppressor Pathway and Accelerates Tumor Formation in Humans

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The coordinate regulation of the p53 and mTOR pathways in cells

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Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li–Fraumeni syndrome

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Activating Mutations for Transformation by p53 Produce a Gene Product That Forms an hsc70-p53 Complex with an Altered Half-Life

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When mutants gain new powers: News from the mutant p53 field

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p53-Mediated Activation of miRNA34 Candidate Tumor-Suppressor Genes

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The antioxidant function of the p53 tumor suppressor

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Cytoplasmic functions of the tumour suppressor p53

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Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

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Identification of p53 as a Sequence-Specific DNA-Binding Protein

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Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound

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p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis.

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Dynamics of the p53-Mdm2 feedback loop in individual cells

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p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

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p53 and metabolism

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ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

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Differential Regulation of microRNAs by p53 Revealed by Massively Parallel Sequencing: miR-34a is a p53 Target That Induces Apoptosis and G1-arrest

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Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells

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Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

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UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells

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Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

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Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells

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p53 isoforms can regulate p53 transcriptional activity

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Presence of a Potent Transcription Activating Sequence in the p53 Protein

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p53 Functions as a Cell Cycle Control Protein in Osteosarcomas

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Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

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The p53–Mdm2 module and the ubiquitin system

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Small molecule RITA binds to p53, blocks p53–HDM-2 interaction and activates p53 function in tumors

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Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients

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A Transcriptionally Active DNA-Binding Site for Human p53 Protein Complexes

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Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation

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Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse.

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Heterozygous Germline Mutations in the p53 Homolog p63 Are the Cause of EEC Syndrome

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Participation of p53 cellular tumour antigen in transformation of normal embryonic cells

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Retrovirus–mediated wild–type P53 gene transfer to tumors of patients with lung cancer.

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Wild-type p53 can inhibit oncogene-mediated focus formation.

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p53 polymorphisms: cancer implications

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