Vascular RhoJ Is an Effective and Selective Target for Tumor Angiogenesis and Vascular Disruption

Hallmarks of Cancer: The Next Generation

Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590

Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

Hanahan, D., & Folkman, J. (1996) · Cell · doi:10.1016/s0092-8674(00)80108-7 · Cited by 6,885

Molecular mechanisms and clinical applications of angiogenesis

Carmeliet, P., & Jain, R. K. (2011) · Nature · doi:10.1038/nature10144 · Cited by 5,467

Modes of resistance to anti-angiogenic therapy

Bergers, G., & Hanahan, D. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2442 · Cited by 2,953 · cited 2×

Angiogenesis as a therapeutic target

Ferrara, N., & Kerbel, R. S. (2005) · Nature · doi:10.1038/nature04483 · Cited by 2,653

Drug Resistance and the Solid Tumor Microenvironment

Tredan, O., Galmarini, C. M., Patel, K., & Tannock, I. F. (2007) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djm135 · Cited by 2,116 · cited 6×

VEGF-targeted therapy: mechanisms of anti-tumour activity

Ellis, L. M., & Hicklin, D. J. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2403 · Cited by 1,673

Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors

Casanovas, O., Hicklin, D. J., Bergers, G., & Hanahan, D. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.09.005 · Cited by 1,621

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis

Wang, Y., Nakayama, M., Pitulescu, M. E., Schmidt, T., Bochenek, M. L., Sakakibara, A., Adams, S., Davy, A., Deutsch, U., Lüthi, U., et al. (2010) · Nature · doi:10.1038/nature09002 · Cited by 1,276

Mechanisms of adverse effects of anti-VEGF therapy for cancer

Kamba, T., & McDonald, D. M. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6603813 · Cited by 1,013

Angiogenic signaling pathways and anti-angiogenic therapy for cancer

Liu, Z., Chen, H., Zheng, L., Sun, L., & Shi, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01460-1 · Cited by 1,486

Rho GTPase signalling in cell migration

Ridley, A. J. (2015) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2015.08.005 · Cited by 764

Combination of anti-angiogenic therapy and immune checkpoint blockade normalizes vascular-immune crosstalk to potentiate cancer immunity

Lee, W. S., Yang, H., Chon, H. J., & Kim, C. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-00500-y · Cited by 736

Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature)

Smolarz, B., Szyłło, K., & Romanowicz, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910554 · Cited by 560

Normalization of Tumor Vessels by Tie2 Activation and Ang2 Inhibition Enhances Drug Delivery and Produces a Favorable Tumor Microenvironment

Park, J.-S., Kim, I.-K., Han, S., Park, I., Kim, C., Bae, J., Oh, S. J., Lee, S., Kim, J. H., Woo, D.-C., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.10.018 · Cited by 327

STING activation reprograms tumor vasculatures and synergizes with VEGFR2 blockade

Yang, H., Lee, W. S., Kong, S. J., Kim, C. G., Kim, J. H., Chang, S. K., Kim, S., Kim, G., Chon, H. J., & Kim, C. (2019) · Journal of Clinical Investigation · doi:10.1172/jci125413 · Cited by 316

Role of glutamine synthetase in angiogenesis beyond glutamine synthesis

Eelen, G., Dubois, C., Cantelmo, A. R., Goveia, J., Brüning, U., DeRan, M., Jarugumilli, G., van Rijssel, J., Saladino, G., Comitani, F., et al. (2018) · Nature · doi:10.1038/s41586-018-0466-7 · Cited by 220

RHOJ controls EMT-associated resistance to chemotherapy

Debaugnies, M., Rodríguez‐Acebes, S., Blondeau, J., Parent, M.-A., Zocco, M., Song, Y., Maertelaer, V. D., Moers, V., Latil, M., Dubois, C., et al. (2023) · Nature · doi:10.1038/s41586-023-05838-7 · Cited by 221

Blocking Blood Flow to Solid Tumors by Destabilizing Tubulin: An Approach to Targeting Tumor Growth

Pérez‐Pérez, M., Priego, E., Bueno, O., Martins, M. S., Canela, M., & Liekens, S. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b00463 · Cited by 187

Rho GTPases modulate malignant transformation of tumor cells

Orgaz, J. L., Herráiz, C., & Sanz‐Moreno, V. (2014) · Small GTPases · doi:10.4161/sgtp.29019 · Cited by 192

Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy

Jung, K., Heishi, T., Khan, O. F., Kowalski, P. S., Incio, J., Rahbari, N. N., Chung, E., Clark, J. W., Willett, C. G., Luster, A. D., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci93182 · Cited by 164

Tumor Microenvironment Remodeling by Intratumoral Oncolytic Vaccinia Virus Enhances the Efficacy of Immune-Checkpoint Blockade

Chon, H. J., Lee, W. S., Yang, H., Kong, S. J., Lee, N. K., Moon, E. S., Choi, J., Han, E. C., Kim, J. H., Ahn, J. B., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-1932 · Cited by 158

Impaired angiopoietin/Tie2 signaling compromises Schlemm’s canal integrity and induces glaucoma

Kim, J., Park, D. Y., Bae, H., Park, D. Y., Kim, D., Lee, C., Song, S., Chung, T.-Y., Lim, D. H., Kubota, Y., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci94668 · Cited by 134

Pancreatic adenocarcinomas with mature blood vessels have better overall survival

Katsuta, E., Qi, Q., Peng, X., Hochwald, S. N., Yan, L., & Takabe, K. (2019) · Scientific Reports · doi:10.1038/s41598-018-37909-5 · Cited by 131

Angiogenesis biomarkers and their targeting ligands as potential targets for tumor angiogenesis

Mashreghi, M., Azarpara, H., Bazaz, M. R., Jafari, A., Masoudifar, A., Mirzaei, H., & Jaafari, M. R. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26049 · Cited by 129

Comprehensive Proteomics Analysis Reveals Metabolic Reprogramming of Tumor-Associated Macrophages Stimulated by the Tumor Microenvironment

Liu, D., Chang, C., Lü, N., Wang, X., Lu, Q., Ren, X., Ren, P., Zhao, D., Wang, L., Zhu, Y., et al. (2016) · Journal of Proteome Research · doi:10.1021/acs.jproteome.6b00604 · Cited by 122

Vascular Normalization: A New Window Opened for Cancer Therapies

Yang, T., Xiao, H., Liu, X., Wang, Z., Zhang, Q., Wei, N., & Guo, X. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.719836 · Cited by 126

STING activation normalizes the intraperitoneal vascular-immune microenvironment and suppresses peritoneal carcinomatosis of colon cancer

Lee, S. J., Yang, H., Kim, W. R., Lee, Y. S., Lee, W. S., Kong, S. J., Lee, H. J., Kim, J. H., Cheon, J., Kang, B., et al. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-002195 · Cited by 118

The development of site-specific drug delivery nanocarriers based on receptor mediation

Wang, X., Li, S., Shi, Y., Chuan, X., Li, J., Zhong, T., Zhang, H., Dai, W., He, B., & Zhang, Q. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.05.028 · Cited by 113

Rho-Associated Coiled-Coil Kinase (ROCK) in Molecular Regulation of Angiogenesis

Liu, J., Wada, Y., Katsura, M., Tozawa, H., Erwin, N. A., Kapron, C. M., Bao, G., & Liu, J. (2018) · Theranostics · doi:10.7150/thno.30305 · Cited by 117

Vascular disrupting agent induced aggregation of gold nanoparticles for photothermally enhanced tumor vascular disruption

Hong, S., Zheng, D., Zhang, C., Huang, Q., Cheng, S., & Zhang, X. (2020) · Science Advances · doi:10.1126/sciadv.abb0020 · Cited by 106

Baicalein: A metabolite with promising antineoplastic activity

Tuli, H. S., Aggarwal, V., Kaur, J., Aggarwal, D., Parashar, G., Parashar, N. C., Tuorkey, M. J., Kaur, G., Savla, R., Sak, K., et al. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118183 · Cited by 102

Endothelial deletion of SHP2 suppresses tumor angiogenesis and promotes vascular normalization

Xu, Z., Guo, C., Ye, Q., Shi, Y., Sun, Y., Zhang, J., Huang, J., Huang, Y., Zeng, C., Zhang, X. Z., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26697-8 · Cited by 100

Diosmetin inhibits tumor development and block tumor angiogenesis in skin cancer

Choi, J., Lee, D.-H., Park, S., & Seol, J. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109091 · Cited by 85

Anti-angiogenesis in cancer therapeutics: the magic bullet

Oguntade, A. S., Al-Amodi, F., Alrumayh, A., Alobaida, M., & Bwalya, M. (2021) · Journal of the Egyptian National Cancer Institute · doi:10.1186/s43046-021-00072-6 · Cited by 86

Metabolic Signatures of Distinct Endothelial Phenotypes

Dumas, S. J., García‐Caballero, M., & Carmeliet, P. (2020) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2020.05.009 · Cited by 82

Intracellular endothelial cell metabolism in vascular function and dysfunction

Citrin, K. M., Chaube, B., Fernandez-Hernando, C. F., & Suárez, Y. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.11.004 · Cited by 81

Rho-associated kinase signalling and the cancer microenvironment: novel biological implications and therapeutic opportunities

Chin, V. T., Nagrial, A. M., Chou, A. S. Y., Biankin, A. V., Gill, A. J., Timpson, P., & Pajic, M. (2015) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2015.17 · Cited by 71

ARHGAP18: an endogenous inhibitor of angiogenesis, limiting tip formation and stabilizing junctions

Chang, G., Lay, A. J., Ting, K. K., Zhao, Y., Coleman, P. R., Powter, E. E., Formaz‐Preston, A., Jolly, C. J., Bower, N. I., Hogan, B. M., et al. (2014) · Small GTPases · doi:10.4161/21541248.2014.975002 · Cited by 72

Piezo2 protein: A novel regulator of tumor angiogenesis and hyperpermeability

Yang, H., Liu, C., Zhou, R., Yao, J., Li, X., Shen, Y., Cheng, H., Yuan, J., Yan, B., & Jiang, Q. (2016) · Oncotarget · doi:10.18632/oncotarget.10134 · Cited by 67

Oncolytic vaccinia virus reinvigorates peritoneal immunity and cooperates with immune checkpoint inhibitor to suppress peritoneal carcinomatosis in colon cancer

Lee, Y. S., Lee, W. S., Kim, C. W., Lee, S. J., Yang, H. J., Kong, S. J., Ning, J., Kang, B., Kang, B., Kim, W. R., et al. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-000857 · Cited by 62

Tumor vessel normalization by the PI3K inhibitor HS-173 enhances drug delivery

Kim, S. J., Jung, K. H., Son, M. K., Park, J. H., YAN, H. H., Fang, Z., Kang, Y. W., Han, B., Lim, J. H., & Hong, S. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.06.035 · Cited by 60

The dynamics of Rho GTPase signaling and implications for targeting cancer and the tumor microenvironment

Pajic, M., Herrmann, D., Vennin, C., Conway, J. R. W., Chin, V. T., Johnsson, A., Welch, H. C. E., & Timpson, P. (2015) · Small GTPases · doi:10.4161/21541248.2014.973749 · Cited by 57

RhoJ interacts with the GIT-PIX complex and regulates focal adhesion disassembly

Wilson, E., Leszczyńska, K. B., Poulter, N. S., Edelmann, F., Salisbury, V. A., Noy, P. J., Bacon, A., Rappoport, J. Z., Heath, J. K., Bicknell, R., et al. (2014) · Journal of Cell Science · doi:10.1242/jcs.140434 · Cited by 55

Combination Immunotherapies to Overcome Intrinsic Resistance to Checkpoint Blockade in Microsatellite Stable Colorectal Cancer

Kim, C. W., Chon, H. J., & Kim, C. (2021) · Cancers · doi:10.3390/cancers13194906 · Cited by 56

Rho-Family Small GTPases: From Highly Polarized Sensory Neurons to Cancer Cells

Ueyama, T. (2019) · Cells · doi:10.3390/cells8020092 · Cited by 48

Angiotensin-converting enzyme inhibitor promotes angiogenesis through Sp1/Sp3-mediated inhibition of notch signaling in male mice

Lu, H., Yuan, P., Ma, X., Jiang, X., Liu, S., Ma, C., Philipsen, S., Zhang, Q., Yang, J., Xu, F., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36409-z · Cited by 48

Analysis of Body-wide Unfractionated Tissue Data to Identify a Core Human Endothelial Transcriptome

Butler, L. M., Hallström, B. M., Fagerberg, L., Pontén, F., Uhlén, M., Renné, T., & Odeberg, J. (2016) · Cell Systems · doi:10.1016/j.cels.2016.08.001 · Cited by 43

Tumor vasculature remolding by thalidomide increases delivery and efficacy of cisplatin

Shen, Y., Li, S., Wang, X., Wang, M., Tian, Q., Yang, J., Wang, B., Wang, B., Liu, P., & Yang, J. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1366-x · Cited by 46

Targeted delivery of nano-radiosensitizers for tumor radiotherapy

Shi, S., Zhong, H., Zhang, Y., & Mei, Q. (2024) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2024.216101 · Cited by 44

The molecular mechanism of baicalein repressing progression of gastric cancer mediating miR-7/FAK/AKT signaling pathway

Qiao, D., Xing, J., Duan, Y., Wang, S., Yao, G., Zhang, S., Jin, J., Lin, Z., Chen, L., & Piao, Y. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154046 · Cited by 41

Actin cytoskeleton in angiogenesis

Nair, N., Samuel, V., Ramesh, L., Marib, A., David, D. T., & Sundararaman, A. (2022) · Biology Open · doi:10.1242/bio.058899 · Cited by 42

Identification and validation of gene module associated with lung cancer through coexpression network analysis

Liu, R., Cheng, Y., Yu, J., Lv, Q., & Zhou, H. (2015) · Gene · doi:10.1016/j.gene.2015.03.008 · Cited by 41

RHOJ Induces Epithelial-to-Mesenchymal Transition by IL-6/STAT3 to Promote Invasion and Metastasis in Gastric Cancer

Ma, Z., Sun, Q., Zhang, C., Zheng, Q., Liu, Y., Xu, H., He, Y., Yao, C., Chen, J., & Xia, H. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.81972 · Cited by 40

RhoJ facilitates angiogenesis in glioblastoma via JNK/VEGFR2 mediated activation of PAK and ERK signaling pathways

Wang, M., Zhang, C., Zheng, Q., Ma, Z., Qi, M., Di, G., Ling, S., Xu, H., Qi, B., Yao, C., et al. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.65653 · Cited by 40

RhoJ Regulates α5β1 Integrin Trafficking to Control Fibronectin Remodeling during Angiogenesis

Sundararaman, A., Fukushima, Y., Norman, J. C., Uemura, A., & Mellor, H. (2020) · Current Biology · doi:10.1016/j.cub.2020.03.042 · Cited by 39

Anti-RhoJ antibody functionalized Au@I nanoparticles as CT-guided tumor vessel-targeting radiosensitizers in patient-derived tumor xenograft model

Liu, S., Li, H., Xia, L., Xu, P., Ding, Y., Huo, D., & Hu, Y. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.06.036 · Cited by 38

Building Blood Vessels—One Rho GTPase at a Time

Barlow, H. R., & Cleaver, O. B. (2019) · Cells · doi:10.3390/cells8060545 · Cited by 36

Baicalein inhibits tumor progression by inhibiting tumor cell growth and tumor angiogenesis

Park, Y.-G., Choi, J., Jung, H.-K., Kim, B., Kim, C., Park, S., & Seol, J.-W. (2017) · Oncology Reports · doi:10.3892/or.2017.6007 · Cited by 35

RhoJ integrates attractive and repulsive cues in directional migration of endothelial cells

Fukushima, Y., Nishiyama, K., Kataoka, H., Fruttiger, M., Fukuhara, S., Nishida, K., Mochizuki, N., Kurihara, H., Nishikawa, S., & Uemura, A. (2020) · The EMBO Journal · doi:10.15252/embj.2019102930 · Cited by 32

Targeting of MCT1 and PFKFB3 influences cell proliferation and apoptosis in bladder cancer by altering the tumor microenvironment

Hu, K., Wang, D. G., Liu, P. F., Cao, Y. W., Wang, Y. H., Yang, X. C., Hu, C., Sun, L. J., & Niu, H. T. (2016) · Oncology Reports · doi:10.3892/or.2016.4884 · Cited by 33

Dysregulation of endothelial colony-forming cell function by a negative feedback loop of circulating miR-146a and -146b in cardiovascular disease patients

Chang, T.-Y., Tsai, W.-C., Huang, T.-S., Su, S., Chang, C.-Y., Ma, H.-Y., Wu, C., Yang, C., Lin, C.-H., Huang, P.-H., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0181562 · Cited by 32

The Formin FMNL3 Controls Early Apical Specification in Endothelial Cells by Regulating the Polarized Trafficking of Podocalyxin

Richards, M., Hetheridge, C., & Mellor, H. (2015) · Current Biology · doi:10.1016/j.cub.2015.07.045 · Cited by 32

Targeted Therapy for Breast Cancer Stem Cells by Liposomal Delivery of siRNA against Fibronectin EDB

Sun, Y., Kim, H. S., Saw, P. E., Jon, S., & Moon, W. K. (2015) · Advanced Healthcare Materials · doi:10.1002/adhm.201500190 · Cited by 30

New variants near RHOJ and C2, HLA-DRA region and susceptibility to endometriosis in the Polish population-The genome-wide association study

Sobalska-Kwapis, M., Smolarz, B., Słomka, M., Szaflik, T., Kępka, E., Kulig, B., Siewierska-Górska, A., Polak, G., Romanowicz, H., Strapagiel, D., et al. (2017) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2017.08.037 · Cited by 29

RGD-decorated redox-responsive d -α-tocopherol polyethylene glycol succinate–poly(lactide) nanoparticles for targeted drug delivery

Guo, Y., Niu, B., Song, Q., Zhao, Y., Bao, Y., Tan, S., Si, L., & Zhang, Z. (2016) · Journal of Materials Chemistry B · doi:10.1039/c6tb00055j · Cited by 29

Small GTPases orchestrate cell-cell communication during collective cell movement

Combedazou, A., Gayral, S., Colombié, N., Fougerat, A., Laffargue, M., & Ramel, D. (2017) · Small GTPases · doi:10.1080/21541248.2017.1366965 · Cited by 28

Novel Glycosylated VEGF Decoy Receptor Fusion Protein, VEGF-Grab, Efficiently Suppresses Tumor Angiogenesis and Progression

Lee, J., Kim, C., Yang, H., Park, I., Oh, N., Hua, S. S., Jeong, H., An, H. J., Kim, S. C., Lee, G. M., et al. (2014) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-14-0968-t · Cited by 30

Coordinated reprogramming of renal cancer transcriptome, metabolome and secretome associates with immune tumor infiltration

Popławski, P., Alseekh, S., Jankowska, U., Skupień-Rabian, B., Iwanicka‐Nowicka, R., Kossowska, H., Fogtman, A., Rybicka, B., Bogusławska, J., Adamiok‐Ostrowska, A., et al. (2023) · Cancer Cell International · doi:10.1186/s12935-022-02845-y · Cited by 28

Tie2-mediated vascular remodeling by ferritin-based protein C nanoparticles confers antitumor and anti-metastatic activities

Choi, Y. S., Jang, H., Gupta, B., Jeong, J.-H., Ge, Y., Yong, C. S., Kim, J. O., Bae, J., Song, I., Kim, I., et al. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00952-9 · Cited by 26

Rhoj Is a Novel Target for Progression and Invasion of Glioblastoma by Impairing Cytoskeleton Dynamics

Wang, M., Jiang, X., Yang, Y., Chen, H., Zhang, C., Xu, H., Qi, B., Yao, C., & Xia, H. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00910-w · Cited by 25

The RhoJ-BAD signaling network: An Achilles’ heel for BRAF mutant melanomas

Ruiz, R., Jahid, S., Harris, M. L., Marzese, D. M., Espitia, F., Vasudeva, P., Chen, C., de Feraudy, S. M., Wu, J., Gillen, D. L., et al. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006913 · Cited by 25

Bioresponsive nanoreactor initiates cascade reactions for tumor vascular normalization and lactate depletion to augment immunotherapy

Chen, J., Bu, C., Lu, Y., Peng, X., Yu, J., Ding, X., Yuan, P., & Hong, S. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123100 · Cited by 25

Rho GTPases in Retinal Vascular Diseases

Uemura, A., & Fukushima, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073684 · Cited by 23

ETV2 (Ets Variant Transcription Factor 2)- Rhoj Cascade Regulates Endothelial Progenitor Cell Migration During Embryogenesis

Singh, B. N., Sierra-Pagán, J. E., Gong, W., Das, S., Theisen, J. W. M., Skie, E., Garry, M. G., & Garry, D. J. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.314488 · Cited by 23

Afadin Facilitates Vascular Endothelial Growth Factor–Induced Network Formation and Migration of Vascular Endothelial Cells by Inactivating Rho-Associated Kinase Through ArhGAP29

Tagashira, T., Fukuda, T., Miyata, M., Nakamura, K., Fujita, H., Takai, Y., Hirata, K., & Rikitake, Y. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.310991 · Cited by 22

The Genetic Background of Endometriosis: Can ESR2 and CYP19A1 Genes Be a Potential Risk Factor for Its Development?

Smolarz, B., Szyłło, K., & Romanowicz, H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218235 · Cited by 23

Rho GTPase RhoJ is Associated with Gastric Cancer Progression and Metastasis

Kim, C., Yang, H., Park, I., Chon, H. J., Kim, J. H., Kwon, W. S., Lee, W. S., Kim, T. S., & Rha, S. Y. (2016) · Journal of Cancer · doi:10.7150/jca.15578 · Cited by 22

Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer

Jahid, S., Ortega, J. A., Vuong, L. M., Acquistapace, I. M., Hachey, S. J., Flesher, J. L., La Serra, M. A., Brindani, N., La Sala, G., Manigrasso, J., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110641 · Cited by 21

Inhibiting endothelial Rhoj blocks profibrotic vascular intussusception and angiocrine factors to sustain lung regeneration

Ma, J., Zhang, L., Zhang, X., Zhang, L., Zhang, H., Zhu, Y., Huang, X., Zhang, T., Tang, X., Wang, Y., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.ado5266 · Cited by 22

Systemic Delivery of a STING Agonist‐Loaded Positively Charged Liposome Selectively Targets Tumor Immune Microenvironment and Suppresses Tumor Angiogenesis

Go, E., Yang, H., Park, W., Lee, S. J., Han, J., Kong, S. J., Lee, W. S., Han, D. K., Chon, H. J., & Kim, C. (2023) · Small · doi:10.1002/smll.202300544 · Cited by 21

RhoJ promotes hypoxia induced endothelial‐to‐mesenchymal transition by activating WDR5 expression

Liu, L., Chen, J., Sun, L., & Xu, Y. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26505 · Cited by 21

Positioning Remodeling Nanogels Mediated Codelivery of Antivascular Drug and Autophagy Inhibitor for Cooperative Tumor Therapy

Zhang, H., Ren, Y., Hou, L., Chang, J., Zhang, Z., & Zhang, H. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b22412 · Cited by 21

Guanine nucleotide exchange factors for Rho GTPases (RhoGEFs) as oncogenic effectors and strategic therapeutic targets in metastatic cancer

Cervantes‐Villagrana, R. D., García‐Jiménez, I., & Vázquez‐Prado, J. (2023) · Cellular Signalling · doi:10.1016/j.cellsig.2023.110749 · Cited by 20

Ultrasound Imaging of Tumor Vascular CD93 with MMRN2 Modified Microbubbles for Immune Microenvironment Prediction

Wang, D., Xing, C., Liang, Y., Wang, C., Zhao, P., Liang, X. H., Li, Q., & Yuan, L. (2024) · Advanced Materials · doi:10.1002/adma.202310421 · Cited by 20

The Adhesome Network: Key Components Shaping the Tumour Stroma

Nikolopoulou, P., Koufaki, M. A., & Kostourou, V. (2021) · Cancers · doi:10.3390/cancers13030525 · Cited by 23

Design, Synthesis, In Vitro and In Vivo Characterization of CDC42 GTPase Interaction Inhibitors for the Treatment of Cancer

Brindani, N., Vuong, L. M., Acquistapace, I. M., Serra, M. A. L., Ortega, J. A., Veronesi, M., Bertozzi, S. M., Summa, M., Girotto, S., Bertorelli, R., et al. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c00276 · Cited by 18

Identify potential drugs for cardiovascular diseases caused by stress-induced genes in vascular smooth muscle cells

Huang, C., Ciou, J.-S., Chen, S.-T., Kok, V. C., Chung, Y., Tsai, J. J. P., Kurubanjerdjit, N., Huang, C. F., & Ng, K. (2016) · PeerJ · doi:10.7717/peerj.2478 · Cited by 22

Epigenetic activation of the small GTPase TCL contributes to colorectal cancer cell migration and invasion

Chen, B., Fan, Z., Sun, L., Chen, J., Feng, Y., Fan, X., & Xu, Y. (2020) · Oncogenesis · doi:10.1038/s41389-020-00269-9 · Cited by 18

Xanthohumol: A Metabolite with Promising Anti-Neoplastic Potential

Tuli, H. S., Aggarwal, V., Parashar, G., Aggarwal, D., Parashar, N. C., Tuorkey, M. J., Varol, M., Sak, K., Kumar, M., & Buttar, H. S. (2021) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520621666210223095021 · Cited by 18

The Role of RhoJ in Endothelial Cell Biology and Tumor Pathology

Shi, T., Li, G., & Xiao, H. (2016) · BioMed Research International · doi:10.1155/2016/6386412 · Cited by 18

A functional antagonism between RhoJ and Cdc42 regulates fibronectin remodelling during angiogenesis

Sundararaman, A., & Mellor, H. (2020) · Small GTPases · doi:10.1080/21541248.2020.1809927 · Cited by 18

Activation of TC10-Like Transcription by Lysine Demethylase KDM4B in Colorectal Cancer Cells

Chen, B., Zhu, Y., Chen, J., Feng, Y., & Xu, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.617549 · Cited by 17

OVOL2 impairs RHO GTPase signaling to restrain mitosis and aggressiveness of Anaplastic Thyroid Cancer

Gugnoni, M., Manzotti, G., Vitale, E., Sauta, E., Torricelli, F., Reggiani, F., Pistoni, M., Piana, S., & Ciarrocchi, A. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02316-2 · Cited by 16

Endostar, a Modified Endostatin Induces Vascular Normalization to Improve Chemotherapy Efficacy Through Suppression of Src Signaling Pathway

Yu, M., Yao, H., Zhuo, H., & Zhang, S. (2018) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.2017.2399 · Cited by 16

Regulating Aggregation‐Induced Emission Luminogen for Multimodal Imaging‐Navigated Synergistic Therapy Involving Anti‐Angiogenesis

Zhang, F., Cui, J. W., Zhang, Y., Yan, M., Wu, X., Liu, X., Yan, D., Zhang, Z., Han, T., Tan, H. F., et al. (2024) · Advanced Science · doi:10.1002/advs.202302713 · Cited by 15

Protumoral bone marrow-derived cells migrate via Gβγ-dependent signaling pathways and exhibit a complex repertoire of RhoGEFs

Cervantes‐Villagrana, R. D., Color-Aparicio, V. M., Reyes‐Cruz, G., & Vázquez‐Prado, J. (2019) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-018-00502-6 · Cited by 15

Preclinical Efficacy and Safety of VEGF-Grab, a Novel Anti-VEGF Drug, and Its Comparison to Aflibercept

Hong, H. K., Park, Y. J., Kim, D. K., Ryoo, N.-K., Ko, Y.-J., Park, K. H., Kim, H. M., & Woo, S. J. (2020) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.61.13.22 · Cited by 15

Repression of RhoJ expression promotes TGF-β-mediated EMT in human non-small-cell lung cancer A549cells

Nozaki, M., & Nishizuka, M. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.06.004 · Cited by 14

Gene Expression Signatures Predictive of Bevacizumab/Erlotinib Therapeutic Benefit in Advanced Nonsquamous Non–Small Cell Lung Cancer Patients (SAKK 19/05 trial)

Franzini, A., Baty, F., Macovei, I. I., Dürr, O., Droege, C., Betticher, D. C., Grigoriu, B. D., Klingbiel, D., Zappa, F., & Brutsche, M. H. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-3135 · Cited by 15

Rho kinase proteins display aberrant upregulation in vascular tumors and contribute to vascular tumor growth

Amaya, C. N., Mitchell, D., & Bryan, B. A. (2017) · BMC Cancer · doi:10.1186/s12885-017-3470-7 · Cited by 14

Long non-coding RNA AK001058 regulates tumor growth and angiogenesis in colorectal cancer via methylation of ADAMTS12.

Zheng, S., Feng, L., Zhang, M., Mu, N., Ge, X., & Fu, J. (2019) · PubMed Central · Cited by 13

Actin-Tethered Junctional Complexes in Angiogenesis and Lymphangiogenesis in Association with Vascular Endothelial Growth Factor

Zankov, D. P., & Ogita, H. (2015) · BioMed Research International · doi:10.1155/2015/314178 · Cited by 13

Bacterial particles retard tumor growth as a novel vascular disrupting agent

Guo, F., Ji, G., Li, Q., Yang, Y., Shui, L., Shen, Y., & Yang, H. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109757 · Cited by 12

Metabolic reprogramming of the ovarian cancer microenvironment in the development of antiangiogenic resistance

Yue, H., & Lü, X. (2023) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2023046 · Cited by 11

A Protective Role for RHOJ in NonSmall Cell Lung Cancer Based on Integrated Bioinformatics Analysis

Zeng, T., Chen, C., Yang, P., Zuo, W., Liu, X., & Zhang, Y. (2019) · Journal of Computational Biology · doi:10.1089/cmb.2019.0209 · Cited by 10

Identifying General Tumor and Specific Lung Cancer Biomarkers by Transcriptomic Analysis

Otálora-Otálora, B. A., Osuna-Garzón, D. A., Carvajal-Parra, M. S., Cañas, A., Montecino, M. A., López-Kleine, L., & Rojas, A. P. (2022) · Biology · doi:10.3390/biology11071082 · Cited by 10

Bioactive constituents of Salvia przewalskii and the molecular mechanism of its antihypoxia effects determined using quantitative proteomics

Wang, Y.-F., Duo, D., Yan, Y., He, R., Wang, S., Wang, A., & Wu, X. (2020) · Pharmaceutical Biology · doi:10.1080/13880209.2020.1762668 · Cited by 8

RhoJ: an emerging biomarker and target in cancer research and treatment

Shen, J., Su, X., Wang, S., Wang, Z., Zhong, C., Huang, Y., & Duan, S. (2024) · Cancer Gene Therapy · doi:10.1038/s41417-024-00792-6 · Cited by 8

TCL/RhoJ Plasma Membrane Localization and Nucleotide Exchange Is Coordinately Regulated by Amino Acids within the N Terminus and a Distal Loop Region

Ackermann, K. L., Gee, R. R. F., Reyes, S. S., Tader, B. R., & Hamann, M. J. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.750026 · Cited by 8

The Role of RhoJ in Endothelial Cell Biology and Tumor Pathology

Shi, T., Li, G., & Xiao, H. (2016) · BioMed Research International · doi:10.1155/2016/6386412 · Cited by 18

Ras homolog family member J (RHOJ)

(2014) · Science-Business eXchange · doi:10.1038/scibx.2014.170

CDC42-effector interaction inhibitors alter patterns of vessel arborization in skin and tumors in vivo

Vuong, L. M., Hachey, S. J., Shiu, J., Xie, D. F., Salvador, N., Brindani, N., Bertozzi, S. M., Summa, M., Bertorelli, R., Armirotti, A., et al. (2025) · iScience · doi:10.1016/j.isci.2025.112971 · Cited by 2

The VEGF/Rho GTPase signalling pathway: A promising target for anti-angiogenic/anti-invasion therapy

van der Meel, R., Symons, M. H., Kudernatsch, R., Kok, R. J., Schiffelers, R. M., Storm, G., Gallagher, W. M., & Byrne, A. T. (2011) · Drug Discovery Today · doi:10.1016/j.drudis.2011.01.005 · Cited by 73

Tumor Angiogenesis and Anti-angiogenic Therapy

Kubota, Y. (2012) · The Keio Journal of Medicine · doi:10.2302/kjm.61.47 · Cited by 132