The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Functional Heterogeneity of Genetically Defined Subclones in Acute Myeloid Leukemia
Open accessAbstract
Summary The relationships between clonal architecture and functional heterogeneity in acute myeloid leukemia (AML) samples are not yet clear. We used targeted sequencing to track AML subclones identified by whole genome sequencing using a variety of experimental approaches. We found that virtually all AML subclones trafficked from the marrow to the peripheral blood, but some were enriched in specific cell populations. Subclones showed variable engraftment potential in immunodeficient mice. Xenografts were predominantly comprised of a single genetically-defined subclone, but there was no predictable relationship between the engrafting subclone and the evolutionary hierarchy of the leukemia. These data demonstrate the importance of integrating genetic and functional data in studies of primary cancer samples, both in xenograft models and in patients.
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Cites
Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing
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Self-citationClonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing
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Self-citationThe origin and evolution of mutations in acute myeloid leukemia
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Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics
Morita, K., Wang, F., Jahn, K., Hu, T., Tanaka, T., Sasaki, Y., Kuipers, J., Loghavi, S., Wang, S. A., Yan, Y., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19119-8 · Cited by 383
Preclinical mouse solid tumour models: status quo, challenges and perspectives
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Metadata
- Authors
- Klco, J. M., Spencer, D. H., Miller, C. A., Griffith, M., Lamprecht, T. L., O’Laughlin, M., Fronick, C., Magrini, V., Demeter, R. T., Fulton, R. S., Eades, W. C., Link, D. C., Graubert, T. A., Walter, M. J., Mardis, E. R., Dipersio, J. F., Wilson, R. K., & Ley, T. J.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 25
- Issue
- 3
- Pages
- 379-392
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2087734794
- Cited by
- 395
- References
- 14
- FWCI
- 33.47
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Klco, J. M., Spencer, D. H., Miller, C. A., Griffith, M., Lamprecht, T. L., O’Laughlin, M., Fronick, C., Magrini, V., Demeter, R. T., Fulton, R. S., Eades, W. C., Link, D. C., Graubert, T. A., Walter, M. J., Mardis, E. R., Dipersio, J. F., Wilson, R. K., & Ley, T. J. (2014). Functional Heterogeneity of Genetically Defined Subclones in Acute Myeloid Leukemia. Cancer Cell. https://doi.org/10.1016/j.ccr.2014.01.031
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
